{"id":"https://openalex.org/W2063993291","doi":"https://doi.org/10.1117/12.388056","title":"Passive adoptive transfer of antitumor immunity induced by laser-dye-immunoadjuvant treatment in a rat metastatic breast cancer model","display_name":"Passive adoptive transfer of antitumor immunity induced by laser-dye-immunoadjuvant treatment in a rat metastatic breast cancer model","publication_year":2000,"publication_date":"2000-06-13","ids":{"openalex":"https://openalex.org/W2063993291","doi":"https://doi.org/10.1117/12.388056","mag":"2063993291"},"language":"en","primary_location":{"id":"doi:10.1117/12.388056","doi":"https://doi.org/10.1117/12.388056","is_oa":false,"landing_page_url":"https://doi.org/10.1117/12.388056","pdf_url":null,"source":{"id":"https://openalex.org/S183492911","display_name":"Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE","issn_l":"0277-786X","issn":["0277-786X","1996-756X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1"],"host_organization":"https://openalex.org/P4310315543","host_organization_name":"SPIE","host_organization_lineage":["https://openalex.org/P4310315543"],"host_organization_lineage_names":["SPIE"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"SPIE Proceedings","raw_type":"proceedings-article"},"volume":null,"type":"conference-paper","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5001447073","display_name":"Wei R. Chen","orcid":"https://orcid.org/0000-0002-7133-5794","observed_orcids":["https://orcid.org/0000-0002-7133-5794"]},"institutions":[{"id":"https://openalex.org/I139325414","display_name":"University of Central Oklahoma","ror":"https://ror.org/02n455404","country_code":"US","type":"education","lineage":["https://openalex.org/I139325414"]},{"id":"https://openalex.org/I8692664","display_name":"University of Oklahoma","ror":"https://ror.org/02aqsxs83","country_code":"US","type":"education","lineage":["https://openalex.org/I8692664"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wei R. Chen","raw_affiliation_strings":["Univ. of Central Oklahoma and Univ. of Oklahoma (United States)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ. of Central Oklahoma and Univ. of Oklahoma (United States)","institution_ids":["https://openalex.org/I139325414","https://openalex.org/I8692664"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100410369","display_name":"Hong Liu","orcid":"https://orcid.org/0000-0003-3611-7131","observed_orcids":["https://orcid.org/0000-0003-3611-7131"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hong Liu","raw_affiliation_strings":["Johns Hopkins Univ. (United States)","Johns\u00a0 Hopkins University, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Johns Hopkins Univ. (United States)","institution_ids":["https://openalex.org/I145311948"]},{"raw_affiliation_string":"Johns\u00a0 Hopkins University, United States","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013047847","display_name":"Anil K. Singhal","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210156144","display_name":"Light Sciences Oncology (United States)","ror":"https://ror.org/05420w677","country_code":"US","type":"company","lineage":["https://openalex.org/I4210156144"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anil K. Singhal","raw_affiliation_strings":["Light Sciences (United States)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Light Sciences (United States)","institution_ids":["https://openalex.org/I4210156144"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5112541359","display_name":"Robert E. Nordquist","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I8692664","display_name":"University of Oklahoma","ror":"https://ror.org/02aqsxs83","country_code":"US","type":"education","lineage":["https://openalex.org/I8692664"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert E. Nordquist","raw_affiliation_strings":["Univ. of Oklahoma and Wound Healing of Oklahoma, Inc. (United States)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ. of Oklahoma and Wound Healing of Oklahoma, Inc. (United States)","institution_ids":["https://openalex.org/I8692664"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.10447761,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"3914","issue":null,"first_page":"26","last_page":"26"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.9740999937057495,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.9740999937057495,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10957","display_name":"Photodynamic Therapy Research Studies","score":0.011800000444054604,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.00570000009611249,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/laser-immunotherapy","display_name":"laser immunotherapy","score":0.8679999709129333},{"id":"https://openalex.org/keywords/antitumor-immunity","display_name":"antitumor