{"id":"https://openalex.org/W2063385233","doi":"https://doi.org/10.1161/01.atv.2.5.396","title":"Roles of lipoprotein lipase and hepatic triglyceride lipase in the catabolism in vivo of triglyceride-rich lipoproteins.","display_name":"Roles of lipoprotein lipase and hepatic triglyceride lipase in the catabolism in vivo of triglyceride-rich lipoproteins.","publication_year":1982,"publication_date":"1982-09-01","ids":{"openalex":"https://openalex.org/W2063385233","doi":"https://doi.org/10.1161/01.atv.2.5.396","mag":"2063385233","pmid":"https://pubmed.ncbi.nlm.nih.gov/7126037"},"language":"en","primary_location":{"id":"doi:10.1161/01.atv.2.5.396","doi":"https://doi.org/10.1161/01.atv.2.5.396","is_oa":true,"landing_page_url":"https://doi.org/10.1161/01.atv.2.5.396","pdf_url":"https://www.ahajournals.org/doi/pdf/10.1161/01.ATV.2.5.396","source":{"id":"https://openalex.org/S4210182225","display_name":"Arteriosclerosis An Official Journal of the American Heart Association Inc","issn_l":"0276-5047","issn":["0276-5047","2330-9180"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arteriosclerosis: An Official Journal of the American Heart Association, Inc.","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.ahajournals.org/doi/pdf/10.1161/01.ATV.2.5.396","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5039977136","display_name":"Michael Reardon","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M F Reardon","raw_affiliation_strings":["M F Reardon"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"M F Reardon","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"H Sakai","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H Sakai","raw_affiliation_strings":["H Sakai"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"H Sakai","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109176818","display_name":"George A. Steiner","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G Steiner","raw_affiliation_strings":["G Steiner"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"G Steiner","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":4.4288,"has_fulltext":true,"cited_by_count":51,"citation_normalized_percentile":{"value":0.93902196,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"2","issue":"5","first_page":"396","last_page":"402"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13430","display_name":"Lipid metabolism and disorders","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T13430","display_name":"Lipid metabolism and disorders","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11844","display_name":"Lipid metabolism and biosynthesis","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10394","display_name":"Lipoproteins and Cardiovascular Health","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lipoprotein-lipase","display_name":"lipoprotein lipase","score":0.9980000257492065},{"id":"https://openalex.org/keywords/hepatic-lipase","display_name":"hepatic lipase","score":0.9990000128746033},{"id":"https://openalex.org/keywords/triglyceride-rich-lipoproteins","display_name":"triglyceride-rich lipoproteins","score":0.9589999914169312},{"id":"https://openalex.org/keywords/vldl-catabolism","display_name":"VLDL catabolism","score":0.8870000243186951},{"id":"https://openalex.org/keywords/vldl-remnants","display_name":"VLDL remnants","score":0.8999999761581421},{"id":"https://openalex.org/keywords/lipoprotein-metabolism","display_name":"lipoprotein metabolism","score":0.6549999713897705}],"concepts":[{"id":"https://openalex.org/C8243546","wikidata":"https://www.wikidata.org/wiki/Q419074","display_name":"Very low-density lipoprotein","level":4,"score":0.872533917427063},{"id":"https://openalex.org/C94879076","wikidata":"https://www.wikidata.org/wiki/Q420014","display_name":"Lipoprotein lipase","level":3,"score":0.862978458404541},{"id":"https://openalex.org/C2778913445","wikidata":"https://www.wikidata.org/wiki/Q186319","display_name":"Triglyceride","level":3,"score":0.7430569529533386},{"id":"https://openalex.org/C2780213950","wikidata":"https://www.wikidata.org/wiki/Q908765","display_name":"Hepatic lipase","level":4,"score":0.7132428288459778},{"id":"https://openalex.org/C2780716463","wikidata":"https://www.wikidata.org/wiki/Q7839871","display_name":"Triglyceride