{"id":"https://openalex.org/W2064064360","doi":"https://doi.org/10.1016/j.juro.2011.02.1726","title":"1618 MULTIPHOTON MICROSCOPY PROVIDES VIRTUAL HISTOLOGY OF PROSTATIC AND PERIPROSTATIC STRUCTURES IN HUMAN RADICAL PROSTATECTOMY SPECIMENS","display_name":"1618 MULTIPHOTON MICROSCOPY PROVIDES VIRTUAL HISTOLOGY OF PROSTATIC AND PERIPROSTATIC STRUCTURES IN HUMAN RADICAL PROSTATECTOMY SPECIMENS","publication_year":2011,"publication_date":"2011-04-01","ids":{"openalex":"https://openalex.org/W2064064360","doi":"https://doi.org/10.1016/j.juro.2011.02.1726","mag":"2064064360"},"language":"en","primary_location":{"id":"doi:10.1016/j.juro.2011.02.1726","doi":"https://doi.org/10.1016/j.juro.2011.02.1726","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.juro.2011.02.1726","pdf_url":null,"source":{"id":"https://openalex.org/S30525748","display_name":"The Journal of Urology","issn_l":"0022-5347","issn":["0022-5347","1527-3792"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Urology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5081702838","display_name":"Sonal Grover","orcid":"https://orcid.org/0000-0002-2940-0177","observed_orcids":["https://orcid.org/0000-0002-2940-0177"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sonal Grover","raw_affiliation_strings":["New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"New York, NY","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025426969","display_name":"Prasanna Sooriakumaran","orcid":"https://orcid.org/0000-0002-1398-3961","observed_orcids":["https://orcid.org/0000-0002-1398-3961"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Prasanna Sooriakumaran","raw_affiliation_strings":["New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"New York, NY","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026214233","display_name":"Abhishek Srivastava","orcid":"https://orcid.org/0000-0002-9480-0847","observed_orcids":["https://orcid.org/0000-0002-9480-0847"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Abhishek Srivastava","raw_affiliation_strings":["New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"New York, NY","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103105550","display_name":"Michael P. Herman","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michael Herman","raw_affiliation_strings":["New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"New York, NY","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004218513","display_name":"Joshua Sterling","orcid":"https://orcid.org/0000-0002-7097-6485","observed_orcids":["https://orcid.org/0000-0002-7097-6485"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Joshua Sterling","raw_affiliation_strings":["New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"New York, NY","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034656949","display_name":"Robert A. Leung","orcid":"https://orcid.org/0009-0000-4971-0941","observed_orcids":["https://orcid.org/0009-0000-4971-0941"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Robert Leung","raw_affiliation_strings":["New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"New York, NY","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102872264","display_name":"Maria Shevchuk","orcid":"https://orcid.org/0009-0009-5768-8807","observed_orcids":["https://orcid.org/0009-0009-5768-8807"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Maria Shevchuk","raw_affiliation_strings":["New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"New York, NY","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031849699","display_name":"Sushmita Mukherjee","orcid":"https://orcid.org/0000-0002-7645-4725","observed_orcids":["https://orcid.org/0000-0002-7645-4725"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sushmita Mukherjee","raw_affiliation_strings":["New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"New York, NY","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5068285584","display_name":"Ashutosh Kumar Tewari","orcid":"https://orcid.org/0000-0002-3146-4524","observed_orcids":["https://orcid.org/0000-0002-3146-4524"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ashutosh Tewari","raw_affiliation_strings":["New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"New York, NY","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3000,"currency":"USD","value_usd":3000},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.18870408,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"185","issue":"4S","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10124","display_name":"Prostate