{"id":"https://openalex.org/W2063672998","doi":"https://doi.org/10.1021/jm900458r","title":"Further Studies on Arylpiperazinyl Alkyl Pyridazinones: Discovery of an Exceptionally Potent, Orally Active, Antinociceptive Agent in Thermally Induced Pain","display_name":"Further Studies on Arylpiperazinyl Alkyl Pyridazinones: Discovery of an Exceptionally Potent, Orally Active, Antinociceptive Agent in Thermally Induced Pain","publication_year":2009,"publication_date":"2009-09-29","ids":{"openalex":"https://openalex.org/W2063672998","doi":"https://doi.org/10.1021/jm900458r","mag":"2063672998","pmid":"https://pubmed.ncbi.nlm.nih.gov/19788200"},"language":"en","primary_location":{"id":"doi:10.1021/jm900458r","doi":"https://doi.org/10.1021/jm900458r","is_oa":false,"landing_page_url":"https://doi.org/10.1021/jm900458r","pdf_url":null,"source":{"id":"https://openalex.org/S162030435","display_name":"Journal of Medicinal Chemistry","issn_l":"0022-2623","issn":["0022-2623","1520-4804"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Medicinal Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5076190719","display_name":"Claudio Biancalani","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I45084792","display_name":"University of Florence","ror":"https://ror.org/04jr1s763","country_code":"IT","type":"education","lineage":["https://openalex.org/I45084792"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Claudio Biancalani","raw_affiliation_strings":["Dipartimento di Scienze Farmaceutiche, via Ugo Schiff 6, 50019 Sesto Fiorentino, Firenze, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dipartimento di Scienze Farmaceutiche, via Ugo Schiff 6, 50019 Sesto Fiorentino, Firenze, Italy","institution_ids":["https://openalex.org/I45084792"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059510963","display_name":"Maria Paola Giovannoni","orcid":"https://orcid.org/0000-0003-0310-7850","observed_orcids":["https://orcid.org/0000-0003-0310-7850"]},"institutions":[{"id":"https://openalex.org/I45084792","display_name":"University of Florence","ror":"https://ror.org/04jr1s763","country_code":"IT","type":"education","lineage":["https://openalex.org/I45084792"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Maria Paola Giovannoni","raw_affiliation_strings":["Dipartimento di Scienze Farmaceutiche, via Ugo Schiff 6, 50019 Sesto Fiorentino, Firenze, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dipartimento di Scienze Farmaceutiche, via Ugo Schiff 6, 50019 Sesto Fiorentino, Firenze, Italy","institution_ids":["https://openalex.org/I45084792"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053697476","display_name":"Stefano Pieretti","orcid":"https://orcid.org/0000-0001-5926-6194","observed_orcids":["https://orcid.org/0000-0001-5926-6194"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Stefano Pieretti","raw_affiliation_strings":["Department of Therapeutic Research and Medicine Evaluation, Viale Regina Elena 299, 00161 Roma, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Therapeutic Research and Medicine Evaluation, Viale Regina Elena 299, 00161 Roma, Italy","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084329510","display_name":"Nicoletta Cesari","orcid":"https://orcid.org/0000-0001-7712-0068","observed_orcids":["https://orcid.org/0000-0001-7712-0068"]},"institutions":[{"id":"https://openalex.org/I45084792","display_name":"University of Florence","ror":"https://ror.org/04jr1s763","country_code":"IT","type":"education","lineage":["https://openalex.org/I45084792"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Nicoletta Cesari","raw_affiliation_strings":["Dipartimento di Scienze Farmaceutiche, via Ugo Schiff 6, 50019 Sesto Fiorentino, Firenze, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dipartimento di Scienze Farmaceutiche, via Ugo Schiff 6, 50019 Sesto Fiorentino, Firenze, Italy","institution_ids":["https://openalex.org/I45084792"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006261369","display_name":"Alessia Graziano","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I45084792","display_name":"University of Florence","ror":"https://ror.org/04jr1s763","country_code":"IT","type":"education","lineage":["https://openalex.org/I45084792"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Alessia Graziano","raw_affiliation_strings":["Dipartimento di Scienze Farmaceutiche, via Ugo Schiff 6, 50019 Sesto Fiorentino, Firenze, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dipartimento di Scienze Farmaceutiche, via Ugo Schiff 6, 50019 Sesto Fiorentino, Firenze, Italy","institution_ids":["https://openalex.org/I45084792"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007196139","display_name":"Claudia Vergelli","orcid":"https://orcid.org/0000-0001-9774-8047","observed_orcids":["https://orcid.org/0000-0001-9774-8047"]},"institutions":[{"id":"https://openalex.org/I45084792","display_name":"University