lipase","level":4,"score":0.6923515200614929},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6829230189323425},{"id":"https://openalex.org/C96942376","wikidata":"https://www.wikidata.org/wiki/Q21130714","display_name":"Catabolism","level":3,"score":0.6527247428894043},{"id":"https://openalex.org/C2779697368","wikidata":"https://www.wikidata.org/wiki/Q380967","display_name":"Lipase","level":3,"score":0.6279311776161194},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.625106930732727},{"id":"https://openalex.org/C2780072125","wikidata":"https://www.wikidata.org/wiki/Q28350","display_name":"Lipoprotein","level":3,"score":0.6115373969078064},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5622462034225464},{"id":"https://openalex.org/C8004288","wikidata":"https://www.wikidata.org/wiki/Q2619230","display_name":"Intermediate-density lipoprotein","level":5,"score":0.5463711023330688},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.33396977186203003},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.29939717054367065},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.2903473377227783},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.17315134406089783},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.14154300093650818}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006493","descriptor_name":"Heparin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008049","descriptor_name":"Lipase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008071","descriptor_name":"Lipoprotein Lipase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008074","descriptor_name":"Lipoproteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008079","descriptor_name":"Lipoproteins, VLDL","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014280","descriptor_name":"Triglycerides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1161/01.atv.2.5.396","doi":"https://doi.org/10.1161/01.atv.2.5.396","is_oa":true,"landing_page_url":"https://doi.org/10.1161/01.atv.2.5.396","pdf_url":"https://www.ahajournals.org/doi/pdf/10.1161/01.ATV.2.5.396","source":{"id":"https://openalex.org/S4210182225","display_name":"Arteriosclerosis An Official Journal of the American Heart Association Inc","issn_l":"0276-5047","issn":["0276-5047","2330-9180"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arteriosclerosis: An Official Journal of the American Heart Association, Inc.","raw_type":"journal-article"},{"id":"pmid:7126037","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7126037","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arteriosclerosis (Dallas, Tex.)","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.973.922","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.973.922","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://atvb.ahajournals.org/content/2/5/396.full.pdf","raw_type":"text"},{"id":"mag:3147642398","doi":null,"is_oa":false,"landing_page_url":"https://www.ahajournals.org/doi/abs/10.1161/atv81.2.5.7126037?cited-by=yesl2%2F5%2F396","pdf_url":null,"source":{"id":"https://openalex.org/S4210182225","display_name":"Arteriosclerosis An Official Journal of the American Heart Association Inc","issn_l":"0276-5047","issn":["0276-5047","2330-9180"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Arteriosclerosis: An Official Journal of the American Heart Association, Inc.","raw_type":null}],"best_oa_location":{"id":"doi:10.1161/01.atv.2.5.396","doi":"https://doi.org/10.1161/01.atv.2.5.396","is_oa":true,"landing_page_url":"https://doi.org/10.1161/01.atv.2.5.396","pdf_url":"https://www.ahajournals.org/doi/pdf/10.1161/01.ATV.2.5.396","source":{"id":"https://openalex.org/S4210182225","display_name":"Arteriosclerosis An Official Journal of the American Heart Association Inc","issn_l":"0276-5047","issn":["0276-5047","2330-9180"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arteriosclerosis: An Official Journal of the American Heart Association, Inc.","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320320442","display_name":"National Heart Foundation of Australia","ror":"https://ror.org/039d9wr27"},{"id":"https://openalex.org/F4320324195","display_name":"Medical Research Council