{"id":"https://openalex.org/W2063464594","doi":"https://doi.org/10.1038/ncomms6724","title":"De novo design of an RNA tile that self-assembles into a homo-octameric nanoprism","display_name":"De novo design of an RNA tile that self-assembles into a homo-octameric nanoprism","publication_year":2015,"publication_date":"2015-01-30","ids":{"openalex":"https://openalex.org/W2063464594","doi":"https://doi.org/10.1038/ncomms6724","mag":"2063464594","pmid":"https://pubmed.ncbi.nlm.nih.gov/25635537"},"language":"en","primary_location":{"id":"doi:10.1038/ncomms6724","doi":"https://doi.org/10.1038/ncomms6724","is_oa":true,"landing_page_url":"https://doi.org/10.1038/ncomms6724","pdf_url":"https://www.nature.com/articles/ncomms6724.pdf","source":{"id":"https://openalex.org/S64187185","display_name":"Nature Communications","issn_l":"2041-1723","issn":["2041-1723"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Communications","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/ncomms6724.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5091670761","display_name":"Jinwen Yu","orcid":"https://orcid.org/0009-0009-5187-1942","observed_orcids":["https://orcid.org/0009-0009-5187-1942"]},"institutions":[{"id":"https://openalex.org/I219193219","display_name":"Purdue University West Lafayette","ror":"https://ror.org/02dqehb95","country_code":"US","type":"education","lineage":["https://openalex.org/I219193219"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jinwen Yu","raw_affiliation_strings":["Department of Chemistry, Purdue University, West Lafayette, Indiana 47907, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Purdue University, West Lafayette, Indiana 47907, USA","institution_ids":["https://openalex.org/I219193219"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100400422","display_name":"Zhiyu Liu","orcid":"https://orcid.org/0000-0003-2681-6967","observed_orcids":["https://orcid.org/0000-0003-2681-6967"]},"institutions":[{"id":"https://openalex.org/I219193219","display_name":"Purdue University West Lafayette","ror":"https://ror.org/02dqehb95","country_code":"US","type":"education","lineage":["https://openalex.org/I219193219"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zhiyu Liu","raw_affiliation_strings":["Department of Chemistry, Purdue University, West Lafayette, Indiana 47907, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Purdue University, West Lafayette, Indiana 47907, USA","institution_ids":["https://openalex.org/I219193219"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031540622","display_name":"Wen Jiang","orcid":"https://orcid.org/0000-0002-1292-2411","observed_orcids":["https://orcid.org/0000-0002-1292-2411"]},"institutions":[{"id":"https://openalex.org/I219193219","display_name":"Purdue University West Lafayette","ror":"https://ror.org/02dqehb95","country_code":"US","type":"education","lineage":["https://openalex.org/I219193219"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wen Jiang","raw_affiliation_strings":["Markey Center for Structural Biology and Department of Biological Sciences, Purdue University, West Lafayette, Indiana 47907, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Markey Center for Structural Biology and Department of Biological Sciences, Purdue University, West Lafayette, Indiana 47907, USA","institution_ids":["https://openalex.org/I219193219"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030618874","display_name":"Guansong Wang","orcid":"https://orcid.org/0000-0002-5184-0777","observed_orcids":["https://orcid.org/0000-0002-5184-0777"]},"institutions":[{"id":"https://openalex.org/I4210117763","display_name":"Xinqiao Hospital","ror":"https://ror.org/02d217z27","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210117763"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Guansong Wang","raw_affiliation_strings":["The Institute of Respiratory Diseases, Xinqiao Hospital, Chongqing 400037, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Institute of Respiratory Diseases, Xinqiao Hospital, Chongqing 400037, China","institution_ids":["https://openalex.org/I4210117763"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5030614446","display_name":"Chengde Mao","orcid":"https://orcid.org/0000-0001-7516-8666","observed_orcids":["https://orcid.org/0000-0001-7516-8666"]},"institutions":[{"id":"https://openalex.org/I219193219","display_name":"Purdue University West Lafayette","ror":"https://ror.org/02dqehb95","country_code":"US","type":"education","lineage":["https://openalex.org/I219193219"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Chengde Mao","raw_affiliation_strings":["Department of Chemistry, Purdue University, West