{"id":"https://openalex.org/W2063040824","doi":"https://doi.org/10.3109/07853899708999360","title":"Childhood Cancer and Later Development of the Metabolic Syndrome","display_name":"Childhood Cancer and Later Development of the Metabolic Syndrome","publication_year":1997,"publication_date":"1997-01-01","ids":{"openalex":"https://openalex.org/W2063040824","doi":"https://doi.org/10.3109/07853899708999360","mag":"2063040824","pmid":"https://pubmed.ncbi.nlm.nih.gov/9453278"},"language":"en","primary_location":{"id":"doi:10.3109/07853899708999360","doi":"https://doi.org/10.3109/07853899708999360","is_oa":true,"landing_page_url":"https://doi.org/10.3109/07853899708999360","pdf_url":"https://www.tandfonline.com/doi/pdf/10.3109/07853899708999360?needAccess=true","source":{"id":"https://openalex.org/S203391715","display_name":"Annals of Medicine","issn_l":"0785-3890","issn":["0785-3890","1365-2060"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","doyens","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320449","host_organization_name":"Informa","host_organization_lineage":["https://openalex.org/P4310320449"],"host_organization_lineage_names":["Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Medicine","raw_type":"journal-article"},"volume":null,"type":"editorial","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.tandfonline.com/doi/pdf/10.3109/07853899708999360?needAccess=true","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112154803","display_name":"Kimmo K. Talvensaari","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I98381234","display_name":"University of Oulu","ror":"https://ror.org/03yj89h83","country_code":"FI","type":"education","lineage":["https://openalex.org/I98381234"]}],"countries":["FI"],"is_corresponding":true,"raw_author_name":"Kimmo Talvensaari","raw_affiliation_strings":["Department of Pediatrics, University of Oulu, Oulu, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, University of Oulu, Oulu, Finland","institution_ids":["https://openalex.org/I98381234"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5000141478","display_name":"Mikael Knip","orcid":"https://orcid.org/0000-0003-0474-0033","observed_orcids":["https://orcid.org/0000-0003-0474-0033"]},"institutions":[{"id":"https://openalex.org/I4210126318","display_name":"Tampere University Hospital","ror":"https://ror.org/02hvt5f17","country_code":"FI","type":"healthcare","lineage":["https://openalex.org/I4210126318"]},{"id":"https://openalex.org/I4387153886","display_name":"University of Tampere","ror":"https://ror.org/05p6qqk79","country_code":"FI","type":"education","lineage":["https://openalex.org/I166825849","https://openalex.org/I4387153886"]},{"id":"https://openalex.org/I98381234","display_name":"University of Oulu","ror":"https://ror.org/03yj89h83","country_code":"FI","type":"education","lineage":["https://openalex.org/I98381234"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Mikael Knip","raw_affiliation_strings":["Department of Pediatrics, University of Oulu, Oulu, Finland; Medical School, University of Tampere and Department of Pediatrics, Tampere University Hospital, Tampere, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, University of Oulu, Oulu, Finland; Medical School, University of Tampere and Department of Pediatrics, Tampere University Hospital, Tampere, Finland","institution_ids":["https://openalex.org/I4210126318","https://openalex.org/I4387153886","https://openalex.org/I98381234"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5112154803"],"corresponding_institution_ids":["https://openalex.org/I98381234"],"apc_list":{"value":2085,"currency":"GBP","value_usd":2557},"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":39,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"29","issue":"5","first_page":"353","last_page":"355"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10748","display_name":"Growth Hormone and Insulin-like Growth Factors","score":0.7559000253677368,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10748","display_name":"Growth Hormone and Insulin-like Growth Factors","score":0.7559000253677368,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11141","display_name":"Childhood Cancer Survivors' Quality of