{"id":"https://openalex.org/W2063593430","doi":"https://doi.org/10.1542/peds.2006-3024","title":"Ontogeny of Bilirubin-Binding Capacity and the Effect of Clinical Status in Premature Infants Born at Less Than 1300 Grams","display_name":"Ontogeny of Bilirubin-Binding Capacity and the Effect of Clinical Status in Premature Infants Born at Less Than 1300 Grams","publication_year":2007,"publication_date":"2007-11-01","ids":{"openalex":"https://openalex.org/W2063593430","doi":"https://doi.org/10.1542/peds.2006-3024","mag":"2063593430","pmid":"https://pubmed.ncbi.nlm.nih.gov/17974745"},"language":"en","primary_location":{"id":"doi:10.1542/peds.2006-3024","doi":"https://doi.org/10.1542/peds.2006-3024","is_oa":false,"landing_page_url":"https://doi.org/10.1542/peds.2006-3024","pdf_url":null,"source":{"id":"https://openalex.org/S77494981","display_name":"PEDIATRICS","issn_l":"0031-4005","issn":["0031-4005","1098-4275"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315734","host_organization_name":"American Academy of Pediatrics","host_organization_lineage":["https://openalex.org/P4310315734"],"host_organization_lineage_names":["American Academy of Pediatrics"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pediatrics","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"George Jesse Bender","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27804330","display_name":"Brown University","ror":"https://ror.org/05gq02987","country_code":"US","type":"education","lineage":["https://openalex.org/I27804330"]},{"id":"https://openalex.org/I4210133025","display_name":"Women & Infants Hospital of Rhode Island","ror":"https://ror.org/03z8sn326","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210133025"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"George Jesse Bender","raw_affiliation_strings":["Department of Pediatrics, Brown Medical School, Women and Infants\u2019 Hospital of Rhode Island, Providence, Rhode Island","Department of Pediatrics, Brown Medical School, Women and Infants' Hospital of Rhode Island, 100 Dudley St, Providence, RI 02860, USA. gbender@wihri.org"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Brown Medical School, Women and Infants\u2019 Hospital of Rhode Island, Providence, Rhode Island","institution_ids":["https://openalex.org/I27804330","https://openalex.org/I4210133025"]},{"raw_affiliation_string":"Department of Pediatrics, Brown Medical School, Women and Infants' Hospital of Rhode Island, 100 Dudley St, Providence, RI 02860, USA. gbender@wihri.org","institution_ids":["https://openalex.org/I27804330","https://openalex.org/I4210133025"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025269927","display_name":"William J. Cashore","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27804330","display_name":"Brown University","ror":"https://ror.org/05gq02987","country_code":"US","type":"education","lineage":["https://openalex.org/I27804330"]},{"id":"https://openalex.org/I4210133025","display_name":"Women & Infants Hospital of Rhode Island","ror":"https://ror.org/03z8sn326","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210133025"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William James Cashore","raw_affiliation_strings":["Department of Pediatrics, Brown Medical School, Women and Infants\u2019 Hospital of Rhode Island, Providence, Rhode Island"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Brown Medical School, Women and Infants\u2019 Hospital of Rhode Island, Providence, Rhode Island","institution_ids":["https://openalex.org/I27804330","https://openalex.org/I4210133025"]}]},{"author_position":"last","author":{"id":null,"display_name":"William Oh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27804330","display_name":"Brown University","ror":"https://ror.org/05gq02987","country_code":"US","type":"education","lineage":["https://openalex.org/I27804330"]},{"id":"https://openalex.org/I4210133025","display_name":"Women & Infants Hospital of Rhode Island","ror":"https://ror.org/03z8sn326","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210133025"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William Oh","raw_affiliation_strings":["Department of Pediatrics, Brown Medical School, Women and Infants\u2019 Hospital of Rhode Island, Providence, Rhode Island"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Brown Medical School, Women and Infants\u2019 Hospital of Rhode Island, Providence, Rhode Island","institution_ids":["https://openalex.org/I27804330","https://openalex.org/I4210133025"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.4613,"has_fulltext":false,"cited_by_count":49,"citation_normalized_percentile":{"value":0.91477539,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"120","issue":"5","first_page":"1067","last_page":"1073"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12068","display_name":"Neonatal