{"id":"https://openalex.org/W2063679927","doi":"https://doi.org/10.1111/j.1471-4159.1993.tb02167.x","title":"Evidence for the Corelease of Dynorphin and Glutamate from Rat Hippocampal Mossy Fiber Terminals","display_name":"Evidence for the Corelease of Dynorphin and Glutamate from Rat Hippocampal Mossy Fiber Terminals","publication_year":1993,"publication_date":"1993-08-01","ids":{"openalex":"https://openalex.org/W2063679927","doi":"https://doi.org/10.1111/j.1471-4159.1993.tb02167.x","mag":"2063679927","pmid":"https://pubmed.ncbi.nlm.nih.gov/7687656"},"language":"en","primary_location":{"id":"doi:10.1111/j.1471-4159.1993.tb02167.x","doi":"https://doi.org/10.1111/j.1471-4159.1993.tb02167.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1471-4159.1993.tb02167.x","pdf_url":null,"source":{"id":"https://openalex.org/S135837084","display_name":"Journal of Neurochemistry","issn_l":"0022-3042","issn":["0022-3042","1471-4159"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neurochemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109135876","display_name":"Teresa Conner\u2010Kerr","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I186335123","display_name":"East Carolina University","ror":"https://ror.org/01vx35703","country_code":"US","type":"education","lineage":["https://openalex.org/I186335123"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Teresa A. Conner\u2010Kerr","raw_affiliation_strings":["Department of Anatomy and Cell Biology, East Carolina University School of Medicine, Greenville, North Carolina 27858","Department of Anatomy and Cell Biology, East Carolina University School of Medicine, Greenville, North Carolina, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomy and Cell Biology, East Carolina University School of Medicine, Greenville, North Carolina 27858","institution_ids":["https://openalex.org/I186335123"]},{"raw_affiliation_string":"Department of Anatomy and Cell Biology, East Carolina University School of Medicine, Greenville, North Carolina, U.S.A","institution_ids":["https://openalex.org/I186335123"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027531357","display_name":"Duncan R. Simmons","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I186335123","display_name":"East Carolina University","ror":"https://ror.org/01vx35703","country_code":"US","type":"education","lineage":["https://openalex.org/I186335123"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Duncan R. Simmons","raw_affiliation_strings":["Department of Anatomy and Cell Biology, East Carolina University School of Medicine, Greenville, North Carolina, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomy and Cell Biology, East Carolina University School of Medicine, Greenville, North Carolina, U.S.A","institution_ids":["https://openalex.org/I186335123"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018498460","display_name":"Gary M. Peterson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I186335123","display_name":"East Carolina University","ror":"https://ror.org/01vx35703","country_code":"US","type":"education","lineage":["https://openalex.org/I186335123"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gary M. Peterson","raw_affiliation_strings":["Department of Anatomy and Cell Biology, East Carolina University School of Medicine, Greenville, North Carolina, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomy and Cell Biology, East Carolina University School of Medicine, Greenville, North Carolina, U.S.A","institution_ids":["https://openalex.org/I186335123"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108201318","display_name":"David M. Terrian","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I186335123","display_name":"East Carolina University","ror":"https://ror.org/01vx35703","country_code":"US","type":"education","lineage":["https://openalex.org/I186335123"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"David M. Terrian","raw_affiliation_strings":["Department of Anatomy and Cell Biology, East Carolina University School of Medicine, Greenville, North Carolina, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomy and Cell Biology, East Carolina University School of Medicine, Greenville, North Carolina, U.S.A","institution_ids":["https://openalex.org/I186335123"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5108201318"],"corresponding_institution_ids":["https://openalex.org/I186335123"],"apc_list":{"value":5330,"currency":"USD","value_usd":5330},"apc_paid":null,"fwci":0.9787,"has_fulltext":false,"cited_by_count":30,"citation_normalized_percentile":{"value":0.73803991,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"61","issue":"2","first_page":"627","last_page":"636"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.6909000277519226,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.6909000277519226,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.2985999882221222,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dynorphin","display_name":"dynorphin","score":0.9879999756813049},{"id":"https://openalex.org/keywords/glutamate","display_name":"glutamate","score":0.8679999709129333},{"id":"https://openalex.org/keywords/co-release","display_name":"CO