Cancer Diagnosis and Treatment","score":0.8227999806404114,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10124","display_name":"Prostate Cancer Diagnosis and Treatment","score":0.8227999806404114,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10540","display_name":"Advanced Fluorescence Microscopy Techniques","score":0.05389999970793724,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.019099999219179153,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/multiphoton-microscopy","display_name":"multiphoton microscopy","score":0.9990000128746033},{"id":"https://openalex.org/keywords/virtual-histology","display_name":"virtual histology","score":0.9959999918937683},{"id":"https://openalex.org/keywords/prostate-cancer","display_name":"prostate cancer","score":0.7089999914169312},{"id":"https://openalex.org/keywords/radical-prostatectomy","display_name":"radical prostatectomy","score":0.8550000190734863},{"id":"https://openalex.org/keywords/nerve-sparing-prostatectomy","display_name":"nerve-sparing radical prostatectomy","score":0.8230000138282776},{"id":"https://openalex.org/keywords/intraoperative-margin-assessment","display_name":"intraoperative margin assessment","score":0.5450000166893005},{"id":"https://openalex.org/keywords/histopathological-correlation","display_name":"histopathological correlation","score":0.6209999918937683},{"id":"https://openalex.org/keywords/prostate-cancer-staging","display_name":"prostate cancer staging","score":0.34599998593330383}],"concepts":[{"id":"https://openalex.org/C2779466945","wikidata":"https://www.wikidata.org/wiki/Q1765251","display_name":"Prostatectomy","level":4,"score":0.842009425163269},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7543161511421204},{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.5401607155799866},{"id":"https://openalex.org/C2776235491","wikidata":"https://www.wikidata.org/wiki/Q9625","display_name":"Prostate","level":3,"score":0.4486978054046631},{"id":"https://openalex.org/C57742111","wikidata":"https://www.wikidata.org/wiki/Q7168","display_name":"Histology","level":2,"score":0.4274044334888458},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.24148908257484436},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.19883477687835693},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.0720367431640625}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/j.juro.2011.02.1726","doi":"https://doi.org/10.1016/j.juro.2011.02.1726","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.juro.2011.02.1726","pdf_url":null,"source":{"id":"https://openalex.org/S30525748","display_name":"The Journal of Urology","issn_l":"0022-5347","issn":["0022-5347","1527-3792"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Urology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.766700029373169,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2560650695","https://openalex.org/W1979862781","https://openalex.org/W2157953565","https://openalex.org/W2160047073","https://openalex.org/W2007540914","https://openalex.org/W2060324906","https://openalex.org/W4244086157","https://openalex.org/W2017727012","https://openalex.org/W2972715752","https://openalex.org/W2006840844"],"abstract_inverted_index":{"You":[0],"have":[1,341],"accessJournal":[2],"of":[3,179,187,195,204,224,252,266,294,300,323,337,387],"UrologyProstate":[4],"Cancer:":[5],"Basic":[6],"Research1":[7],"Apr":[8],"20111618":[9],"MULTIPHOTON":[10],"MICROSCOPY":[11],"PROVIDES":[12],"VIRTUAL":[13],"HISTOLOGY":[14],"OF":[15],"PROSTATIC":[16],"AND":[17,164],"PERIPROSTATIC":[18],"STRUCTURES":[19],"IN":[20],"HUMAN":[21],"RADICAL":[22],"PROSTATECTOMY":[23],"SPECIMENS":[24],"Sonal":[25,44,431],"Grover,":[26],"Prasanna":[27,56,441],"Sooriakumaran,":[28],"Abhishek":[29,68,451],"Srivastava,":[30],"Michael":[31,80,461],"Herman,":[32],"Joshua":[33,92,471],"Sterling,":[34],"Robert":[35,104,481],"Leung,":[36],"Maria":[37,116,491],"Shevchuk,":[38],"Sushmita":[39,128,501],"Mukherjee,":[40],"and":[41,140,176,182,214,231,249,272,288,309,321,332,381,409,427],"Ashutosh":[42,141,511],"Tewari":[43,143,512],"GroverSonal":[45],"Grover":[46,432],"New":[47,59,71,83,95,107,119,131,144,433,443,453,463,473,483,493,503,513],"York,":[48,60,72,84,96,108,120,132,145,434,444,454,464,474,484,494,504