{"id":"https://openalex.org/W2063353933","doi":"https://doi.org/10.1371/journal.pone.0011428","title":"Common Polymorphisms in MTNR1B, G6PC2 and GCK Are Associated with Increased Fasting Plasma Glucose and Impaired Beta-Cell Function in Chinese Subjects","display_name":"Common Polymorphisms in MTNR1B, G6PC2 and GCK Are Associated with Increased Fasting Plasma Glucose and Impaired Beta-Cell Function in Chinese Subjects","publication_year":2010,"publication_date":"2010-07-08","ids":{"openalex":"https://openalex.org/W2063353933","doi":"https://doi.org/10.1371/journal.pone.0011428","mag":"2063353933","pmid":"https://pubmed.ncbi.nlm.nih.gov/20628598","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2900202"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pone.0011428","doi":"https://doi.org/10.1371/journal.pone.0011428","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0011428","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0011428&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0011428&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5009105983","display_name":"Claudia H.T. Tam","orcid":"https://orcid.org/0000-0002-9169-0013","observed_orcids":["https://orcid.org/0000-0002-9169-0013"]},"institutions":[{"id":"https://openalex.org/I177725633","display_name":"Chinese University of Hong Kong","ror":"https://ror.org/00t33hh48","country_code":"HK","type":"education","lineage":["https://openalex.org/I177725633"]},{"id":"https://openalex.org/I4210114914","display_name":"Prince of Wales Hospital","ror":"https://ror.org/02827ca86","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I1294586568","https://openalex.org/I4210114914"]}],"countries":["CN","HK"],"is_corresponding":false,"raw_author_name":"Claudia Ha Ting Tam","raw_affiliation_strings":["Department of Medicine and Therapeutics, The Chinese University of Hong Kong, The Prince of Wales Hospital, Shatin, Hong Kong, Special Administrative Region, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine and Therapeutics, The Chinese University of Hong Kong, The Prince of Wales Hospital, Shatin, Hong Kong, Special Administrative Region, People's Republic of China","institution_ids":["https://openalex.org/I177725633","https://openalex.org/I4210114914"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113754705","display_name":"Janice S. K. Ho","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I177725633","display_name":"Chinese University of Hong Kong","ror":"https://ror.org/00t33hh48","country_code":"HK","type":"education","lineage":["https://openalex.org/I177725633"]},{"id":"https://openalex.org/I4210114914","display_name":"Prince of Wales Hospital","ror":"https://ror.org/02827ca86","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I1294586568","https://openalex.org/I4210114914"]}],"countries":["CN","HK"],"is_corresponding":false,"raw_author_name":"Janice Sin Ka Ho","raw_affiliation_strings":["Department of Medicine and Therapeutics, The Chinese University of Hong Kong, The Prince of Wales Hospital, Shatin, Hong Kong, Special Administrative Region, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine and Therapeutics, The Chinese University of Hong Kong, The Prince of Wales Hospital, Shatin, Hong Kong, Special Administrative Region, People's Republic of China","institution_ids":["https://openalex.org/I177725633","https://openalex.org/I4210114914"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100619277","display_name":"Ying Wang","orcid":"https://orcid.org/0000-0002-6058-9131","observed_orcids":["https://orcid.org/0000-0002-6058-9131"]},"institutions":[{"id":"https://openalex.org/I177725633","display_name":"Chinese University of Hong Kong","ror":"https://ror.org/00t33hh48","country_code":"HK","type":"education","lineage":["https://openalex.org/I177725633"]},{"id":"https://openalex.org/I4210114914","display_name":"Prince of Wales Hospital","ror":"https://ror.org/02827ca86","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I1294586568","https://openalex.org/I4210114914"]}],"countries":["CN","HK"],"is_corresponding":false,"raw_author_name":"Ying Wang","raw_affiliation_strings":["Department of Medicine and Therapeutics, The Chinese University of Hong Kong, The Prince of Wales Hospital, Shatin, Hong Kong, Special Administrative Region, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine