{"id":"https://openalex.org/W2063045388","doi":"https://doi.org/10.1002/art.1780270405","title":"In Vivo and in Vitro Stimulation of Chondrocyte Biosynthetic Activity in Early Experimental Osteoarthritis","display_name":"In Vivo and in Vitro Stimulation of Chondrocyte Biosynthetic Activity in Early Experimental Osteoarthritis","publication_year":1984,"publication_date":"1984-04-01","ids":{"openalex":"https://openalex.org/W2063045388","doi":"https://doi.org/10.1002/art.1780270405","mag":"2063045388","pmid":"https://pubmed.ncbi.nlm.nih.gov/6712755"},"language":"en","primary_location":{"id":"doi:10.1002/art.1780270405","doi":"https://doi.org/10.1002/art.1780270405","is_oa":false,"landing_page_url":"https://doi.org/10.1002/art.1780270405","pdf_url":null,"source":{"id":"https://openalex.org/S132787887","display_name":"Arthritis & Rheumatism","issn_l":"0004-3591","issn":["0004-3591","1529-0131"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arthritis & Rheumatism","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5091178052","display_name":"John D. Sandy","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405264228","display_name":"Kennedy Institute of Rheumatology","ror":"https://ror.org/01ahsqc77","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149","https://openalex.org/I4405264228"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"John D. Sandy","raw_affiliation_strings":["Division of Biochemistry, Kennedy Institute of Rheumatology, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Biochemistry, Kennedy Institute of Rheumatology, London, UK","institution_ids":["https://openalex.org/I4405264228"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014431860","display_name":"Mark E. Adams","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405264228","display_name":"Kennedy Institute of Rheumatology","ror":"https://ror.org/01ahsqc77","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149","https://openalex.org/I4405264228"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Mark E. Adams","raw_affiliation_strings":["Division of Biochemistry, Kennedy Institute of Rheumatology, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Biochemistry, Kennedy Institute of Rheumatology, London, UK","institution_ids":["https://openalex.org/I4405264228"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108685826","display_name":"Michael E. J. Billingham","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405264228","display_name":"Kennedy Institute of Rheumatology","ror":"https://ror.org/01ahsqc77","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149","https://openalex.org/I4405264228"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Michael E. J. Billingham","raw_affiliation_strings":["Division of Biochemistry, Kennedy Institute of Rheumatology, London, UK","Pharmaceuticals Division, Imperial Chemical Industries Ltd., Alderley Park, Cheshire, UK; Anna Plaas, PhD: Research Fellow, Kennedy Institute","Anna Plaas, PhD: Research Fellow, Kennedy Institute","Pharmaceuticals Division, Imperial Chemical Industries Ltd., Alderley Park, Cheshire, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Biochemistry, Kennedy Institute of Rheumatology, London, UK","institution_ids":["https://openalex.org/I4405264228"]},{"raw_affiliation_string":"Pharmaceuticals Division, Imperial Chemical Industries Ltd., Alderley Park, Cheshire, UK; Anna Plaas, PhD: Research Fellow, Kennedy Institute","institution_ids":[]},{"raw_affiliation_string":"Anna Plaas, PhD: Research Fellow, Kennedy Institute","institution_ids":["https://openalex.org/I4405264228"]},{"raw_affiliation_string":"Pharmaceuticals Division, Imperial Chemical Industries Ltd., Alderley Park, Cheshire, UK","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066676304","display_name":"Anna Plaas","orcid":"https://orcid.org/0000-0001-5205-0892","observed_orcids":["https://orcid.org/0000-0001-5205-0892"]},"institutions":[{"id":"https://openalex.org/I4405264228","display_name":"Kennedy Institute of Rheumatology","ror":"https://ror.org/01ahsqc77","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149","https://openalex.org/I4405264228"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Anna Plaas","raw_affiliation_strings":["Division of Biochemistry, Kennedy Institute of Rheumatology, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Biochemistry, Kennedy Institute of Rheumatology, London, UK","institution_ids":["https://openalex.org/I4405264228"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111405860","display_name":"Helen Muir","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405264228","display_name":"Kennedy Institute of Rheumatology","ror":"https://ror.org/01ahsqc77","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149","https://openalex.org/I4405264228"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Helen Muir","raw_affiliation_strings":["Division of Biochemistry, Kennedy Institute of