Health and Biochemistry","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12068","display_name":"Neonatal Health and Biochemistry","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11060","display_name":"Infant Development and Preterm Care","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12460","display_name":"Pediatric Hepatobiliary Diseases and Treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bilirubin-binding-capacity","display_name":"bilirubin binding capacity","score":0.9829999804496765},{"id":"https://openalex.org/keywords/unbound-bilirubin","display_name":"unbound bilirubin","score":0.9200000166893005},{"id":"https://openalex.org/keywords/very-preterm-infants","display_name":"very preterm infants","score":0.7649999856948853},{"id":"https://openalex.org/keywords/very-low-birth-weight-infants","display_name":"very low birth weight infants","score":0.9570000171661377},{"id":"https://openalex.org/keywords/gestational-age","display_name":"gestational age","score":0.7889999747276306},{"id":"https://openalex.org/keywords/neonatal-intensive-care","display_name":"neonatal intensive care","score":0.5440000295639038},{"id":"https://openalex.org/keywords/neonatal-jaundice","display_name":"neonatal jaundice","score":0.6240000128746033},{"id":"https://openalex.org/keywords/albumin-binding","display_name":"albumin binding","score":0.4909999966621399},{"id":"https://openalex.org/keywords/scatchard-analysis","display_name":"Scatchard analysis","score":0.6299999952316284}],"concepts":[{"id":"https://openalex.org/C2777513400","wikidata":"https://www.wikidata.org/wiki/Q104219","display_name":"Bilirubin","level":2,"score":0.9172559976577759},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7894233465194702},{"id":"https://openalex.org/C2778376644","wikidata":"https://www.wikidata.org/wiki/Q2253111","display_name":"Gestational age","level":3,"score":0.6824259757995605},{"id":"https://openalex.org/C2778083895","wikidata":"https://www.wikidata.org/wiki/Q861845","display_name":"Kernicterus","level":3,"score":0.6692626476287842},{"id":"https://openalex.org/C2776125364","wikidata":"https://www.wikidata.org/wiki/Q169219","display_name":"Albumin","level":2,"score":0.5140908360481262},{"id":"https://openalex.org/C46973012","wikidata":"https://www.wikidata.org/wiki/Q28627","display_name":"Gestation","level":3,"score":0.4688514173030853},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4653324484825134},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.4011504650115967},{"id":"https://openalex.org/C42407357","wikidata":"https://www.wikidata.org/wiki/Q521","display_name":"Physiology","level":1,"score":0.35512030124664307},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3418395221233368},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.15838107466697693},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.06923890113830566},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D001034","descriptor_name":"Apgar Score","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001663","descriptor_name":"Bilirubin","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005865","descriptor_name":"Gestational Age","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007231","descriptor_name":"Infant, Newborn","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007234","descriptor_name":"Infant, Premature","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D012709","descriptor_name":"Serum Albumin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015331","descriptor_name":"Cohort Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019102","descriptor_name":"Infant, Very Low Birth Weight","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1542/peds.2006-3024","doi":"https://doi.org/10.1542/peds.2006-3024","is_oa":false,"landing_page_url":"https://doi.org/10.1542/peds.2006-3024","pdf_url":null,"source":{"id":"https://openalex.org/S77494981","display_name":"PEDIATRICS","issn_l":"0031-4005","issn":["0031-4005","1098-4275"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315734","host_organization_name":"American Academy of Pediatrics","host_organization_lineage":["https://openalex.org/P4310315734"],"host_organization_lineage_names":["American Academy of Pediatrics"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pediatrics","raw_type":"journal-article"},{"id":"pmid:17974745","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17974745","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pediatrics","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9763000011444092}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G3174038229","display_name":"NICHD Cooperative Multicenter Neonatal Research