{"id":"https://openalex.org/W2064012016","doi":"https://doi.org/10.1002/1097-0142(19900315)65:6<1391::aid-cncr2820650624>3.0.co;2-k","title":"Prognostic and therapeutic significance of the flow cytometric nuclear DNA content in non-small cell lung cancer","display_name":"Prognostic and therapeutic significance of the flow cytometric nuclear DNA content in non-small cell lung cancer","publication_year":1990,"publication_date":"1990-03-15","ids":{"openalex":"https://openalex.org/W2064012016","doi":"https://doi.org/10.1002/1097-0142(19900315)65:6<1391::aid-cncr2820650624>3.0.co;2-k","mag":"2064012016","pmid":"https://pubmed.ncbi.nlm.nih.gov/2155055"},"language":"en","primary_location":{"id":"doi:10.1002/1097-0142(19900315)65:6<1391::aid-cncr2820650624>3.0.co;2-k","doi":"https://doi.org/10.1002/1097-0142(19900315)65:6<1391::aid-cncr2820650624>3.0.co;2-k","is_oa":true,"landing_page_url":"https://doi.org/10.1002/1097-0142(19900315)65:6<1391::aid-cncr2820650624>3.0.co;2-k","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/1097-0142%2819900315%2965%3A6%3C1391%3A%3AAID-CNCR2820650624%3E3.0.CO%3B2-K","source":{"id":"https://openalex.org/S126033908","display_name":"Cancer","issn_l":"0008-543X","issn":["0008-543X","1045-7410","1097-0142"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/1097-0142%2819900315%2965%3A6%3C1391%3A%3AAID-CNCR2820650624%3E3.0.CO%3B2-K","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5017693924","display_name":"Hiroshi Isobe","orcid":"https://orcid.org/0000-0002-5711-4629","observed_orcids":["https://orcid.org/0000-0002-5711-4629"]},"institutions":[{"id":"https://openalex.org/I205349734","display_name":"Hokkaido University","ror":"https://ror.org/02e16g702","country_code":"JP","type":"education","lineage":["https://openalex.org/I205349734"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Hiroshi Isobe","raw_affiliation_strings":["First Department of Medicine, Hokkaido University, Sapporo, Japan","First Department of Medicine, School of Medicine, Hokkaido University, Sapporo"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"First Department of Medicine, Hokkaido University, Sapporo, Japan","institution_ids":["https://openalex.org/I205349734"]},{"raw_affiliation_string":"First Department of Medicine, School of Medicine, Hokkaido University, Sapporo","institution_ids":["https://openalex.org/I205349734"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090795865","display_name":"Hiroshi Miyamoto","orcid":"https://orcid.org/0000-0002-3715-8894","observed_orcids":["https://orcid.org/0000-0002-3715-8894"]},"institutions":[{"id":"https://openalex.org/I205349734","display_name":"Hokkaido University","ror":"https://ror.org/02e16g702","country_code":"JP","type":"education","lineage":["https://openalex.org/I205349734"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiroshi Miyamoto","raw_affiliation_strings":["First Department of Medicine, School of Medicine, Hokkaido University, Sapporo"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"First Department of Medicine, School of Medicine, Hokkaido University, Sapporo","institution_ids":["https://openalex.org/I205349734"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032672742","display_name":"T\u00f4ru Shimizu","orcid":"https://orcid.org/0000-0002-3950-5554","observed_orcids":["https://orcid.org/0000-0002-3950-5554"]},"institutions":[{"id":"https://openalex.org/I205349734","display_name":"Hokkaido University","ror":"https://ror.org/02e16g702","country_code":"JP","type":"education","lineage":["https://openalex.org/I205349734"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Toru Shimizu","raw_affiliation_strings":["First Department of Medicine, School of Medicine, Hokkaido University, Sapporo"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"First Department of Medicine, School of Medicine, Hokkaido University, Sapporo","institution_ids":["https://openalex.org/I205349734"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065395385","display_name":"Hitoshi Haneda","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I205349734","display_name":"Hokkaido University","ror":"https://ror.org/02e16g702","country_code":"JP","type":"education","lineage":["https://openalex.org/I205349734"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hitoshi Haneda","raw_affiliation_strings":["First