{"id":"https://openalex.org/W2063863569","doi":"https://doi.org/10.1371/journal.pone.0038384","title":"SOCS2-Induced Proteasome-Dependent TRAF6 Degradation: A Common Anti-Inflammatory Pathway for Control of Innate Immune Responses","display_name":"SOCS2-Induced Proteasome-Dependent TRAF6 Degradation: A Common Anti-Inflammatory Pathway for Control of Innate Immune Responses","publication_year":2012,"publication_date":"2012-06-05","ids":{"openalex":"https://openalex.org/W2063863569","doi":"https://doi.org/10.1371/journal.pone.0038384","mag":"2063863569","pmid":"https://pubmed.ncbi.nlm.nih.gov/22693634","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3367914"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pone.0038384","doi":"https://doi.org/10.1371/journal.pone.0038384","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0038384","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0038384&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0038384&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5022218825","display_name":"Cortez McBerry","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1285204247","display_name":"Cincinnati Children's Hospital Medical Center","ror":"https://ror.org/01hcyya48","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285204247"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cortez McBerry","raw_affiliation_strings":["Divisions of Molecular Immunology and Pulmonary Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Divisions of Molecular Immunology and Pulmonary Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, United States of America","institution_ids":["https://openalex.org/I1285204247"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043652258","display_name":"Rosa Maria Salazar Gonzalez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1285204247","display_name":"Cincinnati Children's Hospital Medical Center","ror":"https://ror.org/01hcyya48","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285204247"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rosa Maria Salazar Gonzalez","raw_affiliation_strings":["Divisions of Molecular Immunology and Pulmonary Medicine, Cincinnati Children\u2019s Hospital Medical Center, Cincinnati, Ohio, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Divisions of Molecular Immunology and Pulmonary Medicine, Cincinnati Children\u2019s Hospital Medical Center, Cincinnati, Ohio, United States of America","institution_ids":["https://openalex.org/I1285204247"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088641032","display_name":"Nathaniel Shryock","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1285204247","display_name":"Cincinnati Children's Hospital Medical Center","ror":"https://ror.org/01hcyya48","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285204247"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nathaniel Shryock","raw_affiliation_strings":["Divisions of Molecular Immunology and Pulmonary Medicine, Cincinnati Children\u2019s Hospital Medical Center, Cincinnati, Ohio, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Divisions of Molecular Immunology and Pulmonary Medicine, Cincinnati Children\u2019s Hospital Medical Center, Cincinnati, Ohio, United States of America","institution_ids":["https://openalex.org/I1285204247"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Alexandra Dias","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1285204247","display_name":"Cincinnati Children's Hospital Medical Center","ror":"https://ror.org/01hcyya48","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285204247"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alexandra Dias","raw_affiliation_strings":["Divisions of Molecular Immunology and Pulmonary Medicine, Cincinnati Children\u2019s Hospital Medical Center, Cincinnati, Ohio, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Divisions of Molecular Immunology and Pulmonary Medicine, Cincinnati Children\u2019s Hospital Medical Center, Cincinnati, Ohio, United States of America","institution_ids":["https://openalex.org/I1285204247"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5064351054","display_name":"J\u00falio Aliberti","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1285204247","display_name":"Cincinnati Children's Hospital Medical Center","ror":"https://ror.org/01hcyya48","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285204247"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Julio Aliberti","raw_affiliation_strings":["Divisions of Molecular Immunology and Pulmonary Medicine, Cincinnati Children\u2019s Hospital Medical Center, Cincinnati, Ohio, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Divisions of Molecular Immunology and Pulmonary Medicine, Cincinnati Children\u2019s Hospital Medical Center, Cincinnati, Ohio, United States of America","institution_ids":["https://openalex.org/I1285204247"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5064351054"],"corresponding_institution_ids":["https://openalex.org/I1285204247"],"apc_list":{"value":2382,"currency":"USD","value_usd":2382},"apc_paid":{"value":2382,"currency":"USD","value_usd":2382},"fwci":1.8191,"has_fulltext":true,"cited_by_count":58,"citation_normalized_percentile":{"value":0.83835595,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"7","issue":"6","first_page":"e38384","last_page":"e38384"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.8086000084877014,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.8086000084877014,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11503","display_name":"Cytokine