{"id":"https://openalex.org/W2063192548","doi":"https://doi.org/10.1371/journal.pone.0010659","title":"Alzheimer's Disease Amyloid-\u03b2 Links Lens and Brain Pathology in Down Syndrome","display_name":"Alzheimer's Disease Amyloid-\u03b2 Links Lens and Brain Pathology in Down Syndrome","publication_year":2010,"publication_date":"2010-05-20","ids":{"openalex":"https://openalex.org/W2063192548","doi":"https://doi.org/10.1371/journal.pone.0010659","mag":"2063192548","pmid":"https://pubmed.ncbi.nlm.nih.gov/20502642","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2873949"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pone.0010659","doi":"https://doi.org/10.1371/journal.pone.0010659","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0010659","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0010659&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0010659&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5031668773","display_name":"Juliet A. Moncaster","orcid":"https://orcid.org/0000-0002-7849-4325","observed_orcids":["https://orcid.org/0000-0002-7849-4325"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Juliet A. Moncaster","raw_affiliation_strings":["Molecular Aging & Development Laboratory, Department of Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Aging & Development Laboratory, Department of Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050110783","display_name":"Roberto Pineda","orcid":"https://orcid.org/0000-0002-1592-1991","observed_orcids":["https://orcid.org/0000-0002-1592-1991"]},"institutions":[{"id":"https://openalex.org/I1287163989","display_name":"Massachusetts Eye and Ear Infirmary","ror":"https://ror.org/04g3dn724","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1287163989"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Roberto Pineda","raw_affiliation_strings":["Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts, United States of America","institution_ids":["https://openalex.org/I1287163989","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008848229","display_name":"Robert D. Moir","orcid":"https://orcid.org/0000-0001-5431-3553","observed_orcids":["https://orcid.org/0000-0001-5431-3553"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert D. Moir","raw_affiliation_strings":["Genetics and Aging Research Unit, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genetics and Aging Research Unit, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts, United States of America","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102296736","display_name":"Suqian Lu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Suqian Lu","raw_affiliation_strings":["Molecular Aging & Development Laboratory, Department of Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Aging & Development Laboratory, Department of Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Mark A. Burton","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mark A. Burton","raw_affiliation_strings":["Molecular Aging & Development Laboratory, Department of Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Aging & Development Laboratory, Department of Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102166564","display_name":"Joy G. Ghosh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joy G. Ghosh","raw_affiliation_strings":["Molecular Aging & Development Laboratory, Department of Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Aging & Development Laboratory, Department of Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057017311","display_name":"Maria Ericsson","orcid":"https://orcid.org/0000-0002-4563-3683","observed_orcids":["https://orcid.org/0000-0002-4563-3683"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Maria Ericsson","raw_affiliation_strings":["Electron Microscopy Facility, Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Electron Microscopy Facility, Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, United States of America","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077327841","display_name":"Stephanie J. Soscia","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephanie J. Soscia","raw_affiliation_strings":["Genetics and Aging Research Unit, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genetics and Aging Research Unit, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts, United States of America","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037162032","display_name":"Anca Mocofanescu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anca Mocofanescu","raw_affiliation_strings":["Molecular Aging & Development Laboratory, Department of Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Aging & Development Laboratory, Department of Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044836831","display_name":"Rebecca Dunn Folkerth","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rebecca D. Folkerth","raw_affiliation_strings":["Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003634033","display_name":"Richard M. Robb","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Richard M. Robb","raw_affiliation_strings":["Department of Ophthalmology, Children's Hospital Boston, Harvard Medical School, Boston, Massachusetts, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, Children's