and Therapeutics, The Chinese University of Hong Kong, The Prince of Wales Hospital, Shatin, Hong Kong, Special Administrative Region, People's Republic of China","institution_ids":["https://openalex.org/I177725633","https://openalex.org/I4210114914"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021394512","display_name":"Heung Man Lee","orcid":"https://orcid.org/0000-0002-5199-1778","observed_orcids":["https://orcid.org/0000-0002-5199-1778"]},"institutions":[{"id":"https://openalex.org/I177725633","display_name":"Chinese University of Hong Kong","ror":"https://ror.org/00t33hh48","country_code":"HK","type":"education","lineage":["https://openalex.org/I177725633"]},{"id":"https://openalex.org/I4210114914","display_name":"Prince of Wales Hospital","ror":"https://ror.org/02827ca86","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I1294586568","https://openalex.org/I4210114914"]}],"countries":["CN","HK"],"is_corresponding":false,"raw_author_name":"Heung Man Lee","raw_affiliation_strings":["Department of Medicine and Therapeutics, The Chinese University of Hong Kong, The Prince of Wales Hospital, Shatin, Hong Kong, Special Administrative Region, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine and Therapeutics, The Chinese University of Hong Kong, The Prince of Wales Hospital, Shatin, Hong Kong, Special Administrative Region, People's Republic of China","institution_ids":["https://openalex.org/I177725633","https://openalex.org/I4210114914"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108746587","display_name":"Vincent Kwok Lim Lam","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I177725633","display_name":"Chinese University of Hong Kong","ror":"https://ror.org/00t33hh48","country_code":"HK","type":"education","lineage":["https://openalex.org/I177725633"]},{"id":"https://openalex.org/I4210114914","display_name":"Prince of Wales Hospital","ror":"https://ror.org/02827ca86","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I1294586568","https://openalex.org/I4210114914"]}],"countries":["CN","HK"],"is_corresponding":false,"raw_author_name":"Vincent Kwok Lim Lam","raw_affiliation_strings":["Department of Medicine and Therapeutics, The Chinese University of Hong Kong, The Prince of Wales Hospital, Shatin, Hong Kong, Special Administrative Region, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine and Therapeutics, The Chinese University of Hong Kong, The Prince of Wales Hospital, Shatin, Hong Kong, Special Administrative Region, People's Republic of China","institution_ids":["https://openalex.org/I177725633","https://openalex.org/I4210114914"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022172869","display_name":"S\u00f8ren Germer","orcid":"https://orcid.org/0000-0002-6038-8508","observed_orcids":["https://orcid.org/0000-0002-6038-8508"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Soren Germer","raw_affiliation_strings":["Roche Pharmaceuticals, Nutley, New Jersey, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Roche Pharmaceuticals, Nutley, New Jersey, United States of America","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113140137","display_name":"Mitchell Martin","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mitchell Martin","raw_affiliation_strings":["Roche Pharmaceuticals, Nutley, New Jersey, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Roche Pharmaceuticals, Nutley, New Jersey, United States of America","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064838541","display_name":"Wing Yee So","orcid":"https://orcid.org/0000-0001-8078-7402","observed_orcids":["https://orcid.org/0000-0001-8078-7402"]},"institutions":[{"id":"https://openalex.org/I177725633","display_name":"Chinese University of Hong Kong","ror":"https://ror.org/00t33hh48","country_code":"HK","type":"education","lineage":["https://openalex.org/I177725633"]},{"id":"https://openalex.org/I4210114914","display_name":"Prince of Wales Hospital","ror":"https://ror.org/02827ca86","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I1294586568","https://openalex.org/I4210114914"]}],"countries":["CN","HK"],"is_corresponding":false,"raw_author_name":"Wing Yee So","raw_affiliation_strings":["Department of Medicine and Therapeutics, The Chinese University of Hong Kong, The Prince of Wales Hospital, Shatin, Hong Kong, Special