{"id":"https://openalex.org/W2063537370","doi":"https://doi.org/10.1080/15412550903049140","title":"From Proteomics to Prescription\u2014The Search for COPD Biomarkers","display_name":"From Proteomics to Prescription\u2014The Search for COPD Biomarkers","publication_year":2009,"publication_date":"2009-01-01","ids":{"openalex":"https://openalex.org/W2063537370","doi":"https://doi.org/10.1080/15412550903049140","mag":"2063537370","pmid":"https://pubmed.ncbi.nlm.nih.gov/19811390"},"language":"en","primary_location":{"id":"doi:10.1080/15412550903049140","doi":"https://doi.org/10.1080/15412550903049140","is_oa":true,"landing_page_url":"https://doi.org/10.1080/15412550903049140","pdf_url":"https://www.tandfonline.com/doi/pdf/10.1080/15412550903049140?needAccess=true&role=button","source":{"id":"https://openalex.org/S15387528","display_name":"COPD Journal of Chronic Obstructive Pulmonary Disease","issn_l":"1541-2555","issn":["1541-2555","1541-2563"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310320449","host_organization_name":"Informa","host_organization_lineage":["https://openalex.org/P4310320449"],"host_organization_lineage_names":["Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"COPD: Journal of Chronic Obstructive Pulmonary Disease","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.tandfonline.com/doi/pdf/10.1080/15412550903049140?needAccess=true&role=button","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5031621453","display_name":"Ben Nicholas","orcid":"https://orcid.org/0000-0003-1467-9643","observed_orcids":["https://orcid.org/0000-0003-1467-9643"]},"institutions":[{"id":"https://openalex.org/I2801388914","display_name":"Southampton General Hospital","ror":"https://ror.org/011cztj49","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2801388914","https://openalex.org/I2802965805"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Benjamin L. Nicholas","raw_affiliation_strings":["Division of Infection, Inflammation and Repair, School of Medicine, Southampton General Hospital, Tremona Road, Southampton, SO16 6YD, UK. B.L.Nicholas@soton.ac.uk","Division of Infection, Inflammation and Repair, School of Medicine, Southampton General Hospital, Tremona Road, Southampton, SO16 6YD, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Infection, Inflammation and Repair, School of Medicine, Southampton General Hospital, Tremona Road, Southampton, SO16 6YD, UK. B.L.Nicholas@soton.ac.uk","institution_ids":["https://openalex.org/I2801388914"]},{"raw_affiliation_string":"Division of Infection, Inflammation and Repair, School of Medicine, Southampton General Hospital, Tremona Road, Southampton, SO16 6YD, UK","institution_ids":["https://openalex.org/I2801388914"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022380945","display_name":"C. David O\u2019Connor","orcid":"https://orcid.org/0000-0003-3211-2237","observed_orcids":["https://orcid.org/0000-0003-3211-2237"]},"institutions":[{"id":"https://openalex.org/I43439940","display_name":"University of Southampton","ror":"https://ror.org/01ryk1543","country_code":"GB","type":"education","lineage":["https://openalex.org/I43439940"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"C. David O'Connor","raw_affiliation_strings":["Centre for Proteomic Research and School of Biological Sciences, University of Southampton, Bassett Crescent East, Southampton, SO16 7PX, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Proteomic Research and School of Biological Sciences, University of Southampton, Bassett Crescent East, Southampton, SO16 7PX, United Kingdom","institution_ids":["https://openalex.org/I43439940"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5043576559","display_name":"Ratko Djukanovi\u0107","orcid":"https://orcid.org/0000-0001-6039-5612","observed_orcids":["https://orcid.org/0000-0001-6039-5612"]},"institutions":[{"id":"https://openalex.org/I2801388914","display_name":"Southampton General Hospital","ror":"https://ror.org/011cztj49","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2801388914","https://openalex.org/I2802965805"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Ratko Djukanovic","raw_affiliation_strings":["Division of Infection, Inflammation and Repair, School of Medicine, Southampton General Hospital, Tremona Road, Southampton, SO16 6YD, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Infection, Inflammation and Repair, School of Medicine, Southampton General Hospital, Tremona Road, Southampton, SO16 6YD, United Kingdom","institution_ids":["https://openalex.org/I2801388914"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":2650,"currency":"USD","value_usd":2650},"apc_paid":null,"fwci":0.3332,"has_fulltext":true,"cited_by_count":18,"citation_normalized_percentile":{"value":0.32075472,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"6","issue":"4","first_page":"298","last_page":"303"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10143","display_name":"Chronic Obstructive Pulmonary Disease (COPD) Research","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10143","display_name":"Chronic Obstructive Pulmonary