{"id":"https://openalex.org/W2063870592","doi":"https://doi.org/10.1158/0008-5472.can-14-0350","title":"Twist1 Is a Key Regulator of Cancer-Associated Fibroblasts","display_name":"Twist1 Is a Key Regulator of Cancer-Associated Fibroblasts","publication_year":2014,"publication_date":"2014-11-04","ids":{"openalex":"https://openalex.org/W2063870592","doi":"https://doi.org/10.1158/0008-5472.can-14-0350","mag":"2063870592","pmid":"https://pubmed.ncbi.nlm.nih.gov/25368021"},"language":"en","primary_location":{"id":"doi:10.1158/0008-5472.can-14-0350","doi":"https://doi.org/10.1158/0008-5472.can-14-0350","is_oa":false,"landing_page_url":"https://doi.org/10.1158/0008-5472.can-14-0350","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102996452","display_name":"Keun-Woo Lee","orcid":"https://orcid.org/0000-0002-6777-0312","observed_orcids":["https://orcid.org/0000-0002-6777-0312"]},"institutions":[{"id":"https://openalex.org/I2802194831","display_name":"Samsung Medical Center","ror":"https://ror.org/05a15z872","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I2250650973","https://openalex.org/I2802194831"]},{"id":"https://openalex.org/I848706","display_name":"Sungkyunkwan University","ror":"https://ror.org/04q78tk20","country_code":"KR","type":"education","lineage":["https://openalex.org/I848706"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Keun-Woo Lee","raw_affiliation_strings":["1Department of Pathology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea","2Department of Health Science and Technology, Samsung Advanced Institute for Health Science and Technology, Sungkyunkwan University, Seoul, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Pathology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea","institution_ids":["https://openalex.org/I2802194831","https://openalex.org/I848706"]},{"raw_affiliation_string":"2Department of Health Science and Technology, Samsung Advanced Institute for Health Science and Technology, Sungkyunkwan University, Seoul, Republic of Korea","institution_ids":["https://openalex.org/I848706"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012216626","display_name":"So-Young Yeo","orcid":"https://orcid.org/0000-0002-6330-7873","observed_orcids":["https://orcid.org/0000-0002-6330-7873"]},"institutions":[{"id":"https://openalex.org/I2802194831","display_name":"Samsung Medical Center","ror":"https://ror.org/05a15z872","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I2250650973","https://openalex.org/I2802194831"]},{"id":"https://openalex.org/I848706","display_name":"Sungkyunkwan University","ror":"https://ror.org/04q78tk20","country_code":"KR","type":"education","lineage":["https://openalex.org/I848706"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"So-Young Yeo","raw_affiliation_strings":["1Department of Pathology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea","2Department of Health Science and Technology, Samsung Advanced Institute for Health Science and Technology, Sungkyunkwan University, Seoul, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Pathology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea","institution_ids":["https://openalex.org/I2802194831","https://openalex.org/I848706"]},{"raw_affiliation_string":"2Department of Health Science and Technology, Samsung Advanced Institute for Health Science and Technology, Sungkyunkwan University, Seoul, Republic of Korea","institution_ids":["https://openalex.org/I848706"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016540646","display_name":"Chang Ohk Sung","orcid":"https://orcid.org/0000-0002-8567-456X","observed_orcids":["https://orcid.org/0000-0002-8567-456X"]},"institutions":[{"id":"https://openalex.org/I2801680663","display_name":"Asan Medical Center","ror":"https://ror.org/03s5q0090","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I2801680663","https://openalex.org/I4210167194"]},{"id":"https://openalex.org/I40542001","display_name":"University of Ulsan","ror":"https://ror.org/02c2f8975","country_code":"KR","type":"education","lineage":["https://openalex.org/I40542001"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Chang Ohk Sung","raw_affiliation_strings":["3Department of Pathology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Department of Pathology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea","institution_ids":["https://openalex.org/I2801680663","https://openalex.org/I40542001"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5114626485","display_name":"Seok\u2010Hyung Kim","orcid":"https://orcid.org/0000-0001-9028-6919","observed_orcids":["https://orcid.org/0000-0001-9028-6919"]},"institutions":[{"id":"https://openalex.org/I2802194831","display_name":"Samsung Medical Center","ror":"https://ror.org/05a15z872","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I2250650973","https://openalex.org/I2802194831"]},{"id":"https://openalex.org/I848706","display_name":"Sungkyunkwan University","ror":"https://ror.org/04q78tk20","country_code":"KR","type":"education","lineage":["https://openalex.org/I848706"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Seok-Hyung Kim","raw_affiliation_strings":["1Department of Pathology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea","2Department of Health Science and Technology, Samsung Advanced Institute for Health Science and Technology, Sungkyunkwan University, Seoul, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Pathology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea","institution_ids":["https://openalex.org/I2802194831","https://openalex.org/I848706"]},{"raw_affiliation_string":"2Department