Administrative Region, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine and Therapeutics, The Chinese University of Hong Kong, The Prince of Wales Hospital, Shatin, Hong Kong, Special Administrative Region, People's Republic of China","institution_ids":["https://openalex.org/I177725633","https://openalex.org/I4210114914"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100447655","display_name":"Ronald C.W.","orcid":"https://orcid.org/0000-0002-1227-803X","observed_orcids":["https://orcid.org/0000-0002-1227-803X"]},"institutions":[{"id":"https://openalex.org/I177725633","display_name":"Chinese University of Hong Kong","ror":"https://ror.org/00t33hh48","country_code":"HK","type":"education","lineage":["https://openalex.org/I177725633"]},{"id":"https://openalex.org/I4210114914","display_name":"Prince of Wales Hospital","ror":"https://ror.org/02827ca86","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I1294586568","https://openalex.org/I4210114914"]}],"countries":["CN","HK"],"is_corresponding":true,"raw_author_name":"Ronald Ching Wan Ma","raw_affiliation_strings":["Department of Medicine and Therapeutics, The Chinese University of Hong Kong, The Prince of Wales Hospital, Shatin, Hong Kong, Special Administrative Region, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine and Therapeutics, The Chinese University of Hong Kong, The Prince of Wales Hospital, Shatin, Hong Kong, Special Administrative Region, People's Republic of China","institution_ids":["https://openalex.org/I177725633","https://openalex.org/I4210114914"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091832416","display_name":"Juliana C.N. Chan","orcid":"https://orcid.org/0000-0003-1325-1194","observed_orcids":["https://orcid.org/0000-0003-1325-1194"]},"institutions":[{"id":"https://openalex.org/I177725633","display_name":"Chinese University of Hong Kong","ror":"https://ror.org/00t33hh48","country_code":"HK","type":"education","lineage":["https://openalex.org/I177725633"]},{"id":"https://openalex.org/I4210114914","display_name":"Prince of Wales Hospital","ror":"https://ror.org/02827ca86","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I1294586568","https://openalex.org/I4210114914"]}],"countries":["CN","HK"],"is_corresponding":false,"raw_author_name":"Juliana Chung Ngor Chan","raw_affiliation_strings":["Department of Medicine and Therapeutics, The Chinese University of Hong Kong, The Prince of Wales Hospital, Shatin, Hong Kong, Special Administrative Region, People's Republic of China","Hong Kong Institute of Diabetes and Obesity, The Chinese University of Hong Kong, The Prince of Wales Hospital, Shatin, Hong Kong, Special Administrative Region, People's Republic of China","Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, The Prince of Wales Hospital, Shatin, Hong Kong, Special Administrative Region, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine and Therapeutics, The Chinese University of Hong Kong, The Prince of Wales Hospital, Shatin, Hong Kong, Special Administrative Region, People's Republic of China","institution_ids":["https://openalex.org/I177725633","https://openalex.org/I4210114914"]},{"raw_affiliation_string":"Hong Kong Institute of Diabetes and Obesity, The Chinese University of Hong Kong, The Prince of Wales Hospital, Shatin, Hong Kong, Special Administrative Region, People's Republic of China","institution_ids":["https://openalex.org/I177725633","https://openalex.org/I4210114914"]},{"raw_affiliation_string":"Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, The Prince of Wales Hospital, Shatin, Hong Kong, Special Administrative Region, People's Republic of China","institution_ids":["https://openalex.org/I177725633","https://openalex.org/I4210114914"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5034303175","display_name":"Maggie C.Y. Ng","orcid":"https://orcid.org/0000-0002-4133-2007","observed_orcids":["https://orcid.org/0000-0002-4133-2007"]},"institutions":[{"id":"https://openalex.org/I177725633","display_name":"Chinese University of Hong Kong","ror":"https://ror.org/00t33hh48","country_code":"HK","type":"education","lineage":["https://openalex.org/I177725633"]},{"id":"https://openalex.org/I4210114914","display_name":"Prince of Wales