Network","funder_award_id":"U10HD027904","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"}],"funders":[{"id":"https://openalex.org/F4320313932","display_name":"Institut de Recherche pour le D\u00e9veloppement","ror":"https://ror.org/05q3vnk25"},{"id":"https://openalex.org/F4320337611","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":28,"referenced_works":["https://openalex.org/W1828218942","https://openalex.org/W1893367855","https://openalex.org/W1905825263","https://openalex.org/W1925181037","https://openalex.org/W1928704669","https://openalex.org/W1959738294","https://openalex.org/W1964098939","https://openalex.org/W1998014004","https://openalex.org/W2002842565","https://openalex.org/W2010941052","https://openalex.org/W2018190442","https://openalex.org/W2023950153","https://openalex.org/W2031458328","https://openalex.org/W2042231085","https://openalex.org/W2043835536","https://openalex.org/W2044858360","https://openalex.org/W2055007225","https://openalex.org/W2056178569","https://openalex.org/W2057221557","https://openalex.org/W2070267677","https://openalex.org/W2102029794","https://openalex.org/W2112675479","https://openalex.org/W2117880641","https://openalex.org/W2125123670","https://openalex.org/W2157154175","https://openalex.org/W2395025339","https://openalex.org/W2408888214","https://openalex.org/W4292078941"],"related_works":["https://openalex.org/W2772039650","https://openalex.org/W2081092844","https://openalex.org/W2043835536","https://openalex.org/W2056726786","https://openalex.org/W2102029794","https://openalex.org/W1965575260","https://openalex.org/W2160051428","https://openalex.org/W2767746638","https://openalex.org/W4311860750","https://openalex.org/W7038665506"],"abstract_inverted_index":{"BACKGROUND:":[0],"Bilirubin":[1],"is":[2,166,269,277],"toxic":[3],"to":[4,55,119,162,184,203,272],"the":[5,9,32,57,63,101,112,175,193,211,224,296],"brain":[6,10],"and":[7,62,95,109,123,165,195,279],"enters":[8],"in":[11,68,168,171,192,210,223,283,286,294,300],"unbound":[12,16,96,102,280],"form.":[13],"Serum":[14],"unconjugated,":[15],"bilirubin":[17,24,27,94,97,156,164,281],"may":[18,29,291],"be":[19,292],"a":[20,140,158,181,200],"good":[21],"predictor":[22],"of":[23,35,44,51,59,65,75,90,190,298],"encephalopathy.":[25],"Unbound":[26,155],"levels":[28],"depend":[30],"on":[31],"bilirubin-binding":[33,60,121,178,188,267],"capacity":[34,61,179,207,268,276],"albumin,":[36],"which":[37],"has":[38,157],"not":[39,249],"been":[40],"described":[41],"for":[42,127,143],"neonates":[43,77],"<28":[45],"weeks'":[46,79],"gestation.":[47],"OBJECTIVE:":[48],"The":[49,187],"purpose":[50],"this":[52],"work":[53],"was":[54,130,150,208],"determine":[56],"ontogeny":[58],"effect":[64],"clinical":[66,252],"status":[67,126,254],"very":[69,260,262,301],"preterm":[70],"neonates.":[71,173,288],"METHODS:":[72],"A":[73],"total":[74,92,163],"152":[76],"(23-31":[78],"gestational":[80,185,204,256,273],"age;":[81],"440-1300":[82],"g)":[83],"were":[84,98,117],"enrolled":[85],"prospectively.":[86],"At":[87],"5":[88],"days":[89],"age,":[91],"serum":[93],"measured":[99],"with":[100,111],"bilirubin-A1":[103],"analyzer":[104],"(Arrows":[105],"Co,":[106],"Osaka,":[107],"Japan)":[108],"albumin":[110],"Bromocresol-purple":[113],"method.":[114],"Scatchard":[115],"plots":[116],"used":[118],"estimate":[120],"affinity":[122,247],"capacity.":[124],"Clinical":[125],"each":[128],"infant":[129],"rated":[131],"as":[132],"high,":[133],"moderate,":[134],"or":[135,234,255],"low":[136,263,302],"risk":[137,149,244,253],"by":[138,251],"using":[139],"modified":[141],"Score":[142],"Neonatal":[144],"Acute":[145],"Physiology":[146],"model.":[147],"Low":[148],"considered":[151],"clinically":[152],"stable.":[153],"RESULTS:":[154],"significant,":[159],"direct":[160,182,201],"correlation":[161],"greater":[167,209],"unstable":[169,284],"than":[170,222,285],"stable":[172,287],"For":[174],"entire":[176],"cohort,":[177],"had":[180,199],"relationship":[183,202],"age.":[186,205,257,274],"capacities":[189],"infants":[191],"low-":[194],"high-risk":[196],"groups":[197],"also":[198],"Bilirubin-binding":[206,246,275],"low-risk":[212],"group":[213],"(20.8":[214],"+/-":[215,219,227,231,237,241],"4.6":[216],"mg/dL;":[217,229,239],"356":[218],"79":[220],"micromol/L)":[221,233,243],"moderate-":[225],"(17.8":[226],"3.5":[228],"304":[230],"60":[232],"high-":[235],"(17.3":[236],"3.4":[238],"296":[240],"58":[242],"groups.":[245],"did":[248],"differ":[250],"CONCLUSIONS:":[258],"In":[259],"preterm,":[261],"birth":[264,303],"weight":[265,304],"infants,":[266],"directly":[270],"proportional":[271],"lower":[278],"higher":[282],"These":[289],"data":[290],"useful":[293],"guiding":[295],"management":[297],"hyperbilirubinemia":[299],"infants.":[305]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-01T11:40:01.658920","created_date":"2016-06-24T00:00:00"}