Rheumatology, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Biochemistry, Kennedy Institute of Rheumatology, London, UK","institution_ids":["https://openalex.org/I4405264228"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5091178052"],"corresponding_institution_ids":["https://openalex.org/I4405264228"],"apc_list":null,"apc_paid":null,"fwci":4.4009,"has_fulltext":false,"cited_by_count":172,"citation_normalized_percentile":{"value":0.94194402,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"27","issue":"4","first_page":"388","last_page":"397"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10105","display_name":"Osteoarthritis Treatment and Mechanisms","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10105","display_name":"Osteoarthritis Treatment and Mechanisms","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11131","display_name":"Proteoglycans and glycosaminoglycans research","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10442","display_name":"Knee injuries and reconstruction techniques","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/osteoarthritis","display_name":"osteoarthritis","score":0.906000018119812},{"id":"https://openalex.org/keywords/proteoglycan-synthesis","display_name":"proteoglycan synthesis","score":0.9980000257492065},{"id":"https://openalex.org/keywords/articular-cartilage","display_name":"articular cartilage","score":0.9010000228881836},{"id":"https://openalex.org/keywords/meniscus","display_name":"meniscus","score":0.8769999742507935},{"id":"https://openalex.org/keywords/anterior-cruciate-ligament-transection","display_name":"anterior cruciate ligament transection","score":0.9259999990463257},{"id":"https://openalex.org/keywords/knee-joint","display_name":"knee joint","score":0.3880000114440918},{"id":"https://openalex.org/keywords/mechanical-stimulation","display_name":"mechanical stimulation","score":0.7179999947547913},{"id":"https://openalex.org/keywords/humoral-factors","display_name":"humoral factors","score":0.8700000047683716},{"id":"https://openalex.org/keywords/cartilage-repair","display_name":"cartilage repair","score":0.5},{"id":"https://openalex.org/keywords/beagle-dog-model","display_name":"beagle dog model","score":0.5289999842643738}],"concepts":[{"id":"https://openalex.org/C2780550940","wikidata":"https://www.wikidata.org/wiki/Q502730","display_name":"Cartilage","level":2,"score":0.7333351373672485},{"id":"https://openalex.org/C2776164576","wikidata":"https://www.wikidata.org/wiki/Q62736","display_name":"Osteoarthritis","level":3,"score":0.7135007977485657},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.6893895268440247},{"id":"https://openalex.org/C2779335624","wikidata":"https://www.wikidata.org/wiki/Q407976","display_name":"Proteoglycan","level":3,"score":0.6682465076446533},{"id":"https://openalex.org/C189178095","wikidata":"https://www.wikidata.org/wiki/Q15834833","display_name":"Meniscus","level":3,"score":0.6680606603622437},{"id":"https://openalex.org/C24998067","wikidata":"https://www.wikidata.org/wiki/Q4114622","display_name":"Stimulation","level":2,"score":0.6577864289283752},{"id":"https://openalex.org/C2781403057","wikidata":"https://www.wikidata.org/wiki/Q775480","display_name":"Chondrocyte","level":3,"score":0.6118395924568176},{"id":"https://openalex.org/C2780423099","wikidata":"https://www.wikidata.org/wiki/Q6806071","display_name":"Medial meniscus","level":4,"score":0.5950952768325806},{"id":"https://openalex.org/C2778434673","wikidata":"https://www.wikidata.org/wiki/Q611127","display_name":"Anterior cruciate ligament","level":2,"score":0.5918340682983398},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.5558677911758423},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.5257312059402466},{"id":"https://openalex.org/C3020332539","wikidata":"https://www.wikidata.org/wiki/Q2014564","display_name":"Articular cartilage","level":4,"score":0.5109683275222778},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.45316141843795776},{"id":"https://openalex.org/C2781304689","wikidata":"https://www.wikidata.org/wiki/Q6495635","display_name":"Lateral meniscus","level":3,"score":0.4398890435695648},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.381695032119751},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2507658004760742},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.24835950136184692},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2296479046344757},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.08053350448608398},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.0},{"id":"https://openalex.org/C61511704","wikidata":"https://www.wikidata.org/wiki/Q1671857","display_name":"Incidence (geometry)","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002358","descriptor_name":"Cartilage, Articular","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002358","descriptor_name":"Cartilage, Articular","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D004285","descriptor_name":"Dogs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006025","descriptor_name":"Glycosaminoglycans","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D006603","descriptor_name":"Hexuronic