release","score":0.7749999761581421},{"id":"https://openalex.org/keywords/mossy-fiber-terminals","display_name":"mossy fiber terminals","score":0.875},{"id":"https://openalex.org/keywords/hippocampus","display_name":"hippocampus","score":0.8970000147819519},{"id":"https://openalex.org/keywords/prodynorphin","display_name":"prodynorphin","score":0.8500000238418579},{"id":"https://openalex.org/keywords/synaptosomes","display_name":"synaptosomes","score":0.8460000157356262},{"id":"https://openalex.org/keywords/dentate-gyrus","display_name":"dentate gyrus","score":0.8080000281333923},{"id":"https://openalex.org/keywords/granule-cells","display_name":"granule cells","score":0.7960000038146973},{"id":"https://openalex.org/keywords/u50-488h","display_name":"U50,488H","score":0.8920000195503235},{"id":"https://openalex.org/keywords/kappa-opioid-receptor","display_name":"kappa opioid receptor","score":0.9330000281333923},{"id":"https://openalex.org/keywords/exocytosis","display_name":"exocytosis","score":0.8040000200271606},{"id":"https://openalex.org/keywords/timm-staining","display_name":"Timm staining","score":0.6359999775886536}],"concepts":[{"id":"https://openalex.org/C148762608","wikidata":"https://www.wikidata.org/wiki/Q3748185","display_name":"Hippocampal formation","level":2,"score":0.797939658164978},{"id":"https://openalex.org/C151077648","wikidata":"https://www.wikidata.org/wiki/Q324076","display_name":"Dynorphin","level":5,"score":0.5451639294624329},{"id":"https://openalex.org/C2776464000","wikidata":"https://www.wikidata.org/wiki/Q545787","display_name":"Dentate gyrus","level":3,"score":0.5374671816825867},{"id":"https://openalex.org/C61174792","wikidata":"https://www.wikidata.org/wiki/Q420510","display_name":"Glutamate receptor","level":3,"score":0.5367995500564575},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.531895637512207},{"id":"https://openalex.org/C2776636253","wikidata":"https://www.wikidata.org/wiki/Q326224","display_name":"Colchicine","level":2,"score":0.4608656167984009},{"id":"https://openalex.org/C2777318268","wikidata":"https://www.wikidata.org/wiki/Q6916721","display_name":"Mossy fiber (hippocampus)","level":4,"score":0.45154377818107605},{"id":"https://openalex.org/C49760210","wikidata":"https://www.wikidata.org/wiki/Q5596727","display_name":"Granule (geology)","level":2,"score":0.4453396797180176},{"id":"https://openalex.org/C2778888523","wikidata":"https://www.wikidata.org/wiki/Q1777753","display_name":"Granule cell","level":4,"score":0.43070030212402344},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3729701042175293},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3463832139968872},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.33929702639579773},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.32517367601394653},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.29233187437057495},{"id":"https://openalex.org/C88016717","wikidata":"https://www.wikidata.org/wiki/Q417189","display_name":"Opioid peptide","level":4,"score":0.19473034143447876},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.07792478799819946},{"id":"https://openalex.org/C2781063702","wikidata":"https://www.wikidata.org/wiki/Q427523","display_name":"Opioid","level":3,"score":0.07055264711380005},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.07001727819442749},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003078","descriptor_name":"Colchicine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004399","descriptor_name":"Dynorphins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005089","descriptor_name":"Exocytosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005971","descriptor_name":"Glutamates","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009411","descriptor_name":"Nerve Endings","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010640","descriptor_name":"Phenothiazines","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011188","descriptor_name":"Potassium","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011759","descriptor_name":"Pyrrolidines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D013194","descriptor_name":"Staining and Labeling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013574","descriptor_name":"Synaptosomes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018698","descriptor_name":"Glutamic Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019900","descriptor_name":"3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1111/j.1471-4159.1993.tb02167.x","doi":"https://doi.org/10.1111/j.1471-4159.1993.tb02167.