Life","score":0.19339999556541443,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10832","display_name":"Pituitary Gland Disorders and Treatments","score":0.006300000008195639,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pediatric-cancer-survivors","display_name":"childhood cancer survivors","score":0.9010000228881836},{"id":"https://openalex.org/keywords/metabolic-syndrome","display_name":"metabolic syndrome","score":0.9539999961853027},{"id":"https://openalex.org/keywords/growth-hormone-deficiency","display_name":"growth hormone deficiency","score":0.9950000047683716},{"id":"https://openalex.org/keywords/cranial-irradiation","display_name":"cranial irradiation","score":0.9359999895095825},{"id":"https://openalex.org/keywords/obesity","display_name":"obesity","score":0.7760000228881836},{"id":"https://openalex.org/keywords/hyperinsulinemia","display_name":"hyperinsulinemia","score":0.9020000100135803},{"id":"https://openalex.org/keywords/insulin-resistance","display_name":"insulin resistance","score":0.906000018119812},{"id":"https://openalex.org/keywords/impaired-glucose-tolerance","display_name":"impaired glucose tolerance","score":0.9430000185966492},{"id":"https://openalex.org/keywords/lipid-profile","display_name":"lipid profile","score":0.5059999823570251},{"id":"https://openalex.org/keywords/hdl-cholesterol","display_name":"HDL cholesterol","score":0.7860000133514404},{"id":"https://openalex.org/keywords/cardiovascular-risk","display_name":"cardiovascular risk","score":0.8360000252723694},{"id":"https://openalex.org/keywords/hypothalamic-pituitary-axis","display_name":"hypothalamic-pituitary axis","score":0.9049999713897705}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7651643753051758},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7231760025024414},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6730136871337891},{"id":"https://openalex.org/C2780578515","wikidata":"https://www.wikidata.org/wiki/Q657193","display_name":"Metabolic syndrome","level":3,"score":0.6255911588668823},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.56951904296875},{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.552998960018158},{"id":"https://openalex.org/C511355011","wikidata":"https://www.wikidata.org/wiki/Q12174","display_name":"Obesity","level":2,"score":0.49413564801216125},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.4285888373851776}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006946","descriptor_name":"Hyperinsulinism","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D008055","descriptor_name":"Lipids","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D008659","descriptor_name":"Metabolic Diseases","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D013006","descriptor_name":"Growth Hormone","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false},{"descriptor_ui":"D013006","descriptor_name":"Growth Hormone","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.3109/07853899708999360","doi":"https://doi.org/10.3109/07853899708999360","is_oa":true,"landing_page_url":"https://doi.org/10.3109/07853899708999360","pdf_url":"https://www.tandfonline.com/doi/pdf/10.3109/07853899708999360?needAccess=true","source":{"id":"https://openalex.org/S203391715","display_name":"Annals of Medicine","issn_l":"0785-3890","issn":["0785-3890","1365-2060"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","doyens","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320449","host_organization_name":"Informa","host_organization_lineage":["https://openalex.org/P4310320449"],"host_organization_lineage_names":["Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Medicine","raw_type":"journal-article"},{"id":"pmid:9453278","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9453278","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of medicine","raw_type":"Editorial"}],"best_oa_location":{"id":"doi:10.3109/07853899708999360","doi":"https://doi.org/10.3109/07853899708999360","is_oa":true,"landing_page_url":"https://doi.org/10.3109/07853899708999360","pdf_url":"https://www.tandfonline.com/doi/pdf/10.3109/07853899708999360?needAccess=true","source":{"id":"https://openalex.org/S203391715","display_name":"Annals of