{"id":"https://openalex.org/W2063169293","doi":"https://doi.org/10.1021/bi00185a043","title":"Mapping of DNA Alkylation Sites Induced by Adozelesin and Bizelesin in Human Cells by Ligation-Mediated Polymerase Chain Reaction","display_name":"Mapping of DNA Alkylation Sites Induced by Adozelesin and Bizelesin in Human Cells by Ligation-Mediated Polymerase Chain Reaction","publication_year":1994,"publication_date":"1994-05-17","ids":{"openalex":"https://openalex.org/W2063169293","doi":"https://doi.org/10.1021/bi00185a043","mag":"2063169293","pmid":"https://pubmed.ncbi.nlm.nih.gov/8180230"},"language":"en","primary_location":{"id":"doi:10.1021/bi00185a043","doi":"https://doi.org/10.1021/bi00185a043","is_oa":false,"landing_page_url":"https://doi.org/10.1021/bi00185a043","pdf_url":null,"source":{"id":"https://openalex.org/S104038378","display_name":"Biochemistry","issn_l":"0006-2960","issn":["0006-2960","1520-4995","1943-295X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5078231565","display_name":"Chong-Soon Lee","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chong-Soon Lee","raw_affiliation_strings":["School of Pharmacy, University of Southern California, Los Angeles, 90033"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Pharmacy, University of Southern California, Los Angeles, 90033","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048312997","display_name":"Gerd P. Pfeifer","orcid":"https://orcid.org/0000-0002-5080-9604","observed_orcids":["https://orcid.org/0000-0002-5080-9604"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gerd P. Pfeifer","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5112057559","display_name":"Neil W. Gibson","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Neil W. Gibson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":3.2658,"has_fulltext":false,"cited_by_count":37,"citation_normalized_percentile":{"value":0.92515991,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"33","issue":"19","first_page":"6024","last_page":"6030"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13105","display_name":"Synthesis and pharmacology of benzodiazepine derivatives","score":0.8651999831199646,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T13105","display_name":"Synthesis and pharmacology of benzodiazepine derivatives","score":0.8651999831199646,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11845","display_name":"Cancer therapeutics and mechanisms","score":0.05820000171661377,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10432","display_name":"DNA and Nucleic Acid Chemistry","score":0.025299999862909317,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cc-1065","display_name":"CC-1065","score":0.9070000052452087},{"id":"https://openalex.org/keywords/dna-alkylation","display_name":"DNA alkylation","score":0.8579999804496765},{"id":"https://openalex.org/keywords/interstrand-crosslinks","display_name":"interstrand cross-links","score":0.796999990940094},{"id":"https://openalex.org/keywords/monofunctional-alkylating-agents","display_name":"monofunctional alkylating agents","score":0.921999990940094},{"id":"https://openalex.org/keywords/bifunctional-alkylating-agents","display_name":"bifunctional alkylating agents","score":0.9089999794960022},{"id":"https://openalex.org/keywords/p53-gene","display_name":"p53 gene","score":0.996999979019165},{"id":"https://openalex.org/keywords/at-rich-sequences","display_name":"AT-rich sequences","score":0.7549999952316284},{"id":"https://openalex.org/keywords/sequence-preference","display_name":"sequence preference","score":0.593999981880188},{"id":"https://openalex.org/keywords/colon-cancer-cells","display_name":"colon cancer cells","score":0.7630000114440918},{"id":"https://openalex.org/keywords/ligation-mediated-pcr","display_name":"ligation-mediated PCR","score":0.699999988079071}],"concepts":[{"id":"https://openalex.org/C164361826","wikidata":"https://www.wikidata.org/wiki/Q177604","display_name":"Alkylation","level":3,"score":0.7584670782089233},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.6906794905662537},{"id":"https://openalex.org/C512185932","wikidata":"https://www.wikidata.org/wiki/Q28745","display_name":"Nucleotide","level":3,"score":0.5747542381286621},{"id":"https://openalex.org/C2756471","wikidata":"https://www.wikidata.org/wiki/Q206286","display_name":"DNA polymerase","level":3,"score":0.49595627188682556},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4751979112625122},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4704887866973877},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.46385690569877625},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.425201952457428},{"id":"https://openalex.org/C17757408","wikidata":"https://www.wikidata.org/wiki/Q4135516","display_name":"genomic DNA","level":3,"score":0.42003193497657776},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.39953431487083435},{"id":"https://openalex.org/C161790260","wikidata":"https://www.wikidata.org/wiki/Q82264","display_name":"Catalysis","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000080890","descriptor_name":"Duocarmycins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000477","descriptor_name":"Alkylating Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001572","descriptor_name":"Benzofurans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003509","descriptor_name":"Cyclohexanecarboxylic