{"id":"https://openalex.org/W2063045317","doi":"https://doi.org/10.1097/wad.0b013e3181c53d0d","title":"Serum Nitrosative Stress Levels Are Increased in Alzheimer Disease but Not in Vascular Dementia","display_name":"Serum Nitrosative Stress Levels Are Increased in Alzheimer Disease but Not in Vascular Dementia","publication_year":2010,"publication_date":"2010-04-01","ids":{"openalex":"https://openalex.org/W2063045317","doi":"https://doi.org/10.1097/wad.0b013e3181c53d0d","mag":"2063045317","pmid":"https://pubmed.ncbi.nlm.nih.gov/20505437"},"language":"en","primary_location":{"id":"doi:10.1097/wad.0b013e3181c53d0d","doi":"https://doi.org/10.1097/wad.0b013e3181c53d0d","is_oa":false,"landing_page_url":"https://doi.org/10.1097/wad.0b013e3181c53d0d","pdf_url":null,"source":{"id":"https://openalex.org/S107889856","display_name":"Alzheimer Disease & Associated Disorders","issn_l":"0893-0341","issn":["0893-0341","1546-4156"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alzheimer Disease &amp; Associated Disorders","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5010045620","display_name":"Dildar Konuko\u011flu","orcid":"https://orcid.org/0000-0002-6095-264X","observed_orcids":["https://orcid.org/0000-0002-6095-264X"]},"institutions":[{"id":"https://openalex.org/I4210112471","display_name":"Istanbul University-Cerrahpa\u015fa","ror":"https://ror.org/01dzn5f42","country_code":"TR","type":"education","lineage":["https://openalex.org/I4210112471"]},{"id":"https://openalex.org/I67581229","display_name":"Istanbul University","ror":"https://ror.org/03a5qrr21","country_code":"TR","type":"education","lineage":["https://openalex.org/I67581229"]}],"countries":["TR"],"is_corresponding":true,"raw_author_name":"Konuko\u011flu Dildar","raw_affiliation_strings":["Department of Biochemistry, Cerrahpa\u015fa Medical Faculty, Istanbul University, Istanbul, Turkey. dkonuk@istanbul.edu.tr","Biochemistry"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Cerrahpa\u015fa Medical Faculty, Istanbul University, Istanbul, Turkey. dkonuk@istanbul.edu.tr","institution_ids":["https://openalex.org/I4210112471","https://openalex.org/I67581229"]},{"raw_affiliation_string":"Biochemistry","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102874263","display_name":"Sinem F\u0131rt\u0131na","orcid":"https://orcid.org/0000-0002-8766-7283","observed_orcids":["https://orcid.org/0000-0002-8766-7283"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Firtina Sinem","raw_affiliation_strings":["Biochemistry"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biochemistry","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055008603","display_name":"G\u00f6khan Erkol","orcid":"https://orcid.org/0000-0002-1855-4031","observed_orcids":["https://orcid.org/0000-0002-1855-4031"]},"institutions":[{"id":"https://openalex.org/I4210112471","display_name":"Istanbul University-Cerrahpa\u015fa","ror":"https://ror.org/01dzn5f42","country_code":"TR","type":"education","lineage":["https://openalex.org/I4210112471"]},{"id":"https://openalex.org/I67581229","display_name":"Istanbul University","ror":"https://ror.org/03a5qrr21","country_code":"TR","type":"education","lineage":["https://openalex.org/I67581229"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Erkol G\u00f6khan","raw_affiliation_strings":["Neurology, Cerrahpa\u015fa Medical Faculty, Istanbul University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neurology, Cerrahpa\u015fa Medical Faculty, Istanbul University","institution_ids":["https://openalex.org/I4210112471","https://openalex.org/I67581229"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048212514","display_name":"Orhan Ya\u011f\u0131z","orcid":"https://orcid.org/0000-0003-3573-8040","observed_orcids":["https://orcid.org/0000-0003-3573-8040"]},"institutions":[{"id":"https://openalex.org/I4210092766","display_name":"\u0130stanbul E\u011fitim ve Ara\u015ft\u0131rma Hastanesi","ror":"https://ror.org/00nwc4v84","country_code":"TR","type":"healthcare","lineage":["https://openalex.org/I4210092766"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Ya\u011fiz Orhan","raw_affiliation_strings":["Department of Neurology, Istanbul Education and Research Hospital, \u0130stanbul, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Istanbul Education and Research Hospital, \u0130stanbul, Turkey","institution_ids":["https://openalex.org/I4210092766"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5013086500","display_name":"Filiz