Medicine","issn_l":"0785-3890","issn":["0785-3890","1365-2060"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","doyens","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320449","host_organization_name":"Informa","host_organization_lineage":["https://openalex.org/P4310320449"],"host_organization_lineage_names":["Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","score":0.8700000047683716,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2063040824.pdf","grobid_xml":"https://content.openalex.org/works/W2063040824.grobid-xml"},"referenced_works_count":10,"referenced_works":["https://openalex.org/W1984513597","https://openalex.org/W1990992726","https://openalex.org/W2006508776","https://openalex.org/W2018451075","https://openalex.org/W2028921257","https://openalex.org/W2045075152","https://openalex.org/W2053243825","https://openalex.org/W2058094497","https://openalex.org/W2074323061","https://openalex.org/W2092868590"],"related_works":["https://openalex.org/W2092868590","https://openalex.org/W2340989325","https://openalex.org/W3032502259","https://openalex.org/W2899036324","https://openalex.org/W2004708320","https://openalex.org/W2528640786","https://openalex.org/W2073850554","https://openalex.org/W2149393159","https://openalex.org/W1984860087","https://openalex.org/W2194429575"],"abstract_inverted_index":{"The":[0,162],"improving":[1],"survival":[2],"rate":[3],"of":[4,15,19,36,91,119,135,144,159,182,217,224,230,257],"patients":[5],"with":[6,66,80,164],"childhood":[7,136,225],"cancer":[8,37,226],"has":[9,61],"led":[10],"to":[11,70,227],"a":[12,85,89,117,166,215],"growing":[13],"awareness":[14],"the":[16,49,109,142,160,183,210,231,241,248],"long-term":[17,33,133,222,242],"effects":[18,35],"malignant":[20],"disease":[21,171],"and":[22,41,73,100,124,147,178,192,196,260],"its":[23],"treatment.":[24],"Various":[25],"endocrine":[26],"abnormalities":[27,99],"have":[28,236],"been":[29],"reported":[30],"as":[31,108,187,214,250],"frequent":[32],"adverse":[34],"treatment":[38],"in":[39,88,132,157,209,244,253],"childhood,":[40],"among":[42],"these":[43,245],"growth":[44],"hormone":[45],"(GH)":[46],"deficiency":[47,68],"is":[48,77,106],"most":[50],"common":[51],"one,":[52],"especially":[53],"after":[54],"cranial":[55,218],"irradiation.":[56],"Besides":[57],"promoting":[58],"growth,":[59],"GH":[60,67,176,202],"well-established":[62],"metabolic":[63,92,110,184,232],"effects.":[64],"Patients":[65],"tend":[69],"be":[71,130],"obese,":[72],"obesity":[74],"per":[75],"se":[76],"also":[78,179],"associated":[79],"insulin":[81],"resistance":[82],"which":[83],"plays":[84],"key":[86],"role":[87],"cluster":[90],"derangements":[93],"including":[94],"glucose":[95,121,195],"intolerance,":[96,122],"hypertension,":[97],"lipid":[98,127],"atherosclerotic":[101],"cardiovascular":[102,170,258],"disease.":[103],"This":[104,234],"condition":[105],"known":[107],"syndrome.":[111,233],"Our":[112],"recent":[113],"observations":[114],"indicate":[115],"that":[116],"combination":[118,153],"obesity,":[120,145],"hyperinsulinaemia":[123,146],"an":[125,237,254],"abnormal":[126],"profile":[128,168],"can":[129,235],"observed":[131],"survivors":[134,163,223],"cancer.":[137],"Every":[138],"sixth":[139],"patient":[140],"had":[141,172],"triad":[143],"low":[148],"HDL":[149],"cholesterol,":[150],"whereas":[151],"this":[152],"was":[154],"not":[155],"seen":[156],"any":[158],"controls.":[161],"such":[165,186,251],"high-risk":[167],"for":[169],"markedly":[173],"reduced":[174],"spontaneous":[175],"secretion,":[177,203],"additional":[180],"features":[181],"syndrome,":[185],"higher":[188,193],"systolic":[189],"blood":[190],"pressure":[191],"plasma":[194],"serum":[197],"triglyceride":[198],"levels.":[199],"Accordingly,":[200],"decreased":[201],"or":[204],"alternatively":[205],"some":[206],"other":[207],"disturbance":[208],"hypothalamic-pituitary":[211],"axis,":[212],"emerging":[213],"consequence":[216],"radiation,":[219],"may":[220],"expose":[221],"premature":[228],"evolution":[229],"important":[238],"impact":[239],"on":[240],"prognosis":[243],"patients,":[246],"because":[247],"syndrome":[249],"results":[252],"increased":[255],"risk":[256],"morbidity":[259],"mortality.":[261]},"counts_by_year":[{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2013,"cited_by_count":4}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}