Department of Medicine, School of Medicine, Hokkaido University, Sapporo"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"First Department of Medicine, School of Medicine, Hokkaido University, Sapporo","institution_ids":["https://openalex.org/I205349734"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069640989","display_name":"Masato Hashimoto","orcid":"https://orcid.org/0000-0003-2219-1058","observed_orcids":["https://orcid.org/0000-0003-2219-1058"]},"institutions":[{"id":"https://openalex.org/I205349734","display_name":"Hokkaido University","ror":"https://ror.org/02e16g702","country_code":"JP","type":"education","lineage":["https://openalex.org/I205349734"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masato Hashimoto","raw_affiliation_strings":["Second Department of Surgery, School of Medicine, Hokkaido University, Sapporo"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Second Department of Surgery, School of Medicine, Hokkaido University, Sapporo","institution_ids":["https://openalex.org/I205349734"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109956225","display_name":"Kazuaki Inoue","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I205349734","display_name":"Hokkaido University","ror":"https://ror.org/02e16g702","country_code":"JP","type":"education","lineage":["https://openalex.org/I205349734"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kazuaki Inoue","raw_affiliation_strings":["Department of Pathology, School of Medicine, Hokkaido University, Sapporo"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, School of Medicine, Hokkaido University, Sapporo","institution_ids":["https://openalex.org/I205349734"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111673063","display_name":"Shigetaka Mizuno","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I205349734","display_name":"Hokkaido University","ror":"https://ror.org/02e16g702","country_code":"JP","type":"education","lineage":["https://openalex.org/I205349734"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shigetaka Mizuno","raw_affiliation_strings":["Central Clinical Laboratory, Hokkaido University Dental Hospital, Sapporo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Central Clinical Laboratory, Hokkaido University Dental Hospital, Sapporo, Japan","institution_ids":["https://openalex.org/I205349734"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113687919","display_name":"Yoshikazu Kawakami","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I205349734","display_name":"Hokkaido University","ror":"https://ror.org/02e16g702","country_code":"JP","type":"education","lineage":["https://openalex.org/I205349734"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yoshikazu Kawakami","raw_affiliation_strings":["First Department of Medicine, School of Medicine, Hokkaido University, Sapporo"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"First Department of Medicine, School of Medicine, Hokkaido University, Sapporo","institution_ids":["https://openalex.org/I205349734"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5017693924"],"corresponding_institution_ids":["https://openalex.org/I205349734"],"apc_list":{"value":4790,"currency":"USD","value_usd":4790},"apc_paid":null,"fwci":5.9071,"has_fulltext":true,"cited_by_count":87,"citation_normalized_percentile":{"value":0.96649851,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":87,"max":93},"biblio":{"volume":"65","issue":"6","first_page":"1391","last_page":"1395"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12334","display_name":"Lung Cancer Research Studies","score":0.7124000191688538,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12334","display_name":"Lung Cancer Research Studies","score":0.7124000191688538,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10202","display_name":"Lung Cancer Diagnosis and Treatment","score":0.2750999927520752,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":0.004100000020116568,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/non-small-cell-lung-cancer","display_name":"non-small cell lung cancer","score":0.9980000257492065},{"id":"https://openalex.org/keywords/tumor-dna-content","display_name":"tumor DNA content","score":0.8410000205039978},{"id":"https://openalex.org/keywords/dna-aneuploidy","display_name":"DNA