,514],"NY":[49,61,73,85,97,109,121,133,146,435,445,455,465,475,485,495,505,515],"More":[50,62,74,86,98,110,122,134,147,436,446,456,466,476,486,496,506,516],"articles":[51,63,75,87,99,111,123,135,148,437,447,457,467,477,487,497,507,517],"by":[52,64,76,88,100,112,124,136,149,404,422,438,448,458,468,478,488,498,508,518],"this":[53,65,77,89,101,113,125,137,150,188,439,449,459,469,479,489,499,509,519],"author":[54,66,78,90,102,114,126,138,151,440,450,460,470,480,490,500,510,520],",":[55,67,79,91,103,115,127,139],"SooriakumaranPrasanna":[57],"Sooriakumaran":[58,442],"SrivastavaAbhishek":[69],"Srivastava":[70,452],"HermanMichael":[81],"Herman":[82,462],"SterlingJoshua":[93],"Sterling":[94,472],"LeungRobert":[105],"Leung":[106,482],"ShevchukMaria":[117],"Shevchuk":[118,492],"MukherjeeSushmita":[129],"Mukherjee":[130,502],"TewariAshutosh":[142],"View":[152],"All":[153,522],"Author":[154],"Informationhttps://doi.org/10.1016/j.juro.2011.02.1726AboutPDF":[155],"ToolsAdd":[156],"to":[157,191,197,286,351,392],"favoritesDownload":[158],"CitationsTrack":[159],"CitationsPermissionsReprints":[160],"ShareFacebookTwitterLinked":[161],"InEmail":[162],"INTRODUCTION":[163],"OBJECTIVES":[165],"This":[166,367],"was":[167,190,243,279],"a":[168,202,273,343],"prospective":[169],"study":[170,189],"involving":[171],"Multiphoton":[172],"Microscopy":[173],"(MPM)":[174],"imaging":[175,208,242,348],"histopathologic":[177],"correlations":[178],"human":[180],"prostate":[181,305,327,388],"peri-prostatic":[183],"tissue.":[184],"The":[185,241,281],"aim":[186],"assess":[192],"the":[193,238,253,295,301,324,335,360,385,397],"potential":[194],"MPM":[196,216],"provide":[198,352],"virtual":[199],"histology":[200],"as":[201],"proof":[203],"principle":[205],"for":[206,215,226,291,346,362,370],"real-time":[207],"during":[209,376],"nerve":[210,377],"sparing":[211,378],"radical":[212,379],"prostatectomy":[213,380],"guided":[217],"biopsy.":[218],"METHODS":[219],"We":[220,340],"used":[221,391],"two":[222],"types":[223],"specimens":[225],"imaging:":[227],"(1)":[228],"intraoperative":[229],"margins":[230],"biopsies;":[232],"(2)":[233],"tissue":[234,347,394],"sections":[235],"obtained":[236,314],"from":[237],"excised":[239],"prostate.":[240],"carried":[244],"out":[245],"using":[246],"intrinsic":[247],"fluorescence":[248],"scattering":[250],"properties":[251],"tissues":[254,283],"without":[255,359],"any":[256,363],"exogenous":[257],"dye":[258],"or":[259],"contrast":[260],"agent.":[261],"A":[262],"custom-built":[263],"MPM,":[264],"consisting":[265],"an":[267],"Olympus":[268],"BX61WI":[269],"upright":[270],"frame":[271],"modified":[274],"Bio-Rad":[275],"MRC":[276],"1024":[277],"scanhead":[278],"used.":[280],"corresponding":[282],"were":[284,313],"subjected":[285],"hematoxylin":[287],"eosin":[289],"staining":[290],"histologic":[292],"confirmation":[293,320],"structures.":[296],"RESULTS":[297],"High-resolution":[298],"images":[299],"periprostatic":[302,325],"tissue,":[303,326,358],"nerves,":[304],"capsule,":[306],"underlying":[307],"acini,":[308],"individual":[310],"acinar":[311],"cells":[312],"at":[315],"varying":[316],"magnifications":[317],"(Figure).":[318],"Histologic":[319],"correlation":[322],"gland,":[328],"fat,":[329],"blood":[330],"vessels,":[331],"nerves":[333],"validated":[334],"findings":[336],"MPM.":[338],"CONCLUSIONS":[339],"utilized":[342],"novel":[344],"approach":[345],"which":[349],"appears":[350],"microscopy":[353],"level":[354],"resolution":[355],"in":[356],"fresh":[357],"need":[361],"extrinsic":[364],"labeling":[365],"agents.":[366],"may":[368],"allow":[369],"more":[371],"accurate":[372],"surgical":[373],"decision":[374],"making":[375],"will":[382],"also":[383],"improve":[384],"accuracy":[386],"biopsy":[389],"when":[390],"guide":[393],"sampling,":[395],"once":[396],"technology":[398],"is":[399],"clinically":[400],"translated.":[401],"\u00a9":[402],"2011":[403,421],"American":[405,423],"Urological":[406,424],"Association":[407,425],"Education":[408,426],"Research,":[410,428],"Inc.FiguresReferencesRelatedDetails":[411],"Volume":[412],"185Issue":[413],"4SApril":[414],"2011Page:":[415],"e648-e649":[416],"Advertisement":[417,523,524],"Copyright":[418],"&":[419],"Permissions\u00a9":[420],"Inc.MetricsAuthor":[429],"Information":[430],"Expand":[521],"PDF":[525],"downloadLoading":[526],"...":[527]},"counts_by_year":[],"updated_date":"2026-10-02T10:15:12.560889","created_date":"2016-06-24T00:00:00"}