{"id":"https://openalex.org/W2063097487","doi":"https://doi.org/10.3109/02713689109020356","title":"Evidence endogenous interferon production contributed to the lack of ocular virulence of an HSV intertypic recombinant","display_name":"Evidence endogenous interferon production contributed to the lack of ocular virulence of an HSV intertypic recombinant","publication_year":1991,"publication_date":"1991-01-01","ids":{"openalex":"https://openalex.org/W2063097487","doi":"https://doi.org/10.3109/02713689109020356","mag":"2063097487","pmid":"https://pubmed.ncbi.nlm.nih.gov/1650672"},"language":"en","primary_location":{"id":"doi:10.3109/02713689109020356","doi":"https://doi.org/10.3109/02713689109020356","is_oa":false,"landing_page_url":"https://doi.org/10.3109/02713689109020356","pdf_url":null,"source":{"id":"https://openalex.org/S74941265","display_name":"Current Eye Research","issn_l":"0271-3683","issn":["0271-3683","1460-2202"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Eye Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108365955","display_name":"Robert N. Lausch","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I83809506","display_name":"University of South Alabama","ror":"https://ror.org/01s7b5y08","country_code":"US","type":"education","lineage":["https://openalex.org/I83809506"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert N. Lausch","raw_affiliation_strings":["University of South Alabama, College of Medicine, Department of Microbiology and Immunology, Mobile 36688","University of South Alabama College of Medicine, Department of Microbiology and Immunology, Mobile 36688"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of South Alabama, College of Medicine, Department of Microbiology and Immunology, Mobile 36688","institution_ids":["https://openalex.org/I83809506"]},{"raw_affiliation_string":"University of South Alabama College of Medicine, Department of Microbiology and Immunology, Mobile 36688","institution_ids":["https://openalex.org/I83809506"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072302646","display_name":"Ying\u2010Hsiu Su","orcid":"https://orcid.org/0000-0003-0969-0215","observed_orcids":["https://orcid.org/0000-0003-0969-0215"]},"institutions":[{"id":"https://openalex.org/I83809506","display_name":"University of South Alabama","ror":"https://ror.org/01s7b5y08","country_code":"US","type":"education","lineage":["https://openalex.org/I83809506"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ying-Hsiu Su","raw_affiliation_strings":["Department of Microbiology and Immunology, University of South Alabama, College of Medicine, Mobile, AL, 36688, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, University of South Alabama, College of Medicine, Mobile, AL, 36688, USA","institution_ids":["https://openalex.org/I83809506"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016476337","display_name":"Mary H. Ritchie","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I83809506","display_name":"University of South Alabama","ror":"https://ror.org/01s7b5y08","country_code":"US","type":"education","lineage":["https://openalex.org/I83809506"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mary Ritchie","raw_affiliation_strings":["Department of Microbiology and Immunology, University of South Alabama, College of Medicine, Mobile, AL, 36688, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, University of South Alabama, College of Medicine, Mobile, AL, 36688, USA","institution_ids":["https://openalex.org/I83809506"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5001145950","display_name":"John E. Oakes","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I83809506","display_name":"University of South Alabama","ror":"https://ror.org/01s7b5y08","country_code":"US","type":"education","lineage":["https://openalex.org/I83809506"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John E. Oakes","raw_affiliation_strings":["Department of Microbiology and Immunology, University of South Alabama, College of Medicine, Mobile, AL, 36688, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, University of South Alabama, College of Medicine, Mobile, AL, 36688, USA","institution_ids":["https://openalex.org/I83809506"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I83809506"],"apc_list":null,"apc_paid":null,"fwci":1.0708,"has_fulltext":false,"cited_by_count":13,"citation_normalized_percentile":{"value":0.77660159,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"10","issue":"sup1","first_page":"39","last_page":"45"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10625","display_name":"Herpesvirus Infections and Treatments","score":0.7768999934196472,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10625","display_name":"Herpesvirus Infections and Treatments","score":0.7768999934196472,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11668","display_name":"interferon and immune responses","score":0.17550000548362732,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11826","display_name":"Ocular Infections and Treatments","score":0.033900000154972076,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/herpes-simplex-virus","display_name":"herpes