{"id":"https://openalex.org/W2063872244","doi":"https://doi.org/10.1021/bi00852a008","title":"Recovery of antibody activity on reoxidation of completely reduced polyalanyl heavy chain and its Fd fragment derived from anti-2,4-dinitrophenyl antibody","display_name":"Recovery of antibody activity on reoxidation of completely reduced polyalanyl heavy chain and its Fd fragment derived from anti-2,4-dinitrophenyl antibody","publication_year":1968,"publication_date":"1968-12-01","ids":{"openalex":"https://openalex.org/W2063872244","doi":"https://doi.org/10.1021/bi00852a008","mag":"2063872244","pmid":"https://pubmed.ncbi.nlm.nih.gov/4973471"},"language":"en","primary_location":{"id":"doi:10.1021/bi00852a008","doi":"https://doi.org/10.1021/bi00852a008","is_oa":false,"landing_page_url":"https://doi.org/10.1021/bi00852a008","pdf_url":null,"source":{"id":"https://openalex.org/S104038378","display_name":"Biochemistry","issn_l":"0006-2960","issn":["0006-2960","1520-4995","1943-295X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109949991","display_name":"Jean Claude Jaton","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jean C. Jaton","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113499725","display_name":"Norman R. Klinman","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Norman R. Klinman","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065557474","display_name":"David Givol","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"David. Givol","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5111494072","display_name":"Michael Sela","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michael. Sela","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":8.3765,"has_fulltext":false,"cited_by_count":48,"citation_normalized_percentile":{"value":0.97041785,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":null,"biblio":{"volume":"7","issue":"12","first_page":"4185","last_page":"4195"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.9897000193595886,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.9897000193595886,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.0032999999821186066,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11124","display_name":"Protein purification and stability","score":0.0031999999191612005,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fd-fragment","display_name":"Fd fragment","score":0.6589999794960022},{"id":"https://openalex.org/keywords/antibody-heavy-chain","display_name":"antibody heavy chain","score":0.5690000057220459},{"id":"https://openalex.org/keywords/disulfide-bonds","display_name":"disulfide bonds","score":0.4819999933242798}],"concepts":[{"id":"https://openalex.org/C2778805511","wikidata":"https://www.wikidata.org/wiki/Q1713","display_name":"Citation","level":2,"score":0.7438178658485413},{"id":"https://openalex.org/C2778447006","wikidata":"https://www.wikidata.org/wiki/Q1156474","display_name":"Icon","level":2,"score":0.6710962057113647},{"id":"https://openalex.org/C2776235265","wikidata":"https://www.wikidata.org/wiki/Q18392052","display_name":"Fragment (logic)","level":2,"score":0.5785877108573914},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.576113760471344},{"id":"https://openalex.org/C518677369","wikidata":"https://www.wikidata.org/wiki/Q202833","display_name":"Social media","level":2,"score":0.49152645468711853},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.4156104624271393},{"id":"https://openalex.org/C23123220","wikidata":"https://www.wikidata.org/wiki/Q816826","display_name":"Information retrieval","level":1,"score":0.3692382276058197},{"id":"https://openalex.org/C161191863","wikidata":"https://www.wikidata.org/wiki/Q199655","display_name":"Library science","level":1,"score":0.2742558717727661},{"id":"https://openalex.org/C136764020","wikidata":"https://www.wikidata.org/wiki/Q466","display_name":"World Wide Web","level":1,"score":0.23429080843925476},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.18765750527381897},{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.17993265390396118},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.1413174867630005},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000409","descriptor_name":"Alanine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000906","descriptor_name":"Antibodies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000917","descriptor_name":"Antibody Formation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002850","descriptor_name":"Chromatography, Gel","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003956","descriptor_name":"Dialysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004140","descriptor_name":"Dinitrophenols","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004586","descriptor_name":"Electrophoresis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005779","descriptor_name":"Immunodiffusion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006041","descriptor_name":"Goats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006146","descriptor_name":"Guanidines","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006241","descriptor_name":"Haptens","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D007074","descriptor_name":"Immunoglobulin