{"id":"https://openalex.org/W2063726095","doi":"https://doi.org/10.1046/j.1365-2613.1997.d01-245.x","title":"An age\u2010related change in susceptibility of rat brain to encephalomyocarditis virus infection","display_name":"An age\u2010related change in susceptibility of rat brain to encephalomyocarditis virus infection","publication_year":1997,"publication_date":"1997-04-01","ids":{"openalex":"https://openalex.org/W2063726095","doi":"https://doi.org/10.1046/j.1365-2613.1997.d01-245.x","mag":"2063726095","pmid":"https://pubmed.ncbi.nlm.nih.gov/9203984","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2694528"},"language":"en","primary_location":{"id":"doi:10.1046/j.1365-2613.1997.d01-245.x","doi":"https://doi.org/10.1046/j.1365-2613.1997.d01-245.x","is_oa":false,"landing_page_url":"https://doi.org/10.1046/j.1365-2613.1997.d01-245.x","pdf_url":null,"source":{"id":"https://openalex.org/S82103187","display_name":"International Journal of Experimental Pathology","issn_l":"0959-9673","issn":["0959-9673","1365-2613"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Experimental Pathology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2694528","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103647434","display_name":"Hisashi Ikegami","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"HISASHI IKEGAMI","raw_affiliation_strings":["Department of Veterinary Pathology, Faculty of Agriculture, University of Tokyo, Japan","Department of Veterinary Pathology, Faculty of Agriculture, The University of Tokyo, Yayoi 1\u20101\u20101, Bunkyo\u2010ku, Tokyo 113, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Veterinary Pathology, Faculty of Agriculture, University of Tokyo, Japan","institution_ids":["https://openalex.org/I74801974"]},{"raw_affiliation_string":"Department of Veterinary Pathology, Faculty of Agriculture, The University of Tokyo, Yayoi 1\u20101\u20101, Bunkyo\u2010ku, Tokyo 113, Japan","institution_ids":["https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":null,"display_name":"MAKIO TAKEDA","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"MAKIO TAKEDA","raw_affiliation_strings":["Department of Veterinary Pathology, Faculty of Agriculture, The University of Tokyo, Yayoi 1-1-1, Bunkyo-ku, Tokyo 113, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Veterinary Pathology, Faculty of Agriculture, The University of Tokyo, Yayoi 1-1-1, Bunkyo-ku, Tokyo 113, Japan","institution_ids":["https://openalex.org/I74801974"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111726867","display_name":"Kunio Doi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"KUNIO DOI","raw_affiliation_strings":["Department of Veterinary Pathology, Faculty of Agriculture, The University of Tokyo, Yayoi 1-1-1, Bunkyo-ku, Tokyo 113, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Veterinary Pathology, Faculty of Agriculture, The University of Tokyo, Yayoi 1-1-1, Bunkyo-ku, Tokyo 113, Japan","institution_ids":["https://openalex.org/I74801974"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5111726867"],"corresponding_institution_ids":["https://openalex.org/I74801974"],"apc_list":{"value":3730,"currency":"USD","value_usd":3730},"apc_paid":null,"fwci":1.2167,"has_fulltext":false,"cited_by_count":16,"citation_normalized_percentile":{"value":0.81404502,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"78","issue":"2","first_page":"101","last_page":"107"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11112","display_name":"Viral Infections and Immunology Research","score":0.8036999702453613,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11112","display_name":"Viral Infections and Immunology Research","score":0.8036999702453613,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13201","display_name":"Infectious Encephalopathies and Encephalitis","score":0.10689999908208847,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11135","display_name":"Virology and Viral Diseases","score":0.05990000069141388,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/encephalomyocarditis-virus","display_name":"encephalomyocarditis virus","score":0.9950000047683716},{"id":"https://openalex.org/keywords/age-related-susceptibility","display_name":"age-related susceptibility","score":0.9399999976158142},{"id":"https://openalex.org/keywords/rat-brain","display_name":"rat brain","score":0.5429999828338623},{"id":"https://openalex.org/keywords/meningoencephalitis","display_name":"meningoencephalitis","score":0.9190000295639038},{"id":"https://openalex.org/keywords/neuronal-necrosis","display_name":"neuronal necrosis","score":0.9810000061988831},{"id":"https://openalex.org/keywords/viral-replication","display_name":"viral replication","score":0.6489999890327454},{"id":"https://openalex.org/keywords/hippocampus","display_name":"hippocampus","score":0.8799999952316284},{"id":"https://openalex.org/keywords/thalamus","display_name":"thalamus","score":0.7250000238418579},{"id":"https://openalex.org/keywords/cerebral-cortex","display_name":"cerebral cortex","score":0.9380000233650208},{"id":"https://openalex.org/keywords/immune-maturation","display_name":"immune system maturation","score":0.7319999933242798},{"id":"https://openalex.org/keywords/neurovirus-infection","display_name":"neurovirus infection","score":0.5270000100135803}],"concepts":[{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.6602835655212402},{"id":"https://openalex.org/C140704245","wikidata":"https://www.wikidata.org/wiki/Q3933202","display_name":"Viral