{"id":"https://openalex.org/W2063733729","doi":"https://doi.org/10.1097/ta.0b013e31804d23e1","title":"Coagulation and Complement Protein Differences Between Septic and Uninfected Systemic Inflammatory Response Syndrome Patients","display_name":"Coagulation and Complement Protein Differences Between Septic and Uninfected Systemic Inflammatory Response Syndrome Patients","publication_year":2007,"publication_date":"2007-05-01","ids":{"openalex":"https://openalex.org/W2063733729","doi":"https://doi.org/10.1097/ta.0b013e31804d23e1","mag":"2063733729","pmid":"https://pubmed.ncbi.nlm.nih.gov/17495706"},"language":"en","primary_location":{"id":"doi:10.1097/ta.0b013e31804d23e1","doi":"https://doi.org/10.1097/ta.0b013e31804d23e1","is_oa":false,"landing_page_url":"https://doi.org/10.1097/ta.0b013e31804d23e1","pdf_url":null,"source":{"id":"https://openalex.org/S2312674","display_name":"The Journal of Trauma: Injury, Infection, and Critical Care","issn_l":"0022-5282","issn":["0022-5282","1529-8809"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Trauma: Injury, Infection, and Critical Care","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5046099015","display_name":"Matthew E. Lissauer","orcid":"https://orcid.org/0000-0002-6008-9778","observed_orcids":["https://orcid.org/0000-0002-6008-9778"]},"institutions":[{"id":"https://openalex.org/I126744593","display_name":"University of Maryland, Baltimore","ror":"https://ror.org/04rq5mt64","country_code":"US","type":"education","lineage":["https://openalex.org/I126744593"]},{"id":"https://openalex.org/I1315496137","display_name":"University of Maryland Medical Center","ror":"https://ror.org/00sde4n60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1315496137","https://openalex.org/I14285509"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Matthew E. Lissauer","raw_affiliation_strings":["R. Adams Cowley Shock Trauma Center, University of Maryland Medical Center, Baltimore 21201, USA. mlissauer@umm.edu","University of Maryland, Baltimore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"R. Adams Cowley Shock Trauma Center, University of Maryland Medical Center, Baltimore 21201, USA. mlissauer@umm.edu","institution_ids":["https://openalex.org/I1315496137"]},{"raw_affiliation_string":"University of Maryland, Baltimore","institution_ids":["https://openalex.org/I126744593"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103644976","display_name":"Steven B. Johnson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I126744593","display_name":"University of Maryland, Baltimore","ror":"https://ror.org/04rq5mt64","country_code":"US","type":"education","lineage":["https://openalex.org/I126744593"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Steven B. Johnson","raw_affiliation_strings":["University of Maryland, Baltimore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Maryland, Baltimore","institution_ids":["https://openalex.org/I126744593"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067311581","display_name":"Gary E. Siuzdak","orcid":"https://orcid.org/0000-0002-4749-0014","observed_orcids":["https://orcid.org/0000-0002-4749-0014"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gary Siuzdak","raw_affiliation_strings":["Mass Consortium Corporation"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mass Consortium Corporation","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028603451","display_name":"Grant Vincent Bochicchio","orcid":"https://orcid.org/0000-0002-8313-1449","observed_orcids":["https://orcid.org/0000-0002-8313-1449"]},"institutions":[{"id":"https://openalex.org/I126744593","display_name":"University of Maryland, Baltimore","ror":"https://ror.org/04rq5mt64","country_code":"US","type":"education","lineage":["https://openalex.org/I126744593"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Grant Bochicchio","raw_affiliation_strings":["University of Maryland, Baltimore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Maryland, Baltimore","institution_ids":["https://openalex.org/I126744593"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052669067","display_name":"Craig C. Whiteford","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Craig Whiteford","raw_affiliation_strings":["BD Diagnostic Systems"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BD Diagnostic Systems","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003289713","display_name":"Bill Nussbaumer","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Bill Nussbaumer","raw_affiliation_strings":["BD Diagnostic Systems"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BD Diagnostic Systems","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Richard Moore","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Richard Moore","raw_affiliation_strings":["BD Diagnostic Systems"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BD Diagnostic Systems","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5019706236","display_name":"Thomas Michael