{"id":"https://openalex.org/W2063576429","doi":"https://doi.org/10.1002/jnr.21571","title":"Thrombin\u2010induced oxidative stress contributes to the death of hippocampal neurons: Role of neuronal NADPH oxidase","display_name":"Thrombin\u2010induced oxidative stress contributes to the death of hippocampal neurons: Role of neuronal NADPH oxidase","publication_year":2008,"publication_date":"2008-01-08","ids":{"openalex":"https://openalex.org/W2063576429","doi":"https://doi.org/10.1002/jnr.21571","mag":"2063576429","pmid":"https://pubmed.ncbi.nlm.nih.gov/18183616"},"language":"en","primary_location":{"id":"doi:10.1002/jnr.21571","doi":"https://doi.org/10.1002/jnr.21571","is_oa":false,"landing_page_url":"https://doi.org/10.1002/jnr.21571","pdf_url":null,"source":{"id":"https://openalex.org/S76417895","display_name":"Journal of Neuroscience Research","issn_l":"0360-4012","issn":["0360-4012","1097-4547"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neuroscience Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5003530247","display_name":"Keun W. Park","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I57664883","display_name":"Ajou University","ror":"https://ror.org/03tzb2h73","country_code":"KR","type":"education","lineage":["https://openalex.org/I57664883"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Keun W. Park","raw_affiliation_strings":["Brain Disease Research Center, Neuroscience Graduate Program, Division of Cell Transformation and Restoration, Ajou University School of Medicine, Suwon, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Brain Disease Research Center, Neuroscience Graduate Program, Division of Cell Transformation and Restoration, Ajou University School of Medicine, Suwon, Korea","institution_ids":["https://openalex.org/I57664883"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5060641907","display_name":"Byung Kwan Jin","orcid":"https://orcid.org/0000-0001-9072-6670","observed_orcids":["https://orcid.org/0000-0001-9072-6670"]},"institutions":[{"id":"https://openalex.org/I57664883","display_name":"Ajou University","ror":"https://ror.org/03tzb2h73","country_code":"KR","type":"education","lineage":["https://openalex.org/I57664883"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Byung K. Jin","raw_affiliation_strings":["Brain Disease Research Center, Neuroscience Graduate Program, Division of Cell Transformation and Restoration, Ajou University School of Medicine, Suwon, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Brain Disease Research Center, Neuroscience Graduate Program, Division of Cell Transformation and Restoration, Ajou University School of Medicine, Suwon, Korea","institution_ids":["https://openalex.org/I57664883"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5060641907"],"corresponding_institution_ids":["https://openalex.org/I57664883"],"apc_list":{"value":4840,"currency":"USD","value_usd":4840},"apc_paid":null,"fwci":1.792,"has_fulltext":false,"cited_by_count":44,"citation_normalized_percentile":{"value":0.84132273,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"86","issue":"5","first_page":"1053","last_page":"1063"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11884","display_name":"Redox biology and oxidative stress","score":0.7465999722480774,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11884","display_name":"Redox biology and oxidative stress","score":0.7465999722480774,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11597","display_name":"Neutrophil, Myeloperoxidase and Oxidative Mechanisms","score":0.11819999665021896,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.03709999844431877,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/thrombin","display_name":"thrombin","score":1.0},{"id":"https://openalex.org/keywords/nadph-oxidase","display_name":"NADPH oxidase","score":0.8659999966621399},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.8899999856948853},{"id":"https://openalex.org/keywords/hippocampal-neurons","display_name":"hippocampal neurons","score":0.9010000228881836},{"id":"https://openalex.org/keywords/neurodegeneration","display_name":"neurodegeneration","score":0.8169999718666077},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.9890000224113464},{"id":"https://openalex.org/keywords/p47phox","display_name":"p47phox","score":0.847000002861023},{"id":"https://openalex.org/keywords/p67phox","display_name":"p67phox","score":0.9990000128746033},{"id":"https://openalex.org/keywords/gp91phox","display_name":"gp91phox","score":0.9549999833106995},{"id":"https://openalex.org/keywords/rac1","display_name":"Rac1","score":0.9430000185966492},{"id":"https://openalex.org/keywords/neurotoxicity","display_name":"neurotoxicity","score":0.796999990940094},{"id":"https://openalex.org/keywords/antioxidants","display_name":"antioxidants","score":0.746999979019165},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.8090000152587891}],"concepts":[{"id":"https://openalex.org/C2779719074","wikidata":"https://www.wikidata.org/wiki/Q2038057","display_name":"NADPH