Hospital Boston, Harvard Medical School, Boston, Massachusetts, United States of America","institution_ids":["https://openalex.org/I1288882113","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110902095","display_name":"Jer R. Kuszak","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1285301757","display_name":"Rush University Medical Center","ror":"https://ror.org/01j7c0b24","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285301757"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jer R. Kuszak","raw_affiliation_strings":["Departments of Ophthalmology and Pathology, Rush University Medical Center, Chicago, Illinois, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Ophthalmology and Pathology, Rush University Medical Center, Chicago, Illinois, United States of America","institution_ids":["https://openalex.org/I1285301757"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079281560","display_name":"John I. Clark","orcid":"https://orcid.org/0000-0002-6651-5205","observed_orcids":["https://orcid.org/0000-0002-6651-5205"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John I. Clark","raw_affiliation_strings":["Departments of Biological Structure and Ophthalmology, University of Washington, Seattle, Washington, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Biological Structure and Ophthalmology, University of Washington, Seattle, Washington, United States of America","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050004777","display_name":"Rudolph E. Tanzi","orcid":"https://orcid.org/0000-0002-7032-1454","observed_orcids":["https://orcid.org/0000-0002-7032-1454"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rudolph E. Tanzi","raw_affiliation_strings":["Genetics and Aging Research Unit, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genetics and Aging Research Unit, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts, United States of America","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026161368","display_name":"David G. Hunter","orcid":"https://orcid.org/0000-0002-4587-4794","observed_orcids":["https://orcid.org/0000-0002-4587-4794"]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David G. Hunter","raw_affiliation_strings":["Department of Ophthalmology, Children's Hospital Boston, Harvard Medical School, Boston, Massachusetts, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, Children's Hospital Boston, Harvard Medical School, Boston, Massachusetts, United States of America","institution_ids":["https://openalex.org/I1288882113","https://openalex.org/I136199984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5045045118","display_name":"Lee E. Goldstein","orcid":"https://orcid.org/0000-0001-8419-9800","observed_orcids":["https://orcid.org/0000-0001-8419-9800"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Lee E. Goldstein","raw_affiliation_strings":["Molecular Aging & Development Laboratory, Department of Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Aging & Development Laboratory, Department of Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5045045118"],"corresponding_institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"],"apc_list":{"value":2382,"currency":"USD","value_usd":2382},"apc_paid":{"value":2382,"currency":"USD","value_usd":2382},"fwci":9.5247,"has_fulltext":true,"cited_by_count":143,"citation_normalized_percentile":{"value":0.98594872,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":100},"biblio":{"volume":"5","issue":"5","first_page":"e10659","last_page":"e10659"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.8208000063896179,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.8208000063896179,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11015","display_name":"Down syndrome and intellectual disability research","score":0.17470000684261322,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/down-syndrome","display_name":"Down syndrome","score":0.9909999966621399},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.8569999933242798},{"id":"https://openalex.org/keywords/amyloid-beta","display_name":"amyloid-beta","score":0.9760000109672546},{"id":"https://openalex.org/keywords/lens-pathology","display_name":"lens pathology","score":0.7139999866485596},{"id":"https://openalex.org/keywords/cataract","display_name":"cataract","score":0.7599999904632568},{"id":"https://openalex.org/keywords/lens-fiber-cells","display_name":"lens fiber cells","score":0.6629999876022339},{"id":"https://openalex.org/keywords/amyloid-fibril-formation","display_name":"amyloid fibril formation","score":0.6510000228881836},{"id":"https://openalex.org/keywords/protein-aggregation","display_name":"protein aggregation","score":0.5040000081062317}],"concepts":[{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.5838488340377808},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5454774498939514},{"id":"https://openalex.org/C2777633098","wikidata":"https://www.wikidata.org/wiki/Q2736051","display_name":"Amyloid (mycology)","level":2,"score":0.5283361673355103},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.500417947769165},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.42200514674186707},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.35116416215896606},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.24362295866012573}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D002386","descriptor_name":"Cataract","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002675","descriptor_name":"Child, Preschool","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004314","descriptor_name":"Down Syndrome","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004314","descriptor_name":"Down Syndrome","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D005136","descriptor_name":"Eye Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005136","descriptor_name":"Eye Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007908","descriptor_name":"Lens, Crystalline","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D007908","descriptor_name":"Lens, Crystalline","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D008027","descriptor_name":"Light","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012542","descriptor_name":"Scattering, Radiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016229","descriptor_name":"Amyloid beta-Peptides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016229","descriptor_name":"Amyloid beta-Peptides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D020836","descriptor_name":"Protein Structure, Quaternary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1371/journal.pone.0010659","doi":"https://doi.org/10.1371/journal.pone.0010659","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0010659","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0010659&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2873949","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2873949","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS One","raw_type":"Text"},{"id":"pmid:20502642","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20502642","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PloS one","raw_type":"Journal Article"},{"id":"pmh:oai:dash.harvard.edu:1/10198948","doi":null,"is_oa":true,"landing_page_url":"http://nrs.harvard.edu/urn-3:HUL.InstRepos:10198948","pdf_url":null,"source":{"id":"https://openalex.org/S4306401540","display_name":"Digital Access to Scholarship at Harvard (DASH) (Harvard University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I136199984","host_organization_name":"Harvard University","host_organization_lineage":["https://openalex.org/I136199984"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:68140f0c02854f30afc460197196eda9","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/68140f0c02854f30afc460197196eda9","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, Vol 5, Iss 5, p e10659 (2010)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1371/journal.pone.0010659","doi":"https://doi.org/10.1371/journal.pone.0010659","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0010659","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0010659&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.5600000023841858,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G3623401109","display_name":"AD LENS PATHOLOGY: BIOCHEMISTRY & DIAGNOSTIC IMAGING","funder_award_id":"R01GM075986","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G4305535625","display_name":"Development and Maintenance of Lens Transparency","funder_award_id":"R01EY004542","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"},{"id":"https://openalex.org/G5309786721","display_name":"Alzheimer's Disease beta-Amyloid in the Lens","funder_award_id":"K23AG024792","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G7618461031","display_name":"Boston University Alzheimer's Disease Center","funder_award_id":"P30AG013846","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"}],"funders":[{"id":"https://openalex.org/F4320306219","display_name":"Alzheimer's Association","ror":"https://ror.org/0375f4d26"},{"id":"https://openalex.org/F4320306229","display_name":"American Health Assistance Foundation","ror":"https://ror.org/03cvfxv40"},{"id":"https://openalex.org/F4320309647","display_name":"School of Medicine, Boston University","ror":"https://ror.org/05qwgg493"},{"id":"https://openalex.org/F4320309944","display_name":"Cure Alzheimer's Fund","ror":"https://ror.org/05ewr7t48"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"},{"id":"https://openalex.org/F4320337350","display_name":"National Eye Institute","ror":"https://ror.org/03wkg3b53"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2063192548.pdf","grobid_xml":"https://content.openalex.org/works/W2063192548.grobid-xml"},"referenced_works_count":55,"referenced_works":["https://openalex.org/W15997792","https://openalex.org/W106379059","https://openalex.org/W160661472","https://openalex.org/W167117959","https://openalex.org/W367511919","https://openalex.org/W616909742","https://openalex.org/W650129494","https://openalex.org/W1483242733","https://openalex.org/W1592049170","https://openalex.org/W1716232538","https://openalex.org/W1963680576","https://openalex.org/W1969271586","https://openalex.org/W1979767932","https://openalex.org/W1980309511","https://openalex.org/W1985323612","https://openalex.org/W1994573232","https://openalex.org/W1995718879","https://openalex