{"id":"https://openalex.org/W2063442011","doi":"https://doi.org/10.1002/eji.200838630","title":"Proliferation of weakly suppressive regulatory CD4+ T cells is associated with over\u2010active CD4+ T\u2010cell responses in HIV\u2010positive patients with mycobacterial immune restoration disease","display_name":"Proliferation of weakly suppressive regulatory CD4+ T cells is associated with over\u2010active CD4+ T\u2010cell responses in HIV\u2010positive patients with mycobacterial immune restoration disease","publication_year":2009,"publication_date":"2009-01-29","ids":{"openalex":"https://openalex.org/W2063442011","doi":"https://doi.org/10.1002/eji.200838630","mag":"2063442011","pmid":"https://pubmed.ncbi.nlm.nih.gov/19180462"},"language":"en","primary_location":{"id":"doi:10.1002/eji.200838630","doi":"https://doi.org/10.1002/eji.200838630","is_oa":true,"landing_page_url":"https://doi.org/10.1002/eji.200838630","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/eji.200838630","source":{"id":"https://openalex.org/S126191069","display_name":"European Journal of Immunology","issn_l":"0014-2980","issn":["0014-2980","1521-4141"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Immunology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/eji.200838630","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5003820675","display_name":"Nabila Seddiki","orcid":"https://orcid.org/0000-0002-0379-8527","observed_orcids":["https://orcid.org/0000-0002-0379-8527"]},"institutions":[{"id":"https://openalex.org/I31746571","display_name":"UNSW Sydney","ror":"https://ror.org/03r8z3t63","country_code":"AU","type":"education","lineage":["https://openalex.org/I31746571"]},{"id":"https://openalex.org/I4210087284","display_name":"St Vincent's Hospital Sydney","ror":"https://ror.org/000ed3w25","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I4210087284"]}],"countries":["AU"],"is_corresponding":true,"raw_author_name":"Nabila Seddiki","raw_affiliation_strings":["Centre for Immunology, St Vincent's Hospital, Darlinghurst, NSW, Australia. n.seddiki@cfi.unsw.edu.au","Centre for Immunology, St Vincent's Hospital, Darlinghurst, NSW, Australia","National Centre in HIV Epidemiology and Clinical Research, The University of NSW, Kensington, NSW, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Immunology, St Vincent's Hospital, Darlinghurst, NSW, Australia. n.seddiki@cfi.unsw.edu.au","institution_ids":["https://openalex.org/I4210087284"]},{"raw_affiliation_string":"Centre for Immunology, St Vincent's Hospital, Darlinghurst, NSW, Australia","institution_ids":["https://openalex.org/I4210087284"]},{"raw_affiliation_string":"National Centre in HIV Epidemiology and Clinical Research, The University of NSW, Kensington, NSW, Australia","institution_ids":["https://openalex.org/I31746571"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068579872","display_name":"Sarah Christina Sasson","orcid":"https://orcid.org/0000-0002-5329-9072","observed_orcids":["https://orcid.org/0000-0002-5329-9072"]},"institutions":[{"id":"https://openalex.org/I31746571","display_name":"UNSW Sydney","ror":"https://ror.org/03r8z3t63","country_code":"AU","type":"education","lineage":["https://openalex.org/I31746571"]},{"id":"https://openalex.org/I4210087284","display_name":"St Vincent's Hospital Sydney","ror":"https://ror.org/000ed3w25","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I4210087284"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Sarah C. Sasson","raw_affiliation_strings":["Centre for Immunology, St Vincent's Hospital, Darlinghurst, NSW, Australia","National Centre in HIV Epidemiology and Clinical Research, The University of NSW, Kensington, NSW, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Immunology, St Vincent's Hospital, Darlinghurst, NSW, Australia","institution_ids":["https://openalex.org/I4210087284"]},{"raw_affiliation_string":"National Centre in HIV Epidemiology and Clinical Research, The University of NSW, Kensington, NSW, Australia","institution_ids":["https://openalex.org/I31746571"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071682048","display_name":"Brigitte Santner\u2010Nanan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129604602","display_name":"The University of Sydney","ror":"https://ror.org/0384j8v12","country_code":"AU","type":"education","lineage":["https://openalex.org/I129604602"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Brigitte Santner\u2010Nanan","raw_affiliation_strings":["Discipline