{"id":"https://openalex.org/W2063301738","doi":"https://doi.org/10.1083/jcb.114.3.413","title":"A single amino acid change in the cytoplasmic domain alters the polarized delivery of influenza virus hemagglutinin.","display_name":"A single amino acid change in the cytoplasmic domain alters the polarized delivery of influenza virus hemagglutinin.","publication_year":1991,"publication_date":"1991-08-01","ids":{"openalex":"https://openalex.org/W2063301738","doi":"https://doi.org/10.1083/jcb.114.3.413","mag":"2063301738","pmid":"https://pubmed.ncbi.nlm.nih.gov/1860878","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2289095"},"language":"en","primary_location":{"id":"doi:10.1083/jcb.114.3.413","doi":"https://doi.org/10.1083/jcb.114.3.413","is_oa":true,"landing_page_url":"https://doi.org/10.1083/jcb.114.3.413","pdf_url":"https://rupress.org/jcb/article-pdf/114/3/413/1061666/413.pdf","source":{"id":"https://openalex.org/S96410829","display_name":"The Journal of Cell Biology","issn_l":"0021-9525","issn":["0021-9525","1540-8140"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315676","host_organization_name":"Rockefeller University Press","host_organization_lineage":["https://openalex.org/P4310315676"],"host_organization_lineage_names":["Rockefeller University Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of cell biology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://rupress.org/jcb/article-pdf/114/3/413/1061666/413.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5016946693","display_name":"Colleen B. Brewer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C B Brewer","raw_affiliation_strings":["Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas 75235-9038"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas 75235-9038","institution_ids":["https://openalex.org/I867280407"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5017784230","display_name":"Michael G. Roth","orcid":"https://orcid.org/0000-0002-9056-332X","observed_orcids":["https://orcid.org/0000-0002-9056-332X"]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M G Roth","raw_affiliation_strings":["Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas 75235-9038"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas 75235-9038","institution_ids":["https://openalex.org/I867280407"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I867280407"],"apc_list":null,"apc_paid":null,"fwci":8.6222,"has_fulltext":true,"cited_by_count":263,"citation_normalized_percentile":{"value":0.98536706,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"114","issue":"3","first_page":"413","last_page":"421"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10167","display_name":"Influenza Virus Research Studies","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10724","display_name":"Ion Transport and Channel Regulation","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/influenza-virus-hemagglutinin","display_name":"influenza virus hemagglutinin","score":0.9890000224113464},{"id":"https://openalex.org/keywords/apical-sorting","display_name":"apical sorting","score":0.7680000066757202},{"id":"https://openalex.org/keywords/cytoplasmic-domain","display_name":"cytoplasmic domain","score":0.9049999713897705},{"id":"https://openalex.org/keywords/single-amino-acid-mutations","display_name":"single amino acid mutations","score":0.7879999876022339},{"id":"https://openalex.org/keywords/coated-pits","display_name":"coated pits","score":0.5920000076293945},{"id":"https://openalex.org/keywords/mdck-cells","display_name":"MDCK cells","score":0.9020000100135803},{"id":"https://openalex.org/keywords/membrane-glycoproteins","display_name":"membrane glycoproteins","score":0.781000018119812}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8583350777626038},{"id":"https://openalex.org/C2778692840","wikidata":"https://www.wikidata.org/wiki/Q9136673","display_name":"Hemagglutinin (influenza)","level":3,"score":0.8183988332748413},{"id":"https://openalex.org/C28005876","wikidata":"https://www.wikidata.org/wiki/Q189814","display_name":"Endocytosis","level":3,"score":0.7003965377807617},{"id":"https://openalex.org/C190062978","wikidata":"https://www.wikidata.org/wiki/Q79899","display_name":"Cytoplasm","level":2,"score":0.6856303215026855},{"id":"https://openalex.org/C108625454","wikidata":"https://www.wikidata.org/wiki/Q187126","display_name":"Glycoprotein","level":2,"score":0.5909696221351624},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.5101809501647949},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.49809813499450684},{"id":"https://openalex.org/C39587587","wikidata":"https://www.wikidata.org/wiki/Q5383698","display_name":"Epithelial