Manga G\u00fcnayd\u0131n","orcid":"https://orcid.org/0000-0001-8115-4447","observed_orcids":["https://orcid.org/0000-0001-8115-4447"]},"institutions":[{"id":"https://openalex.org/I4210092766","display_name":"\u0130stanbul E\u011fitim ve Ara\u015ft\u0131rma Hastanesi","ror":"https://ror.org/00nwc4v84","country_code":"TR","type":"healthcare","lineage":["https://openalex.org/I4210092766"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Manga Filiz","raw_affiliation_strings":["Department of Neurology, Istanbul Education and Research Hospital, \u0130stanbul, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Istanbul Education and Research Hospital, \u0130stanbul, Turkey","institution_ids":["https://openalex.org/I4210092766"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5010045620","https://openalex.org/A5102874263"],"corresponding_institution_ids":["https://openalex.org/I4210112471","https://openalex.org/I67581229"],"apc_list":null,"apc_paid":null,"fwci":1.5348,"has_fulltext":false,"cited_by_count":27,"citation_normalized_percentile":{"value":0.81427179,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":98},"biblio":{"volume":"24","issue":"2","first_page":"194","last_page":"197"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.8769999742507935,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.8769999742507935,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.08869999647140503,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.011800000444054604,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.9449999928474426},{"id":"https://openalex.org/keywords/vascular-dementia","display_name":"vascular dementia","score":0.9980000257492065},{"id":"https://openalex.org/keywords/nitrosative-stress","display_name":"nitrosative stress","score":0.9940000176429749},{"id":"https://openalex.org/keywords/nitric-oxide","display_name":"nitric oxide","score":0.949999988079071},{"id":"https://openalex.org/keywords/oxidized-ldl","display_name":"oxidized LDL","score":0.9390000104904175},{"id":"https://openalex.org/keywords/3-nitrotyrosine","display_name":"nitrotyrosine","score":0.996999979019165},{"id":"https://openalex.org/keywords/serum-biomarkers","display_name":"serum biomarkers","score":0.8230000138282776},{"id":"https://openalex.org/keywords/cognitive-impairment","display_name":"cognitive impairment","score":0.8569999933242798},{"id":"https://openalex.org/keywords/mini-mental-state-examination","display_name":"Mini-Mental State Examination","score":0.9229999780654907}],"concepts":[{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.806226909160614},{"id":"https://openalex.org/C2779483572","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Dementia","level":3,"score":0.7423108220100403},{"id":"https://openalex.org/C2777952318","wikidata":"https://www.wikidata.org/wiki/Q583908","display_name":"Vascular dementia","level":4,"score":0.7380596399307251},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.6067610383033752},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5436621308326721},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5001504421234131},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.44604742527008057},{"id":"https://openalex.org/C2777466421","wikidata":"https://www.wikidata.org/wiki/Q1266890","display_name":"Vascular disease","level":2,"score":0.43925681710243225},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.381421834230423}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008077","descriptor_name":"Lipoproteins, LDL","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009483","descriptor_name":"Neuropsychological Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009569","descriptor_name":"Nitric Oxide","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D009603","descriptor_name":"Nitroso Compounds","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D014443","descriptor_name":"Tyrosine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D014443","descriptor_name":"Tyrosine","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D015140","descriptor_name":"Dementia, Vascular","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1097/wad.0b013e3181c53d0d","doi":"https://doi.org/10.1097/wad.0b013e3181c53d0d","is_oa":false,"landing_page_url":"https://doi.org/10.1097/wad.0b013e3181c53d0d","pdf_url":null,"source":{"id":"https://openalex.org/S107889856","display_name":"Alzheimer Disease & Associated