aneuploidy","score":0.9229999780654907},{"id":"https://openalex.org/keywords/dna-diploidy","display_name":"DNA diploidy","score":0.9340000152587891},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.8399999737739563},{"id":"https://openalex.org/keywords/survival","display_name":"survival","score":0.8040000200271606},{"id":"https://openalex.org/keywords/adenocarcinoma","display_name":"adenocarcinoma","score":0.972000002861023},{"id":"https://openalex.org/keywords/squamous-cell-carcinoma","display_name":"squamous cell carcinoma","score":1.0},{"id":"https://openalex.org/keywords/pathological-stage","display_name":"pathological stage","score":0.765999972820282},{"id":"https://openalex.org/keywords/therapeutic-implications","display_name":"therapeutic implications","score":0.32199999690055847}],"concepts":[{"id":"https://openalex.org/C2781182431","wikidata":"https://www.wikidata.org/wiki/Q356033","display_name":"Adenocarcinoma","level":3,"score":0.7061979174613953},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6344077587127686},{"id":"https://openalex.org/C553184892","wikidata":"https://www.wikidata.org/wiki/Q1141429","display_name":"Flow cytometry","level":2,"score":0.5899826288223267},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.5709603428840637},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.5438464879989624},{"id":"https://openalex.org/C63363279","wikidata":"https://www.wikidata.org/wiki/Q5133848","display_name":"Clinical significance","level":2,"score":0.5298794507980347},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.5296962857246399},{"id":"https://openalex.org/C115960442","wikidata":"https://www.wikidata.org/wiki/Q769863","display_name":"Nuclear DNA","level":4,"score":0.5268703103065491},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5109695196151733},{"id":"https://openalex.org/C2779672484","wikidata":"https://www.wikidata.org/wiki/Q529622","display_name":"Aneuploidy","level":4,"score":0.5030810236930847},{"id":"https://openalex.org/C146357865","wikidata":"https://www.wikidata.org/wiki/Q1123245","display_name":"Stage (stratigraphy)","level":2,"score":0.48909884691238403},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.468481183052063},{"id":"https://openalex.org/C2777546739","wikidata":"https://www.wikidata.org/wiki/Q33525","display_name":"Carcinoma","level":2,"score":0.46404024958610535},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.46283435821533203},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4248647093772888},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.19384193420410156},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.1873871386051178},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.08703666925430298},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C30481170","wikidata":"https://www.wikidata.org/wiki/Q37748","display_name":"Chromosome","level":3,"score":0.0},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C24586158","wikidata":"https://www.wikidata.org/wiki/Q27075","display_name":"Mitochondrial DNA","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D002294","descriptor_name":"Carcinoma, Squamous Cell","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D002294","descriptor_name":"Carcinoma, Squamous Cell","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D002294","descriptor_name":"Carcinoma, Squamous Cell","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002294","descriptor_name":"Carcinoma, Squamous Cell","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D002467","descriptor_name":"Cell Nucleus","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D004273","descriptor_name":"DNA, Neoplasm","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D005434","descriptor_name":"Flow Cytometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D009367","descriptor_name":"Neoplasm