Hospital","ror":"https://ror.org/02827ca86","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I1294586568","https://openalex.org/I4210114914"]}],"countries":["CN","HK"],"is_corresponding":false,"raw_author_name":"Maggie Chor Yin Ng","raw_affiliation_strings":["Department of Medicine and Therapeutics, The Chinese University of Hong Kong, The Prince of Wales Hospital, Shatin, Hong Kong, Special Administrative Region, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine and Therapeutics, The Chinese University of Hong Kong, The Prince of Wales Hospital, Shatin, Hong Kong, Special Administrative Region, People's Republic of China","institution_ids":["https://openalex.org/I177725633","https://openalex.org/I4210114914"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5100447655"],"corresponding_institution_ids":["https://openalex.org/I177725633","https://openalex.org/I4210114914"],"apc_list":{"value":2382,"currency":"USD","value_usd":2382},"apc_paid":{"value":2382,"currency":"USD","value_usd":2382},"fwci":5.5699,"has_fulltext":true,"cited_by_count":81,"citation_normalized_percentile":{"value":0.96733935,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"5","issue":"7","first_page":"e11428","last_page":"e11428"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.7797999978065491,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.7797999978065491,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.15729999542236328,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11171","display_name":"Diabetes and associated disorders","score":0.018400000408291817,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.9509999752044678},{"id":"https://openalex.org/keywords/mtnr1b","display_name":"MTNR1B","score":0.8700000047683716},{"id":"https://openalex.org/keywords/g6pc2","display_name":"G6PC2","score":0.9419999718666077},{"id":"https://openalex.org/keywords/glucokinase","display_name":"glucokinase","score":0.9639999866485596},{"id":"https://openalex.org/keywords/gckr","display_name":"GCKR","score":0.9710000157356262},{"id":"https://openalex.org/keywords/single-nucleotide-polymorphisms","display_name":"single nucleotide polymorphisms","score":0.9440000057220459},{"id":"https://openalex.org/keywords/fasting-blood-glucose","display_name":"fasting blood glucose","score":0.9940000176429749},{"id":"https://openalex.org/keywords/beta-cell-function","display_name":"beta-cell function","score":0.9610000252723694},{"id":"https://openalex.org/keywords/insulin-secretion","display_name":"insulin secretion","score":0.7960000038146973},{"id":"https://openalex.org/keywords/glucose-homeostasis","display_name":"glucose homeostasis","score":0.953000009059906},{"id":"https://openalex.org/keywords/genetic-susceptibility","display_name":"genetic susceptibility","score":0.628000020980835},{"id":"https://openalex.org/keywords/chinese-population","display_name":"Chinese population","score":0.6940000057220459},{"id":"https://openalex.org/keywords/dose-effect","display_name":"dosage effect","score":0.6520000100135803},{"id":"https://openalex.org/keywords/additive-genetic-effects","display_name":"additive genetic effects","score":0.4729999899864197},{"id":"https://openalex.org/keywords/hyperglycemia","display_name":"hyperglycemia","score":0.746999979019165},{"id":"https://openalex.org/keywords/adolescents","display_name":"adolescents","score":0.4869999885559082},{"id":"https://openalex.org/keywords/adults","display_name":"adults","score":0.6790000200271606},{"id":"https://openalex.org/keywords/homa-beta","display_name":"HOMA-\u03b2","score":0.7490000128746033},{"id":"https://openalex.org/keywords/rs10830963","display_name":"rs10830963","score":0.9150000214576721}],"concepts":[{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7690519094467163},{"id":"https://openalex.org/C98335778","wikidata":"https://www.wikidata.org/wiki/Q425185","display_name":"Glucokinase","level":3,"score":0.7582464218139648},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6964921951293945},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.6215790510177612},{"id":"https://openalex.org/C3018667095","wikidata":"https://www.wikidata.org/wiki/Q3455903","display_name":"Glucose homeostasis","level":4,"score":0.6151232719421387},{"id":"https://openalex.org/C2777180221","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 