Scalea","orcid":"https://orcid.org/0000-0001-8794-4108","observed_orcids":["https://orcid.org/0000-0001-8794-4108"]},"institutions":[{"id":"https://openalex.org/I126744593","display_name":"University of Maryland, Baltimore","ror":"https://ror.org/04rq5mt64","country_code":"US","type":"education","lineage":["https://openalex.org/I126744593"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thomas M. Scalea","raw_affiliation_strings":["University of Maryland, Baltimore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Maryland, Baltimore","institution_ids":["https://openalex.org/I126744593"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.3804,"has_fulltext":false,"cited_by_count":26,"citation_normalized_percentile":{"value":0.88369767,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"62","issue":"5","first_page":"1082","last_page":"1094"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10218","display_name":"Sepsis Diagnosis and Treatment","score":0.9911999702453613,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10218","display_name":"Sepsis Diagnosis and Treatment","score":0.9911999702453613,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10519","display_name":"Advanced Proteomics Techniques and Applications","score":0.002300000051036477,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T14165","display_name":"Inflammation biomarkers and pathways","score":0.0019000000320374966,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/systemic-inflammatory-response-syndrome","display_name":"systemic inflammatory response syndrome","score":0.8989999890327454},{"id":"https://openalex.org/keywords/sepsis","display_name":"sepsis","score":0.9980000257492065},{"id":"https://openalex.org/keywords/coagulation-cascade","display_name":"coagulation cascade","score":0.7020000219345093},{"id":"https://openalex.org/keywords/complement-system","display_name":"complement system","score":0.9649999737739563},{"id":"https://openalex.org/keywords/plasma-protein-profiling","display_name":"plasma protein profiling","score":0.8560000061988831},{"id":"https://openalex.org/keywords/sepsis-prediction","display_name":"sepsis prediction","score":0.5879999995231628},{"id":"https://openalex.org/keywords/intensive-care-unit-patients","display_name":"intensive care unit patients","score":0.5609999895095825},{"id":"https://openalex.org/keywords/proteomics","display_name":"proteomics","score":0.3700000047683716},{"id":"https://openalex.org/keywords/classical-complement-pathway","display_name":"classical complement pathway","score":0.6159999966621399},{"id":"https://openalex.org/keywords/lectin-complement-pathway","display_name":"lectin pathway","score":0.7950000166893005}],"concepts":[{"id":"https://openalex.org/C2778384902","wikidata":"https://www.wikidata.org/wiki/Q183134","display_name":"Sepsis","level":2,"score":0.7313322424888611},{"id":"https://openalex.org/C111684460","wikidata":"https://www.wikidata.org/wiki/Q334848","display_name":"Complement system","level":3,"score":0.6812792420387268},{"id":"https://openalex.org/C2781090800","wikidata":"https://www.wikidata.org/wiki/Q776030","display_name":"Systemic inflammatory response syndrome","level":3,"score":0.6590760946273804},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5780323147773743},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5039317011833191},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3976421058177948},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.322867214679718},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.2962866425514221}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001779","descriptor_name":"Blood Coagulation Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D003165","descriptor_name":"Complement System Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015599","descriptor_name":"Trauma Severity Indices","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016638","descriptor_name":"Critical Illness","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018746","descriptor_name":"Systemic Inflammatory Response Syndrome","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D018805","descriptor_name":"Sepsis","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D018805","descriptor_name":"Sepsis","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D021241","descriptor_name":"Spectrometry, Mass, Electrospray Ionization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1097/ta.0b013e31804d23e1","doi":"https://doi.org/10.1097/ta.0b013e31804d23e1","is_oa":false,"landing_page_url":"https://doi.org/10.1097/ta.0b013e31804d23e1","pdf_url":null,"source":{"id":"https://openalex.org/S2312674","display_name":"The Journal of Trauma: Injury, Infection, and Critical Care","issn_l":"0022-5282","issn":["0022-5282","1529-8809"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Trauma: Injury, Infection, and Critical Care","raw_type":"journal-article"},{"id":"pmid:17495706","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17495706","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of