Acids","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D010003","descriptor_name":"Osteoarthritis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010003","descriptor_name":"Osteoarthritis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D011509","descriptor_name":"Proteoglycans","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1002/art.1780270405","doi":"https://doi.org/10.1002/art.1780270405","is_oa":false,"landing_page_url":"https://doi.org/10.1002/art.1780270405","pdf_url":null,"source":{"id":"https://openalex.org/S132787887","display_name":"Arthritis & Rheumatism","issn_l":"0004-3591","issn":["0004-3591","1529-0131"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arthritis & Rheumatism","raw_type":"journal-article"},{"id":"pmid:6712755","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6712755","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arthritis and rheumatism","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8048999905586243}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":31,"referenced_works":["https://openalex.org/W5395365","https://openalex.org/W15887737","https://openalex.org/W41470836","https://openalex.org/W1265146923","https://openalex.org/W1596577347","https://openalex.org/W1656955268","https://openalex.org/W1801949341","https://openalex.org/W1965821379","https://openalex.org/W1967291382","https://openalex.org/W1969221593","https://openalex.org/W1974624312","https://openalex.org/W1980248641","https://openalex.org/W1995634013","https://openalex.org/W1999652145","https://openalex.org/W2011704293","https://openalex.org/W2028730779","https://openalex.org/W2052188292","https://openalex.org/W2059029818","https://openalex.org/W2080548572","https://openalex.org/W2084267570","https://openalex.org/W2089820063","https://openalex.org/W2101302324","https://openalex.org/W2115041793","https://openalex.org/W2120840387","https://openalex.org/W2270639279","https://openalex.org/W2309357188","https://openalex.org/W2342903910","https://openalex.org/W2399736458","https://openalex.org/W2461875665","https://openalex.org/W2482794061","https://openalex.org/W4292542165"],"related_works":["https://openalex.org/W2030660996","https://openalex.org/W2517365089","https://openalex.org/W1996381947","https://openalex.org/W2591917248","https://openalex.org/W2626707897","https://openalex.org/W2287928432","https://openalex.org/W4232961663","https://openalex.org/W2408770939","https://openalex.org/W2113536495","https://openalex.org/W2110700170"],"abstract_inverted_index":{"The":[0,26,69,108,178],"biosynthesis":[1],"of":[2,10,14,23,28,45,101,110,159,169,180],"proteoglycans":[3],"in":[4,19,35,59,67,104,114,131,138,142,145,163,184,186,211],"the":[5,11,20,46,76,80,85,91,99,105,164,170,175],"menisci":[6],"and":[7,40,62,79,119,134,151,166,173,190],"articular":[8,60,132,171],"cartilages":[9,61,133,187],"knee":[12],"(stifle)":[13],"mature":[15],"beagles":[16],"was":[17,50,72,87,124,147,195],"studied":[18],"early":[21],"stages":[22],"experimental":[24],"osteoarthritis.":[25],"rate":[27,109,179],"proteoglycan":[29,111,181],"synthesis,":[30],"determined":[31,113,183],"by":[32,149],"systemic":[33],"labeling":[34],"vivo":[36],"at":[37,116],"21,":[38],"42,":[39],"84":[41],"days":[42,121],"after":[43,122],"sectioning":[44],"anterior":[47],"cruciate":[48],"ligament,":[49],"generally":[51],"found":[52],"to":[53,153,156,199],"be":[54,154],"1.5-2.5-fold":[55],"higher":[56,64,128,137],"than":[57,65,75,90,129],"control":[58,66,130],"3-10-fold":[63],"menisci.":[68,139],"medial":[70,81],"meniscus":[71,86],"more":[73,88],"stimulated":[74,89],"lateral":[77],"meniscus,":[78],"tibial":[82,93],"plateau":[83],"under":[84],"adjacent":[92],"area.":[94],"This":[95,140],"area-specific":[96],"stimulation":[97,158],"suggests":[98],"involvement":[100],"mechanical":[102,207],"factors":[103,208],"cellular":[106],"response.":[107],"synthesis":[112,182],"vitro":[115,146,185],"7,":[117],"14,":[118],"21":[120],"operation":[123],"also":[125,196],"about":[126,135],"2-fold":[127],"3-fold":[136],"increase":[141],"biosynthetic":[143],"activity":[144],"confirmed":[148],"35S-autoradiography":[150],"appeared":[152],"due":[155],"general":[157],"existing":[160],"chondrocytes,":[161],"particularly":[162],"middle":[165],"deep":[167],"zones":[168],"cartilage":[172],"throughout":[174],"meniscal":[176],"cartilage.":[177],"from":[188],"2-week":[189],"3-week":[191],"sham":[192],"operated":[193],"joints":[194],"increased":[197],"relative":[198],"controls,":[200],"suggesting":[201],"that":[202],"humoral":[203],"as":[204,206],"well":[205],"are":[209],"involved":[210],"stimulating":[212],"chondrocyte":[213],"activity.":[214]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}