{"id":"https://openalex.org/W2063581273","doi":"https://doi.org/10.1016/s0006-2952(01)00533-0","title":"Proteolytic activation of membrane-bound guanylate cyclase","display_name":"Proteolytic activation of membrane-bound guanylate cyclase","publication_year":2001,"publication_date":"2001-04-01","ids":{"openalex":"https://openalex.org/W2063581273","doi":"https://doi.org/10.1016/s0006-2952(01)00533-0","mag":"2063581273","pmid":"https://pubmed.ncbi.nlm.nih.gov/11274978"},"language":"en","primary_location":{"id":"doi:10.1016/s0006-2952(01)00533-0","doi":"https://doi.org/10.1016/s0006-2952(01)00533-0","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0006-2952(01)00533-0","pdf_url":null,"source":{"id":"https://openalex.org/S185534594","display_name":"Biochemical Pharmacology","issn_l":"0006-2952","issn":["0006-2952","1873-2968"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical Pharmacology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108064842","display_name":"Zi\u2010Jiang Chen","orcid":"https://orcid.org/0000-0001-6637-6631","observed_orcids":["https://orcid.org/0000-0001-6637-6631"]},"institutions":[{"id":"https://openalex.org/I4210116517","display_name":"Shandong Provincial Hospital","ror":"https://ror.org/02ar2nf05","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210116517"]},{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["CN","US"],"is_corresponding":false,"raw_author_name":"Zi-Jiang Chen","raw_affiliation_strings":["Department of Medicine, Division of Hypertension, Case Western Reserve University, School of Medicine, W-165, 10900 Euclid Ave, Cleveland, OH 44106-4982, USA","Department of Medicine, Reproductive Research Center, Shandong Provincial Hospital, Shandong Medical University, Jinan 250012, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Division of Hypertension, Case Western Reserve University, School of Medicine, W-165, 10900 Euclid Ave, Cleveland, OH 44106-4982, USA","institution_ids":["https://openalex.org/I58956616"]},{"raw_affiliation_string":"Department of Medicine, Reproductive Research Center, Shandong Provincial Hospital, Shandong Medical University, Jinan 250012, People's Republic of China","institution_ids":["https://openalex.org/I4210116517"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101909617","display_name":"Dongli Song","orcid":"https://orcid.org/0000-0002-0697-2949","observed_orcids":["https://orcid.org/0000-0002-0697-2949","https://orcid.org/0000-0002-7505-0980"]},"institutions":[{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dong-Li Song","raw_affiliation_strings":["Department of Medicine, Division of Hypertension, Case Western Reserve University, School of Medicine, W-165, 10900 Euclid Ave., Cleveland, OH 44106-4982, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Division of Hypertension, Case Western Reserve University, School of Medicine, W-165, 10900 Euclid Ave., Cleveland, OH 44106-4982, USA","institution_ids":["https://openalex.org/I58956616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112312397","display_name":"Zhenhua Miao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zhenhua Miao","raw_affiliation_strings":["Department of Medicine, Division of Hypertension, Case Western Reserve University, School of Medicine, W-165, 10900 Euclid Ave., Cleveland, OH 44106-4982, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Division of Hypertension, Case Western Reserve University, School of Medicine, W-165, 10900 Euclid Ave., Cleveland, OH 44106-4982, USA","institution_ids":["https://openalex.org/I58956616"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5077611881","display_name":"Chung\u2010Ho Chang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Chung-Ho Chang","raw_affiliation_strings":["Department of Medicine, Division of Hypertension, Case Western Reserve University, School of Medicine, W-165, 10900 Euclid Ave., Cleveland, OH 44106-4982, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Division of Hypertension, Case Western Reserve University, School of Medicine, W-165, 10900 Euclid Ave., Cleveland, OH 44106-4982, USA","institution_ids":["https://openalex.org/I58956616"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5077611881"],"corresponding_institution_ids":["https://openalex.org/I58956616"],"apc_list":{"value":3590,"currency":"USD","value_usd":3590},"apc_paid":null,"fwci":0.2327,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.51278529,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":93},"biblio":{"volume":"61","issue":"7","first_page":"915","last_page":"920"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.8695999979972839,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.8695999979972839,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.09610000252723694,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14486","display_name":"Cardiovascular, Neuropeptides, and Oxidative Stress Research","score":0.011800000444054604,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/atrial-natriuretic-peptide","display_name":"atrial natriuretic peptide","score":0.9509999752044678},{"id":"https://openalex.org/keywords/proteolytic-activation","display_name":"proteolytic activation","score":0.7570000290870667},{"id":"https://openalex.org/keywords/limited-proteolysis","display_name":"limited proteolysis","score":0.8809999823570251},{"id":"https://openalex.org/keywords/pronase","display_name":"pronase","score":0.9789999723434448},{"id":"https://openalex.org/keywords/thermolysin","display_name":"thermolysin","score":0.9990000128746033},{"id":"https://openalex.org/keywords/receptor-conformational-change","display_name":"receptor