diabetes","level":3,"score":0.5813928842544556},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5525413751602173},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.388049453496933},{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.260763943195343},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.24982094764709473},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.19462373852729797},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.19336673617362976},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.13580942153930664}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001786","descriptor_name":"Blood Glucose","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005215","descriptor_name":"Fasting","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005941","descriptor_name":"Glucokinase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D005952","descriptor_name":"Glucose-6-Phosphatase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D044094","descriptor_name":"Receptors, Melatonin","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D044466","descriptor_name":"Asian People","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D048868","descriptor_name":"Adaptor Proteins, Signal Transducing","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D050417","descriptor_name":"Insulin-Secreting Cells","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D050417","descriptor_name":"Insulin-Secreting Cells","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true}],"locations_count":6,"locations":[{"id":"doi:10.1371/journal.pone.0011428","doi":"https://doi.org/10.1371/journal.pone.0011428","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0011428","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0011428&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2900202","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2900202","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS One","raw_type":"Text"},{"id":"pmid:20628598","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20628598","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PloS one","raw_type":"Journal Article"},{"id":"pmh:oai:RePEc:plo:pone00:0011428","doi":null,"is_oa":false,"landing_page_url":"https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0011428","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:doaj.org/article:b9fae586310a4eb090493d47f4a01baf","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/b9fae586310a4eb090493d47f4a01baf","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, Vol 5, Iss 7, p e11428 (2010)","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/142764","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/Common_Polymorphisms_in_MTNR1B_G6PC2_and_GCK_Are_Associated_with_Increased_Fasting_Plasma_Glucose_and_Impaired_Beta_Cell_Function_in_Chinese_Subjects/142764","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"}],"best_oa_location":{"id":"doi:10.1371/journal.pone.0011428","doi":"https://doi.org/10.1371/journal.pone.0011428","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0011428","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0011428&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9940000176429749,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320322170","display_name":"University of Hong Kong","ror":"https://ror.org/02zhqgq86"},{"id":"https://openalex.org/F4320322942","display_name":"Chinese University of Hong Kong","ror":"https://ror.org/00t33hh48"},{"id":"https://openalex.org/F4320329815","display_name":"Hong Kong Government","ror":"https://ror.org/034179816"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2063353933.pdf","grobid_xml":"https://content.openalex.org/works/W2063353933.grobid-xml"},"referenced_works_count":52,"referenced_works":["https://openalex.org/W1970412103","https://openalex.org/W1971412377","https://openalex.org/W1975535652","https://openalex.org/W1978215768","https://openalex.org/W1979423827","https://openalex.org/W1981452461","https://openalex.org/W1992216829","https://openalex.org/W1992777999","https://openalex.org/W1998204538","https://openalex.org/W2016370483","https://openalex.org/W2022842991","https://openalex.org/W2038961236","https://openalex.org/W2043068094","https://openalex.org/W2044980718","https://openalex.org/W2048755332","https://openalex.org/W2055626561","https://openalex.org/W2080926694","https://openalex.org/W2083954139","https://openalex.