of Paediatrics, Nepean Clinical School, The University of Sydney, Penrith, NSW, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Discipline of Paediatrics, Nepean Clinical School, The University of Sydney, Penrith, NSW, Australia","institution_ids":["https://openalex.org/I129604602"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041528010","display_name":"Cynthia Mee Ling Munier","orcid":"https://orcid.org/0000-0002-6419-142X","observed_orcids":["https://orcid.org/0000-0002-6419-142X"]},"institutions":[{"id":"https://openalex.org/I31746571","display_name":"UNSW Sydney","ror":"https://ror.org/03r8z3t63","country_code":"AU","type":"education","lineage":["https://openalex.org/I31746571"]},{"id":"https://openalex.org/I4210087284","display_name":"St Vincent's Hospital Sydney","ror":"https://ror.org/000ed3w25","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I4210087284"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Meeling Munier","raw_affiliation_strings":["Centre for Immunology, St Vincent's Hospital, Darlinghurst, NSW, Australia","National Centre in HIV Epidemiology and Clinical Research, The University of NSW, Kensington, NSW, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Immunology, St Vincent's Hospital, Darlinghurst, NSW, Australia","institution_ids":["https://openalex.org/I4210087284"]},{"raw_affiliation_string":"National Centre in HIV Epidemiology and Clinical Research, The University of NSW, Kensington, NSW, Australia","institution_ids":["https://openalex.org/I31746571"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060263230","display_name":"David J van Bockel","orcid":"https://orcid.org/0000-0003-0048-5813","observed_orcids":["https://orcid.org/0000-0003-0048-5813"]},"institutions":[{"id":"https://openalex.org/I31746571","display_name":"UNSW Sydney","ror":"https://ror.org/03r8z3t63","country_code":"AU","type":"education","lineage":["https://openalex.org/I31746571"]},{"id":"https://openalex.org/I4210087284","display_name":"St Vincent's Hospital Sydney","ror":"https://ror.org/000ed3w25","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I4210087284"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"David van Bockel","raw_affiliation_strings":["Centre for Immunology, St Vincent's Hospital, Darlinghurst, NSW, Australia","National Centre in HIV Epidemiology and Clinical Research, The University of NSW, Kensington, NSW, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Immunology, St Vincent's Hospital, Darlinghurst, NSW, Australia","institution_ids":["https://openalex.org/I4210087284"]},{"raw_affiliation_string":"National Centre in HIV Epidemiology and Clinical Research, The University of NSW, Kensington, NSW, Australia","institution_ids":["https://openalex.org/I31746571"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026897654","display_name":"Susanna Ip","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I31746571","display_name":"UNSW Sydney","ror":"https://ror.org/03r8z3t63","country_code":"AU","type":"education","lineage":["https://openalex.org/I31746571"]},{"id":"https://openalex.org/I4210087284","display_name":"St Vincent's Hospital Sydney","ror":"https://ror.org/000ed3w25","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I4210087284"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Susanna Ip","raw_affiliation_strings":["Centre for Immunology, St Vincent's Hospital, Darlinghurst, NSW, Australia","National Centre in HIV Epidemiology and Clinical Research, The University of NSW, Kensington, NSW, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Immunology, St Vincent's Hospital, Darlinghurst, NSW, Australia","institution_ids":["https://openalex.org/I4210087284"]},{"raw_affiliation_string":"National Centre in HIV Epidemiology and Clinical Research, The University of NSW, Kensington, NSW, Australia","institution_ids":["https://openalex.org/I31746571"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075134150","display_name":"Debbie Marriott","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210087284","display_name":"St Vincent's Hospital Sydney","ror":"https://ror.org/000ed3w25","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I4210087284"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Debbie Marriott","raw_affiliation_strings":["HIV, Immunology and Infectious Diseases Clinical Services Unit, St Vincent's Hospital, Darlinghurst, NSW, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"HIV, Immunology and Infectious