Signaling Pathways and Interactions","score":0.11710000038146973,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11591","display_name":"NF-\u03baB Signaling Pathways","score":0.009100000374019146,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/traf6","display_name":"TRAF6","score":0.7730000019073486},{"id":"https://openalex.org/keywords/socs2","display_name":"SOCS2","score":0.9369999766349792},{"id":"https://openalex.org/keywords/proteasomal-degradation","display_name":"proteasomal degradation","score":0.7239999771118164},{"id":"https://openalex.org/keywords/lipoxins","display_name":"lipoxins","score":0.9599999785423279},{"id":"https://openalex.org/keywords/l-kynurenine","display_name":"L-kynurenine","score":0.9449999928474426},{"id":"https://openalex.org/keywords/aryl-hydrocarbon-receptor","display_name":"aryl hydrocarbon receptor","score":0.8989999890327454},{"id":"https://openalex.org/keywords/tryptophan-metabolism","display_name":"tryptophan metabolism","score":0.7440000176429749},{"id":"https://openalex.org/keywords/innate-immune-regulation","display_name":"innate immune regulation","score":0.5899999737739563},{"id":"https://openalex.org/keywords/anti-inflammatory-signaling","display_name":"anti-inflammatory signaling","score":0.8130000233650208},{"id":"https://openalex.org/keywords/polyubiquitination","display_name":"polyubiquitination","score":0.8949999809265137},{"id":"https://openalex.org/keywords/toll-like-receptor-signaling","display_name":"Toll-like receptor signaling","score":0.7900000214576721},{"id":"https://openalex.org/keywords/cytokine-receptor-signaling","display_name":"cytokine receptor signaling","score":0.921999990940094},{"id":"https://openalex.org/keywords/toxoplasmosis","display_name":"toxoplasmosis","score":0.9409999847412109},{"id":"https://openalex.org/keywords/inflammation-control","display_name":"inflammation control","score":0.3889999985694885}],"concepts":[{"id":"https://openalex.org/C136449434","wikidata":"https://www.wikidata.org/wiki/Q428253","display_name":"Innate immune system","level":3,"score":0.81661057472229},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5250799059867859},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4578808844089508},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.456989049911499},{"id":"https://openalex.org/C27740335","wikidata":"https://www.wikidata.org/wiki/Q14878333","display_name":"Proteasome","level":2,"score":0.4506620466709137},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4416342079639435},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.2992923855781555}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005434","descriptor_name":"Flow Cytometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007113","descriptor_name":"Immunity, Innate","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007113","descriptor_name":"Immunity, Innate","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D007371","descriptor_name":"Interferon-gamma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007371","descriptor_name":"Interferon-gamma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D046988","descriptor_name":"Proteasome Endopeptidase Complex","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D047988","descriptor_name":"Tumor Necrosis Factor Receptor-Associated Peptides and Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D047988","descriptor_name":"Tumor Necrosis Factor Receptor-Associated Peptides and Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D048029","descriptor_name":"TNF Receptor-Associated Factor 6","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D048029","descriptor_name":"TNF Receptor-Associated Factor 6","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D050826","descriptor_name":"Suppressor of Cytokine Signaling Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D050826","descriptor_name":"Suppressor of Cytokine Signaling Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054875","descriptor_name":"Ubiquitination","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D054875","descriptor_name":"Ubiquitination","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D060888","descriptor_name":"Real-Time Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1371/journal.pone.0038384","doi":"https://doi.org/10.1371/journal.pone.0038384","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0038384","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0038384&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2378491","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3367914","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:22693634","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22693634","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PloS one","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3367914","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3367914/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS One","raw_type":"Text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.792.6581","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.792.6581","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/85/c2/pone.0038384.PMC3367914.pdf","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:a7d9a0a3b7774290ab91be05d8181a45","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/a7d9a0a3b7774290ab91be05d8181a45","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, Vol 7, Iss 6, p e38384 (2012)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1371/journal.pone.0038384","doi":"https://doi.org/10.1371/journal.pone.0038384","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0038384","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0038384&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3878406769","display_name":"Control of Immune responses by lipoxins during tuberculosis","funder_award_id":"R01AI075038","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G6567436628","display_name":"Innate Immune Responses during Toxoplasmosis","funder_award_id":"R01AI078969","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2063863569.pdf","grobid_xml":"https://content.openalex.org/works/W2063863569.grobid-xml"},"referenced_works_count":36,"referenced_works":["https://openalex.org/W1534709281","https://openalex.org/W1603640418","https://openalex.org/W1935728713","https://openalex.org/W1971662379","https://openalex.org/W1973251492","https://openalex.org/W1975929837","https://openalex.org/W1981495176","https://openalex.org/W1988088217","https://openalex.org/W1988941798","https://openalex.org/W1994825511","https://openalex.org/W1998692754","https://openalex.org/W2001678293","https://openalex.org/W2006475888","https://openalex.org/W2013144840","https://openalex.org/W2020873521","https://openalex.org/W2023650245","https://openalex.org/W2031200148","https://openalex.org/W2037454778","https://openalex.org/W2041831203","https://openalex.org/W2050135489","https://openalex.org/W2052436251","https://openalex.org/W2067627058","https://openalex.org/W2068167523","https://openalex.org/W2068912461","https://openalex.org/W2074374052","https://openalex.org/W2093442991","https://openalex.org/W2102189561","https://openalex.org/W2111220263","https://openalex.org/W2111873809","https://openalex.org/W2127130381","https://openalex.org/W2138005968","https://openalex.org/W2143565660","https://openalex.org/W2147709293","https://openalex.org/W2165777029","https://openalex.org/W2170457291","https://openalex.org/W2402932721"],"related_works":["https://openalex.org/W7098766654","https://openalex.org/W2178216880","https://openalex.org/W2052436251","https://openalex.org/W4249776739","https://openalex.org/W2074587127","https://openalex.org/W3083776805","https://openalex.org/W1979945691","https://openalex.org/W3010891774","https://openalex.org/W2091789919","https://openalex.org/W2771381310"],"abstract_inverted_index":{"Pattern":[0],"recognition":[1],"receptors":[2,4],"and":[3,126,146,157,168,172,191,196,216,242,250],"for":[5,136,235],"pro-inflammatory":[6,214],"cytokines":[7],"provide":[8],"critical":[9,244],"signals":[10],"to":[11,18,25,70,131,205,207,212],"drive":[12],"the":[13,81,123,137,176,236,248],"development":[14,138],"of":[15,54,90,96,115,118,139,175,183,189,228],"protective":[16],"immunity":[17],"infection.":[19],"Therefore,":[20],"counter-regulatory":[21,75,245],"pathways":[22],"are":[23,94],"required":[24],"ensure":[26],"that":[27,36,108,121,155],"overwhelming":[28],"inflammation":[29,44],"harm":[30],"host":[31],"tissues.":[32],"Previously,":[33],"we":[34,78,153],"showed":[35],"lipoxins":[37,87,145,241],"modulate":[38],"immune":[39,92,140,252],"response":[40],"during":[41,45,219],"infection,":[42],"restraining":[43],"infectious":[46],"diseases":[47],"in":[48,73,180,200,247],"an":[49,149],"Aryl":[50],"hydrocarbon":[51],"receptor":[52,125,129],"(AhR)/suppressors":[53],"cytokine":[55,192,197],"signaling":[56,93,133],"(SOCS)2-dependent-manner.":[57],"Recently,":[58],"Indoleamine-pyrrole":[59],"2,3-":[60],"dioxygenase":[61],"(IDO)-derived":[62],"tryptophan":[63],"metabolites,":[64],"including":[65],"L-kynurenine,":[66,243],"were":[67],"also":[68,101],"shown":[69],"be":[71],"involved":[72],"several":[74],"mechanisms.":[76],"Herein,":[77],"addressed":[79],"whether":[80],"intracellular":[82,132],"molecular":[83,185,233],"events":[84,134],"induced":[85],"by":[86,103,143,240],"mediating":[88],"control":[89],"innate":[91,249],"part":[95],"a":[97,116,231],"common":[98],"regulatory":[99],"pathway":[100,238],"shared":[102],"L-kynurenine":[104,147],"exposure.":[105],"We":[106],"demonstrate":[107],"Tumor":[109],"necrosis":[110],"factor":[111,113],"receptor-associated":[112],"(TRAF)6--member":[114],"family":[117],"adapter":[119,177],"molecules":[120],"couple":[122],"TNF":[124],"interleukin-1":[127],"receptor/Toll-like":[128],"families":[130],"essential":[135],"responses--is":[141],"targeted":[142],"both":[144],"via":[148],"AhR/SOCS2-dependent":[150],"pathway.":[151],"Furthermore,":[152],"show":[154],"LXA\u2084-":[156],"L-kynurenine-induced":[158],"AhR":[159],"activation,":[160],"its":[161],"subsequent":[162],"nuclear":[163],"translocation,":[164],"leading":[165],"SOCS2":[166],"expression":[167],"TRAF6":[169,229],"Lys47-linked":[170],"poly-ubiquitination":[171],"proteosome-mediated":[173],"degradation":[174,227],"proteins.":[178],"The":[179],"vitro":[181],"consequences":[182],"such":[184],"interactions":[186],"included":[187],"inhibition":[188,203],"TLR-":[190],"receptor-driven":[193],"signal":[194],"transduction":[195],"production.":[198],"Subsequently,":[199],"vivo":[201],"proteosome":[202],"led":[204],"unresponsiveness":[206],"lipoxins,":[208],"as":[209,211,230],"well":[210],"uncontrolled":[213],"reactions":[215],"elevated":[217],"mortality":[218],"toxoplasmosis.":[220],"In":[221],"summary,":[222],"our":[223],"results":[224],"establish":[225],"proteasome":[226],"key":[232],"target":[234],"anti-inflammatory":[237],"triggered":[239],"mediators":[246],"adaptive":[251],"systems.":[253]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":9},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