.org/W2003986175","https://openalex.org/W2006124071","https://openalex.org/W2006450908","https://openalex.org/W2011698149","https://openalex.org/W2018358250","https://openalex.org/W2027036934","https://openalex.org/W2027186506","https://openalex.org/W2034579187","https://openalex.org/W2041789591","https://openalex.org/W2043165986","https://openalex.org/W2045201077","https://openalex.org/W2054489063","https://openalex.org/W2056046302","https://openalex.org/W2058753016","https://openalex.org/W2065668337","https://openalex.org/W2082429191","https://openalex.org/W2085790004","https://openalex.org/W2090060333","https://openalex.org/W2091505182","https://openalex.org/W2092203161","https://openalex.org/W2096389402","https://openalex.org/W2096410114","https://openalex.org/W2097030000","https://openalex.org/W2103440561","https://openalex.org/W2113784071","https://openalex.org/W2121819507","https://openalex.org/W2136095513","https://openalex.org/W2145047800","https://openalex.org/W2154566696","https://openalex.org/W2160114614","https://openalex.org/W2164344373","https://openalex.org/W2165462380","https://openalex.org/W2203956326","https://openalex.org/W2555325264","https://openalex.org/W3157530731","https://openalex.org/W3169556079","https://openalex.org/W4256487141","https://openalex.org/W4299683912"],"related_works":["https://openalex.org/W2153385161","https://openalex.org/W7101028037","https://openalex.org/W2029880594","https://openalex.org/W2025830618","https://openalex.org/W2130974366","https://openalex.org/W2026972247","https://openalex.org/W2475347717","https://openalex.org/W4212992853","https://openalex.org/W1009759088","https://openalex.org/W1575230904"],"abstract_inverted_index":{"Down":[0],"syndrome":[1],"(DS,":[2],"trisomy":[3],"21)":[4],"is":[5,250],"the":[6,12,29,34,44,93,103,111,174,187,215,228,232,240],"most":[7],"common":[8,254],"chromosomal":[9,255],"disorder":[10],"and":[11,62,88,128,137,161,184,189,210,218,238,243,271,277],"leading":[13,50],"genetic":[14,229],"cause":[15],"of":[16,24,43,54,76,96,120,131,142,149,192,198,231],"intellectual":[17],"disability":[18],"in":[19,92,178,194,222,236,252,274],"humans.":[20],"In":[21],"DS,":[22,135],"triplication":[23],"chromosome":[25],"21":[26],"invariably":[27],"includes":[28,71],"APP":[30,45,48],"gene":[31,46],"(21q21)":[32],"encoding":[33],"Alzheimer's":[35],"disease":[36],"(AD)":[37],"amyloid":[38,86,159,208],"precursor":[39],"protein":[40,204,206],"(APP).":[41],"Triplication":[42],"accelerates":[47],"expression":[49],"to":[51,169,173],"cerebral":[52],"accumulation":[53,191,263],"APP-derived":[55],"amyloid-beta":[56],"peptides":[57],"(Abeta),":[58],"early-onset":[59,73],"AD":[60],"neuropathology,":[61],"age-dependent":[63],"cognitive":[64],"sequelae.":[65],"The":[66],"DS":[67,121,143,195,223,237,276],"phenotype":[68,114,235],"complex":[69],"also":[70],"distinctive":[72,112,233],"cerulean":[74],"cataracts":[75,91],"unknown":[77],"etiology.":[78],"Previously,":[79],"we":[80,101],"reported":[81],"increased":[82,190,261],"Abeta":[83,108,156,165,193,200,262],"accumulation,":[84,157],"co-localizing":[85,158],"pathology,":[87,160],"disease-linked":[89],"supranuclear":[90,150,155],"ocular":[94],"lenses":[95,132,144],"subjects":[97,122],"with":[98,116,125,201],"AD.":[99,179,278],"Here,":[100],"investigate":[102],"hypothesis":[104],"that":[105,213],"related":[106],"AD-linked":[107],"pathology":[109,176,217,249,273],"underlies":[110],"lens":[113,175,203,234,248,270],"associated":[115],"DS.":[117],"Ophthalmological":[118],"examinations":[119],"were":[123],"correlated":[124],"phenotypic,":[126],"histochemical,":[127],"biochemical":[129],"analyses":[130],"obtained":[133],"from":[134],"AD,":[136],"normal":[138],"control":[139],"subjects.":[140],"Evaluation":[141],"revealed":[145],"a":[146,265],"characteristic":[147],"pattern":[148],"opacification":[151],"accompanied":[152],"by":[153,246],"accelerated":[154],"fiber":[162],"cell":[163],"cytoplasmic":[164],"aggregates":[166],"(approximately":[167],"5":[168],"50":[170],"nm)":[171],"identical":[172],"identified":[177],"Peptide":[180],"sequencing,":[181],"immunoblot":[182],"analysis,":[183],"ELISA":[185],"confirmed":[186],"identity":[188],"lenses.":[196,224],"Incubation":[197],"synthetic":[199],"human":[202],"promoted":[205],"aggregation,":[207],"formation,":[209],"light":[211],"scattering":[212],"recapitulated":[214],"molecular":[216,241],"clinical":[219],"features":[220],"observed":[221],"These":[225],"results":[226],"establish":[227],"etiology":[230],"identify":[239],"origin":[242],"pathogenic":[244,267],"mechanism":[245],"which":[247],"expressed":[251],"this":[253],"disorder.":[256],"Moreover,":[257],"these":[258],"findings":[259],"confirm":[260],"as":[264],"key":[266],"determinant":[268],"linking":[269],"brain":[272],"both":[275]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":10},{"year":2021,"cited_by_count":8},{"year":2020,"cited_by_count":13},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":7},{"year":2017,"cited_by_count":10},{"year":2016,"cited_by_count":11},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":10},{"year":2013,"cited_by_count":15},{"year":2012,"cited_by_count":12}],"updated_date":"2026-11-01T11:40:01.658920","created_date":"2016-06-24T00:00:00"}