org/W2096880956","https://openalex.org/W2098452298","https://openalex.org/W2098558143","https://openalex.org/W2107328434","https://openalex.org/W2107625934","https://openalex.org/W2112076791","https://openalex.org/W2119503252","https://openalex.org/W2119706813","https://openalex.org/W2121351699","https://openalex.org/W2126718294","https://openalex.org/W2126776706","https://openalex.org/W2127388779","https://openalex.org/W2127992904","https://openalex.org/W2130259798","https://openalex.org/W2133795831","https://openalex.org/W2133972493","https://openalex.org/W2134293572","https://openalex.org/W2135912670","https://openalex.org/W2136006194","https://openalex.org/W2145025818","https://openalex.org/W2149891865","https://openalex.org/W2151714976","https://openalex.org/W2153171441","https://openalex.org/W2159394707","https://openalex.org/W2159422401","https://openalex.org/W2159679004","https://openalex.org/W2160234571","https://openalex.org/W2161633633","https://openalex.org/W2166774283","https://openalex.org/W2402491945","https://openalex.org/W2406893215","https://openalex.org/W2520432709","https://openalex.org/W4205321574","https://openalex.org/W6979199192"],"related_works":["https://openalex.org/W1989768080","https://openalex.org/W2057556962","https://openalex.org/W2092357969","https://openalex.org/W1998204538","https://openalex.org/W7095784501","https://openalex.org/W2083954139","https://openalex.org/W2127992904","https://openalex.org/W7074560108","https://openalex.org/W7095928912","https://openalex.org/W3168988278"],"abstract_inverted_index":{"BACKGROUND:":[0],"Previous":[1],"studies":[2],"identified":[3],"melatonin":[4],"receptor":[5],"1B":[6],"(MTNR1B),":[7],"islet-specific":[8],"glucose":[9,36,53],"6":[10],"phosphatase":[11],"catalytic":[12],"subunit-related":[13],"protein":[14,21],"(G6PC2),":[15],"glucokinase":[16,19],"(GCK)":[17],"and":[18,52,71,75,85,88,97,104,163,175,186,193,199],"regulatory":[20],"(GCKR)":[22],"as":[23],"candidate":[24],"genes":[25,49],"for":[26,121],"type":[27],"2":[28],"diabetes":[29],"(T2D)":[30],"acting":[31],"through":[32],"elevated":[33,191],"fasting":[34],"plasma":[35],"(FPG).":[37],"We":[38],"examined":[39],"the":[40,43,98,125,147],"associations":[41,158],"of":[42,47,94,100,127,138,150,172,183],"reported":[44],"common":[45],"variants":[46,182],"these":[48,151,203],"with":[50,108,123,133,144,159,190],"T2D":[51,90],"homeostasis":[54,135],"in":[55,80,112,156,211],"three":[56],"independent":[57],"Chinese":[58],"cohorts.":[59],"METHODOLOGY/PRINCIPAL":[60],"FINDINGS:":[61],"Five":[62],"single":[63],"nucleotide":[64],"polymorphisms":[65],"(SNPs),":[66],"MTNR1B":[67,95,173],"rs10830963,":[68],"G6PC2":[69,102,176,185],"rs16856187":[70,103,177],"rs478333,":[72],"GCK":[73,128,187],"rs1799884":[74,129],"GCKR":[76,145],"rs780094,":[77,146],"were":[78,106],"genotyped":[79],"1644":[81],"controls":[82],"(583":[83],"adults":[84],"1061":[86],"adolescents)":[87],"1342":[89],"patients.":[91],"The":[92],"G-allele":[93],"rs10830963":[96,174],"C-alleles":[99],"both":[101,197],"rs478333":[105],"associated":[107,132,189],"higher":[109],"FPG":[110,161,192],"(0.0034<P<6.6x10(-5))":[111],"healthy":[113],"controls.":[114],"In":[115],"addition":[116],"to":[117],"our":[118],"previous":[119],"report":[120],"association":[122],"FPG,":[124],"A-allele":[126],"was":[130],"also":[131],"reduced":[134,164],"model":[136],"assessment":[137],"beta-cell":[139],"function":[140],"(HOMA-B)":[141],"(P=0.0015).":[142],"Together":[143],"risk":[148,204],"alleles":[149,205],"SNPs":[152],"exhibited":[153],"dosage":[154],"effect":[155],"their":[157],"increased":[160],"(P=2.9x10(-9))":[162],"HOMA-B":[165],"(P=1.1x10(-3)).":[166],"Meta-analyses":[167],"strongly":[168],"supported":[169],"additive":[170],"effects":[171],"on":[178],"FPG.":[179],"CONCLUSIONS/SIGNIFICANCE:":[180],"Common":[181],"MTNR1B,":[184],"are":[188],"impaired":[194],"insulin":[195],"secretion,":[196],"individually":[198],"jointly,":[200],"suggesting":[201],"that":[202],"may":[206],"precipitate":[207],"or":[208],"perpetuate":[209],"hyperglycemia":[210],"predisposed":[212],"individuals.":[213]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":8},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":8},{"year":2013,"cited_by_count":11},{"year":2012,"cited_by_count":11}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