Diseases Clinical Services Unit, St Vincent's Hospital, Darlinghurst, NSW, Australia","institution_ids":["https://openalex.org/I4210087284"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021731943","display_name":"Sarah Lilian Pett","orcid":"https://orcid.org/0000-0002-4851-4727","observed_orcids":["https://orcid.org/0000-0002-4851-4727"]},"institutions":[{"id":"https://openalex.org/I129604602","display_name":"The University of Sydney","ror":"https://ror.org/0384j8v12","country_code":"AU","type":"education","lineage":["https://openalex.org/I129604602"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Sarah Pett","raw_affiliation_strings":["Discipline of Paediatrics, Nepean Clinical School, The University of Sydney, Penrith, NSW, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Discipline of Paediatrics, Nepean Clinical School, The University of Sydney, Penrith, NSW, Australia","institution_ids":["https://openalex.org/I129604602"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063672060","display_name":"Ralph  Kay Heinrich Nanan","orcid":"https://orcid.org/0000-0002-1749-6378","observed_orcids":["https://orcid.org/0000-0002-1749-6378"]},"institutions":[{"id":"https://openalex.org/I129604602","display_name":"The University of Sydney","ror":"https://ror.org/0384j8v12","country_code":"AU","type":"education","lineage":["https://openalex.org/I129604602"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Ralph Nanan","raw_affiliation_strings":["Discipline of Paediatrics, Nepean Clinical School, The University of Sydney, Penrith, NSW, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Discipline of Paediatrics, Nepean Clinical School, The University of Sydney, Penrith, NSW, Australia","institution_ids":["https://openalex.org/I129604602"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107834622","display_name":"David A. Cooper","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I31746571","display_name":"UNSW Sydney","ror":"https://ror.org/03r8z3t63","country_code":"AU","type":"education","lineage":["https://openalex.org/I31746571"]},{"id":"https://openalex.org/I4210087284","display_name":"St Vincent's Hospital Sydney","ror":"https://ror.org/000ed3w25","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I4210087284"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"David A. Cooper","raw_affiliation_strings":["Centre for Immunology, St Vincent's Hospital, Darlinghurst, NSW, Australia","HIV, Immunology and Infectious Diseases Clinical Services Unit, St Vincent's Hospital, Darlinghurst, NSW, Australia","National Centre in HIV Epidemiology and Clinical Research, The University of NSW, Kensington, NSW, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Immunology, St Vincent's Hospital, Darlinghurst, NSW, Australia","institution_ids":["https://openalex.org/I4210087284"]},{"raw_affiliation_string":"HIV, Immunology and Infectious Diseases Clinical Services Unit, St Vincent's Hospital, Darlinghurst, NSW, Australia","institution_ids":["https://openalex.org/I4210087284"]},{"raw_affiliation_string":"National Centre in HIV Epidemiology and Clinical Research, The University of NSW, Kensington, NSW, Australia","institution_ids":["https://openalex.org/I31746571"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088309165","display_name":"John James Zaunders","orcid":"https://orcid.org/0000-0002-5912-5989","observed_orcids":["https://orcid.org/0000-0002-5912-5989"]},"institutions":[{"id":"https://openalex.org/I4210087284","display_name":"St Vincent's Hospital Sydney","ror":"https://ror.org/000ed3w25","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I4210087284"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"John J. Zaunders","raw_affiliation_strings":["Centre for Immunology, St Vincent's Hospital, Darlinghurst, NSW, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Immunology, St Vincent's Hospital, Darlinghurst, NSW, Australia","institution_ids":["https://openalex.org/I4210087284"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5068421356","display_name":"Anthony Dominic Kelleher","orcid":"https://orcid.org/0000-0002-0009-3337","observed_orcids":["https://orcid.org/0000-0002-0009-3337"]},"institutions":[{"id":"https://openalex.org/I31746571","display_name":"UNSW Sydney","ror":"https://ror.org/03r8z3t63","country_code":"AU","type":"education","lineage":["https://openalex.org/I31746571"]},{"id":"https://openalex.org/I4210087284","display_name":"St Vincent's Hospital