conformational change","score":0.7009999752044678},{"id":"https://openalex.org/keywords/enzyme-activation","display_name":"enzyme activation","score":0.48100000619888306}],"concepts":[{"id":"https://openalex.org/C2776708817","wikidata":"https://www.wikidata.org/wiki/Q4380751","display_name":"Pronase","level":4,"score":0.8517950773239136},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.7022309899330139},{"id":"https://openalex.org/C117644","wikidata":"https://www.wikidata.org/wiki/Q18026682","display_name":"GUCY1B3","level":5,"score":0.6272176504135132},{"id":"https://openalex.org/C13121076","wikidata":"https://www.wikidata.org/wiki/Q1552797","display_name":"Guanylate cyclase 2C","level":4,"score":0.6201620697975159},{"id":"https://openalex.org/C27093228","wikidata":"https://www.wikidata.org/wiki/Q18026679","display_name":"GUCY1A3","level":5,"score":0.5365785360336304},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5280286073684692},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.47227510809898376},{"id":"https://openalex.org/C2781307694","wikidata":"https://www.wikidata.org/wiki/Q33123","display_name":"Proteolysis","level":3,"score":0.43255162239074707},{"id":"https://openalex.org/C125209161","wikidata":"https://www.wikidata.org/wiki/Q422816","display_name":"Enzyme activator","level":3,"score":0.418520987033844},{"id":"https://openalex.org/C2780069284","wikidata":"https://www.wikidata.org/wiki/Q5198121","display_name":"Cyclase","level":3,"score":0.356195330619812},{"id":"https://openalex.org/C2780340462","wikidata":"https://www.wikidata.org/wiki/Q127450","display_name":"Trypsin","level":3,"score":0.23861342668533325}],"mesh":[{"descriptor_ui":"D000255","descriptor_name":"Adenosine Triphosphate","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D004789","descriptor_name":"Enzyme Activation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006162","descriptor_name":"Guanylate Cyclase","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006162","descriptor_name":"Guanylate Cyclase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006162","descriptor_name":"Guanylate Cyclase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009320","descriptor_name":"Atrial Natriuretic Factor","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011402","descriptor_name":"Pronase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012995","descriptor_name":"Solubility","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013820","descriptor_name":"Thermolysin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/s0006-2952(01)00533-0","doi":"https://doi.org/10.1016/s0006-2952(01)00533-0","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0006-2952(01)00533-0","pdf_url":null,"source":{"id":"https://openalex.org/S185534594","display_name":"Biochemical Pharmacology","issn_l":"0006-2952","issn":["0006-2952","1873-2968"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical Pharmacology","raw_type":"journal-article"},{"id":"pmid:11274978","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11274978","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical pharmacology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1950975364","display_name":null,"funder_award_id":"R01 HL 56791","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G2983857543","display_name":"MOLECULAR MECHANISMS OF GUANYLATE CYCLASE ACTIVATION","funder_award_id":"5r01hl056791-04","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G5831655718","display_name":"VASOACTIVE HORMONES:  RECEPTORS AND SIGNALING MECHANISM","funder_award_id":"P01HL041618","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320306230","display_name":"American Heart Association","ror":"https://ror.org/013kjyp64"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":32,"referenced_works":["https://openalex.org/W98022268","https://openalex.org/W1508917021","https://openalex.org/W1510945532","https://openalex.org/W1523250495","https://openalex.org/W1542122911","https://openalex.org/W1603537849","https://openalex.org/W1670623565","https://openalex.org/W1691568282","https://openalex.org/W1905627889","https://openalex.org/W1972616722","https://openalex.org/W1973136336","https://openalex.org/W1985761104","https://openalex.org/W1998371231","https://openalex.org/W1998465616","https://openalex.org/W2015599928","https://openalex.org/W2017320604","https://openalex.org/W2021765529","https://openalex.org/W2030712051","https://openalex.org/W2032359283","https://openalex.org/W2039247251","https://openalex.org/W2049854509","https://openalex.org/W2056557821","https://openalex.org/W2062801036","https://openalex.org/W2069757419","https://openalex.org/W2077686814","https://openalex.org/W2081840059","https://openalex.org/W2089420469","https://openalex.org/W2093948248","https://openalex.org/W2103174300","https://openalex.org/W2138391109","https://openalex.org/W2339899462","https://openalex.org/W2407934265"],"related_works":["https://openalex.org/W1508917021","https://openalex.org/W1998371231","https://openalex.org/W2076295967","https://openalex.org/W2080658831","https://openalex.org/W2062008733","https://openalex.org/W1985761104","https://openalex.org/W2049854509","https://openalex.org/W1510945532","https://openalex.org/W1520611194","https://openalex.org/W1977227107"],"abstract_inverted_index":null,"counts_by_year":[{"year":2022,"cited_by_count":1}],"updated_date":"2026-11-01T11:40:01.658920","created_date":"2016-06-24T00:00:00"}