simplex virus","score":0.8880000114440918},{"id":"https://openalex.org/keywords/herpes-simplex-virus-type-1","display_name":"herpes simplex virus type 1","score":0.9049999713897705},{"id":"https://openalex.org/keywords/herpes-simplex-virus-type-2","display_name":"herpes simplex virus type 2","score":1.0},{"id":"https://openalex.org/keywords/type-i-interferon","display_name":"type I interferon","score":0.9369999766349792},{"id":"https://openalex.org/keywords/interferon-resistance","display_name":"interferon resistance","score":0.47600001096725464},{"id":"https://openalex.org/keywords/stromal-keratitis","display_name":"stromal keratitis","score":0.8640000224113464},{"id":"https://openalex.org/keywords/blepharitis","display_name":"blepharitis","score":0.9819999933242798},{"id":"https://openalex.org/keywords/corneal-fibroblasts","display_name":"corneal fibroblasts","score":0.8640000224113464},{"id":"https://openalex.org/keywords/corneal-infection","display_name":"corneal infection","score":0.6940000057220459}],"concepts":[{"id":"https://openalex.org/C32611913","wikidata":"https://www.wikidata.org/wiki/Q2166189","display_name":"Titer","level":3,"score":0.6697790026664734},{"id":"https://openalex.org/C40767141","wikidata":"https://www.wikidata.org/wiki/Q285697","display_name":"Recombinant DNA","level":3,"score":0.6547358632087708},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6317445039749146},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.6221798062324524},{"id":"https://openalex.org/C91523082","wikidata":"https://www.wikidata.org/wiki/Q420496","display_name":"Antiserum","level":3,"score":0.5564953684806824},{"id":"https://openalex.org/C2776882836","wikidata":"https://www.wikidata.org/wiki/Q168291","display_name":"Cornea","level":2,"score":0.5447304248809814},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.48817187547683716},{"id":"https://openalex.org/C2776178377","wikidata":"https://www.wikidata.org/wiki/Q188269","display_name":"Interferon","level":2,"score":0.46744096279144287},{"id":"https://openalex.org/C2778560704","wikidata":"https://www.wikidata.org/wiki/Q757838","display_name":"Keratitis","level":2,"score":0.4574112594127655},{"id":"https://openalex.org/C203233990","wikidata":"https://www.wikidata.org/wiki/Q1511135","display_name":"Multiplicity of infection","level":3,"score":0.42922282218933105},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3654025197029114},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.24630260467529297},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003315","descriptor_name":"Cornea","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D003315","descriptor_name":"Cornea","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D003315","descriptor_name":"Cornea","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D004279","descriptor_name":"DNA, Viral","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004279","descriptor_name":"DNA, Viral","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004279","descriptor_name":"DNA, Viral","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D007370","descriptor_name":"Interferon Type I","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D007370","descriptor_name":"Interferon Type I","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D007370","descriptor_name":"Interferon Type I","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D007370","descriptor_name":"Interferon Type I","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D007370","descriptor_name":"Interferon Type I","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D007370","descriptor_name":"Interferon Type I","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D007635","descriptor_name":"Keratitis, Dendritic","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D007635","descriptor_name":"Keratitis, Dendritic","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D007635","descriptor_name":"Keratitis, Dendritic","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014162","descriptor_name":"Transfection","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014162","descriptor_name":"Transfection","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014162","descriptor_name":"Transfection","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014774","descriptor_name":"Virulence","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D014774","descriptor_name":"Virulence","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D014774","descriptor_name":"Virulence","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D014779","descriptor_name":"Virus Replication","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D014779","descriptor_name":"Virus Replication","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D014779","descriptor_name":"Virus