polarity","level":3,"score":0.49027636647224426},{"id":"https://openalex.org/C2777459641","wikidata":"https://www.wikidata.org/wiki/Q6815130","display_name":"Membrane glycoproteins","level":3,"score":0.48941484093666077},{"id":"https://openalex.org/C2777546802","wikidata":"https://www.wikidata.org/wiki/Q834390","display_name":"Influenza A virus","level":3,"score":0.48143312335014343},{"id":"https://openalex.org/C167625842","wikidata":"https://www.wikidata.org/wiki/Q899763","display_name":"Peptide sequence","level":3,"score":0.4630221724510193},{"id":"https://openalex.org/C2780340462","wikidata":"https://www.wikidata.org/wiki/Q127450","display_name":"Trypsin","level":3,"score":0.4265856444835663},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.3940303921699524},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.2977660000324249},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.29024988412857056},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.21901845932006836},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000906","descriptor_name":"Antibodies","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D001692","descriptor_name":"Biological Transport","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003593","descriptor_name":"Cytoplasm","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003593","descriptor_name":"Cytoplasm","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D004705","descriptor_name":"Endocytosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006389","descriptor_name":"Hemagglutinins, Viral","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006389","descriptor_name":"Hemagglutinins, Viral","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008715","descriptor_name":"Methionine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011233","descriptor_name":"Precipitin Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014162","descriptor_name":"Transfection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014168","descriptor_name":"Transferrin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014357","descriptor_name":"Trypsin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014443","descriptor_name":"Tyrosine","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D014443","descriptor_name":"Tyrosine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D019267","descriptor_name":"Hemagglutinin Glycoproteins, Influenza Virus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1083/jcb.114.3.413","doi":"https://doi.org/10.1083/jcb.114.3.413","is_oa":true,"landing_page_url":"https://doi.org/10.1083/jcb.114.3.413","pdf_url":"https://rupress.org/jcb/article-pdf/114/3/413/1061666/413.pdf","source":{"id":"https://openalex.org/S96410829","display_name":"The Journal of Cell Biology","issn_l":"0021-9525","issn":["0021-9525","1540-8140"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315676","host_organization_name":"Rockefeller University Press","host_organization_lineage":["https://openalex.org/P4310315676"],"host_organization_lineage_names":["Rockefeller University Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of cell biology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2289095","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2289095","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Cell Biol","raw_type":"Text"},{"id":"pmid:1860878","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1860878","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of cell biology","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.282.942","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.282.942","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/1c/f4/J_Cell_Biol_1991_Aug_1_114(3)_413-421.tar.gz","raw_type":"text"}],"best_oa_location":{"id":"doi:10.1083/jcb.114.3.413","doi":"https://doi.org/10.1083/jcb.114.3.413","is_oa":true,"landing_page_url":"https://doi.org/10.1083/jcb.114.3.413","pdf_url":"https://rupress.org/jcb/article-pdf/114/3/413/1061666/413.pdf","source":{"id":"https://openalex.org/S96410829","display_name":"The Journal of Cell Biology","issn_l":"0021-9525","issn":["0021-9525","1540-8140"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315676","host_organization_name":"Rockefeller