Lafayette, Indiana 47907, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Purdue University, West Lafayette, Indiana 47907, USA","institution_ids":["https://openalex.org/I219193219"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5030614446","https://openalex.org/A5030618874"],"corresponding_institution_ids":["https://openalex.org/I219193219","https://openalex.org/I4210117763"],"apc_list":{"value":6990,"currency":"USD","value_usd":6990},"apc_paid":{"value":6990,"currency":"USD","value_usd":6990},"fwci":3.6562,"has_fulltext":true,"cited_by_count":76,"citation_normalized_percentile":{"value":0.94568823,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":94,"max":99},"biblio":{"volume":"6","issue":"1","first_page":"5724","last_page":"5724"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10207","display_name":"Advanced biosensing and bioanalysis techniques","score":0.6890000104904175,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10207","display_name":"Advanced biosensing and bioanalysis techniques","score":0.6890000104904175,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.24889999628067017,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11419","display_name":"Supramolecular Self-Assembly in Materials","score":0.011099999770522118,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rna-nanostructures","display_name":"RNA nanostructures","score":0.8629999756813049},{"id":"https://openalex.org/keywords/de-novo-design","display_name":"de novo design","score":0.7820000052452087},{"id":"https://openalex.org/keywords/self-assembly","display_name":"self-assembly","score":0.8119999766349792},{"id":"https://openalex.org/keywords/rna-nanotechnology","display_name":"RNA nanotechnology","score":0.6460000276565552},{"id":"https://openalex.org/keywords/nucleic-acid-nanostructures","display_name":"nucleic acid nanostructures","score":0.7200000286102295}],"concepts":[{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.8254453539848328},{"id":"https://openalex.org/C186187911","wikidata":"https://www.wikidata.org/wiki/Q1093894","display_name":"Nanostructure","level":2,"score":0.6649953126907349},{"id":"https://openalex.org/C53105671","wikidata":"https://www.wikidata.org/wiki/Q14777816","display_name":"Rational design","level":2,"score":0.6286146640777588},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.6075944900512695},{"id":"https://openalex.org/C2780728851","wikidata":"https://www.wikidata.org/wiki/Q468402","display_name":"Tile","level":2,"score":0.5680234432220459},{"id":"https://openalex.org/C129275984","wikidata":"https://www.wikidata.org/wiki/Q602847","display_name":"DNA nanotechnology","level":3,"score":0.5592056512832642},{"id":"https://openalex.org/C24107716","wikidata":"https://www.wikidata.org/wiki/Q123619","display_name":"Nucleic acid","level":2,"score":0.5062581896781921},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.4920744299888611},{"id":"https://openalex.org/C74214498","wikidata":"https://www.wikidata.org/wiki/Q631739","display_name":"Nanowire","level":2,"score":0.4399198293685913},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3627297878265381},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.35930973291397095},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3343266248703003},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.16669249534606934},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.08956396579742432},{"id":"https://openalex.org/C159985019","wikidata":"https://www.wikidata.org/wiki/Q181790","display_name":"Composite material","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D012313","descriptor_name":"RNA","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D036103","descriptor_name":"Nanotechnology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D049329","descriptor_name":"Nanostructures","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1038/ncomms6724","doi":"https://doi.org/10.1038/ncomms6724","is_oa":true,"landing_page_url":"https://doi.org/10.1038/ncomms6724","pdf_url":"https://www.nature.com/articles/ncomms6724.pdf","source":{"id":"https://openalex.org/S64187185","display_name":"Nature Communications","issn_l":"2041-1723","issn":["2041-1723"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Communications","raw_type":"journal-article"},{"id":"pmid:25635537","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25635537","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature communications","raw_type":"Journal