Acids","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007211","descriptor_name":"Indoles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010735","descriptor_name":"Phosphoglycerate Kinase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014508","descriptor_name":"Urea","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D014508","descriptor_name":"Urea","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D016133","descriptor_name":"Polymerase Chain Reaction","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D016158","descriptor_name":"Genes, p53","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053138","descriptor_name":"Cyclohexenes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1021/bi00185a043","doi":"https://doi.org/10.1021/bi00185a043","is_oa":false,"landing_page_url":"https://doi.org/10.1021/bi00185a043","pdf_url":null,"source":{"id":"https://openalex.org/S104038378","display_name":"Biochemistry","issn_l":"0006-2960","issn":["0006-2960","1520-4995","1943-295X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"journal-article"},{"id":"pmid:8180230","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8180230","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.46810001134872437,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G8053201134","display_name":"ANTICANCER DRUG INDUCED DNA DAMAGE AND REPAIR","funder_award_id":"R01CA059537","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":38,"referenced_works":["https://openalex.org/W1483838925","https://openalex.org/W1491951542","https://openalex.org/W1558516755","https://openalex.org/W1563595970","https://openalex.org/W1566156137","https://openalex.org/W1965480599","https://openalex.org/W1967259286","https://openalex.org/W1967522414","https://openalex.org/W1976190681","https://openalex.org/W1987520782","https://openalex.org/W1993120989","https://openalex.org/W2007342946","https://openalex.org/W2009471244","https://openalex.org/W2010763622","https://openalex.org/W2013255015","https://openalex.org/W2015232786","https://openalex.org/W2020181395","https://openalex.org/W2034979558","https://openalex.org/W2046865715","https://openalex.org/W2054389310","https://openalex.org/W2056151723","https://openalex.org/W2062263965","https://openalex.org/W2062630273","https://openalex.org/W2064375802","https://openalex.org/W2071749549","https://openalex.org/W2078565719","https://openalex.org/W2094089146","https://openalex.org/W2103939013","https://openalex.org/W2144515939","https://openalex.org/W2156510371","https://openalex.org/W2158132292","https://openalex.org/W2192716493","https://openalex.org/W2197237365","https://openalex.org/W2398025271","https://openalex.org/W2416123001","https://openalex.org/W2417538191","https://openalex.org/W2418412420","https://openalex.org/W2951713390"],"related_works":["https://openalex.org/W1986231955","https://openalex.org/W1987962470","https://openalex.org/W2039851847","https://openalex.org/W1982057424","https://openalex.org/W1992071872","https://openalex.org/W2025223558","https://openalex.org/W1985721791","https://openalex.org/W7099166953","https://openalex.org/W2052014756","https://openalex.org/W2103939013"],"abstract_inverted_index":{"In":[0],"this":[1],"study,":[2],"we":[3],"have":[4],"mapped":[5,42],"the":[6,23,37,44,127,131,177],"intracellular":[7,165],"alkylation":[8,74,101,180],"sites":[9,72,86,119,144,166],"of":[10,17,39,51,73,87,97,145,167,179],"adozelesin":[11,33,60,183],"and":[12,34,36,46,102,137,153,184],"bizelesin,":[13,35],"two":[14,132],"potent":[15],"analogs":[16],"CC-1065,":[18],"in":[19,126,186,197],"individual":[20],"genes":[21,48],"at":[22],"single-nucleotide":[24],"level.":[25],"Human":[26],"colon":[27],"carcinoma":[28],"cells":[29],"were":[30,41,75,82,140],"treated":[31],"with":[32,150],"position":[38],"adducts":[40],"within":[43,68,77],"PGK-1":[45],"p53":[47],"by":[49,182],"means":[50],"ligation-mediated":[52],"polymerase":[53],"chain":[54],"reaction.":[55],"The":[56],"monofunctional":[57,100,174],"alkylating":[58],"agent":[59],"was":[61,107],"found":[62,109],"to":[63,84,89,110,194],"alkylate":[64,111],"genomic":[65,187],"DNA":[66,99,103,116,146,169,188],"predominantly":[67],"5'-(A/T)(A/T)A*":[69,112],"sequences.":[70,113],"Additional":[71],"observed":[76,162,196],"5'-(A/T)(G/C)(A/T)A*":[78],"sequences;":[79],"however,":[80],"these":[81],"considered":[83],"represent":[85],"medium":[88],"low":[90],"preference.":[91],"Bizelesin,":[92],"a":[93],"bifunctional":[94],"analog":[95],"capable":[96],"both":[98],"interstrand":[104,117,147,170],"cross-link":[105,118,148],"formation,":[106],"also":[108],"Putative":[114],"bizelesin":[115,185],"indicated":[120],"that":[121,195],"AT-rich":[122],"sequences":[123,155],"are":[124,160,189],"preferred":[125],"intervening":[128],"sequence":[129],"between":[130],"cross-linked":[133],"adenines.":[134],"Both":[135],"six-":[136],"seven-nucleotide":[138],"regions":[139],"identified":[141],"as":[142,163],"putative":[143],"formation":[149,172],"5'-TTTTTTA*,":[151],"5'-TTTATCA*":[152],"5'-GTACTAA*":[154],"being":[156],"preferred.":[157],"Non-adenine":[158],"bases":[159],"not":[161,192],"potential":[164],"either":[168],"cross-linking":[171],"or":[173],"alkylation.":[175],"Thus,":[176],"patterns":[178],"induced":[181],"similar":[190],"but":[191],"identical":[193],"purified":[198],"cell-free":[199],"DNA.":[200]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2014,"cited_by_count":2}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}