Canada","ror":"https://ror.org/01gavpb45"},{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2063385233.pdf","grobid_xml":"https://content.openalex.org/works/W2063385233.grobid-xml"},"referenced_works_count":34,"referenced_works":["https://openalex.org/W1946244962","https://openalex.org/W1967041734","https://openalex.org/W1975936284","https://openalex.org/W1976745624","https://openalex.org/W1983853341","https://openalex.org/W1986246279","https://openalex.org/W1991997766","https://openalex.org/W1994789322","https://openalex.org/W1998310851","https://openalex.org/W2005500043","https://openalex.org/W2008805998","https://openalex.org/W2015966785","https://openalex.org/W2019068323","https://openalex.org/W2025604105","https://openalex.org/W2035998346","https://openalex.org/W2042666257","https://openalex.org/W2044217031","https://openalex.org/W2057600299","https://openalex.org/W2063756021","https://openalex.org/W2063885280","https://openalex.org/W2065481372","https://openalex.org/W2073142473","https://openalex.org/W2086879239","https://openalex.org/W2092903259","https://openalex.org/W2103744176","https://openalex.org/W2112770128","https://openalex.org/W2117348699","https://openalex.org/W2162226921","https://openalex.org/W2162704852","https://openalex.org/W2263742981","https://openalex.org/W2307575785","https://openalex.org/W2416780158","https://openalex.org/W2417716261","https://openalex.org/W2474324535"],"related_works":["https://openalex.org/W7099351282","https://openalex.org/W2389539814","https://openalex.org/W1978115696","https://openalex.org/W2160332038","https://openalex.org/W2028760915","https://openalex.org/W2081765934","https://openalex.org/W1964513423","https://openalex.org/W2165307225","https://openalex.org/W1976562742","https://openalex.org/W2003507074"],"abstract_inverted_index":{"To":[0],"define":[1],"the":[2,14,21,24,27,34,51,65,106,150,171,179,228,239,250,264,287],"roles,":[3],"in":[4,13,30,89,152,183,249,286],"vivo,":[5],"of":[6,16,26,38,55,64,67,80,110,170,227,252,266,268,289],"hepatic":[7,81,221,279],"triglyceride":[8,82,222,280],"lipase":[9,12,83,86,116,140,208,223,243,281],"and":[10,33,44,57,71,84,112,136,204,225,273,277],"lipoprotein":[11,74,85,115,139,207,242],"catabolism":[15,251,288],"triglyceride-rich":[17,253],"lipoproteins,":[18],"we":[19],"investigated":[20],"relationship":[22,129],"between":[23,105,132,199,218],"activities":[25,79],"above":[28],"enzymes":[29],"postheparin":[31,113,137,205,219],"plasma":[32,90,114,138,206,220],"fractional":[35,52,107,134,201,229],"removal":[36,53,108,135,202,230],"rates":[37,54,231],"very":[39],"low":[40,274],"density":[41,270,275],"lipoproteins":[42],"(VLDL)":[43],"VLDL":[45,56,111,271,290],"remnant":[46,133,160,172,190,200],"particles.":[47,293],"In":[48,157,167],"22":[49,123],"patients,":[50],"VLDL-remnant":[58,292],"particles":[59,267],"were":[60,87,125,232],"determined":[61,88],"from":[62,178],"analyses":[63],"disappearance":[66],"radioiodinated":[68],"Sf":[69,72],"60-400":[70],"12-60":[73],"B":[75],"apoprotein.":[76],"The":[77],"maximal":[78],"samples":[91],"drawn":[92],"2-60":[93],"minutes":[94],"after":[95],"heparin":[96],"injection":[97],"(60":[98],"U/kg).":[99],"A":[100],"positive":[101,197],"correlation":[102,198],"was":[103,130],"observed":[104],"rate":[109,203],"activity":[117,209,224],"(r":[118],"=":[119,211],"0.65).":[120],"When":[121],"all":[122,159,189],"patients":[124],"considered":[126],"together,":[127],"no":[128,283],"demonstrable":[131],"activity.":[141],"However,":[142],"humans":[143],"may":[144,161,173],"be":[145,162,175],"subdivided":[146],"with":[147,238],"respect":[148],"to":[149,164,193,260],"way":[151],"which":[153],"they":[154],"catabolize":[155],"remnants.":[156],"some,":[158],"catabolized":[163],"form":[165],"LDL.":[166],"others,":[168],"some":[169],"also":[174],"directly":[176],"removed":[177],"circulation.":[180],"Those":[181],"subjects":[182],"whom":[184],"previous":[185],"studies":[186],"indicate":[187],"that":[188],"is":[191],"converted":[192],"LDL":[194],"demonstrated":[195],"a":[196,245],"(n":[210],"8,":[212],"r":[213],"-":[214],"0.83).":[215],"No":[216],"correlations":[217],"any":[226],"found.":[233],"These":[234],"data":[235],"are":[236],"consistent":[237],"following:":[240],"1)":[241],"plays":[244,282],"key":[246],"regulatory":[247],"role":[248,257,285],"lipoproteins;":[254],"2)":[255],"this":[256],"applies":[258],"only":[259],"those":[261],"catabolic":[262],"involving":[263],"formation":[265],"higher":[269],"remnants":[272],"lipoprotein;":[276],"3)":[278],"rate-limiting":[284],"or":[291]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}