{"id":"https://openalex.org/W2063460322","doi":"https://doi.org/10.1074/jbc.272.44.28001","title":"Isolation and Characterization of cDNAs Corresponding to an Additional Member of the Human Histone Deacetylase Gene Family","display_name":"Isolation and Characterization of cDNAs Corresponding to an Additional Member of the Human Histone Deacetylase Gene Family","publication_year":1997,"publication_date":"1997-10-01","ids":{"openalex":"https://openalex.org/W2063460322","doi":"https://doi.org/10.1074/jbc.272.44.28001","mag":"2063460322","pmid":"https://pubmed.ncbi.nlm.nih.gov/9346952"},"language":"en","primary_location":{"id":"doi:10.1074/jbc.272.44.28001","doi":"https://doi.org/10.1074/jbc.272.44.28001","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.272.44.28001","pdf_url":"http://www.jbc.org/article/S002192581880357X/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"http://www.jbc.org/article/S002192581880357X/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5010411205","display_name":"Wen\u2010Ming Yang","orcid":"https://orcid.org/0000-0002-5871-5979","observed_orcids":["https://orcid.org/0000-0002-5871-5979"]},"institutions":[{"id":"https://openalex.org/I2613432","display_name":"University of South Florida","ror":"https://ror.org/032db5x82","country_code":"US","type":"education","lineage":["https://openalex.org/I2613432"]},{"id":"https://openalex.org/I3019308854","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019308854"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wen-Ming Yang","raw_affiliation_strings":["Moffitt Cancer Center and Research Institute, the Department of Medical Microbiology and Immunology, College of Medicine, University of South Florida, Tampa, Florida 33612, USA","Moffitt Cancer Center and Research Institute, the Department of Medical Microbiology and Immunology, and the Department of Biochemistry and Molecular Biology, College of Medicine, University of South Florida, Tampa, Florida 33612"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Moffitt Cancer Center and Research Institute, the Department of Medical Microbiology and Immunology, College of Medicine, University of South Florida, Tampa, Florida 33612, USA","institution_ids":["https://openalex.org/I2613432","https://openalex.org/I3019308854"]},{"raw_affiliation_string":"Moffitt Cancer Center and Research Institute, the Department of Medical Microbiology and Immunology, and the Department of Biochemistry and Molecular Biology, College of Medicine, University of South Florida, Tampa, Florida 33612","institution_ids":["https://openalex.org/I2613432","https://openalex.org/I3019308854"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071411150","display_name":"Yali Yao","orcid":"https://orcid.org/0000-0003-3612-3742","observed_orcids":["https://orcid.org/0000-0003-3612-3742"]},"institutions":[{"id":"https://openalex.org/I2613432","display_name":"University of South Florida","ror":"https://ror.org/032db5x82","country_code":"US","type":"education","lineage":["https://openalex.org/I2613432"]},{"id":"https://openalex.org/I3019308854","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019308854"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ya-Li Yao","raw_affiliation_strings":["Moffitt Cancer Center and Research Institute, the Department of Medical Microbiology and Immunology, and the Department of Biochemistry and Molecular Biology, College of Medicine, University of South Florida, Tampa, Florida 33612"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Moffitt Cancer Center and Research Institute, the Department of Medical Microbiology and Immunology, and the Department of Biochemistry and Molecular Biology, College of Medicine, University of South Florida, Tampa, Florida 33612","institution_ids":["https://openalex.org/I2613432","https://openalex.org/I3019308854"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007506207","display_name":"Jian-Min Sun","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I46247651","display_name":"University of Manitoba","ror":"https://ror.org/02gfys938","country_code":"CA","type":"education","lineage":["https://openalex.org/I46247651"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Jian-Min Sun","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, University of Manitoba, Winnipeg, Manitoba R3E OW3, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, University of Manitoba, Winnipeg, Manitoba R3E OW3, Canada","institution_ids":["https://openalex.org/I46247651"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048849645","display_name":"James Davie","orcid":"https://orcid.org/0000-0002-0420-6888","observed_orcids":["https://orcid.org/0000-0002-0420-6888"]},"institutions":[{"id":"https://openalex.org/I46247651","display_name":"University of Manitoba","ror":"https://ror.org/02gfys938","country_code":"CA","type":"education","lineage":["https://openalex.org/I46247651"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"James