{"id":"https://openalex.org/W2064052095","doi":"https://doi.org/10.1093/nar/9.24.6917","title":"Hormonal modulation of \u03b1-fetoprotein gene expression in newborn rat livers","display_name":"Hormonal modulation of \u03b1-fetoprotein gene expression in newborn rat livers","publication_year":1981,"publication_date":"1981-01-01","ids":{"openalex":"https://openalex.org/W2064052095","doi":"https://doi.org/10.1093/nar/9.24.6917","mag":"2064052095","pmid":"https://pubmed.ncbi.nlm.nih.gov/6174948","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/327651"},"language":"en","primary_location":{"id":"doi:10.1093/nar/9.24.6917","doi":"https://doi.org/10.1093/nar/9.24.6917","is_oa":false,"landing_page_url":"https://doi.org/10.1093/nar/9.24.6917","pdf_url":null,"source":{"id":"https://openalex.org/S134668137","display_name":"Nucleic Acids Research","issn_l":"0305-1048","issn":["0305-1048","1362-4954","1362-4962"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/327651","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110010109","display_name":"Jen\u2010Fu Chiu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111236770","display_name":"University of Vermont","ror":"https://ror.org/0155zta11","country_code":"US","type":"education","lineage":["https://openalex.org/I111236770"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jen-Fu Chiu","raw_affiliation_strings":["Department of Biochemistry, University of Vermont, College of MedicineBurlington, VT 05405, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, University of Vermont, College of MedicineBurlington, VT 05405, USA","institution_ids":["https://openalex.org/I111236770"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031830915","display_name":"Ronald J. Massari","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111236770","display_name":"University of Vermont","ror":"https://ror.org/0155zta11","country_code":"US","type":"education","lineage":["https://openalex.org/I111236770"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ronald J. Massari","raw_affiliation_strings":["Department of Biochemistry, University of Vermont, College of MedicineBurlington, VT 05405, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, University of Vermont, College of MedicineBurlington, VT 05405, USA","institution_ids":["https://openalex.org/I111236770"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072815495","display_name":"Charles E. Schwartz","orcid":"https://orcid.org/0000-0002-7770-1943","observed_orcids":["https://orcid.org/0000-0002-7770-1943"]},"institutions":[{"id":"https://openalex.org/I111236770","display_name":"University of Vermont","ror":"https://ror.org/0155zta11","country_code":"US","type":"education","lineage":["https://openalex.org/I111236770"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Charles E. Schwartz","raw_affiliation_strings":["Department of Biochemistry, University of Vermont, College of MedicineBurlington, VT 05405, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, University of Vermont, College of MedicineBurlington, VT 05405, USA","institution_ids":["https://openalex.org/I111236770"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058028158","display_name":"Natalie T. Meisler","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111236770","display_name":"University of Vermont","ror":"https://ror.org/0155zta11","country_code":"US","type":"education","lineage":["https://openalex.org/I111236770"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Natalie T. Meisler","raw_affiliation_strings":["Department of Biochemistry, University of Vermont, College of MedicineBurlington, VT 05405, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, University of Vermont, College of MedicineBurlington, VT 05405, USA","institution_ids":["https://openalex.org/I111236770"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5036093409","display_name":"John W. Thanassi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111236770","display_name":"University of Vermont","ror":"https://ror.org/0155zta11","country_code":"US","type":"education","lineage":["https://openalex.org/I111236770"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John W. Thanassi","raw_affiliation_strings":["Department of Biochemistry, University of Vermont, College of MedicineBurlington, VT 05405, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, University of Vermont, College of MedicineBurlington, VT 05405, USA","institution_ids":["https://openalex.org/I111236770"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I111236770"],"apc_list":{"value":3992,"currency":"USD","value_usd":3992},"apc_paid":null,"fwci":3.4173,"has_fulltext":false,"cited_by_count":27,"citation_normalized_percentile":{"value":0.92348181,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"9","issue":"24","first_page":"6917","last_page":"6933"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.3781999945640564,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.3781999945640564,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":0.12430000305175781,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.11219999939203262,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alpha-fetoprotein","display_name":"alpha-fetoprotein","score":0.9980000257492065},{"id":"https://openalex.org/keywords/glucocorticoids","display_name":"glucocorticoids","score":0.8370000123977661},{"id":"https://openalex.org/keywords/dexamethasone","display_name":"dexamethasone","score":1.0},{"id":"https://openalex.org/keywords/gene-expression-regulation","display_name":"gene expression regulation","score":0.800000011920929},{"id":"https://openalex.org/keywords/mrna-synthesis","display_name":"mRNA synthesis","score":0.7940000295639038},{"id":"https://openalex.org/keywords/polysomes","display_name":"polysomes","score":0.8230000138282776},{"id":"https://openalex.org/keywords/ornithine-decarboxylase","display_name":"ornithine