immunity","score":0.878000020980835},{"id":"https://openalex.org/keywords/splenocytes","display_name":"splenocytes","score":0.9539999961853027},{"id":"https://openalex.org/keywords/metastatic-breast-cancer","display_name":"metastatic breast cancer","score":0.9419999718666077},{"id":"https://openalex.org/keywords/tumor-resistance","display_name":"tumor resistance","score":0.621999979019165},{"id":"https://openalex.org/keywords/t-cell-suppression","display_name":"T cell suppression","score":0.6690000295639038},{"id":"https://openalex.org/keywords/immunoadjuvant","display_name":"immunoadjuvant","score":0.6759999990463257}],"concepts":[{"id":"https://openalex.org/C2909935589","wikidata":"https://www.wikidata.org/wiki/Q967453","display_name":"Immunoadjuvant","level":3,"score":0.8993984460830688},{"id":"https://openalex.org/C2779341262","wikidata":"https://www.wikidata.org/wiki/Q182581","display_name":"Immunity","level":3,"score":0.684370756149292},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6033312678337097},{"id":"https://openalex.org/C2775930923","wikidata":"https://www.wikidata.org/wiki/Q12859063","display_name":"Metastatic breast cancer","level":4,"score":0.6017704606056213},{"id":"https://openalex.org/C90375314","wikidata":"https://www.wikidata.org/wiki/Q3537484","display_name":"Adoptive cell transfer","level":4,"score":0.5961679816246033},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5276747345924377},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.5173365473747253},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.45020830631256104},{"id":"https://openalex.org/C2780931953","wikidata":"https://www.wikidata.org/wiki/Q9371","display_name":"Spleen","level":2,"score":0.43708914518356323},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.42789414525032043},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.40312689542770386},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.35322949290275574},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.3260415196418762},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.2656796872615814}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1117/12.388056","doi":"https://doi.org/10.1117/12.388056","is_oa":false,"landing_page_url":"https://doi.org/10.1117/12.388056","pdf_url":null,"source":{"id":"https://openalex.org/S183492911","display_name":"Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE","issn_l":"0277-786X","issn":["0277-786X","1996-756X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1"],"host_organization":"https://openalex.org/P4310315543","host_organization_name":"SPIE","host_organization_lineage":["https://openalex.org/P4310315543"],"host_organization_lineage_names":["SPIE"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"SPIE Proceedings","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1538210790","https://openalex.org/W1995480523","https://openalex.org/W1978230988","https://openalex.org/W1973400474","https://openalex.org/W2157180829","https://openalex.org/W1966727101","https://openalex.org/W2062371827","https://openalex.org/W2033458284","https://openalex.org/W2013081307","https://openalex.org/W2034721929"],"abstract_inverted_index":{"The":[0,57,93,109],"ideal":[1],"cancer":[2],"treatment":[3,51,81],"modalities":[4],"should":[5],"not":[6],"only":[7],"cause":[8],"tumor":[9,31,67,118,123,132],"regression":[10],"and":[11,28,41],"eradication":[12],"but":[13],"also":[14,127],"induce":[15],"a":[16,36,38,47,53],"systemic":[17],"anti-tumor":[18],"immunity.":[19],"This":[20,141],"is":[21],"essential":[22],"for":[23,29],"control":[24],"of":[25,52,73,131,137],"metastatic":[26,55],"tumors":[27],"long-term":[30,48],"resistance.":[32],"Laser":[33],"immunotherapy":[34],"using":[35,88],"laser,":[37],"laser-absorbing":[39],"dye":[40],"an":[42,121],"immunoadjuvant":[43],"has":[44],"induced":[45,77],"such":[46],"immunity":[49,76,104,142],"in":[50,105,133,152],"mammary":[54],"tumor.":[56],"successfully":[58,98],"treated":[59,99],"rats":[60,101,114],"established":[61],"total":[62],"resistance":[63],"to":[64,117],"multiple":[65],"subsequent":[66],"challenges.":[68],"For":[69],"further":[70],"mechanistic":[71],"studies":[72],"the":[74,106,129,134,147],"antitumor":[75],"by":[78],"this":[79],"novel":[80],"modality,":[82],"passive":[83],"adoptive":[84],"transfer":[85,143],"was":[86,144],"performed":[87],"splenocytes":[89,126],"as":[90],"immune":[91,116],"cells.":[92],"spleen":[94],"cells":[95],"harvested":[96],"from":[97],"tumor-bearing":[100],"provided":[102],"100%":[103],"naive":[107,138],"recipients.":[108,153],"passively":[110],"protected":[111],"first":[112],"cohort":[113,136],"were":[115],"challenge":[119],"with":[120],"increased":[122],"dose;":[124],"their":[125],"prevented":[128],"establishment":[130],"second":[135],"recipient":[139],"rats.":[140],"accomplished":[145],"without":[146],"usually":[148],"required":[149],"T-cell":[150],"suppression":[151]},"counts_by_year":[],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2016-06-24T00:00:00"}