Sydney","ror":"https://ror.org/000ed3w25","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I4210087284"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Anthony D. Kelleher","raw_affiliation_strings":["Centre for Immunology, St Vincent's Hospital, Darlinghurst, NSW, Australia","HIV, Immunology and Infectious Diseases Clinical Services Unit, St Vincent's Hospital, Darlinghurst, NSW, Australia","National Centre in HIV Epidemiology and Clinical Research, The University of NSW, Kensington, NSW, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Immunology, St Vincent's Hospital, Darlinghurst, NSW, Australia","institution_ids":["https://openalex.org/I4210087284"]},{"raw_affiliation_string":"HIV, Immunology and Infectious Diseases Clinical Services Unit, St Vincent's Hospital, Darlinghurst, NSW, Australia","institution_ids":["https://openalex.org/I4210087284"]},{"raw_affiliation_string":"National Centre in HIV Epidemiology and Clinical Research, The University of NSW, Kensington, NSW, Australia","institution_ids":["https://openalex.org/I31746571"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5003820675"],"corresponding_institution_ids":["https://openalex.org/I31746571","https://openalex.org/I4210087284"],"apc_list":{"value":4550,"currency":"USD","value_usd":4550},"apc_paid":null,"fwci":8.482,"has_fulltext":true,"cited_by_count":121,"citation_normalized_percentile":{"value":0.98189964,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"39","issue":"2","first_page":"391","last_page":"403"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.5590999722480774,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.5590999722480774,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.39969998598098755,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11381","display_name":"Infectious Diseases and Tuberculosis","score":0.0052999998442828655,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/regulatory-t-cells","display_name":"regulatory T cells","score":0.925000011920929},{"id":"https://openalex.org/keywords/immune-reconstitution-inflammatory-syndrome","display_name":"immune reconstitution inflammatory syndrome","score":0.6790000200271606},{"id":"https://openalex.org/keywords/hiv","display_name":"HIV","score":0.5740000009536743},{"id":"https://openalex.org/keywords/mycobacterial-infection","display_name":"mycobacterial infection","score":0.8119999766349792},{"id":"https://openalex.org/keywords/cd4-t-cells","display_name":"CD4+ T cells","score":0.8309999704360962},{"id":"https://openalex.org/keywords/treg-dysfunction","display_name":"Treg dysfunction","score":0.5960000157356262},{"id":"https://openalex.org/keywords/foxp3","display_name":"Foxp3","score":0.7670000195503235},{"id":"https://openalex.org/keywords/cd127","display_name":"CD127","score":0.8870000243186951},{"id":"https://openalex.org/keywords/interleukin-7","display_name":"IL-7","score":0.7319999933242798},{"id":"https://openalex.org/keywords/il-10","display_name":"IL-10","score":0.9190000295639038},{"id":"https://openalex.org/keywords/interferon-gamma","display_name":"interferon-gamma","score":0.8980000019073486},{"id":"https://openalex.org/keywords/interleukin-2","display_name":"interleukin-2","score":0.9169999957084656},{"id":"https://openalex.org/keywords/treg-suppressive-function","display_name":"Treg suppressive function","score":0.4959999918937683},{"id":"https://openalex.org/keywords/antiretroviral-therapy","display_name":"antiretroviral therapy","score":0.8370000123977661},{"id":"https://openalex.org/keywords/late-stage-hiv","display_name":"late-stage HIV","score":0.8700000047683716}],"concepts":[{"id":"https://openalex.org/C123982805","wikidata":"https://www.wikidata.org/wiki/Q6046964","display_name":"Interleukin-7 receptor","level":5,"score":0.8461466431617737},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7862125635147095},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.7397357225418091},{"id":"https://openalex.org/C2779727006","wikidata":"https://www.wikidata.org/wiki/Q426188","display_name":"FOXP3","level":3,"score":0.7258173823356628},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.7157857418060303},{"id":"https://openalex.org/C79484868","wikidata":"https://www.wikidata.org/wiki/Q5971673","display_name":"IL-2 