R. Davie","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, University of Manitoba, Winnipeg, Manitoba R3E OW3, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, University of Manitoba, Winnipeg, Manitoba R3E OW3, Canada","institution_ids":["https://openalex.org/I46247651"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5004256523","display_name":"Edward Seto","orcid":"https://orcid.org/0000-0001-7562-7316","observed_orcids":["https://orcid.org/0000-0001-7562-7316"]},"institutions":[{"id":"https://openalex.org/I2613432","display_name":"University of South Florida","ror":"https://ror.org/032db5x82","country_code":"US","type":"education","lineage":["https://openalex.org/I2613432"]},{"id":"https://openalex.org/I3019308854","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019308854"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Edward Seto","raw_affiliation_strings":["Moffitt Cancer Center and Research Institute, the Department of Medical Microbiology and Immunology, and the Department of Biochemistry and Molecular Biology, College of Medicine, University of South Florida, Tampa, Florida 33612"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Moffitt Cancer Center and Research Institute, the Department of Medical Microbiology and Immunology, and the Department of Biochemistry and Molecular Biology, College of Medicine, University of South Florida, Tampa, Florida 33612","institution_ids":["https://openalex.org/I2613432","https://openalex.org/I3019308854"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5004256523"],"corresponding_institution_ids":["https://openalex.org/I2613432","https://openalex.org/I3019308854"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":10.3485,"has_fulltext":true,"cited_by_count":433,"citation_normalized_percentile":{"value":0.98997987,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":100},"biblio":{"volume":"272","issue":"44","first_page":"28001","last_page":"28007"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11736","display_name":"Histone Deacetylase Inhibitors Research","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11736","display_name":"Histone Deacetylase Inhibitors Research","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hdac3","display_name":"HDAC3","score":0.8980000019073486},{"id":"https://openalex.org/keywords/histone-deacetylase","display_name":"histone deacetylase","score":0.9679999947547913},{"id":"https://openalex.org/keywords/hdac1","display_name":"HDAC1","score":0.8700000047683716},{"id":"https://openalex.org/keywords/hdac2","display_name":"HDAC2","score":0.9990000128746033},{"id":"https://openalex.org/keywords/cdna-cloning","display_name":"cDNA cloning","score":0.7429999709129333},{"id":"https://openalex.org/keywords/sequence-homology","display_name":"sequence homology","score":0.6549999713897705},{"id":"https://openalex.org/keywords/transcriptional-repression","display_name":"transcriptional repression","score":0.9179999828338623},{"id":"https://openalex.org/keywords/protein-expression","display_name":"protein expression","score":0.3499999940395355}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6565597653388977},{"id":"https://openalex.org/C71723506","wikidata":"https://www.wikidata.org/wiki/Q18026859","display_name":"Histone deacetylase 2","level":5,"score":0.6526846885681152},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5770245790481567},{"id":"https://openalex.org/C45946802","wikidata":"https://www.wikidata.org/wiki/Q18033449","display_name":"SAP30","level":5,"score":0.568456768989563},{"id":"https://openalex.org/C167625842","wikidata":"https://www.wikidata.org/wiki/Q899763","display_name":"Peptide sequence","level":3,"score":0.4886172413825989},{"id":"https://openalex.org/C4951695","wikidata":"https://www.wikidata.org/wiki/Q18046437","display_name":"HDAC11","level":5,"score":0.47219598293304443},{"id":"https://openalex.org/C27253355","wikidata":"https://www.wikidata.org/wiki/Q18034954","display_name":"Histone deacetylase 5","level":5,"score":0.4342391788959503},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.39602985978126526},{"id":"https://openalex.org/C2778305200","wikidata":"https://www.wikidata.org/wiki/Q174378","display_name":"Histone deacetylase","level":4,"score":0.3787177801132202},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.30845344066619873},{"id":"https://openalex.org/C64927066","wikidata":"https://www.wikidata.org/wiki/Q36293","display_name":"Histone","level":3,"score":0.29924917221069336}],"mesh":[{"descriptor_ui":"D000099186","descriptor_name":"Histone Deacetylase 3","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003001","descriptor_name":"Cloning, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005810","descriptor_name":"Multigene Family","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006367","descriptor_name":"HeLa Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006655","descriptor_name":"Histone Deacetylases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006655","descriptor_name":"Histone