{"id":"https://openalex.org/W2063785537","doi":"https://doi.org/10.1097/00005344-199106184-00012","title":"The Kidney in Hypertension","display_name":"The Kidney in Hypertension","publication_year":1991,"publication_date":"1991-01-01","ids":{"openalex":"https://openalex.org/W2063785537","doi":"https://doi.org/10.1097/00005344-199106184-00012","mag":"2063785537","pmid":"https://pubmed.ncbi.nlm.nih.gov/1721981"},"language":"en","primary_location":{"id":"doi:10.1097/00005344-199106184-00012","doi":"https://doi.org/10.1097/00005344-199106184-00012","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00005344-199106184-00012","pdf_url":null,"source":{"id":"https://openalex.org/S61167191","display_name":"Journal of Cardiovascular Pharmacology","issn_l":"0160-2446","issn":["0160-2446","1533-4023"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cardiovascular Pharmacology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113527981","display_name":"Norman K. Hollenberg","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Norman K. Hollenberg","raw_affiliation_strings":["Department of Radiology, Brigham and Women's Hospital, Boston, Massachusetts 02115"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology, Brigham and Women's Hospital, Boston, Massachusetts 02115","institution_ids":["https://openalex.org/I1283280774"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5016612074","display_name":"Jos\u00e9 Luis Rodicio","orcid":"https://orcid.org/0000-0002-3223-6128","observed_orcids":["https://orcid.org/0000-0002-3223-6128"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jose L. Rodicio","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.15748075,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"18","issue":null,"first_page":"S57","last_page":"S68"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10144","display_name":"Blood Pressure and Hypertension Studies","score":0.8246999979019165,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10144","display_name":"Blood Pressure and Hypertension Studies","score":0.8246999979019165,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10408","display_name":"Chronic Kidney Disease and Diabetes","score":0.11900000274181366,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11001","display_name":"Renin-Angiotensin System Studies","score":0.030799999833106995,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hypertension","display_name":"hypertension","score":0.9459999799728394},{"id":"https://openalex.org/keywords/kidney-disease","display_name":"kidney disease","score":0.9200000166893005},{"id":"https://openalex.org/keywords/renal-injury-progression","display_name":"renal injury progression","score":0.6579999923706055},{"id":"https://openalex.org/keywords/ace-inhibitors","display_name":"ACE inhibitors","score":0.8889999985694885},{"id":"https://openalex.org/keywords/beta-blockers","display_name":"beta-blockers","score":0.9070000052452087},{"id":"https://openalex.org/keywords/cardiovascular-risk-reduction","display_name":"cardiovascular risk reduction","score":0.8320000171661377},{"id":"https://openalex.org/keywords/coronary-events","display_name":"coronary events","score":0.8389999866485596},{"id":"https://openalex.org/keywords/antihypertensive-therapy","display_name":"antihypertensive therapy","score":0.8240000009536743}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8403750658035278},{"id":"https://openalex.org/C2778425758","wikidata":"https://www.wikidata.org/wiki/Q180762","display_name":"Angina","level":3,"score":0.5788220763206482},{"id":"https://openalex.org/C2778468042","wikidata":"https://www.wikidata.org/wiki/Q273976","display_name":"Blockade","level":3,"score":0.571866512298584},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.5425534844398499},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5234058499336243},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.46332496404647827},{"id":"https://openalex.org/C2778653478","wikidata":"https://www.wikidata.org/wiki/Q1054718","display_name":"Kidney disease","level":2,"score":0.4551120400428772},{"id":"https://openalex.org/C2991844318","wikidata":"https://www.wikidata.org/wiki/Q476921","display_name":"Renal injury","level":3,"score":0.41123995184898376},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.38792628049850464},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.33776456117630005},{"id":"https://openalex.org/C500558357","wikidata":"https://www.wikidata.org/wiki/Q12152","display_name":"Myocardial