Replication","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D018139","descriptor_name":"Simplexvirus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018139","descriptor_name":"Simplexvirus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018139","descriptor_name":"Simplexvirus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018139","descriptor_name":"Simplexvirus","qualifier_ui":"Q000472","qualifier_name":"pathogenicity","is_major_topic":false},{"descriptor_ui":"D018139","descriptor_name":"Simplexvirus","qualifier_ui":"Q000472","qualifier_name":"pathogenicity","is_major_topic":false},{"descriptor_ui":"D018139","descriptor_name":"Simplexvirus","qualifier_ui":"Q000472","qualifier_name":"pathogenicity","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.3109/02713689109020356","doi":"https://doi.org/10.3109/02713689109020356","is_oa":false,"landing_page_url":"https://doi.org/10.3109/02713689109020356","pdf_url":null,"source":{"id":"https://openalex.org/S74941265","display_name":"Current Eye Research","issn_l":"0271-3683","issn":["0271-3683","1460-2202"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Eye Research","raw_type":"journal-article"},{"id":"pmid:1650672","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1650672","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current eye research","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9763000011444092,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","score":0.6600000262260437,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G329231973","display_name":null,"funder_award_id":"EY05099","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"},{"id":"https://openalex.org/G6178321505","display_name":"MOLECULAR ANALYSIS OF HERPESVIRUS CORNEAL INFECTION","funder_award_id":"5r01ey005099-12","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337350","display_name":"National Eye Institute","ror":"https://ror.org/03wkg3b53"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":18,"referenced_works":["https://openalex.org/W55244722","https://openalex.org/W69115750","https://openalex.org/W154956868","https://openalex.org/W191931267","https://openalex.org/W1491330607","https://openalex.org/W1902050125","https://openalex.org/W1944135917","https://openalex.org/W1972528203","https://openalex.org/W1989006782","https://openalex.org/W1990209762","https://openalex.org/W2001839145","https://openalex.org/W2038965275","https://openalex.org/W2051181298","https://openalex.org/W2073178994","https://openalex.org/W2081762746","https://openalex.org/W2110109382","https://openalex.org/W2129382212","https://openalex.org/W2150415624"],"related_works":["https://openalex.org/W1989006782","https://openalex.org/W1491330607","https://openalex.org/W2092009940","https://openalex.org/W1547550787","https://openalex.org/W2081762746","https://openalex.org/W2329793641","https://openalex.org/W2050625127","https://openalex.org/W2079097010","https://openalex.org/W2068957057","https://openalex.org/W2152214788"],"abstract_inverted_index":{"An":[0],"intertypic":[1,56],"recombinant":[2,71],"isolated":[3],"from":[4],"rabbit":[5,124],"kidney":[6],"cells":[7],"following":[8],"co-transfection":[9],"of":[10,54,80,107,119,123,148,169,180,205,221],"HSV-1(17)":[11],"and":[12,193],"HSV-2(186)":[13],"DNA":[14],"failed":[15],"to":[16,60,76,127,135,142,164,174,207,217,226],"induce":[17,61,208],"overt":[18],"ocular":[19,209],"pathology":[20,63],"when":[21,152],"inoculated":[22],"onto":[23],"the":[24,52,55,70,77,85,110,128,146,170,181,196,203,218],"murine":[25],"sacrificed":[26],"cornea":[27],"at":[28,44,103,213],"concentrations":[29],"as":[30,32],"high":[31],"10(7)":[33],"PFU":[34],"per":[35],"eye.":[36],"In":[37],"contrast,":[38],"both":[39],"parents":[40],"induced":[41],"corneal":[42,62,89,101,166,184],"disease":[43,210],"a":[45,104,133],"1000-fold":[46],"lower":[47,116],"dose.":[48],"The":[49],"reason(s)":[50],"for":[51],"failure":[53],"recombinant,":[57],"designated":[58],"RO25X,":[59],"was":[64,67,72,113,187,211],"investigated.":[65],"It":[66],"found":[68],"that":[69,118,202],"100-fold":[73],"more":[74],"sensitive":[75],"inhibitory":[78,219],"effects":[79,220],"interferon":[81,222],"(IFN)":[82],"alpha/beta":[83,126,160],"than":[84,117],"parent":[86],"strains":[87],"in":[88,93,98,132,138,145,156,191,195,215,224],"button":[90],"growth":[91,144],"studies":[92],"vitro.":[94],"R025X":[95,206],"readily":[96],"grew":[97],"cultured":[99],"mouse":[100],"fibroblasts":[102],"low":[105],"multiplicity":[106],"infection.":[108,227],"However,":[109],"peak":[111],"titer":[112,140],"approximately":[114],"8-fold":[115],"strain":[120],"17.":[121],"Addition":[122],"anti-IFN":[125,159],"culture":[129],"medium":[130],"resulted":[131],"4":[134],"5-fold":[136],"increase":[137],"infectious":[139],"compared":[141],"its":[143],"absence":[147],"antiserum.":[149],"Most":[150],"significantly,":[151],"mice":[153],"were":[154],"pre-treated":[155],"vivo":[157],"with":[158],"24":[161],"hours":[162],"prior":[163],"virus":[165],"infection,":[167],"67%":[168],"recipients":[171],"developed":[172,183],"moderate":[173],"severe":[175],"stromal":[176],"keratitis,":[177],"whereas":[178],"none":[179],"controls":[182],"pathology.":[185],"Blepharitis":[186],"also":[188],"significantly":[189],"increased":[190],"incidence":[192],"severity":[194],"antiserum":[197],"treated":[198],"hosts.":[199],"We":[200],"conclude":[201],"inability":[204],"due,":[212],"least":[214],"part,":[216],"produced":[223],"response":[225]},"counts_by_year":[],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2016-06-24T00:00:00"}