replication","level":3,"score":0.6585448980331421},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.6020298004150391},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5980128049850464},{"id":"https://openalex.org/C2781161787","wikidata":"https://www.wikidata.org/wiki/Q48360","display_name":"Hippocampus","level":2,"score":0.5199376344680786},{"id":"https://openalex.org/C180032290","wikidata":"https://www.wikidata.org/wiki/Q1664296","display_name":"Inoculation","level":2,"score":0.5103091597557068},{"id":"https://openalex.org/C2778621254","wikidata":"https://www.wikidata.org/wiki/Q2346415","display_name":"Meningoencephalitis","level":2,"score":0.5088139176368713},{"id":"https://openalex.org/C2779246727","wikidata":"https://www.wikidata.org/wiki/Q184215","display_name":"Thalamus","level":2,"score":0.4887099266052246},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.4231628179550171},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.4151368737220764},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.35448044538497925},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.26420891284942627},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.22194647789001465},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.10743853449821472},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002540","descriptor_name":"Cerebral Cortex","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002540","descriptor_name":"Cerebral Cortex","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D004198","descriptor_name":"Disease Susceptibility","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004686","descriptor_name":"Encephalomyocarditis virus","qualifier_ui":"Q000472","qualifier_name":"pathogenicity","is_major_topic":true},{"descriptor_ui":"D004686","descriptor_name":"Encephalomyocarditis virus","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008590","descriptor_name":"Meningoencephalitis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008590","descriptor_name":"Meningoencephalitis","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":true},{"descriptor_ui":"D011916","descriptor_name":"Rats, Inbred F344","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014779","descriptor_name":"Virus Replication","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017403","descriptor_name":"In Situ Hybridization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018188","descriptor_name":"Cardiovirus Infections","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D018188","descriptor_name":"Cardiovirus Infections","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1046/j.1365-2613.1997.d01-245.x","doi":"https://doi.org/10.1046/j.1365-2613.1997.d01-245.x","is_oa":false,"landing_page_url":"https://doi.org/10.1046/j.1365-2613.1997.d01-245.x","pdf_url":null,"source":{"id":"https://openalex.org/S82103187","display_name":"International Journal of Experimental Pathology","issn_l":"0959-9673","issn":["0959-9673","1365-2613"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Experimental Pathology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2694528","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2694528","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Exp Pathol","raw_type":"Text"},{"id":"pmid:9203984","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9203984","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of experimental pathology","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2694528","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2694528","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Exp Pathol","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2138045302","https://openalex.org/W2021118351","https://openalex.org/W2311626496","https://openalex.org/W1996990557","https://openalex.org/W2365138532","https://openalex.org/W2343026550","https://openalex.org/W2313271309","https://openalex.org/W2332359217","https://openalex.org/W1992590182","https://openalex.org/W4239595872"],"abstract_inverted_index":{"Rats":[0],"were":[1,49,74,93,133,145],"inoculated":[2,54,65,154],"intraperitoneally":[3],"(i.p.)":[4],"or":[5,30],"intracerebrally":[6],"(i.c.)":[7],"with":[8,98],"1":[9],"x":[10],"10(4)":[11],"plaque":[12],"forming":[13],"units":[14],"(PFU)/animal":[15],"of":[16,20,33,60,71,127,151,158,170,185,193],"the":[17,41,52,63,77,85,102,119,149,168,183,194],"D":[18],"variant":[19],"encephalomyocarditis":[21],"virus":[22,175],"(EMC-D)":[23],"at":[24,55,155],"2,":[25],"4,":[26],"7,":[27],"14,":[28],"28":[29,56,156],"56":[31,58],"days":[32,59,70,157],"age":[34],"for":[35],"virological":[36],"and":[37,57,88,106,108,143],"histopathological":[38],"examination.":[39],"In":[40,62,118],"i.p.-inoculation":[42],"study,":[43,121],"neither":[44],"viral":[45,80,109,141],"replication":[46,81,142],"nor":[47],"lesions":[48,73,92,144],"detected":[50,83,112,147],"in":[51,84,101,113,125,148,167,182,191],"animals":[53,64,153],"age.":[61,159],"when":[66],"younger":[67],"than":[68],"14":[69],"age,":[72],"restricted":[75],"to":[76,130,173],"brain":[78,91,129,172],"although":[79],"was":[82,111,139],"brain,":[86],"heart":[87],"pancreas.":[89],"The":[90],"characterized":[94],"by":[95],"acute":[96],"meningoencephalitis":[97],"neuronal":[99],"necrosis":[100],"cerebral":[103],"cortex,":[104],"hippocampus":[105,150],"thalamus,":[107],"RNA":[110],"degenerated":[114],"and/or":[115],"intact":[116],"neurons.":[117],"i.c.-inoculation":[120],"similar":[122],"age-related":[123,165,180],"changes":[124],"susceptibility":[126,169,184],"rat":[128,171],"EMC-D":[131],"infection":[132,176],"observed,":[134],"but":[135],"a":[136],"minor":[137],"difference":[138],"that":[140,163],"still":[146],"some":[152],"These":[160],"results":[161],"suggest":[162],"an":[164,179],"decrease":[166],"EMC":[174],"may":[177],"reflect":[178],"change":[181],"neurons":[186],"themselves":[187],"as":[188,190],"well":[189],"maturation":[192],"immune":[195],"system.":[196]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