oxidase","level":3,"score":0.8580372333526611},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.7192517518997192},{"id":"https://openalex.org/C2776925932","wikidata":"https://www.wikidata.org/wiki/Q1755122","display_name":"Neurodegeneration","level":3,"score":0.6789718866348267},{"id":"https://openalex.org/C148762608","wikidata":"https://www.wikidata.org/wiki/Q3748185","display_name":"Hippocampal formation","level":2,"score":0.6723852157592773},{"id":"https://openalex.org/C48349386","wikidata":"https://www.wikidata.org/wiki/Q424361","display_name":"Reactive oxygen species","level":2,"score":0.6060056090354919},{"id":"https://openalex.org/C2777292125","wikidata":"https://www.wikidata.org/wiki/Q409166","display_name":"Thrombin","level":3,"score":0.5385241508483887},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.499894380569458},{"id":"https://openalex.org/C98539663","wikidata":"https://www.wikidata.org/wiki/Q220599","display_name":"Cytosol","level":3,"score":0.44414612650871277},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.432504802942276},{"id":"https://openalex.org/C2779491297","wikidata":"https://www.wikidata.org/wiki/Q3338704","display_name":"Neurotoxicity","level":3,"score":0.42118000984191895},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4112854301929474},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.37424761056900024},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.348613977432251},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.1977996528148651},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.1492891013622284},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.11787381768226624},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.08456513285636902},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.06642097234725952},{"id":"https://openalex.org/C89560881","wikidata":"https://www.wikidata.org/wiki/Q101026","display_name":"Platelet","level":2,"score":0.0},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000975","descriptor_name":"Antioxidants","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000975","descriptor_name":"Antioxidants","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D009410","descriptor_name":"Nerve Degeneration","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D009410","descriptor_name":"Nerve Degeneration","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009410","descriptor_name":"Nerve Degeneration","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009498","descriptor_name":"Neurotoxins","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D009498","descriptor_name":"Neurotoxins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009498","descriptor_name":"Neurotoxins","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D010750","descriptor_name":"Phosphoproteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010750","descriptor_name":"Phosphoproteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013917","descriptor_name":"Thrombin","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D013917","descriptor_name":"Thrombin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013917","descriptor_name":"Thrombin","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D016923","descriptor_name":"Cell Death","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D016923","descriptor_name":"Cell Death","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017382","descriptor_name":"Reactive Oxygen Species","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D019255","descriptor_name":"NADPH Oxidases","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D019255","descriptor_name":"NADPH Oxidases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019255","descriptor_name":"NADPH Oxidases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D020271","descriptor_name":"Heredodegenerative Disorders, Nervous System","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D020271","descriptor_name":"Heredodegenerative Disorders, Nervous System","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020271","descriptor_name":"Heredodegenerative Disorders, Nervous System","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1002/jnr.21571","doi":"https://doi.org/10.1002/jnr.21571","is_oa":false,"landing_page_url":"https://doi.org/10.1002/jnr.21571","pdf_url":null,"source":{"id":"https://openalex.org/S76417895","display_name":"Journal of Neuroscience Research","issn_l":"0360-4012","issn":["0360-4012","1097-4547"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neuroscience Research","raw_type":"journal-article"},{"id":"pmid:18183616","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18183616","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of neuroscience