receptor","level":4,"score":0.613650381565094},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.4664596617221832},{"id":"https://openalex.org/C2780648854","wikidata":"https://www.wikidata.org/wiki/Q2745824","display_name":"Immunopathology","level":2,"score":0.4359317719936371},{"id":"https://openalex.org/C51785407","wikidata":"https://www.wikidata.org/wiki/Q2627568","display_name":"Effector","level":2,"score":0.4256572425365448}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007371","descriptor_name":"Interferon-gamma","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D007371","descriptor_name":"Interferon-gamma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009161","descriptor_name":"Mycobacterium","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D014376","descriptor_name":"Tuberculosis","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D014376","descriptor_name":"Tuberculosis","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D015847","descriptor_name":"Interleukin-4","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D015850","descriptor_name":"Interleukin-6","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D015851","descriptor_name":"Interleukin-7","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D023241","descriptor_name":"Antiretroviral Therapy, Highly Active","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050378","descriptor_name":"T-Lymphocytes, Regulatory","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D050378","descriptor_name":"T-Lymphocytes, Regulatory","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D054019","descriptor_name":"Immune Reconstitution Inflammatory Syndrome","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D054019","descriptor_name":"Immune Reconstitution Inflammatory Syndrome","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D054019","descriptor_name":"Immune Reconstitution Inflammatory Syndrome","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1002/eji.200838630","doi":"https://doi.org/10.1002/eji.200838630","is_oa":true,"landing_page_url":"https://doi.org/10.1002/eji.200838630","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/eji.200838630","source":{"id":"https://openalex.org/S126191069","display_name":"European Journal of Immunology","issn_l":"0014-2980","issn":["0014-2980","1521-4141"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Immunology","raw_type":"journal-article"},{"id":"pmid:19180462","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19180462","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European journal of immunology","raw_type":"Journal Article"},{"id":"pmh:oai:eprints.ucl.ac.uk.OAI2:1422454","doi":null,"is_oa":false,"landing_page_url":"http://discovery.ucl.ac.uk/1422454/","pdf_url":null,"source":{"id":"https://openalex.org/S4306400024","display_name":"UCL Discovery (University College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I45129253","host_organization_name":"University College London","host_organization_lineage":["https://openalex.org/I45129253"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"EUROPEAN JOURNAL OF IMMUNOLOGY , 39 (2) pp. 391-403. (2009)","raw_type":"Article"}],"best_oa_location":{"id":"doi:10.1002/eji.200838630","doi":"https://doi.org/10.1002/eji.200838630","is_oa":true,"landing_page_url":"https://doi.org/10.1002/eji.200838630","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/eji.200838630","source":{"id":"https://openalex.org/S126191069","display_name":"European Journal of Immunology","issn_l":"0014-2980","issn":["0014-2980","1521-4141"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Immunology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.7200000286102295,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320315885","display_name":"Australian Government","ror":"https://ror.org/0314h5y94"},{"id":"https://openalex.org/F4320320965","display_name":"University of New South Wales","ror":"https://ror.org/03r8z3t63"},{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"},{"id":"https://openalex.org/F4320334705","display_name":"National Health and Medical Research