{"id":"https://openalex.org/W2063095645","doi":"https://doi.org/10.1007/bf00589097","title":"Effects of 4-aminopyridine on inward rectifying and pacemaker currents of cardiac purkinje fibres","display_name":"Effects of 4-aminopyridine on inward rectifying and pacemaker currents of cardiac purkinje fibres","publication_year":1982,"publication_date":"1982-09-01","ids":{"openalex":"https://openalex.org/W2063095645","doi":"https://doi.org/10.1007/bf00589097","mag":"2063095645","pmid":"https://pubmed.ncbi.nlm.nih.gov/7145603"},"language":"en","primary_location":{"id":"doi:10.1007/bf00589097","doi":"https://doi.org/10.1007/bf00589097","is_oa":false,"landing_page_url":"https://doi.org/10.1007/bf00589097","pdf_url":null,"source":{"id":"https://openalex.org/S203465302","display_name":"Pfl\u00fcgers Archiv - European Journal of Physiology","issn_l":"0031-6768","issn":["0031-6768","0365-267X","1432-2013"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pfl\u00fcgers Archiv","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113576553","display_name":"Pierre Paul Van Bogaert","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I149213910","display_name":"University of Antwerp","ror":"https://ror.org/008x57b05","country_code":"BE","type":"education","lineage":["https://openalex.org/I149213910"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"P. P. Van Bogaert","raw_affiliation_strings":["Laboratory of Physiology, University of Antwerp, (RUCA), Groenenborgerlaan 171, B-2020, Antwerpen, Belgium","Laboratory of Physiology, University of Antwerp, (RUCA), Antwerpen, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Physiology, University of Antwerp, (RUCA), Groenenborgerlaan 171, B-2020, Antwerpen, Belgium","institution_ids":["https://openalex.org/I149213910"]},{"raw_affiliation_string":"Laboratory of Physiology, University of Antwerp, (RUCA), Antwerpen, Belgium","institution_ids":["https://openalex.org/I149213910"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5071594443","display_name":"Dirk J. Snyders","orcid":"https://orcid.org/0000-0001-7142-6672","observed_orcids":["https://orcid.org/0000-0001-7142-6672"]},"institutions":[{"id":"https://openalex.org/I149213910","display_name":"University of Antwerp","ror":"https://ror.org/008x57b05","country_code":"BE","type":"education","lineage":["https://openalex.org/I149213910"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"D. J. Snyders","raw_affiliation_strings":["Laboratory of Physiology, University of Antwerp, (RUCA), Groenenborgerlaan 171, B-2020, Antwerpen, Belgium","Laboratory of Physiology, University of Antwerp, (RUCA), Antwerpen, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Physiology, University of Antwerp, (RUCA), Groenenborgerlaan 171, B-2020, Antwerpen, Belgium","institution_ids":["https://openalex.org/I149213910"]},{"raw_affiliation_string":"Laboratory of Physiology, University of Antwerp, (RUCA), Antwerpen, Belgium","institution_ids":["https://openalex.org/I149213910"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I149213910"],"apc_list":{"value":4390,"currency":"USD","value_usd":4390},"apc_paid":null,"fwci":2.4157,"has_fulltext":false,"cited_by_count":44,"citation_normalized_percentile":{"value":0.88213573,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"394","issue":"3","first_page":"230","last_page":"238"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.8949999809265137,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.8949999809265137,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.10440000146627426,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10724","display_name":"Ion Transport and Channel Regulation","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/4-aminopyridine","display_name":"4-aminopyridine","score":1.0},{"id":"https://openalex.org/keywords/cardiac-purkinje-fibers","display_name":"cardiac Purkinje fibers","score":0.8830000162124634},{"id":"https://openalex.org/keywords/inward-rectifier-potassium-current","display_name":"inward rectifier potassium current","score":0.8809999823570251},{"id":"https://openalex.org/keywords/pacemaker-current","display_name":"pacemaker current","score":0.9860000014305115},{"id":"https://openalex.org/keywords/action-potential-duration","display_name":"action potential duration","score":0.7059999704360962},{"id":"https://openalex.org/keywords/spontaneous-activity","display_name":"spontaneous activity","score":0.8659999966621399},{"id":"https://openalex.org/keywords/resting-membrane-potential","display_name":"resting membrane potential","score":0.7200000286102295},{"id":"https://openalex.org/keywords/transient-outward-current","display_name":"transient outward current","score":0.765999972820282},{"id":"https://openalex.org/keywords/voltage-dependence","display_name":"voltage dependence","score":0.5460000038146973},{"id":"https://openalex.org/keywords/sheep-heart","display_name":"sheep heart","score":0.5519999861717224}],"concepts":[{"id":"https://openalex.org/C2777463368","wikidata":"https://www.wikidata.org/wiki/Q2014587","display_name":"Purkinje fibers","level":3,"score":0.8257521390914917},{"id":"https://openalex.org/C101404756","wikidata":"https://www.wikidata.org/wiki/Q5038336","display_name":"Cardiac transient outward potassium current","level":4,"score":0.7898674011230469},{"id":"https://openalex.org/C2780922449","wikidata":"https://www.wikidata.org/wiki/Q372539","display_name":"4-Aminopyridine","level":3,"score":0.7084293365478516},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6563511490821838},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.6366739273071289},{"id":"https://openalex.org/C158494493","wikidata":"https://www.wikidata.org/wiki/Q383566","display_name":"Resting