{"id":"https://openalex.org/W2063341329","doi":"https://doi.org/10.1016/0166-6851(91)90150-5","title":"Substrate-dependent pH optima of gp63 purified from seven strains of Leishmania","display_name":"Substrate-dependent pH optima of gp63 purified from seven strains of Leishmania","publication_year":1991,"publication_date":"1991-07-01","ids":{"openalex":"https://openalex.org/W2063341329","doi":"https://doi.org/10.1016/0166-6851(91)90150-5","mag":"2063341329","pmid":"https://pubmed.ncbi.nlm.nih.gov/1857388"},"language":"en","primary_location":{"id":"doi:10.1016/0166-6851(91)90150-5","doi":"https://doi.org/10.1016/0166-6851(91)90150-5","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0166-6851(91)90150-5","pdf_url":null,"source":{"id":"https://openalex.org/S144099348","display_name":"Molecular and Biochemical Parasitology","issn_l":"0166-6851","issn":["0166-6851","1872-9428"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular and Biochemical Parasitology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5043031774","display_name":"Athina K. Tzinia","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210123780","display_name":"Pasteur Hellenic Institute","ror":"https://ror.org/035cy3r13","country_code":"GR","type":"nonprofit","lineage":["https://openalex.org/I4210123780"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Athina K. Tzinia","raw_affiliation_strings":["Laboratory of Biochemistry, Hellenic Pasteur Institute, Athens, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Biochemistry, Hellenic Pasteur Institute, Athens, Greece","institution_ids":["https://openalex.org/I4210123780"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5047209786","display_name":"Ketty Soteriadou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210123780","display_name":"Pasteur Hellenic Institute","ror":"https://ror.org/035cy3r13","country_code":"GR","type":"nonprofit","lineage":["https://openalex.org/I4210123780"]}],"countries":["GR"],"is_corresponding":true,"raw_author_name":"Ketty P. Soteriadou","raw_affiliation_strings":["Laboratory of Biochemistry, Hellenic Pasteur Institute, Athens, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Biochemistry, Hellenic Pasteur Institute, Athens, Greece","institution_ids":["https://openalex.org/I4210123780"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5047209786"],"corresponding_institution_ids":["https://openalex.org/I4210123780"],"apc_list":{"value":3460,"currency":"USD","value_usd":3460},"apc_paid":null,"fwci":7.2867,"has_fulltext":false,"cited_by_count":42,"citation_normalized_percentile":{"value":0.96798279,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"47","issue":"1","first_page":"83","last_page":"89"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10823","display_name":"Research on Leishmaniasis Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10823","display_name":"Research on Leishmaniasis Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10890","display_name":"Trypanosoma species research and implications","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13767","display_name":"Leech Biology and Applications","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1103","display_name":"Animal Science and Zoology"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gp63","display_name":"gp63","score":0.9649999737739563},{"id":"https://openalex.org/keywords/leishmania","display_name":"Leishmania","score":0.8949999809265137},{"id":"https://openalex.org/keywords/major-surface-glycoprotein","display_name":"major surface glycoprotein","score":0.8560000061988831},{"id":"https://openalex.org/keywords/metalloproteinases","display_name":"metalloproteinases","score":0.9470000267028809},{"id":"https://openalex.org/keywords/optimal-ph","display_name":"pH optimum","score":0.800000011920929},{"id":"https://openalex.org/keywords/promastigotes","display_name":"promastigotes","score":0.8550000190734863},{"id":"https://openalex.org/keywords/leishmania-donovani-complex","display_name":"Leishmania donovani complex","score":0.906000018119812},{"id":"https://openalex.org/keywords/leishmania-infantum","display_name":"Leishmania infantum","score":0.9200000166893005},{"id":"https://openalex.org/keywords/leishmania-donovani","display_name":"Leishmania donovani","score":0.9819999933242798},{"id":"https://openalex.org/keywords/leishmania-major","display_name":"Leishmania major","score":0.996999979019165},{"id":"https://openalex.org/keywords/leishmania-tropica","display_name":"Leishmania tropica","score":0.9950000047683716},{"id":"https://openalex.org/keywords/leishmania-amazonensis","display_name":"Leishmania amazonensis","score":0.9940000176429749},{"id":"https://openalex.org/keywords/enzyme-purification","display_name":"enzyme purification","score":0.6140000224113464},{"id":"https://openalex.org/keywords/1-10-phenanthroline-inhibition","display_name":"1,10-phenanthroline inhibition","score":0.7940000295639038},{"id":"https://openalex.org/keywords/insulin-b-chain-cleavage","display_name":"insulin B-chain cleavage","score":0.6740000247955322},{"id":"https://openalex.org/keywords/azocasein","display_name":"azocasein","score":0.921999990940094}],"concepts":[{"id":"https://openalex.org/C2781092759","wikidata":"https://www.wikidata.org/wiki/Q524818","display_name":"Leishmania","level":3,"score":0.7695711851119995},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.6211385726928711},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.6209011077880859},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5622429251670837},{"id":"https://openalex.org/C2777289219","wikidata":"https://www.wikidata.org/wiki/Q7632154","display_name":"Substrate (aquarium)","level":2,"score":0.5354613661766052},{"id":"https://openalex.org/C2780599195","wikidata":"https://www.wikidata.org/wiki/Q1950715","display_name":"Leishmania major","level":4,"score":0.5108610987663269},{"id":"https://openalex.org/C55728118","wikidata":"https://www.wikidata.org/wiki/Q425402","display_name":"Metalloproteinase","level":3,"score":0.44372987747192383},{"id":"https://openalex.org/C2778338367","wikidata":"https://www.wikidata.org/wiki/Q1950818","display_name":"Leishmania tropica","level":4,"score":0.4415803551673889},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.431761771440506},{"id":"https://openalex.org/C2781371782","wikidata":"https://www.wikidata.org/wiki/Q2493771","display_name":"Leishmania mexicana","level":4,"score":0.4131668210029602},{"id":"https://openalex.org/C2780865716","wikidata":"https://www.wikidata.org/wiki/Q411575","display_name":"PMSF","level":3,"score":0.4128343462944031},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.29285454750061035},{"id":"https://openalex.org/C2778702967","wikidata":"https://www.wikidata.org/wiki/Q2590966","display_name":"Cutaneous leishmaniasis","level":3,"score":0.17188319563865662},{"id":"https://openalex.org/C2776555147","wikidata":"https://www.wikidata.org/wiki/Q331283","display_name":"Leishmaniasis","level":2,"score":0.1539255976676941},{"id":"https://openalex.org/C71928629","wikidata":"https://www.wikidata.org/wiki/Q804206","display_name":"Parasite hosting","level":2,"score":0.10480862855911255},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.0},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.0},{"id":"https://openalex.org/C136764020","wikidata":"https://www.wikidata.org/wiki/Q466","display_name":"World Wide Web","level":1,"score":0.0},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006863","descriptor_name":"Hydrogen-Ion Concentration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006868","descriptor_name":"Hydrolysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007891","descriptor_name":"Leishmania","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D007891","descriptor_name":"Leishmania","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D007893","descriptor_name":"Leishmania donovani","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007894","descriptor_name":"Leishmania mexicana","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007895","descriptor_name":"Leishmania tropica","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008562","descriptor_name":"Membrane Glycoproteins","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":true},{"descriptor_ui":"D008562","descriptor_name":"Membrane Glycoproteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008666","descriptor_name":"Metalloendopeptidases","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":true},{"descriptor_ui":"D008666","descriptor_name":"Metalloendopeptidases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010450","descriptor_name":"Endopeptidases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013379","descriptor_name":"Substrate Specificity","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015800","descriptor_name":"Protozoan Proteins","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":true},{"descriptor_ui":"D015800","descriptor_name":"Protozoan Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/0166-6851(91)90150-5","doi":"https://doi.org/10.1016/0166-6851(91)90150-5","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0166-6851(91)90150-5","pdf_url":null,"source":{"id":"https://openalex.org/S144099348","display_name":"Molecular and Biochemical Parasitology","issn_l":"0166-6851","issn":["0166-6851","1872-9428"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular and Biochemical Parasitology","raw_type":"journal-article"},{"id":"pmid:1857388","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1857388","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular and biochemical parasitology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321917","display_name":"General Secretariat for Research and Technology","ror":"https://ror.org/04yeh8h63"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":24,"referenced_works":["https://openalex.org/W1501665702","https://openalex.org/W1543111690","https://openalex.org/W1604033226","https://openalex.org/W1741609474","https://openalex.org/W1775749144","https://openalex.org/W1925876495","https://openalex.org/W1959117053","https://openalex.org/W1963822760","https://openalex.org/W1966864969","https://openalex.org/W1987421193","https://openalex.org/W1989117371","https://openalex.org/W1990382291","https://openalex.org/W2007118729","https://openalex.org/W2021807514","https://openalex.org/W2033785962","https://openalex.org/W2039077381","https://openalex.org/W2063026492","https://openalex.org/W2068118564","https://openalex.org/W2100837269","https://openalex.org/W2101108802","https://openalex.org/W2125795592","https://openalex.org/W2161832062","https://openalex.org/W2168641937","https://openalex.org/W4247241827"],"related_works":["https://openalex.org/W7096142961","https://openalex.org/W1963822760","https://openalex.org/W1999380188","https://openalex.org/W2007118729","https://openalex.org/W1959117053","https://openalex.org/W2123750120","https://openalex.org/W820321736","https://openalex.org/W4245516414","https://openalex.org/W1981974446","https://openalex.org/W2082777134"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