Article"},{"id":"pmh:oai:RePEc:nat:natcom:v:6:y:2015:i:1:d:10.1038_ncomms6724","doi":null,"is_oa":false,"landing_page_url":"https://www.nature.com/articles/ncomms6724","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"}],"best_oa_location":{"id":"doi:10.1038/ncomms6724","doi":"https://doi.org/10.1038/ncomms6724","is_oa":true,"landing_page_url":"https://doi.org/10.1038/ncomms6724","pdf_url":"https://www.nature.com/articles/ncomms6724.pdf","source":{"id":"https://openalex.org/S64187185","display_name":"Nature Communications","issn_l":"2041-1723","issn":["2041-1723"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Communications","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G5911408595","display_name":null,"funder_award_id":"81429001","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320309036","display_name":"Purdue University","ror":"https://ror.org/02dqehb95"},{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2063464594.pdf","grobid_xml":"https://content.openalex.org/works/W2063464594.grobid-xml"},"referenced_works_count":34,"referenced_works":["https://openalex.org/W1611419331","https://openalex.org/W2003403354","https://openalex.org/W2010889932","https://openalex.org/W2024003310","https://openalex.org/W2036158851","https://openalex.org/W2036235120","https://openalex.org/W2038156304","https://openalex.org/W2064140868","https://openalex.org/W2067299834","https://openalex.org/W2076051065","https://openalex.org/W2079290717","https://openalex.org/W2081958778","https://openalex.org/W2082741569","https://openalex.org/W2083552586","https://openalex.org/W2088232691","https://openalex.org/W2088382214","https://openalex.org/W2095914211","https://openalex.org/W2099540110","https://openalex.org/W2100455255","https://openalex.org/W2104525153","https://openalex.org/W2121819501","https://openalex.org/W2125536449","https://openalex.org/W2133819505","https://openalex.org/W2134069036","https://openalex.org/W2140444174","https://openalex.org/W2141577560","https://openalex.org/W2142055951","https://openalex.org/W2164530723","https://openalex.org/W2165092268","https://openalex.org/W2171962490","https://openalex.org/W2325444608","https://openalex.org/W2325501754","https://openalex.org/W2330559723","https://openalex.org/W3024389904"],"related_works":["https://openalex.org/W2736325698","https://openalex.org/W4249843187","https://openalex.org/W3199745117","https://openalex.org/W2315586106","https://openalex.org/W2980393658","https://openalex.org/W1978553367","https://openalex.org/W4206295521","https://openalex.org/W2562991274","https://openalex.org/W2081958778","https://openalex.org/W2587854835"],"abstract_inverted_index":{"Rational,":[0],"de":[1],"novo":[2],"design":[3,77,131],"of":[4,13,57,132],"RNA":[5,33,79,87,91,115,154],"nanostructures":[6,19,135],"can":[7,51,82,140],"potentially":[8],"integrate":[9],"a":[10,55,85,145,152,161],"wide":[11],"array":[12],"structural":[14,120],"and":[15,50,101],"functional":[16],"diversities.":[17],"Such":[18],"have":[20],"great":[21],"promises":[22],"in":[23,29],"biomedical":[24],"applications.":[25],"Despite":[26],"impressive":[27],"progress":[28],"this":[30,74,111],"field,":[31],"all":[32],"building":[34,137,155],"blocks":[35,138],"(or":[36],"tiles)":[37],"reported":[38],"so":[39],"far":[40],"are":[41,47,71],"not":[42],"geometrically":[43],"well":[44],"defined.":[45],"They":[46],"generally":[48],"flexible":[49],"only":[52],"assemble":[53],"into":[54,84,144,160],"mixture":[56],"complexes":[58],"with":[59,68,126],"different":[60,69],"sizes.":[61],"To":[62],"achieve":[63],"defined":[64],"structures,":[65],"multiple":[66],"tiles":[67],"sequences":[70],"needed.":[72],"In":[73],"study,":[75],"we":[76],"an":[78],"tile":[80],"that":[81,108,122,139],"homo-oligomerize":[83],"uniform":[86,146],"nanostructure.":[88],"The":[89,129],"designed":[90,153],"nanostructure":[92],"is":[93,123],"characterized":[94],"by":[95],"gel":[96],"electrophoresis,":[97],"atomic":[98],"force":[99],"microscopy":[100,104],"cryogenic":[102],"electron":[103],"imaging.":[105],"We":[106],"believe":[107],"development":[109],"along":[110],"line":[112],"would":[113],"help":[114],"nanotechnology":[116],"to":[117,158],"reach":[118],"the":[119,149],"control":[121],"currently":[124],"associated":[125],"DNA":[127],"nanotechnology.":[128],"rational":[130],"nucleic":[133],"acid":[134],"requires":[136],"be":[141],"predictably":[142],"combined":[143],"structure.":[147],"Here,":[148],"authors":[150],"present":[151],"block":[156],"able":[157],"self-assemble":[159],"homo-octameric":[162],"cube.":[163]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":8},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":10},{"year":2019,"cited_by_count":8},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":12},{"year":2016,"cited_by_count":8},{"year":2015,"cited_by_count":5}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}