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1471-4159.1993.tb02167.x","pdf_url":null,"source":{"id":"https://openalex.org/S135837084","display_name":"Journal of Neurochemistry","issn_l":"0022-3042","issn":["0022-3042","1471-4159"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neurochemistry","raw_type":"journal-article"},{"id":"pmid:7687656","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7687656","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of neurochemistry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.5683000087738037,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":36,"referenced_works":["https://openalex.org/W1184698435","https://openalex.org/W1951222626","https://openalex.org/W1964535311","https://openalex.org/W1975653561","https://openalex.org/W1996875271","https://openalex.org/W2021682635","https://openalex.org/W2029308903","https://openalex.org/W2030449290","https://openalex.org/W2031268387","https://openalex.org/W2049981218","https://openalex.org/W2050032667","https://openalex.org/W2056422235","https://openalex.org/W2060203976","https://openalex.org/W2061631138","https://openalex.org/W2063659779","https://openalex.org/W2064153354","https://openalex.org/W2064538491","https://openalex.org/W2064729669","https://openalex.org/W2067413031","https://openalex.org/W2075302089","https://openalex.org/W2075462723","https://openalex.org/W2076050540","https://openalex.org/W2076140555","https://openalex.org/W2077718443","https://openalex.org/W2078997494","https://openalex.org/W2087340189","https://openalex.org/W2092936040","https://openalex.org/W2093467598","https://openalex.org/W2095355752","https://openalex.org/W2102131116","https://openalex.org/W2105876871","https://openalex.org/W2133851327","https://openalex.org/W2141176965","https://openalex.org/W2142686469","https://openalex.org/W2145379951","https://openalex.org/W2412812854"],"related_works":["https://openalex.org/W2075462723","https://openalex.org/W2006544286","https://openalex.org/W1975653561","https://openalex.org/W1926673207","https://openalex.org/W2167099934","https://openalex.org/W2049981218","https://openalex.org/W2035187847","https://openalex.org/W1964543428","https://openalex.org/W2027973107","https://openalex.org/W2061631138"],"abstract_inverted_index":{"Hippocampal":[0],"mossy":[1],"fiber":[2],"(MF)":[3],"nerve":[4],"endings":[5],"may":[6],"be":[7,147],"isolated":[8],"in":[9,22,57,86,110,121],"a":[10,23,35,77,111],"subcellular":[11,99,197],"fraction":[12,60,168],"(P3)":[13],"that":[14,52,61,186,199,227,253,275],"releases":[15],"both":[16,263],"prodynorphin-derived":[17],"peptides":[18,277],"and":[19,50,94,113,163,173,181,211,265,278],"glutamate":[20],"(Glu)":[21],"calcium-dependent":[24],"manner":[25],"when":[26],"depolarized.":[27],"However,":[28],"this":[29,69,152,247],"isolation":[30],"procedure":[31],"does":[32],"not":[33,201,238],"yield":[34],"pure":[36],"preparation":[37],"of":[38,47,63,80,92,103,116,130,139,155,161,178,208,231,243,258],"MF":[39,64,141,156,190,244,264,284],"synaptosomes.":[40,267],"The":[41,126,176],"present":[42,224],"study":[43],"evaluates":[44],"the":[45,58,73,81,90,97,106,117,122,131,137,140,158,166,193,209,218,223,228,232,241,273],"proportion":[46],"dynorphin":[48],"(Dyn)":[49],"Glu":[51,95,164,213,260,279],"is":[53,256],"released":[54],"from":[55,96,165,192,246,262,282],"synaptosomes":[56,191],"P3":[59,98,167,194,219],"are":[62,270,280],"origin.":[65],"We":[66],"have":[67],"addressed":[68],"issue":[70],"by":[71,149,171,203,216,240],"determining":[72],"degree":[74],"to":[75,136,146],"which":[76,134],"selective":[78,114],"lesion":[79],"dentate":[82,107],"granule":[83,118],"cell/MF":[84,119],"system":[85],"vivo":[87],"concomitantly":[88],"reduces":[89],"exocytosis":[91,261],"Dyn":[93,162,183,276],"fraction.":[100,195,220],"Unilateral":[101],"injections":[102],"colchicine":[104,187,204],"into":[105],"gyrus":[108],"resulted":[109],"substantial":[112],"degeneration":[115],"pathway":[120],"rat":[123],"hippocampal":[124,283],"formation.":[125],"overall":[127],"integrated":[128],"density":[129],"Timm-stained":[132],"band,":[133],"corresponds":[135],"position":[138],"terminal":[142],"field,":[143],"was":[144,169,237],"estimated":[145],"reduced":[148,170],"75%.":[150],"After":[151],"extensive":[153],"loss":[154,177],"boutons,":[157],"K(+)-evoked":[159],"release":[160,184,214],"95":[172],"51%,":[174],"respectively.":[175],"Timm":[179],"staining":[180],"evoked":[182,212],"indicate":[185],"effectively":[188],"eliminated":[189],"Those":[196],"entities":[198],"were":[200],"destroyed":[202],"comprised":[205],"approximately":[206],"50%":[207],"protein":[210],"measured":[215],"using":[217],"In":[221],"addition,":[222],"results":[225,269],"demonstrate":[226],"inhibitory":[229],"potency":[230],"kappa":[233],"opioid":[234],"agonist":[235],"U-50,488H":[236],"altered":[239],"elimination":[242],"boutons":[245],"synaptosomal":[248],"preparation.":[249],"This":[250],"finding":[251],"indicates":[252],"U-50,":[254],"488H":[255],"capable":[257],"suppressing":[259],"non-MF":[266],"These":[268],"consistent":[271],"with":[272],"hypothesis":[274],"co-released":[281],"terminals.":[285]},"counts_by_year":[{"year":2022,"cited_by_count":2},{"year":2018,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}