University Press","host_organization_lineage":["https://openalex.org/P4310315676"],"host_organization_lineage_names":["Rockefeller University Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of cell biology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.46810001134872437,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2191227274","display_name":"ISOLATION OF CELLS DEFECTIVE IN SORTING GLYCOPROTEINS","funder_award_id":"R01GM041050","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G2715454153","display_name":null,"funder_award_id":"GM-41050","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G3018511264","display_name":"RECOGNITION AND SORTING OF GLYCOPROTEINS","funder_award_id":"R01GM037547","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320306230","display_name":"American Heart Association","ror":"https://ror.org/013kjyp64"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2063301738.pdf","grobid_xml":"https://content.openalex.org/works/W2063301738.grobid-xml"},"referenced_works_count":46,"referenced_works":["https://openalex.org/W152472878","https://openalex.org/W1495462148","https://openalex.org/W1505708906","https://openalex.org/W1526966570","https://openalex.org/W1527704924","https://openalex.org/W1583703772","https://openalex.org/W1715587256","https://openalex.org/W1965381942","https://openalex.org/W1972653235","https://openalex.org/W1973888589","https://openalex.org/W1983742904","https://openalex.org/W1989526931","https://openalex.org/W1990747840","https://openalex.org/W1992995998","https://openalex.org/W2017070390","https://openalex.org/W2017222795","https://openalex.org/W2025033304","https://openalex.org/W2026482135","https://openalex.org/W2034556361","https://openalex.org/W2044343226","https://openalex.org/W2049583570","https://openalex.org/W2059031237","https://openalex.org/W2059478908","https://openalex.org/W2064310127","https://openalex.org/W2070947895","https://openalex.org/W2071115686","https://openalex.org/W2073862596","https://openalex.org/W2076816515","https://openalex.org/W2082091164","https://openalex.org/W2082946230","https://openalex.org/W2086651259","https://openalex.org/W2105122105","https://openalex.org/W2108136135","https://openalex.org/W2110347627","https://openalex.org/W2120768505","https://openalex.org/W2124287787","https://openalex.org/W2126904693","https://openalex.org/W2133301365","https://openalex.org/W2134578455","https://openalex.org/W2136513361","https://openalex.org/W2141478144","https://openalex.org/W2161237546","https://openalex.org/W2167974813","https://openalex.org/W2185842814","https://openalex.org/W2397233491","https://openalex.org/W6607603391"],"related_works":["https://openalex.org/W7096322316","https://openalex.org/W2085456911","https://openalex.org/W2124287787","https://openalex.org/W2084392102","https://openalex.org/W2044343226","https://openalex.org/W1983742904","https://openalex.org/W2122240125","https://openalex.org/W1526966570","https://openalex.org/W1961273031","https://openalex.org/W7096365158"],"abstract_inverted_index":{"In":[0],"the":[1,7,38,68,86,95],"polarized":[2],"kidney":[3],"cell":[4],"line":[5],"MDCK,":[6],"influenza":[8],"virus":[9],"hemagglutinin":[10],"(HA)":[11],"has":[12,29],"been":[13],"well":[14],"characterized":[15],"as":[16],"a":[17,32,46,102],"model":[18],"for":[19],"apically":[20],"sorted":[21],"membrane":[22],"glycoproteins.":[23],"Previous":[24],"work":[25],"from":[26,45,51],"our":[27],"laboratory":[28],"shown":[30,72],"that":[31,48,56,76,101],"single":[33],"amino":[34],"acid":[35],"change":[36],"in":[37,73],"cytoplasmic":[39,103],"sequence":[40],"of":[41],"HA":[42,77],"converts":[43],"it":[44],"protein":[47,66],"is":[49,57,81,91],"excluded":[50],"coated":[52],"pits":[53],"to":[54,64,85,94,106],"one":[55],"efficiently":[58],"internalized.":[59],"Using":[60],"trypsin":[61],"or":[62],"antibodies":[63],"mark":[65],"on":[67],"surface,":[69],"we":[70],"have":[71],"MDCK":[74],"cells":[75],"containing":[78],"this":[79],"mutation":[80],"no":[82],"longer":[83],"transported":[84],"apical":[87],"surface":[88],"but":[89],"instead":[90],"delivered":[92],"directly":[93],"basolateral":[96,113],"plasma":[97],"membrane.":[98],"We":[99],"propose":[100],"feature":[104],"similar":[105],"an":[107],"endocytosis":[108],"signal":[109],"can":[110],"cause":[111],"exclusive":[112],"delivery.":[114]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