of Health Science and Technology, Samsung Advanced Institute for Health Science and Technology, Sungkyunkwan University, Seoul, Republic of Korea","institution_ids":["https://openalex.org/I848706"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":6.0612,"has_fulltext":false,"cited_by_count":147,"citation_normalized_percentile":{"value":0.97704344,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"75","issue":"1","first_page":"73","last_page":"85"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.8794000148773193,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.8794000148773193,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11501","display_name":"TGF-\u03b2 signaling in diseases","score":0.10369999706745148,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11313","display_name":"Immune cells in cancer","score":0.0020000000949949026,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/twist1","display_name":"TWIST1","score":0.9980000257492065},{"id":"https://openalex.org/keywords/cancer-associated-fibroblasts","display_name":"cancer-associated fibroblasts","score":1.0},{"id":"https://openalex.org/keywords/fibroblast-transdifferentiation","display_name":"fibroblast transdifferentiation","score":0.9269999861717224},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.7039999961853027},{"id":"https://openalex.org/keywords/stat3-phosphorylation","display_name":"STAT3 phosphorylation","score":0.9330000281333923},{"id":"https://openalex.org/keywords/cxcl12","display_name":"CXCL12","score":0.9539999961853027},{"id":"https://openalex.org/keywords/gastric-cancer","display_name":"gastric cancer","score":0.746999979019165},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.9940000176429749},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.9190000295639038},{"id":"https://openalex.org/keywords/premature-senescence","display_name":"premature senescence","score":0.7900000214576721},{"id":"https://openalex.org/keywords/epithelial-mesenchymal-transition","display_name":"epithelial-mesenchymal transition","score":0.9350000023841858}],"concepts":[{"id":"https://openalex.org/C60870556","wikidata":"https://www.wikidata.org/wiki/Q2300675","display_name":"Transdifferentiation","level":3,"score":0.6510500907897949},{"id":"https://openalex.org/C97037327","wikidata":"https://www.wikidata.org/wiki/Q5334291","display_name":"Ectopic expression","level":3,"score":0.5943017601966858},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5935623645782471},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5712156295776367},{"id":"https://openalex.org/C76419328","wikidata":"https://www.wikidata.org/wiki/Q74419","display_name":"Epithelial\u2013mesenchymal transition","level":4,"score":0.5562371611595154},{"id":"https://openalex.org/C2776107976","wikidata":"https://www.wikidata.org/wiki/Q1786433","display_name":"Tumor microenvironment","level":3,"score":0.5428228378295898},{"id":"https://openalex.org/C2778893926","wikidata":"https://www.wikidata.org/wiki/Q575849","display_name":"Twist transcription factor","level":5,"score":0.5264131426811218},{"id":"https://openalex.org/C2909706936","wikidata":"https://www.wikidata.org/wiki/Q42417562","display_name":"Cancer-Associated Fibroblasts","level":4,"score":0.523517906665802},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4760955572128296},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.4570607542991638},{"id":"https://openalex.org/C111798993","wikidata":"https://www.wikidata.org/wiki/Q21117471","display_name":"Fibroblast activation protein, alpha","level":3,"score":0.4496966004371643},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.2869827151298523},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.2513391375541687},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.2197991907596588},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.1450960338115692},{"id":"https://openalex.org/C3020616263","wikidata":"https://www.wikidata.org/wiki/Q1216998","display_name":"Tumor cells","level":2,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008819","descriptor_name":"Mice, Nude","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009687","descriptor_name":"Nuclear Proteins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D009687","descriptor_name":"Nuclear Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009687","descriptor_name":"Nuclear Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D013274","descriptor_name":"Stomach Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D013274","descriptor_name":"Stomach Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013274","descriptor_name":"Stomach Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D015850","descriptor_name":"Interleukin-6","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015854","descriptor_name":"Up-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D050796","descriptor_name":"STAT3 Transcription Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051879","descriptor_name":"Twist-Related Protein 1","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D051879","descriptor_name":"Twist-Related Protein 1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051879","descriptor_name":"Twist-Related Protein 1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D054377","descriptor_name":"Chemokine CXCL12","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D061986","descriptor_name":"MCF-7 