of Florence","ror":"https://ror.org/04jr1s763","country_code":"IT","type":"education","lineage":["https://openalex.org/I45084792"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Claudia Vergelli","raw_affiliation_strings":["Dipartimento di Scienze Farmaceutiche, via Ugo Schiff 6, 50019 Sesto Fiorentino, Firenze, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dipartimento di Scienze Farmaceutiche, via Ugo Schiff 6, 50019 Sesto Fiorentino, Firenze, Italy","institution_ids":["https://openalex.org/I45084792"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048007859","display_name":"Agostino Cilibrizzi","orcid":"https://orcid.org/0000-0002-9711-5183","observed_orcids":["https://orcid.org/0000-0002-9711-5183"]},"institutions":[{"id":"https://openalex.org/I45084792","display_name":"University of Florence","ror":"https://ror.org/04jr1s763","country_code":"IT","type":"education","lineage":["https://openalex.org/I45084792"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Agostino Cilibrizzi","raw_affiliation_strings":["Dipartimento di Scienze Farmaceutiche, via Ugo Schiff 6, 50019 Sesto Fiorentino, Firenze, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dipartimento di Scienze Farmaceutiche, via Ugo Schiff 6, 50019 Sesto Fiorentino, Firenze, Italy","institution_ids":["https://openalex.org/I45084792"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110089748","display_name":"Amalia Di Giannuario","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Amalia Di Gianuario","raw_affiliation_strings":["Department of Therapeutic Research and Medicine Evaluation, Viale Regina Elena 299, 00161 Roma, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Therapeutic Research and Medicine Evaluation, Viale Regina Elena 299, 00161 Roma, Italy","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022526058","display_name":"Mariantonella Colucci","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mariantonella Colucci","raw_affiliation_strings":["Department of Therapeutic Research and Medicine Evaluation, Viale Regina Elena 299, 00161 Roma, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Therapeutic Research and Medicine Evaluation, Viale Regina Elena 299, 00161 Roma, Italy","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026432245","display_name":"Giorgina Mangano","orcid":"https://orcid.org/0000-0003-1201-4007","observed_orcids":["https://orcid.org/0000-0003-1201-4007"]},"institutions":[{"id":"https://openalex.org/I4210159862","display_name":"Angelini Pharma (Italy)","ror":"https://ror.org/05bz49965","country_code":"IT","type":"company","lineage":["https://openalex.org/I4210159862"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Giorgina Mangano","raw_affiliation_strings":["Angelini Research Center, Piazzale della Stazione, 00040 S. Palomba-Pomezia, Roma, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Angelini Research Center, Piazzale della Stazione, 00040 S. Palomba-Pomezia, Roma, Italy","institution_ids":["https://openalex.org/I4210159862"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086746725","display_name":"Beatrice Garrone","orcid":"https://orcid.org/0000-0002-8318-2975","observed_orcids":["https://orcid.org/0000-0002-8318-2975"]},"institutions":[{"id":"https://openalex.org/I4210159862","display_name":"Angelini Pharma (Italy)","ror":"https://ror.org/05bz49965","country_code":"IT","type":"company","lineage":["https://openalex.org/I4210159862"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Beatrice Garrone","raw_affiliation_strings":["Angelini Research Center, Piazzale della Stazione, 00040 S. Palomba-Pomezia, Roma, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Angelini Research Center, Piazzale della Stazione, 00040 S. Palomba-Pomezia, Roma, Italy","institution_ids":["https://openalex.org/I4210159862"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073588244","display_name":"Lorenzo Polenzani","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210159862","display_name":"Angelini Pharma (Italy)","ror":"https://ror.org/05bz49965","country_code":"IT","type":"company","lineage":["https://openalex.org/I4210159862"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Lorenzo Polenzani","raw_affiliation_strings":["Angelini Research Center, Piazzale della Stazione, 00040 S. Palomba-Pomezia, Roma, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Angelini Research Center, Piazzale della Stazione, 00040 S. Palomba-Pomezia, Roma, Italy","institution_ids":["https://openalex.org/I4210159862"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5067011169","display_name":"Vittorio Dal Piaz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I45084792","display_name":"University of Florence","ror":"https://ror.org/04jr1s763","country_code":"IT","type":"education","lineage":["https://openalex.org/I45084792"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Vittorio