decarboxylase","score":0.9710000157356262}],"concepts":[{"id":"https://openalex.org/C65666806","wikidata":"https://www.wikidata.org/wiki/Q970614","display_name":"Polysome","level":5,"score":0.8382843732833862},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8224796056747437},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.7770531177520752},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.769271731376648},{"id":"https://openalex.org/C2780841215","wikidata":"https://www.wikidata.org/wiki/Q422549","display_name":"Glucocorticoid","level":2,"score":0.5903754234313965},{"id":"https://openalex.org/C2780401358","wikidata":"https://www.wikidata.org/wiki/Q422252","display_name":"Dexamethasone","level":2,"score":0.5735347270965576},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.5475555062294006},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.54578697681427},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.43171426653862},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.24805769324302673},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2453521192073822},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.14252427220344543},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0},{"id":"https://openalex.org/C88478588","wikidata":"https://www.wikidata.org/wiki/Q42244","display_name":"Ribosome","level":4,"score":0.0}],"mesh":[{"descriptor_ui":"D000509","descriptor_name":"alpha-Fetoproteins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D000509","descriptor_name":"alpha-Fetoproteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000831","descriptor_name":"Animals, Newborn","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003907","descriptor_name":"Dexamethasone","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011132","descriptor_name":"Polyribosomes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1093/nar/9.24.6917","doi":"https://doi.org/10.1093/nar/9.24.6917","is_oa":false,"landing_page_url":"https://doi.org/10.1093/nar/9.24.6917","pdf_url":null,"source":{"id":"https://openalex.org/S134668137","display_name":"Nucleic Acids Research","issn_l":"0305-1048","issn":["0305-1048","1362-4954","1362-4962"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Research","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:1296438","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/327651","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:327651","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/327651","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Res","raw_type":"Text"},{"id":"pmid:6174948","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6174948","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic acids research","raw_type":"Comparative Study"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:1296438","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/327651","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320332505","display_name":"U.S. Public Health Service","ror":"https://ror.org/05xf94514"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":43,"referenced_works":["https://openalex.org/W37947217","https://openalex.org/W41633212","https://openalex.org/W138829560","https://openalex.org/W591649578","https://openalex.org/W985575737","https://openalex.org/W1493110577","https://openalex.org/W1505015263","https://openalex.org/W1521883432","https://openalex.org/W1530294395","https://openalex.org/W1533418542","https://openalex.org/W1536757979","https://openalex.org/W1549140967","https://openalex.org/W1575056372","https://openalex.org/W1576239999","https://openalex.org/W1605803926","https://openalex.org/W1628443897","https://openalex.org/W1671715243","https://openalex.org/W1967619163","https://openalex.org/W1974922801","https://openalex.org/W1982635432","https://openalex.org/W1996419255","https://openalex.org/W2006633837","https://openalex.org/W2015786533","https://openalex.org/W2019518050","https://openalex.org/W2020207893","https://openalex.org/W2023491888","https://openalex.org/W2034567494","https://openalex.org/W2036903205","https://openalex.org/W2036941847","https://openalex.org/W2043620737","https://openalex.org/W2046365254","https://openalex.org/W2066131819","https://openalex.org/W2071188523","https://openalex.org/W2076510744","https://openalex.org/W2077077811","https://openalex.org/W2085374716","https://openalex.org/W2087942186","https://openalex.org/W2092592958","https://openalex.org/W2095488937","https://openalex.org/W2127385301","https://openalex.org/W2132068224","https://openalex.org/W2149471576","https://openalex.org/W2430636231"],"related_works":["https://openalex.org/W2066312284","https://openalex.org/W1992756906","https://openalex.org/W3019161947","https://openalex.org/W2144617645","https://openalex.org/W1507890231","https://openalex.org/W7099374231","https://openalex.org/W2046365254","https://openalex.org/W2085692778","https://openalex.org/W2107390824","https://openalex.org/W1990861710"],"abstract_inverted_index":{"Suppression":[0],"of":[1,16,21,30,58,60,65,67,75,90,94,101,115,125,141,154,170],"serum":[2,34],"alpha-fetoprotein":[3],"(AFP)":[4],"levels":[5,51,82],"in":[6,32,49,83,118,145,158,167,175],"glucocorticoid":[7],"treated":[8,136],"newborn":[9,24],"rats":[10,25,85,103],"was":[11,132],"investigated.":[12],"Daily":[13],"intraperitoneal":[14],"injection":[15],"2":[17],"micrograms/g":[18],"body":[19],"weight":[20],"dexamethasone":[22,135],"into":[23],"greatly":[26],"reduced":[27],"the":[28,33,71,80,88,99,113,126,168],"concentration":[29],"AFP":[31,50,61,69,81,95,142,155,171,176],"and":[35,148,174],"liver":[36,43,72,76,121,146,160],"cytosol.":[37],"In":[38],"contrast,":[39],"this":[40],"treatment":[41],"stimulated":[42],"ornithine":[44],"decarboxylase":[45],"activity.":[46],"The":[47,92,151],"reduction":[48],"is":[52,122],"not":[53],"due":[54],"to":[55],"a":[56,165],"change":[57],"distribution":[59],"molecular":[62],"variants,":[63],"inhibition":[64],"secretion":[66],"synthesized":[68],"by":[70,86,163],"or":[73],"disruption":[74],"polysomes.":[77],"Glucocorticoids":[78],"decrease":[79,166],"hormone-treated":[84,119,159],"supressing":[87],"synthesis":[89],"AFP.":[91],"size":[93],"polysomes":[96,117],"isolated":[97],"from":[98,109],"livers":[100,137],"dexamethasone-treated":[102],"were":[104],"as":[105,107],"large":[106],"those":[108],"normal":[110],"rats.":[111],"However,":[112],"amount":[114],"AFP-producing":[116],"rat":[120],"only":[123],"14%":[124],"controls.":[127],"By":[128],"hybridization":[129],"assays,":[130],"it":[131],"found":[133],"that":[134],"contained":[138],"decreased":[139,152],"amounts":[140,153],"mRNA":[143,156,172,177],"sequences":[144,157],"cytoplasmic":[147],"nuclear":[149],"RNAs.":[150],"are":[161],"caused":[162],"both":[164],"rate":[169],"transcription":[173],"stability.":[178]},"counts_by_year":[{"year":2014,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