infarction","level":2,"score":0.1555231213569641},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.07398480176925659}],"mesh":[{"descriptor_ui":"D000319","descriptor_name":"Adrenergic beta-Antagonists","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000959","descriptor_name":"Antihypertensive Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006973","descriptor_name":"Hypertension","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D007674","descriptor_name":"Kidney Diseases","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1097/00005344-199106184-00012","doi":"https://doi.org/10.1097/00005344-199106184-00012","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00005344-199106184-00012","pdf_url":null,"source":{"id":"https://openalex.org/S61167191","display_name":"Journal of Cardiovascular Pharmacology","issn_l":"0160-2446","issn":["0160-2446","1533-4023"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cardiovascular Pharmacology","raw_type":"journal-article"},{"id":"doi:10.1097/00005344-199118041-00012","doi":"https://doi.org/10.1097/00005344-199118041-00012","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00005344-199118041-00012","pdf_url":null,"source":{"id":"https://openalex.org/S61167191","display_name":"Journal of Cardiovascular Pharmacology","issn_l":"0160-2446","issn":["0160-2446","1533-4023"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cardiovascular Pharmacology","raw_type":"journal-article"},{"id":"pmid:1721981","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1721981","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of cardiovascular pharmacology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9922999739646912,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2038628432","https://openalex.org/W2417494548","https://openalex.org/W2075054538","https://openalex.org/W2046810411","https://openalex.org/W2397939064","https://openalex.org/W2523512917","https://openalex.org/W2007514532","https://openalex.org/W2123865460","https://openalex.org/W2032418399","https://openalex.org/W2417536730"],"abstract_inverted_index":{"As":[0],"in":[1,9,81,93,158,191],"any":[2],"patient":[3,12,112,193],"with":[4,13,113,186,194],"hypertension,":[5,66],"the":[6,10,19,44,53,71,111,162,166,173,187,192],"first":[7],"goal":[8,23,40],"hypertensive":[11],"renal":[14,47,76,96,169,195],"disease":[15,48],"is":[16,24,41,58,140],"to":[17,25,42,61,142,176,184],"control":[18,64],"hypertension.":[20],"The":[21,38],"second":[22],"reduce":[26],"overall":[27],"cardiovascular":[28],"risk,":[29],"which":[30],"includes":[31],"an":[32],"increased":[33],"likelihood":[34,45],"of":[35,55,65,73,75,160,168,172,189],"coronary":[36,124],"events.":[37],"third":[39],"minimize":[43,52],"that":[46,63,86,144,149],"will":[49,69,180],"progress,":[50],"or":[51,126],"rate":[54,72],"progression.":[56],"There":[57],"substantial":[59],"evidence":[60,139],"indicate":[62],"however":[67],"achieved,":[68],"slow":[70],"progression":[74],"injury":[77],"and":[78,98],"destruction.":[79],"Studies":[80],"animal":[82],"models":[83],"have":[84,100],"indicated":[85],"angiotensin-converting":[87],"enzyme":[88],"inhibitors":[89],"are":[90],"more":[91,102],"consistent":[92],"preventing":[94],"progressive":[95],"injury,":[97,170],"perhaps":[99],"a":[101,114,122,129,145,151],"sustained":[103],"action":[104,153],"than":[105],"standard":[106],"agents":[107],"employed":[108],"hitherto.":[109],"In":[110,165],"clear":[115],"indication":[116],"for":[117],"beta-adrenergic":[118,130,146],"blockade,":[119],"such":[120],"as":[121],"prior":[123],"event":[125],"angina":[127],"pectoris,":[128],"blocking":[131,147],"agent":[132,148],"should":[133],"be":[134],"employed.":[135],"Preliminary,":[136],"but":[137],"intriguing,":[138],"available":[141],"suggest":[143],"incorporates":[150],"vasodilator":[152],"may":[154],"enjoy":[155],"special":[156],"benefits":[157],"terms":[159],"achieving":[161],"three":[163],"goals.":[164],"case":[167],"completion":[171],"studies":[174],"required":[175],"prove":[177],"this":[178],"point":[179],"improve":[181],"our":[182],"ability":[183],"deal":[185],"problem":[188],"hypertension":[190],"disease.":[196]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