G","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007106","descriptor_name":"Immune Sera","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010084","descriptor_name":"Oxidation-Reduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012995","descriptor_name":"Solubility","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013440","descriptor_name":"Sulfides","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1021/bi00852a008","doi":"https://doi.org/10.1021/bi00852a008","is_oa":false,"landing_page_url":"https://doi.org/10.1021/bi00852a008","pdf_url":null,"source":{"id":"https://openalex.org/S104038378","display_name":"Biochemistry","issn_l":"0006-2960","issn":["0006-2960","1520-4995","1943-295X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"journal-article"},{"id":"pmid:4973471","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/4973471","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":30,"referenced_works":["https://openalex.org/W110174836","https://openalex.org/W121396384","https://openalex.org/W1489773305","https://openalex.org/W1579116430","https://openalex.org/W1586757195","https://openalex.org/W1623096992","https://openalex.org/W1786523947","https://openalex.org/W1982587463","https://openalex.org/W1990355025","https://openalex.org/W1991873742","https://openalex.org/W1997133987","https://openalex.org/W2010855096","https://openalex.org/W2017470279","https://openalex.org/W2019244584","https://openalex.org/W2025539616","https://openalex.org/W2062067807","https://openalex.org/W2065454656","https://openalex.org/W2066149280","https://openalex.org/W2068427009","https://openalex.org/W2068747743","https://openalex.org/W2072814150","https://openalex.org/W2086855538","https://openalex.org/W2092844618","https://openalex.org/W2197220942","https://openalex.org/W2209930309","https://openalex.org/W2258043690","https://openalex.org/W2317334995","https://openalex.org/W2318690634","https://openalex.org/W2402857130","https://openalex.org/W2419553692"],"related_works":["https://openalex.org/W1579116430","https://openalex.org/W1586757195","https://openalex.org/W1969520408","https://openalex.org/W1515461687","https://openalex.org/W2412899408","https://openalex.org/W2011126675","https://openalex.org/W2065902619","https://openalex.org/W4252326978","https://openalex.org/W1492151977","https://openalex.org/W2013307330"],"abstract_inverted_index":{"ADVERTISEMENT":[0],"RETURN":[1],"TO":[2],"ISSUEPREVArticleNEXTRecovery":[3],"of":[4,9,64,99,125],"antibody":[5],"activity":[6],"on":[7,136,164],"reoxidation":[8],"completely":[10],"reduced":[11],"polyalanyl":[12],"heavy":[13],"chain":[14],"and":[15,30,74,79,108,152,169,185,187],"its":[16],"Fd":[17],"fragment":[18],"derived":[19],"from":[20],"anti-2,4-dinitrophenyl":[21],"antibodyJean":[22],"C.":[23],"Jaton,":[24],"Norman":[25],"R.":[26],"Klinman,":[27],"David.":[28],"Givol,":[29],"Michael.":[31],"SelaCite":[32],"this:":[33],"Biochemistry":[34],"1968,":[35],"7,":[36],"12,":[37],"4185\u20134195Publication":[38],"Date":[39],"(Print):December":[40],"1,":[41],"1968Publication":[42],"History":[43],"Published":[44],"online1":[45],"May":[46],"2002Published":[47],"inissue":[48],"1":[49],"December":[50],"1968https://pubs.acs.org/doi/10.1021/bi00852a008https://doi.org/10.1021/bi00852a008research-articleACS":[51],"PublicationsRequest":[52],"reuse":[53],"permissionsArticle":[54],"Views71Altmetric-Citations28LEARN":[55],"ABOUT":[56],"THESE":[57],"METRICSArticle":[58],"Views":[59],"are":[60,83,96],"the":[61,92,97,126,137,150,153,158,165,171],"COUNTER-compliant":[62],"sum":[63],"full":[65],"text":[66],"article":[67,131],"downloads":[68],"since":[69],"November":[70],"2008":[71],"(both":[72],"PDF":[73],"HTML)":[75],"across":[76],"all":[77],"institutions":[78],"individuals.":[80],"These":[81],"metrics":[82],"regularly":[84],"updated":[85,109],"to":[86,91],"reflect":[87],"usage":[88],"leading":[89],"up":[90],"last":[93],"few":[94],"days.Citations":[95],"number":[98],"other":[100],"articles":[101],"citing":[102],"this":[103],"article,":[104],"calculated":[105],"by":[106],"Crossref":[107,115],"daily.":[110],"Find":[111,161],"more":[112,162],"information":[113,163],"about":[114,149],"citation":[116],"counts.The":[117],"Altmetric":[118,166],"Attention":[119,167],"Score":[120,168],"is":[121,173],"a":[122,129,142],"quantitative":[123],"measure":[124],"attention":[127],"that":[128],"research":[130],"has":[132],"received":[133],"online.":[134],"Clicking":[135],"donut":[138],"icon":[139],"will":[140],"load":[141],"page":[143],"at":[144],"altmetric.com":[145],"with":[146,181],"additional":[147],"details":[148],"score":[151,172],"social":[154],"media":[155],"presence":[156],"for":[157],"given":[159],"article.":[160],"how":[170],"calculated.":[174],"Share":[175,190],"Add":[176],"toView":[177],"InAdd":[178],"Full":[179],"Text":[180],"ReferenceAdd":[182],"Description":[183],"ExportRISCitationCitation":[184],"abstractCitation":[186],"referencesMore":[188],"Options":[189],"onFacebookTwitterWechatLinked":[191],"InRedditEmail":[192],"Other":[193],"access":[194],"optionsGet":[195],"e-Alertsclose":[196],"Get":[197],"e-Alerts":[198]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}