Dal Piaz","raw_affiliation_strings":["Dipartimento di Scienze Farmaceutiche, via Ugo Schiff 6, 50019 Sesto Fiorentino, Firenze, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dipartimento di Scienze Farmaceutiche, via Ugo Schiff 6, 50019 Sesto Fiorentino, Firenze, Italy","institution_ids":["https://openalex.org/I45084792"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5059510963"],"corresponding_institution_ids":["https://openalex.org/I45084792"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":1.0556,"has_fulltext":false,"cited_by_count":40,"citation_normalized_percentile":{"value":0.7151764,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":98},"biblio":{"volume":"52","issue":"23","first_page":"7397","last_page":"7409"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10274","display_name":"Heterocyclic Compound Synthesis and Bioactivity","score":0.4528999924659729,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10274","display_name":"Heterocyclic Compound Synthesis and Bioactivity","score":0.4528999924659729,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.31520000100135803,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11199","display_name":"Pain Management and Opioid Use","score":0.11180000007152557,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/antinociceptive-agents","display_name":"antinociceptive agents","score":0.8769999742507935},{"id":"https://openalex.org/keywords/thermal-pain","display_name":"thermal pain","score":0.7459999918937683},{"id":"https://openalex.org/keywords/acute-nociception","display_name":"acute nociception","score":0.7450000047683716},{"id":"https://openalex.org/keywords/oral-bioavailability","display_name":"oral bioavailability","score":0.7580000162124634},{"id":"https://openalex.org/keywords/morphine-comparison","display_name":"morphine comparison","score":0.7990000247955322},{"id":"https://openalex.org/keywords/adrenergic-system","display_name":"adrenergic system","score":0.9620000123977661},{"id":"https://openalex.org/keywords/alpha2-adrenergic-receptors","display_name":"alpha2-adrenoceptors","score":0.8199999928474426},{"id":"https://openalex.org/keywords/tail-flick-test","display_name":"tail-flick test","score":0.6930000185966492},{"id":"https://openalex.org/keywords/hot-plate-test","display_name":"hot plate test","score":0.9710000157356262},{"id":"https://openalex.org/keywords/structure-activity-relationship","display_name":"structure-activity relationship","score":0.6150000095367432}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.9108076095581055},{"id":"https://openalex.org/C15490471","wikidata":"https://www.wikidata.org/wiki/Q2734305","display_name":"Nociception","level":3,"score":0.7036004066467285},{"id":"https://openalex.org/C3017990168","wikidata":"https://www.wikidata.org/wiki/Q285166","display_name":"Orally active","level":3,"score":0.5853039026260376},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5557610988616943},{"id":"https://openalex.org/C2780263894","wikidata":"https://www.wikidata.org/wiki/Q335268","display_name":"Alkyl","level":2,"score":0.5383058786392212},{"id":"https://openalex.org/C193042331","wikidata":"https://www.wikidata.org/wiki/Q1772003","display_name":"Structure\u2013activity relationship","level":3,"score":0.4162937104701996},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.26381105184555054},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.18844005465507507},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.11552822589874268},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.059139758348464966},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.052042752504348755}],"mesh":[{"descriptor_ui":"D000077489","descriptor_name":"Piperazine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000284","descriptor_name":"Administration, Oral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000700","descriptor_name":"Analgesics","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D000700","descriptor_name":"Analgesics","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000700","descriptor_name":"Analgesics","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000700","descriptor_name":"Analgesics","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006358","descriptor_name":"Hot Temperature","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010146","descriptor_name":"Pain","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D010146","descriptor_name":"Pain","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D010146","descriptor_name":"Pain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010879","descriptor_name":"Piperazines","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D011724","descriptor_name":"Pyridazines","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D011724","descriptor_name":"Pyridazines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011724","descriptor_name":"Pyridazines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D011724","descriptor_name":"Pyridazines","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011869","descriptor_name":"Radioligand