Staging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011003","descriptor_name":"Ploidies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/1097-0142(19900315)65:6<1391::aid-cncr2820650624>3.0.co;2-k","doi":"https://doi.org/10.1002/1097-0142(19900315)65:6<1391::aid-cncr2820650624>3.0.co;2-k","is_oa":true,"landing_page_url":"https://doi.org/10.1002/1097-0142(19900315)65:6<1391::aid-cncr2820650624>3.0.co;2-k","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/1097-0142%2819900315%2965%3A6%3C1391%3A%3AAID-CNCR2820650624%3E3.0.CO%3B2-K","source":{"id":"https://openalex.org/S126033908","display_name":"Cancer","issn_l":"0008-543X","issn":["0008-543X","1045-7410","1097-0142"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer","raw_type":"journal-article"},{"id":"pmid:2155055","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2155055","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1002/1097-0142(19900315)65:6<1391::aid-cncr2820650624>3.0.co;2-k","doi":"https://doi.org/10.1002/1097-0142(19900315)65:6<1391::aid-cncr2820650624>3.0.co;2-k","is_oa":true,"landing_page_url":"https://doi.org/10.1002/1097-0142(19900315)65:6<1391::aid-cncr2820650624>3.0.co;2-k","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/1097-0142%2819900315%2965%3A6%3C1391%3A%3AAID-CNCR2820650624%3E3.0.CO%3B2-K","source":{"id":"https://openalex.org/S126033908","display_name":"Cancer","issn_l":"0008-543X","issn":["0008-543X","1045-7410","1097-0142"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9763000011444092}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2064012016.pdf","grobid_xml":"https://content.openalex.org/works/W2064012016.grobid-xml"},"referenced_works_count":26,"referenced_works":["https://openalex.org/W1590772267","https://openalex.org/W1920279839","https://openalex.org/W1979300931","https://openalex.org/W1982638231","https://openalex.org/W1993757818","https://openalex.org/W2018019360","https://openalex.org/W2018708063","https://openalex.org/W2020637930","https://openalex.org/W2020787388","https://openalex.org/W2020907225","https://openalex.org/W2039626364","https://openalex.org/W2046018597","https://openalex.org/W2051924937","https://openalex.org/W2056793762","https://openalex.org/W2058992557","https://openalex.org/W2064159964","https://openalex.org/W2069356704","https://openalex.org/W2092165225","https://openalex.org/W2099573064","https://openalex.org/W2112449242","https://openalex.org/W2143594378","https://openalex.org/W2315179830","https://openalex.org/W2430417818","https://openalex.org/W3041047318","https://openalex.org/W3141948287","https://openalex.org/W4231423721"],"related_works":["https://openalex.org/W2465081920","https://openalex.org/W2076048952","https://openalex.org/W3139785018","https://openalex.org/W2042276940","https://openalex.org/W2412821535","https://openalex.org/W2003531247","https://openalex.org/W2079418802","https://openalex.org/W2327193825","https://openalex.org/W2087066238","https://openalex.org/W1964969325"],"abstract_inverted_index":{"To":[0],"evaluate":[1],"prognostic":[2,107,118],"and":[3,66,100,143,145,161],"therapeutic":[4],"significance,":[5],"tumor":[6],"DNA":[7,33,67,102,113,132,152],"content":[8,103,114,133,153],"was":[9,52,115],"determined":[10],"by":[11],"flow":[12],"cytometry":[13],"in":[14,40,43,54,61,80,120,126],"310":[15],"paraffin-embedded":[16],"tissue":[17],"samples":[18],"obtained":[19],"surgically":[20],"from":[21],"130":[22],"patients":[23,31,79],"with":[24],"non-small":[25],"cell":[26,45,122,159],"lung":[27],"cancer.":[28],"Ninety-six":[29],"(76.8%)":[30],"had":[32],"aneuploid":[34],"patterns":[35],"that":[36,95,131,146],"were":[37,104],"statistically":[38],"higher":[39],"adenocarcinoma":[41],"than":[42,60,72],"squamous":[44,121,158],"carcinoma.":[46],"A":[47,56],"better":[48],"5-year":[49],"survival":[50,75],"rate":[51],"observed":[53],"Group":[55,62,81],"(DNA":[57,64],"diploidy,":[58],"69.6%)":[59],"B":[63,82],"aneuploidy":[65],"peridiploidy,":[68],"33.2%;":[69],"P":[70],"less":[71],"0.001).":[73],"The":[74],"curves":[76],"of":[77,140,150],"the":[78,87,97,101,105,112,138,147,151],"continued":[83],"to":[84],"decrease":[85],"during":[86],"next":[88],"2.5":[89],"years.":[90],"Cox's":[91],"model":[92],"analysis":[93,134],"showed":[94],"both":[96],"pathologic":[98],"stage":[99],"significant":[106],"factors":[108],"for":[109,137],"survival.":[110],"However,":[111],"an":[116],"independent":[117],"factor":[119],"carcinoma,":[123],"but":[124],"not":[125],"adenocarcinoma.":[127,162],"These":[128],"results":[129],"indicate":[130],"is":[135],"useful":[136],"evaluation":[139],"clinical":[141,148],"behavior":[142],"prognosis,":[144],"value":[149],"must":[154],"be":[155],"differentiated":[156],"between":[157],"carcinoma":[160]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}