Disease (COPD) Research","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10519","display_name":"Advanced Proteomics Techniques and Applications","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chronic-obstructive-pulmonary-disease","display_name":"chronic obstructive pulmonary disease","score":0.9079999923706055},{"id":"https://openalex.org/keywords/biomarkers","display_name":"biomarkers","score":0.9110000133514404},{"id":"https://openalex.org/keywords/biomarker-discovery","display_name":"biomarker discovery","score":0.7860000133514404},{"id":"https://openalex.org/keywords/proteomics","display_name":"proteomics","score":0.6859999895095825},{"id":"https://openalex.org/keywords/treatment-response","display_name":"treatment response","score":0.8080000281333923},{"id":"https://openalex.org/keywords/diagnosis","display_name":"diagnosis","score":0.574999988079071},{"id":"https://openalex.org/keywords/body-fluids","display_name":"biological fluids","score":0.7509999871253967},{"id":"https://openalex.org/keywords/imaging-biomarkers","display_name":"imaging biomarkers","score":0.9210000038146973}],"concepts":[{"id":"https://openalex.org/C124535831","wikidata":"https://www.wikidata.org/wiki/Q4915074","display_name":"Biomarker discovery","level":4,"score":0.8442864418029785},{"id":"https://openalex.org/C2776780178","wikidata":"https://www.wikidata.org/wiki/Q199804","display_name":"COPD","level":2,"score":0.7801440358161926},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.7063134908676147},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5896810293197632},{"id":"https://openalex.org/C46111723","wikidata":"https://www.wikidata.org/wiki/Q471857","display_name":"Proteomics","level":3,"score":0.53805011510849},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.4983975887298584},{"id":"https://openalex.org/C2992779976","wikidata":"https://www.wikidata.org/wiki/Q3286546","display_name":"Pulmonary disease","level":2,"score":0.48350027203559875},{"id":"https://openalex.org/C2426938","wikidata":"https://www.wikidata.org/wiki/Q3355478","display_name":"Medical prescription","level":2,"score":0.47452512383461},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.4500657320022583},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.41495370864868164},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.25402215123176575},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.23538067936897278},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.11975419521331787},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.11578485369682312},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D003952","descriptor_name":"Diagnostic Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004797","descriptor_name":"Enzyme-Linked Immunosorbent Assay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D019032","descriptor_name":"Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D029424","descriptor_name":"Pulmonary Disease, Chronic Obstructive","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D029424","descriptor_name":"Pulmonary Disease, Chronic Obstructive","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D029424","descriptor_name":"Pulmonary Disease, Chronic Obstructive","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D029424","descriptor_name":"Pulmonary Disease, Chronic Obstructive","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D040901","descriptor_name":"Proteomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1080/15412550903049140","doi":"https://doi.org/10.1080/15412550903049140","is_oa":true,"landing_page_url":"https://doi.org/10.1080/15412550903049140","pdf_url":"https://www.tandfonline.com/doi/pdf/10.1080/15412550903049140?needAccess=true&role=button","source":{"id":"https://openalex.org/S15387528","display_name":"COPD Journal of Chronic Obstructive Pulmonary Disease","issn_l":"1541-2555","issn":["1541-2555","1541-2563"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310320449","host_organization_name":"Informa","host_organization_lineage":["https://openalex.org/P4310320449"],"host_organization_lineage_names":["Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"COPD: Journal of Chronic Obstructive Pulmonary Disease","raw_type":"journal-article"},{"id":"pmid:19811390","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19811390","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"COPD","raw_type":"Journal Article"},{"id":"pmh:oai:eprints.soton.ac.uk:146345","doi":null,"is_oa":false,"landing_page_url":"https://eprints.soton.ac.uk/146345/","pdf_url":null,"source":{"id":"https://openalex.org/S4306401019","display_name":"ePrints Soton (University of Southampton)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I43439940","host_organization_name":"University of Southampton","host_organization_lineage":["https://openalex.org/I43439940"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"}],"best_oa_location":{"id":"doi:10.1080/15412550903049140","doi":"https://doi.org/10.1080/15412550903049140","is_oa":true,"landing_page_url":"https://doi.org/10.1080/15412550903049140","pdf_url":"https://www.tandfonline.com/doi/pdf/10.1080/15412550903049140?needAccess=true&role=button","source":{"id":"https://openalex.org/S15387528","display_name":"COPD