Council","ror":"https://ror.org/011kf5r70"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2063442011.pdf","grobid_xml":"https://content.openalex.org/works/W2063442011.grobid-xml"},"referenced_works_count":53,"referenced_works":["https://openalex.org/W92262244","https://openalex.org/W1508696496","https://openalex.org/W1760518103","https://openalex.org/W1801247541","https://openalex.org/W1963966543","https://openalex.org/W1968504178","https://openalex.org/W1979915348","https://openalex.org/W1985266927","https://openalex.org/W1992037894","https://openalex.org/W2000512731","https://openalex.org/W2002863111","https://openalex.org/W2004998289","https://openalex.org/W2005227771","https://openalex.org/W2008858092","https://openalex.org/W2016031470","https://openalex.org/W2020630202","https://openalex.org/W2021603971","https://openalex.org/W2023814018","https://openalex.org/W2026836824","https://openalex.org/W2033330275","https://openalex.org/W2033879292","https://openalex.org/W2040810722","https://openalex.org/W2050184813","https://openalex.org/W2054523235","https://openalex.org/W2063679726","https://openalex.org/W2068639447","https://openalex.org/W2079169004","https://openalex.org/W2084560238","https://openalex.org/W2085011832","https://openalex.org/W2085132811","https://openalex.org/W2089940207","https://openalex.org/W2092713406","https://openalex.org/W2094179245","https://openalex.org/W2097811455","https://openalex.org/W2121348193","https://openalex.org/W2124319307","https://openalex.org/W2127899649","https://openalex.org/W2132926599","https://openalex.org/W2135698322","https://openalex.org/W2140516087","https://openalex.org/W2146329405","https://openalex.org/W2147239532","https://openalex.org/W2148847506","https://openalex.org/W2156964052","https://openalex.org/W2159101109","https://openalex.org/W2161152348","https://openalex.org/W2161827428","https://openalex.org/W2162819001","https://openalex.org/W2163343178","https://openalex.org/W2163493315","https://openalex.org/W2165779188","https://openalex.org/W2168628806","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W2275846802","https://openalex.org/W2163493315","https://openalex.org/W2143362480","https://openalex.org/W4408175677","https://openalex.org/W2132926599","https://openalex.org/W7084264257","https://openalex.org/W2044770733","https://openalex.org/W2004998289","https://openalex.org/W2088662624","https://openalex.org/W1991787050"],"abstract_inverted_index":{"The":[0],"role":[1],"of":[2,48,62,111,125,135,149,161],"Treg":[3,31,127,136,176,184],"in":[4,35,52,128,156,165,186],"patients":[5,53,66,87,107,130,166],"with":[6,54,67,82,116],"late-stage":[7,64],"HIV":[8,65],"disease,":[9],"who":[10,73,93],"commence":[11],"combination":[12],"antiretroviral":[13],"therapy":[14,84],"(cART)":[15],"and":[16,40,57,113,131,152,171,193],"develop":[17,96],"pathogen-specific":[18],"immunopathology":[19],"manifesting":[20],"as":[21],"immune":[22,50,197],"restoration":[23],"disease":[24],"(IRD)":[25],"remains":[26],"unclear.":[27],"We":[28],"hypothesised":[29],"that":[30,181],"could":[32],"be":[33],"defective":[34],"either":[36],"numbers":[37],"and/or":[38],"function":[39],"therefore":[41],"unable":[42],"to":[43,137,190],"ensure":[44],"the":[45,49],"physiological":[46],"equilibrium":[47],"system":[51],"IRD.":[55],"Phenotypic":[56],"functional":[58,147],"CD4(+)":[59,102],"T-cell":[60],"subsets":[61,139],"eight":[63],"nadir":[68],"CD4":[69,89],"count":[70,90],"<50":[71,91],"cells/microL,":[72],"developed":[74],"mycobacterial":[75],"IRD":[76,98,106,129,157],"upon":[77],"commencing":[78],"cART":[79],"were":[80,163],"compared":[81,115],"six":[83],"naive":[85],"HIV(+)":[86],"(nadir":[88],"cells/microL),":[92],"did":[94],"not":[95],"an":[97],"after":[99],"cART.":[100],"Mycobacterium-avium-specific":[101],"T":[103],"cells":[104,151],"from":[105],"produced":[108],"high":[109],"levels":[110,160],"IFN-gamma":[112],"IL-2":[114],"controls":[117],"(p<0.001).":[118,140],"Surprisingly,":[119],"we":[120],"found":[121],"a":[122,132],"significant":[123],"expansion":[124,185],"CD127(lo)Foxp3(+)CD25(+)":[126],"higher":[133],"ratio":[134],"effector/memory":[138],"In":[141],"vitro":[142],"suppression":[143],"assays":[144],"demonstrated":[145],"reduced":[146],"capacity":[148],"suppressor":[150],"diminished":[153],"IL-10":[154],"secretion":[155],"patients.":[158],"Plasma":[159],"IL-7":[162,170],"increased":[164],"and,":[167],"interestingly,":[168],"exogenous":[169],"other":[172],"cytokines":[173],"strongly":[174],"inhibited":[175],"suppression.":[177],"These":[178],"data":[179],"suggest":[180],"despite":[182],"substantial":[183],"IRD,":[187],"their":[188],"ability":[189],"induce":[191],"suppression,":[192],"thereby":[194],"downregulate":[195],"aberrant":[196],"responses,":[198],"is":[199],"compromised.":[200]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":9},{"year":2015,"cited_by_count":11},{"year":2014,"cited_by_count":10},{"year":2013,"cited_by_count":11},{"year":2012,"cited_by_count":13}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}