Assay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011941","descriptor_name":"Receptors, Adrenergic","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055808","descriptor_name":"Drug Discovery","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1021/jm900458r","doi":"https://doi.org/10.1021/jm900458r","is_oa":false,"landing_page_url":"https://doi.org/10.1021/jm900458r","pdf_url":null,"source":{"id":"https://openalex.org/S162030435","display_name":"Journal of Medicinal Chemistry","issn_l":"0022-2623","issn":["0022-2623","1520-4804"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Medicinal Chemistry","raw_type":"journal-article"},{"id":"pmid:19788200","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19788200","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of medicinal chemistry","raw_type":"Journal Article"},{"id":"pmh:oai:flore.unifi.it:2158/372772","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/2158/372772","pdf_url":null,"source":{"id":"https://openalex.org/S4306402033","display_name":"Florence Research (University of Florence)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I45084792","host_organization_name":"University of Florence","host_organization_lineage":["https://openalex.org/I45084792"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":37,"referenced_works":["https://openalex.org/W1594307292","https://openalex.org/W1880198815","https://openalex.org/W1964094521","https://openalex.org/W1964645954","https://openalex.org/W1966698033","https://openalex.org/W1970217771","https://openalex.org/W1975019277","https://openalex.org/W1976026600","https://openalex.org/W1996198969","https://openalex.org/W1997319847","https://openalex.org/W2003665762","https://openalex.org/W2005856563","https://openalex.org/W2007003323","https://openalex.org/W2014101780","https://openalex.org/W2018501386","https://openalex.org/W2018762970","https://openalex.org/W2021101385","https://openalex.org/W2026108176","https://openalex.org/W2030793740","https://openalex.org/W2059566065","https://openalex.org/W2064588169","https://openalex.org/W2076891371","https://openalex.org/W2079309109","https://openalex.org/W2086290261","https://openalex.org/W2090221910","https://openalex.org/W2092983896","https://openalex.org/W2093869050","https://openalex.org/W2129208878","https://openalex.org/W2139239114","https://openalex.org/W2156960407","https://openalex.org/W2323388788","https://openalex.org/W2401188729","https://openalex.org/W2515468538","https://openalex.org/W2605720527","https://openalex.org/W2950070511","https://openalex.org/W2950772358","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W1964094521","https://openalex.org/W2018762970","https://openalex.org/W1979097674","https://openalex.org/W1205704783","https://openalex.org/W2087951810","https://openalex.org/W6989470993","https://openalex.org/W2951296442","https://openalex.org/W1976026600","https://openalex.org/W2139239114","https://openalex.org/W2081924167"],"abstract_inverted_index":{"A":[0],"number":[1],"of":[2,17,59,95,120],"pyridazinone":[3],"derivatives":[4],"bearing":[5],"an":[6,41],"arylpiperazinylalkyl":[7],"chain":[8],"were":[9],"synthesized":[10],"and":[11,31,110],"tested":[12],"icv":[13],"in":[14,24,34,72,87,105,111,128],"a":[15,46,77],"model":[16],"acute":[18],"nociception":[19],"induced":[20],"by":[21,55,100,127],"thermal":[22],"stimuli":[23],"mice":[25],"(tail":[26],"flick).":[27],"The":[28,80,92],"most":[29],"interesting":[30],"potent":[32,69],"compound":[33,82],"this":[35],"series":[36],"was":[37,66,97,125],"6a,":[38],"which":[39,124],"showed":[40,84],"ED(50)":[42],"=":[43],"3.5":[44],"microg,":[45],"value":[47],"about":[48],"3-fold":[49],"higher":[50],"with":[51,102],"respect":[52],"to":[53],"morphine":[54,71],"the":[56,73,88,106,112,118,121],"same":[57,74,81],"route":[58],"administration.":[60],"When":[61],"administered":[62],"per":[63],"os,":[64],"6a":[65,96],"4-fold":[67],"more":[68],"than":[70],"test,":[75],"suggesting":[76],"significant":[78],"bioavailability.":[79],"also":[83],"high":[85],"potency":[86],"hot":[89,107],"plate":[90,108],"test.":[91,115],"antinociceptive":[93],"effect":[94],"completely":[98],"reversed":[99],"pretreatment":[101],"yohimbine":[103],"both":[104],"test":[109],"tail":[113],"flick":[114],"This":[116],"demonstrated":[117],"involvement":[119],"adrenergic":[122],"system,":[123],"confirmed":[126],"vitro":[129],"radioligand":[130],"binding":[131],"studies.":[132]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