trauma","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.532.2596","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.532.2596","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://masspec.scripps.edu/publications/public_pdf/125_Lissauer_art.pdf","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":35,"referenced_works":["https://openalex.org/W1507312029","https://openalex.org/W1713440487","https://openalex.org/W1970172365","https://openalex.org/W1981576946","https://openalex.org/W1987242103","https://openalex.org/W1998865265","https://openalex.org/W2007810526","https://openalex.org/W2027776285","https://openalex.org/W2045010042","https://openalex.org/W2050728328","https://openalex.org/W2058670939","https://openalex.org/W2070621614","https://openalex.org/W2080974189","https://openalex.org/W2087203965","https://openalex.org/W2087746647","https://openalex.org/W2102260352","https://openalex.org/W2113603408","https://openalex.org/W2122683221","https://openalex.org/W2127938920","https://openalex.org/W2138482047","https://openalex.org/W2148471980","https://openalex.org/W2152354908","https://openalex.org/W2159230166","https://openalex.org/W2159482845","https://openalex.org/W2160691650","https://openalex.org/W2163814324","https://openalex.org/W2165674132","https://openalex.org/W2167097725","https://openalex.org/W2322121630","https://openalex.org/W2768146862","https://openalex.org/W3216465316","https://openalex.org/W4232903880","https://openalex.org/W4245690870","https://openalex.org/W4246578140","https://openalex.org/W4294216483"],"related_works":["https://openalex.org/W2027776285","https://openalex.org/W2079481922","https://openalex.org/W2143760625","https://openalex.org/W4378473278","https://openalex.org/W1588939100","https://openalex.org/W2626219705","https://openalex.org/W4390034238","https://openalex.org/W7134803550","https://openalex.org/W2050425350","https://openalex.org/W1520056568"],"abstract_inverted_index":{"BACKGROUND:":[0],"Systemic":[1],"inflammatory":[2],"response":[3,9],"syndrome":[4],"(SIRS)":[5],"represents":[6],"a":[7,59,85,93,120],"host":[8],"to":[10,28,45,53,135,171,181,188,195,212,224,236],"various":[11],"insults.":[12],"Recent":[13],"advances":[14],"have":[15],"demonstrated":[16],"an":[17,54],"interconnection":[18],"between":[19,35,164],"inflammation,":[20],"complement,":[21],"and":[22,80,92,119,140,174,191],"coagulation.":[23],"This":[24],"experiment":[25],"was":[26,101,138],"designed":[27],"evaluate":[29],"differences":[30],"in":[31,208,229],"plasma":[32],"protein":[33,227],"profiles":[34,228],"clinically":[36],"identical":[37],"patients:":[38],"septic":[39,230],"versus":[40,231],"uninfected":[41,232],"SIRS":[42,66,94,233],"patients,":[43],"prior":[44,235],"clinical":[46,237],"diagnosis":[47,238],"of":[48,58,64,73,116,152,157,167,239],"infection.":[49],"METHODS:":[50],"Patients":[51],"admitted":[52],"intensive":[55],"care":[56],"unit":[57],"major":[60],"university,":[61],"meeting":[62],"two":[63,83],"four":[65],"criteria":[67],"were":[68,77,125,161,203,222],"followed":[69],"prospectively":[70],"for":[71],"development":[72],"sepsis.":[74,240],"Plasma":[75],"samples":[76],"collected":[78],"daily":[79],"divided":[81],"into":[82],"groups:":[84],"preseptic":[86],"group":[87,95],"that":[88,96],"subsequently":[89],"developed":[90],"sepsis":[91,209],"remained":[97],"uninfected.":[98],"Protein":[99],"profiling":[100],"accomplished":[102],"by":[103],"three-dimensional":[104],"liquid":[105],"chromatography":[106],"fractionation":[107],"with":[108,144],"electrospray":[109],"ion":[110],"trap":[111],"mass":[112,218],"spectrometry":[113,219],"after":[114],"immunodepletion":[115],"abundant":[117],"proteins":[118,160],"trypsin":[121],"digest.":[122],"Spectra":[123],"peaks":[124],"identified":[126],"using":[127],"Agilent":[128],"Technologies":[129],"Spectrum":[130],"Mill":[131],"Workbench":[132],"software.":[133],"Relevance":[134],"biologic":[136],"pathways":[137,202],"analyzed":[139],"statistical":[141],"significance":[142],"determined":[143],"DAVID":[145],"2.1":[146],"available":[147],"at":[148],"the":[149,172],"National":[150],"Institutes":[151],"Health.":[153],"RESULTS:":[154],"A":[155],"total":[156],"134":[158],"unique":[159],"significantly":[162,205],"different":[163],"groups.":[165],"Thirty-two":[166],"these":[168],"(23.5%)":[169],"mapped":[170,180,187,194],"complement":[173,183,189,198],"coagulation":[175],"cascade":[176],"(KEGG),":[177],"10":[178],"(7.5%)":[179],"classic":[182],"pathway;":[184],"11":[185],"(8.2%)":[186],"pathway,":[190],"8":[192],"(6.0%)":[193],"lectin":[196],"binding":[197],"pathway":[199],"(Biocarta).":[200],"These":[201],"all":[204],"(p<0.0001)":[206],"over-represented":[207],"patients":[210,234],"compared":[211],"SIRS-only":[213],"patients.":[214],"CONCLUSION:":[215],"Using":[216],"novel":[217],"methodology,":[220],"we":[221],"able":[223],"demonstrate":[225],"differential":[226]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