Deacetylases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017386","descriptor_name":"Sequence Homology, Amino Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018076","descriptor_name":"DNA, Complementary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019894","descriptor_name":"Peptide YY","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1074/jbc.272.44.28001","doi":"https://doi.org/10.1074/jbc.272.44.28001","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.272.44.28001","pdf_url":"http://www.jbc.org/article/S002192581880357X/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmid:9346952","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9346952","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1074/jbc.272.44.28001","doi":"https://doi.org/10.1074/jbc.272.44.28001","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.272.44.28001","pdf_url":"http://www.jbc.org/article/S002192581880357X/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G4555474253","display_name":"Mechanisms of Transcriptional Repressors and                Co-repressors","funder_award_id":"9631067","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320324195","display_name":"Medical Research Council Canada","ror":"https://ror.org/01gavpb45"},{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2063460322.pdf","grobid_xml":"https://content.openalex.org/works/W2063460322.grobid-xml"},"referenced_works_count":38,"referenced_works":["https://openalex.org/W138153588","https://openalex.org/W1511138521","https://openalex.org/W1519860621","https://openalex.org/W1594700207","https://openalex.org/W1830935920","https://openalex.org/W1963539429","https://openalex.org/W1965372133","https://openalex.org/W1966156883","https://openalex.org/W1968112541","https://openalex.org/W1971859861","https://openalex.org/W1972065726","https://openalex.org/W1972766406","https://openalex.org/W1974112332","https://openalex.org/W1978921101","https://openalex.org/W1982598173","https://openalex.org/W1985063313","https://openalex.org/W1987271093","https://openalex.org/W1999952815","https://openalex.org/W2004988279","https://openalex.org/W2016567695","https://openalex.org/W2026441085","https://openalex.org/W2036639816","https://openalex.org/W2041785424","https://openalex.org/W2042315437","https://openalex.org/W2060696024","https://openalex.org/W2068881539","https://openalex.org/W2074096799","https://openalex.org/W2075496313","https://openalex.org/W2086778920","https://openalex.org/W2088186319","https://openalex.org/W2095223507","https://openalex.org/W2104788426","https://openalex.org/W2107424534","https://openalex.org/W2144206181","https://openalex.org/W2144634347","https://openalex.org/W2149732532","https://openalex.org/W2314225431","https://openalex.org/W4206302388"],"related_works":["https://openalex.org/W2113261653","https://openalex.org/W2054208176","https://openalex.org/W11512602","https://openalex.org/W2084194105","https://openalex.org/W1992725701","https://openalex.org/W1994189928","https://openalex.org/W7096496298","https://openalex.org/W1970543410","https://openalex.org/W2062414406","https://openalex.org/W3168602648"],"abstract_inverted_index":{"Several":[0],"human":[1,58,66],"cDNAs":[2],"encoding":[3],"a":[4,31,102],"histone":[5,94],"deacetylase":[6,95],"protein,":[7],"HDAC3,":[8],"have":[9],"been":[10],"isolated.":[11],"Analysis":[12],"of":[13,19,26,35,61],"the":[14,55,62],"predicted":[15,32],"amino":[16,28],"acid":[17],"sequence":[18,46,52,64,77],"HDAC3":[20,39,63,86,114],"revealed":[21],"an":[22],"open":[23],"reading":[24],"frame":[25],"428":[27],"acids":[29],"with":[30,54,65,72],"molecular":[33],"mass":[34],"49":[36],"kDa.":[37],"The":[38,84],"protein":[40,51,82,87],"is":[41,88,115],"50%":[42],"identical":[43,49],"in":[44,50,75,81,118],"DNA":[45,76],"and":[47,78,104,112],"53%":[48],"compared":[53],"previously":[56],"cloned":[57],"HDAC1.":[59],"Comparison":[60],"HDAC2":[67],"also":[68],"yielded":[69],"similar":[70],"results,":[71],"51%":[73],"identity":[74,80],"52%":[79],"sequence.":[83],"expressed":[85,117],"functionally":[89],"active":[90],"because":[91],"it":[92],"possesses":[93],"activity,":[96],"represses":[97],"transcription":[98,106],"when":[99],"tethered":[100],"to":[101,110],"promoter,":[103],"binds":[105],"factor":[107],"YY1.":[108],"Similar":[109],"HDAC1":[111],"HDAC2,":[113],"ubiquitously":[116],"many":[119],"different":[120],"cell":[121],"types.":[122]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":9},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":8},{"year":2022,"cited_by_count":13},{"year":2021,"cited_by_count":14},{"year":2020,"cited_by_count":11},{"year":2019,"cited_by_count":10},{"year":2018,"cited_by_count":7},{"year":2017,"cited_by_count":13},{"year":2016,"cited_by_count":8},{"year":2015,"cited_by_count":10},{"year":2014,"cited_by_count":16},{"year":2013,"cited_by_count":13},{"year":2012,"cited_by_count":12}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