Disorders","issn_l":"0893-0341","issn":["0893-0341","1546-4156"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alzheimer Disease &amp; Associated Disorders","raw_type":"journal-article"},{"id":"pmid:20505437","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20505437","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alzheimer disease and associated disorders","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9922999739646912}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":40,"referenced_works":["https://openalex.org/W1472536133","https://openalex.org/W1508140332","https://openalex.org/W1562946553","https://openalex.org/W1573348274","https://openalex.org/W1662308449","https://openalex.org/W1847168837","https://openalex.org/W1976159963","https://openalex.org/W1979243823","https://openalex.org/W1988359488","https://openalex.org/W1989611868","https://openalex.org/W1989927249","https://openalex.org/W1990046751","https://openalex.org/W1993993136","https://openalex.org/W1999589434","https://openalex.org/W2003631236","https://openalex.org/W2003833794","https://openalex.org/W2008273403","https://openalex.org/W2012388298","https://openalex.org/W2013367070","https://openalex.org/W2015372700","https://openalex.org/W2026241376","https://openalex.org/W2032575260","https://openalex.org/W2039628403","https://openalex.org/W2055249962","https://openalex.org/W2062340282","https://openalex.org/W2077768879","https://openalex.org/W2079248334","https://openalex.org/W2084970815","https://openalex.org/W2104204371","https://openalex.org/W2111001050","https://openalex.org/W2112150247","https://openalex.org/W2127590581","https://openalex.org/W2128987869","https://openalex.org/W2138215031","https://openalex.org/W2140857653","https://openalex.org/W2148643206","https://openalex.org/W2153855592","https://openalex.org/W2156220037","https://openalex.org/W2179702494","https://openalex.org/W2467275024"],"related_works":["https://openalex.org/W1976159963","https://openalex.org/W2330917979","https://openalex.org/W2011808912","https://openalex.org/W2343571661","https://openalex.org/W2055146338","https://openalex.org/W2038330398","https://openalex.org/W2077768879","https://openalex.org/W3181402691","https://openalex.org/W2365613061","https://openalex.org/W2071695216"],"abstract_inverted_index":{"The":[0],"aim":[1],"of":[2,127,173],"this":[3,187],"study":[4,117],"was":[5,135,175],"to":[6,25,189,192],"investigate":[7],"whether":[8],"there":[9],"is":[10],"a":[11,136],"difference":[12],"between":[13,112,140],"Alzheimer":[14],"disease":[15],"(AD)":[16],"dementia":[17,21,128,150],"and":[18,39,58,77,92,94,98,107,114,145,186,196],"pure":[19],"vascular":[20],"(VaD)":[22],"in":[23,43,80,88,104,123,149,170,177,183],"relation":[24],"nitrosative":[26],"stress":[27],"levels.":[28],"We":[29],"determined":[30],"serum":[31,75,146,162,171],"nitric":[32],"oxide":[33],"(NO),":[34],"oxidized":[35],"low-density":[36],"lipoproteins":[37],"(ox-LDL),":[38],"3-nitrotyrosine":[40],"levels":[41,79,109,148,156,164,172,195],"(3-NT)":[42],"healthy":[44],"elderly":[45],"individuals":[46],"(controls,":[47],"n=15,":[48],"mean":[49,55,62],"age=73.4+/-7.9":[50],"y),":[51],"AD":[52,81,179],"patients":[53,60,82,96,129,151,180],"(n=30;":[54],"age=71.2+/-12.7":[56],"y)":[57],"VaD":[59,95,113,184],"(n=20;":[61],"age=75.2+/-7.5":[63],"y).":[64],"Patients":[65],"were":[66,84,110,157],"under":[67],"anticholinesterase":[68],"drug":[69],"therapy.":[70],"Our":[71,116],"results":[72],"showed":[73],"that":[74],"NO":[76,106,147,155,174],"ox-LDL":[78,108,163,194],"group":[83],"significantly":[85],"higher":[86],"than":[87],"both":[89,193],"controls":[90],"(P<0.001":[91],"P<0.001)":[93],"(P<0.01":[97],"P<0.001).":[99],"However,":[100],"no":[101],"significant":[102,121,137],"differences":[103,122],"plasma":[105,124],"found":[111],"controls.":[115,133],"did":[118],"not":[119,182],"reveal":[120],"3-NT":[125],"values":[126],"when":[130],"compared":[131],"with":[132,161],"There":[134],"negative":[138],"correlation":[139],"Mini-Mental":[141],"State":[142],"Examination":[143],"score":[144],"(r=-0.349,":[152],"P<0.01).":[153,166],"Serum":[154],"also":[158],"positively":[159],"correlated":[160],"(r=0.358,":[165],"In":[167],"conclusion,":[168],"elevation":[169],"present":[176],"probable":[178],"but":[181],"patients,":[185],"seems":[188],"be":[190],"related":[191],"cognitive":[197],"status.":[198]},"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2016-06-24T00:00:00"}