Journal of Chronic Obstructive Pulmonary Disease","issn_l":"1541-2555","issn":["1541-2555","1541-2563"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310320449","host_organization_name":"Informa","host_organization_lineage":["https://openalex.org/P4310320449"],"host_organization_lineage_names":["Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"COPD: Journal of Chronic Obstructive Pulmonary Disease","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2063537370.pdf","grobid_xml":"https://content.openalex.org/works/W2063537370.grobid-xml"},"referenced_works_count":78,"referenced_works":["https://openalex.org/W53222977","https://openalex.org/W91108901","https://openalex.org/W1571712967","https://openalex.org/W1965011257","https://openalex.org/W1968535634","https://openalex.org/W1973516598","https://openalex.org/W1981450018","https://openalex.org/W1983615053","https://openalex.org/W1989058855","https://openalex.org/W1990457819","https://openalex.org/W1991060266","https://openalex.org/W1996282628","https://openalex.org/W1999128589","https://openalex.org/W2000641235","https://openalex.org/W2001627247","https://openalex.org/W2003615253","https://openalex.org/W2005820953","https://openalex.org/W2006813853","https://openalex.org/W2007286329","https://openalex.org/W2011964798","https://openalex.org/W2016018917","https://openalex.org/W2019571295","https://openalex.org/W2025549732","https://openalex.org/W2038488430","https://openalex.org/W2041297715","https://openalex.org/W2042151879","https://openalex.org/W2042368647","https://openalex.org/W2047752721","https://openalex.org/W2051997502","https://openalex.org/W2056467018","https://openalex.org/W2058830415","https://openalex.org/W2061532879","https://openalex.org/W2062203307","https://openalex.org/W2064106755","https://openalex.org/W2064564846","https://openalex.org/W2071598883","https://openalex.org/W2072668743","https://openalex.org/W2074598493","https://openalex.org/W2079700276","https://openalex.org/W2084809520","https://openalex.org/W2085601127","https://openalex.org/W2089927844","https://openalex.org/W2094275247","https://openalex.org/W2097108952","https://openalex.org/W2098666638","https://openalex.org/W2099277710","https://openalex.org/W2103487488","https://openalex.org/W2104178795","https://openalex.org/W2105173228","https://openalex.org/W2110476296","https://openalex.org/W2112224076","https://openalex.org/W2112334970","https://openalex.org/W2116569033","https://openalex.org/W2118278377","https://openalex.org/W2120131386","https://openalex.org/W2122430069","https://openalex.org/W2122489740","https://openalex.org/W2126991164","https://openalex.org/W2135543983","https://openalex.org/W2135939624","https://openalex.org/W2138253751","https://openalex.org/W2140917767","https://openalex.org/W2141494492","https://openalex.org/W2142259789","https://openalex.org/W2143501283","https://openalex.org/W2144633516","https://openalex.org/W2145466675","https://openalex.org/W2151695888","https://openalex.org/W2154266638","https://openalex.org/W2158001245","https://openalex.org/W2158744780","https://openalex.org/W2160050642","https://openalex.org/W2160485370","https://openalex.org/W2165280737","https://openalex.org/W2167941825","https://openalex.org/W2171451434","https://openalex.org/W2429585782","https://openalex.org/W2430645367"],"related_works":["https://openalex.org/W2895692848","https://openalex.org/W2242338668","https://openalex.org/W2317066939","https://openalex.org/W2172592858","https://openalex.org/W1964587074","https://openalex.org/W3048690598","https://openalex.org/W2189269796","https://openalex.org/W2409023605","https://openalex.org/W2031085697","https://openalex.org/W2367889358"],"abstract_inverted_index":{"Biomarkers":[0],"that":[1],"describe":[2,29],"the":[3,10,30,39,62,84],"severity":[4],"and":[5,9,42,61,73,83,102],"progression":[6],"of":[7,12,23,33,35,45,50,65,71,87],"COPD":[8,46,78],"responses":[11],"patients":[13],"to":[14,20,57],"treatment":[15],"are":[16,68,81,90],"a":[17],"desirable":[18,63],"addition":[19],"clinical":[21],"measures":[22],"disease.":[24],"In":[25],"this":[26],"review,":[27],"we":[28],"current":[31],"state":[32],"knowledge":[34],"biomarkers":[36,52,104],"used":[37,95],"for":[38,77,96],"diagnosis,":[40],"staging":[41],"therapeutic":[43],"response":[44],"patients.":[47],"The":[48],"nature":[49],"these":[51,88],"is":[53,109],"considered":[54],"in":[55,100,105],"relation":[56],"their":[58],"intended":[59],"use,":[60],"qualities":[64],"such":[66],"entities":[67],"examined.":[69],"Examples":[70],"biased":[72],"unbiased":[74],"discovery":[75,80],"platforms":[76],"biomarker":[79,97],"given,":[82],"major":[85],"findings":[86],"studies":[89],"discussed.":[91],"Cutting":[92],"edge":[93],"technology":[94],"discovery,":[98],"quantitation":[99],"biofluids":[101],"imaging":[103],"whole":[106],"body":[107],"systems":[108],"reviewed.":[110]},"counts_by_year":[{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}