potential","level":3,"score":0.627860963344574},{"id":"https://openalex.org/C177832589","wikidata":"https://www.wikidata.org/wiki/Q3909524","display_name":"Pacemaker potential","level":3,"score":0.6248179078102112},{"id":"https://openalex.org/C181911157","wikidata":"https://www.wikidata.org/wiki/Q389844","display_name":"Membrane potential","level":2,"score":0.6245601177215576},{"id":"https://openalex.org/C100837961","wikidata":"https://www.wikidata.org/wiki/Q10290897","display_name":"Voltage clamp","level":3,"score":0.5653238296508789},{"id":"https://openalex.org/C81370116","wikidata":"https://www.wikidata.org/wiki/Q1335249","display_name":"Time constant","level":2,"score":0.4628215730190277},{"id":"https://openalex.org/C185263204","wikidata":"https://www.wikidata.org/wiki/Q1154774","display_name":"Electrophysiology","level":2,"score":0.4101825952529907},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.352201372385025},{"id":"https://openalex.org/C147944092","wikidata":"https://www.wikidata.org/wiki/Q176366","display_name":"Patch clamp","level":3,"score":0.23512521386146545},{"id":"https://openalex.org/C83743174","wikidata":"https://www.wikidata.org/wiki/Q423778","display_name":"Potassium channel","level":2,"score":0.20234465599060059},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.12304890155792236},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.09588691592216492},{"id":"https://openalex.org/C119599485","wikidata":"https://www.wikidata.org/wiki/Q43035","display_name":"Electrical engineering","level":1,"score":0.0},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000200","descriptor_name":"Action Potentials","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D000631","descriptor_name":"Aminopyridines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006329","descriptor_name":"Heart Conduction System","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D009467","descriptor_name":"Neuromuscular Depolarizing Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D011188","descriptor_name":"Potassium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011690","descriptor_name":"Purkinje Fibers","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D011690","descriptor_name":"Purkinje Fibers","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D012756","descriptor_name":"Sheep","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015761","descriptor_name":"4-Aminopyridine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1007/bf00589097","doi":"https://doi.org/10.1007/bf00589097","is_oa":false,"landing_page_url":"https://doi.org/10.1007/bf00589097","pdf_url":null,"source":{"id":"https://openalex.org/S203465302","display_name":"Pfl\u00fcgers Archiv - European Journal of Physiology","issn_l":"0031-6768","issn":["0031-6768","0365-267X","1432-2013"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pfl\u00fcgers Archiv","raw_type":"journal-article"},{"id":"pmid:7145603","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7145603","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pflugers Archiv : European journal of physiology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.5683000087738037,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":50,"referenced_works":["https://openalex.org/W634463560","https://openalex.org/W1608320903","https://openalex.org/W1833860015","https://openalex.org/W1920702481","https://openalex.org/W1966814916","https://openalex.org/W1968710751","https://openalex.org/W1972720169","https://openalex.org/W1974222702","https://openalex.org/W1974424266","https://openalex.org/W1974842872","https://openalex.org/W1979690457","https://openalex.org/W1981582879","https://openalex.org/W1984623782","https://openalex.org/W1985380946","https://openalex.org/W1986459950","https://openalex.org/W1998497067","https://openalex.org/W2000152950","https://openalex.org/W2001968244","https://openalex.org/W2003671283","https://openalex.org/W2007496475","https://openalex.org/W2008648729","https://openalex.org/W2016115444","https://openalex.org/W2020927690","https://openalex.org/W2027449317","https://openalex.org/W2032820088","https://openalex.org/W2034223710","https://openalex.org/W2040951237","https://openalex.org/W2041491402","https://openalex.org/W2045376669","https://openalex.org/W2048434382","https://openalex.org/W2063873117","https://openalex.org/W2085982621","https://openalex.org/W2089280756","https://openalex.org/W2095548487","https://openalex.org/W2115583482","https://openalex.org/W2119072221","https://openalex.org/W2137067311","https://openalex.org/W2141056714","https://openalex.org/W2151622659","https://openalex.org/W2152224256","https://openalex.org/W2155099992","https://openalex.org/W2205496930","https://openalex.org/W2234826772","https://openalex.org/W2396956452","https://openalex.org/W2399215793","https://openalex.org/W2403168987","https://openalex.org/W2405199379","https://openalex.org/W2414333700","https://openalex.org/W2432871598","https://openalex.org/W4289964149"],"related_works":["https://openalex.org/W202411505","https://openalex.org/W1979954740","https://openalex.org/W2137067311","https://openalex.org/W2010317434","https://openalex.org/W2136235912","https://openalex.org/W6981360912","https://openalex.org/W2071948316","https://openalex.org/W2154505281","https://openalex.org/W2063873117","https://openalex.org/W2040560309"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2018,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}