research","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.494.9671","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.494.9671","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.abd.or.kr/htm/paper/2008-4.pdf","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9476000070571899}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":47,"referenced_works":["https://openalex.org/W1489032270","https://openalex.org/W1493941654","https://openalex.org/W1519347646","https://openalex.org/W1549264432","https://openalex.org/W1584833838","https://openalex.org/W1963687683","https://openalex.org/W1971701992","https://openalex.org/W1972317764","https://openalex.org/W1973797728","https://openalex.org/W1975199357","https://openalex.org/W1976625832","https://openalex.org/W1977280291","https://openalex.org/W1980132212","https://openalex.org/W1982562954","https://openalex.org/W1988396863","https://openalex.org/W2000636649","https://openalex.org/W2001531946","https://openalex.org/W2011481598","https://openalex.org/W2012342018","https://openalex.org/W2016883839","https://openalex.org/W2018954820","https://openalex.org/W2025695179","https://openalex.org/W2027189256","https://openalex.org/W2027884493","https://openalex.org/W2034354351","https://openalex.org/W2039222951","https://openalex.org/W2049262684","https://openalex.org/W2052119252","https://openalex.org/W2060694569","https://openalex.org/W2063960864","https://openalex.org/W2065062958","https://openalex.org/W2066888066","https://openalex.org/W2079080506","https://openalex.org/W2081312692","https://openalex.org/W2081475948","https://openalex.org/W2082294005","https://openalex.org/W2086370850","https://openalex.org/W2094960332","https://openalex.org/W2096901938","https://openalex.org/W2115478737","https://openalex.org/W2123548739","https://openalex.org/W2130753450","https://openalex.org/W2133739669","https://openalex.org/W2138760592","https://openalex.org/W2153945143","https://openalex.org/W4230951225","https://openalex.org/W4323238718"],"related_works":["https://openalex.org/W7097580808","https://openalex.org/W2079080506","https://openalex.org/W2136493211","https://openalex.org/W2159118237","https://openalex.org/W2344182823","https://openalex.org/W2138760592","https://openalex.org/W2033331725","https://openalex.org/W2077088913","https://openalex.org/W2367415799","https://openalex.org/W2082237681"],"abstract_inverted_index":{"The":[0,132],"present":[1,158],"study":[2,159],"investigated":[3],"whether":[4,22],"thrombin":[5,42,70,188,198],"can":[6,189,201],"induce":[7],"the":[8,96,105,114,117,157,161],"production":[9,52],"of":[10,17,76,98,107,119,127,140,197],"reactive":[11],"oxygen":[12],"species":[13],"(ROS)":[14],"through":[15],"activation":[16],"neuronal":[18,179],"NADPH":[19,77,149,180],"oxidase":[20,78,150],"and":[21,28,33,60,81,89,103,111,116,129,138,195],"this":[23],"contributes":[24],"to":[25,30,113,163],"oxidative":[26,182,207],"damage":[27],"consequently":[29],"neurodegeneration.":[31],"Immunocytochemical":[32],"biochemical":[34],"evidence":[35],"demonstrated":[36,73],"that,":[37,165],"in":[38,45,95,124,166,175],"neuron-enriched":[39],"hippocampal":[40,125,142,168,209],"cultures,":[41],"induces":[43],"neurodegeneration":[44],"a":[46],"dose-dependent":[47],"manner.":[48],"In":[49,84],"parallel,":[50],"ROS":[51,134],"was":[53],"evident":[54],"as":[55,191,213],"assessed":[56],"by":[57,147,153,178],"analyzing":[58],"DCF":[59],"hydroethidine.":[61],"Real-time":[62],"PCR":[63],"analysis,":[64],"at":[65,173],"various":[66],"time":[67],"points":[68],"after":[69],"treatment,":[71],"also":[72],"that":[74,187],"expression":[75,97,123],"subunits":[79],"(p47(phox)":[80,110],"p67(phox))":[82,112],"occurs.":[83],"addition,":[85],"Western":[86],"blot":[87],"analysis":[88],"double-label":[90],"immunocytochemistry":[91],"showed":[92],"an":[93,148,192],"up-regulation":[94],"cytosolic":[99,108],"components":[100],"(Rac":[101],"1":[102],"p67(phox)),":[104],"translocation":[106],"proteins":[109],"membrane,":[115],"localization":[118],"gp91(phox)":[120],"or":[121],"p47(phox)":[122],"neurons":[126,143],"cultures":[128],"CA1":[130],"layer.":[131],"thrombin-induced":[133,170],"production,":[135],"protein":[136],"oxidation,":[137],"loss":[139],"cultured":[141,167],"were":[144],"partially":[145],"attenuated":[146],"inhibitor":[151],"and/or":[152,199],"several":[154],"antioxidants.":[155],"Collectively,":[156],"is":[160],"first":[162],"demonstrate":[164],"neurons,":[169],"neurotoxicity":[171],"is,":[172],"least":[174],"part,":[176],"caused":[177],"oxidase-mediated":[181],"stress.":[183],"This":[184],"strongly":[185],"suggests":[186],"act":[190],"endogenous":[193],"neurotoxin,":[194],"inhibitors":[196],"antioxidants":[200],"be":[202],"useful":[203],"agents":[204],"for":[205],"treating":[206],"stress-mediated":[208],"neurodegenerative":[210],"diseases,":[211],"such":[212],"Alzheimer's":[214],"disease.":[215]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":3},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":6}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