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D064593","descriptor_name":"Heterografts","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1158/0008-5472.can-14-0350","doi":"https://doi.org/10.1158/0008-5472.can-14-0350","is_oa":false,"landing_page_url":"https://doi.org/10.1158/0008-5472.can-14-0350","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},{"id":"pmid:25368021","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25368021","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":46,"referenced_works":["https://openalex.org/W1970281904","https://openalex.org/W1973519930","https://openalex.org/W1980404014","https://openalex.org/W1983231547","https://openalex.org/W1983575915","https://openalex.org/W1989807918","https://openalex.org/W1990906641","https://openalex.org/W1996994627","https://openalex.org/W2006532804","https://openalex.org/W2014622924","https://openalex.org/W2014868340","https://openalex.org/W2016838970","https://openalex.org/W2018211174","https://openalex.org/W2028758423","https://openalex.org/W2029176324","https://openalex.org/W2031409539","https://openalex.org/W2036008499","https://openalex.org/W2036447097","https://openalex.org/W2041149072","https://openalex.org/W2049416925","https://openalex.org/W2049903387","https://openalex.org/W2051940224","https://openalex.org/W2055568216","https://openalex.org/W2058437379","https://openalex.org/W2058799146","https://openalex.org/W2062809449","https://openalex.org/W2063407256","https://openalex.org/W2066735451","https://openalex.org/W2068756348","https://openalex.org/W2073650418","https://openalex.org/W2078502914","https://openalex.org/W2083798214","https://openalex.org/W2085457955","https://openalex.org/W2086834665","https://openalex.org/W2096764577","https://openalex.org/W2097598334","https://openalex.org/W2101037339","https://openalex.org/W2102729369","https://openalex.org/W2114497102","https://openalex.org/W2117199255","https://openalex.org/W2120734105","https://openalex.org/W2128318768","https://openalex.org/W2145234793","https://openalex.org/W2162562455","https://openalex.org/W2168631000","https://openalex.org/W7217031427"],"related_works":["https://openalex.org/W2052001217","https://openalex.org/W2907731332","https://openalex.org/W2616138310","https://openalex.org/W2301585873","https://openalex.org/W2619135413","https://openalex.org/W130577457","https://openalex.org/W3154760929","https://openalex.org/W2398317880","https://openalex.org/W4407037567","https://openalex.org/W4391480326"],"abstract_inverted_index":{"Cancer-associated":[0],"fibroblasts":[1,40,94,142,209],"(CAF)":[2],"are":[3],"key":[4],"contributors":[5],"to":[6,41,77,88,146,228],"malignant":[7,152],"progression,":[8],"but":[9],"their":[10,173],"critical":[11],"regulators":[12],"remain":[13],"largely":[14],"unknown.":[15],"In":[16,73,103],"this":[17],"study,":[18],"we":[19,44,179],"examined":[20],"the":[21,35,78,166,181,230,234],"role":[22],"of":[23,28,37,108,138,168,177,205,233],"Twist1,":[24,178],"a":[25,185,225],"central":[26],"regulator":[27],"epithelial-mesenchymal":[29],"transition":[30],"in":[31,34,84,92,118,140,154,159,162,170,195,198,207,218],"carcinoma":[32],"cells,":[33],"transdifferentiation":[36],"normal":[38,93,141,208],"quiescent":[39],"CAF":[42,57,134,148],"and":[43,49,56,64,95,131,151,161,190],"defined":[45,180],"its":[46],"upstream":[47],"controls":[48],"downstream":[50],"effectors.":[51],"Primary":[52],"human":[53],"gastric":[54,119,155,199],"fibroblast":[55],"cultures":[58],"were":[59,193],"established":[60],"from":[61],"gastrectomy":[62],"specimens":[63],"validated":[65],"as":[66,184,224],"nontumor":[67],"cells":[68,157],"by":[69,114],"somatic":[70],"mutation":[71],"analyses.":[72],"these":[74],"cultures,":[75],"exposure":[76],"proinflammatory":[79],"cytokine":[80],"IL6":[81,116],"commonly":[82],"expressed":[83],"tumors":[85],"was":[86,111,129,143],"sufficient":[87,132,145],"induce":[89],"Twist1":[90,127,139,169,191,206,214,223],"expression":[91,117,128,137,150,167,192,204],"transdifferentiate":[96],"them":[97],"into":[98],"CAFs":[99,110,171,196],"via":[100],"STAT3":[101],"phosphorylation.":[102],"xenograft":[104],"models,":[105],"tumor":[106,200],"infiltration":[107],"Twist1-expressing":[109],"enhanced":[112],"strongly":[113],"ectopic":[115,203],"or":[120],"breast":[121],"cancer":[122,156,235],"cells.":[123],"We":[124],"found":[125],"that":[126],"necessary":[130],"for":[133],"transdifferentiation.":[135],"Enforced":[136],"also":[144],"drive":[147],"marker":[149],"character":[153],"both":[158],"vitro":[160],"vivo.":[163],"Conversely,":[164],"silencing":[165],"abrogated":[172],"tumor-promoting":[174],"properties.":[175],"Downstream":[176],"chemokine":[182],"CXCL12":[183,189],"transcriptional":[186],"target.":[187],"Clinically,":[188],"correlated":[194],"present":[197],"specimens.":[201],"Finally,":[202],"suppressed":[210],"premature":[211],"senescence,":[212],"whereas":[213],"attenuation":[215],"accelerated":[216],"senescence":[217],"CAFs.":[219],"Our":[220],"findings":[221],"define":[222],"compelling":[226],"target":[227],"deprogram":[229],"tumor-supporting":[231],"features":[232],"microenvironment.":[236]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":9},{"year":2024,"cited_by_count":12},{"year":2023,"cited_by_count":15},{"year":2022,"cited_by_count":14},{"year":2021,"cited_by_count":15},{"year":2020,"cited_by_count":16},{"year":2019,"cited_by_count":13},{"year":2018,"cited_by_count":10},{"year":2017,"cited_by_count":12},{"year":2016,"cited_by_count":17},{"year":2015,"cited_by_count":8}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2016-06-24T00:00:00"}