{"id":"https://openalex.org/W2063024845","doi":"https://doi.org/10.1111/j.1749-6632.1996.tb17489.x","title":"Transport of Pituitary Adenylate Cyclase-Activating Polypeptide Across the Blood-Brain Barrier and the Prevention of Ischemia-Induced Death of Hippocampal Neurons","display_name":"Transport of Pituitary Adenylate Cyclase-Activating Polypeptide Across the Blood-Brain Barrier and the Prevention of Ischemia-Induced Death of Hippocampal Neurons","publication_year":2006,"publication_date":"2006-12-17","ids":{"openalex":"https://openalex.org/W2063024845","doi":"https://doi.org/10.1111/j.1749-6632.1996.tb17489.x","mag":"2063024845","pmid":"https://pubmed.ncbi.nlm.nih.gov/8993409"},"language":"en","primary_location":{"id":"doi:10.1111/j.1749-6632.1996.tb17489.x","doi":"https://doi.org/10.1111/j.1749-6632.1996.tb17489.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1749-6632.1996.tb17489.x","pdf_url":null,"source":{"id":"https://openalex.org/S8802318","display_name":"Annals of the New York Academy of Sciences","issn_l":"0077-8923","issn":["0077-8923","1749-6632"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of the New York Academy of Sciences","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5054959155","display_name":"William A. Banks","orcid":"https://orcid.org/0000-0002-0496-3619","observed_orcids":["https://orcid.org/0000-0002-0496-3619"]},"institutions":[{"id":"https://openalex.org/I114832834","display_name":"Tulane University","ror":"https://ror.org/04vmvtb21","country_code":"US","type":"education","lineage":["https://openalex.org/I114832834"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"WILLIAM A. BANKS","raw_affiliation_strings":["U.S.-Japan Biomedical Research Laboratories, Tulane University Hebert Center, Belle Chasse, Louisiana 70037, USA. bbbpts@mailhost.tcs.tulane.edu","Veterans Affairs Medical Center and Tulane University School of Medicine, New Orleans, Louisiana 70146"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"U.S.-Japan Biomedical Research Laboratories, Tulane University Hebert Center, Belle Chasse, Louisiana 70037, USA. bbbpts@mailhost.tcs.tulane.edu","institution_ids":["https://openalex.org/I114832834"]},{"raw_affiliation_string":"Veterans Affairs Medical Center and Tulane University School of Medicine, New Orleans, Louisiana 70146","institution_ids":["https://openalex.org/I114832834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110394829","display_name":"Daigaku Uchida","orcid":"https://orcid.org/0000-0001-9115-8089","observed_orcids":["https://orcid.org/0000-0001-9115-8089"]},"institutions":[{"id":"https://openalex.org/I114832834","display_name":"Tulane University","ror":"https://ror.org/04vmvtb21","country_code":"US","type":"education","lineage":["https://openalex.org/I114832834"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"DAIGAKU UCHIDA","raw_affiliation_strings":["U.S.-Japan Biomedical Research Laboratories, Tulane University Hebert Center, Belle Chasse, Louisiana 70037"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"U.S.-Japan Biomedical Research Laboratories, Tulane University Hebert Center, Belle Chasse, Louisiana 70037","institution_ids":["https://openalex.org/I114832834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078024136","display_name":"Akira Arimura","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114832834","display_name":"Tulane University","ror":"https://ror.org/04vmvtb21","country_code":"US","type":"education","lineage":["https://openalex.org/I114832834"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"AKIRA ARIMURA","raw_affiliation_strings":["U.S.-Japan Biomedical Research Laboratories, Tulane University Hebert Center, Belle Chasse, Louisiana 70037"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"U.S.-Japan Biomedical Research Laboratories, Tulane University Hebert Center, Belle Chasse, Louisiana 70037","institution_ids":["https://openalex.org/I114832834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102116739","display_name":"Anik\u00f3 Somogyv\u00e1ri-Vigh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114832834","display_name":"Tulane University","ror":"https://ror.org/04vmvtb21","country_code":"US","type":"education","lineage":["https://openalex.org/I114832834"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"ANIKO SOMOGYV\u00c1RI-VIGH","raw_affiliation_strings":["U.S.-Japan Biomedical Research Laboratories, Tulane University Hebert Center, Belle Chasse, Louisiana 70037"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"U.S.-Japan Biomedical Research Laboratories, Tulane University Hebert Center, Belle Chasse, Louisiana 70037","institution_ids":["https://openalex.org/I114832834"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5020196813","display_name":"Seiji Shioda","orcid":"https://orcid.org/0000-0002-4164-6743","observed_orcids":["https://orcid.org/0000-0002-4164-6743"]},"institutions":[{"id":"https://openalex.org/I114832834","display_name":"Tulane University","ror":"https://ror.org/04vmvtb21","country_code":"US","type":"education","lineage":["https://openalex.org/I114832834"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"SEIJI SHIODA","raw_affiliation_strings":["U.S.-Japan Biomedical Research Laboratories, Tulane University Hebert Center, Belle Chasse, Louisiana 70037"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"U.S.-Japan Biomedical Research Laboratories, Tulane University Hebert Center, Belle Chasse, Louisiana 70037","institution_ids":["https://openalex.org/I114832834"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5054959155"],"corresponding_institution_ids":["https://openalex.org/I114832834"],"apc_list":{"value":5080,"currency":"USD","value_usd":5080},"apc_paid":null,"fwci":0.6439,"has_fulltext":false,"cited_by_count":78,"citation_normalized_percentile":{"value":0.48689655,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"805","issue":"1","first_page":"270","last_page":"277"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.9746000170707703,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.9746000170707703,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11872","display_name":"Barrier Structure and Function Studies","score":0.009800000116229057,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13505","display_name":"Apelin-related biomedical research","score":0.00860000029206276,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pituitary-adenylate-cyclase-activating-polypeptide","display_name":"pituitary adenylate cyclase-activating polypeptide","score":0.9810000061988831},{"id":"https://openalex.org/keywords/pacap","display_name":"PACAP","score":0.9350000023841858},{"id":"https://openalex.org/keywords/blood-brain-barrier","display_name":"blood-brain barrier","score":0.8410000205039978},{"id":"https://openalex.org/keywords/peptide-transport","display_name":"peptide transport","score":0.8700000047683716},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.8119999766349792},{"id":"https://openalex.org/keywords/ischemic-neuronal-death","display_name":"ischemic neuronal death","score":0.7009999752044678},{"id":"https://openalex.org/keywords/ca1-pyramidal-neurons","display_name":"CA1 pyramidal neurons","score":0.8930000066757202},{"id":"https://openalex.org/keywords/stroke","display_name":"stroke","score":0.8059999942779541},{"id":"https://openalex.org/keywords/cardiac-arrest","display_name":"cardiac arrest","score":0.968999981880188},{"id":"https://openalex.org/keywords/hypotension","display_name":"hypotension","score":0.7059999704360962}],"concepts":[{"id":"https://openalex.org/C25498285","wikidata":"https://www.wikidata.org/wiki/Q1981368","display_name":"Neuroprotection","level":2,"score":0.9125688076019287},{"id":"https://openalex.org/C148762608","wikidata":"https://www.wikidata.org/wiki/Q3748185","display_name":"Hippocampal formation","level":2,"score":0.7960758209228516},{"id":"https://openalex.org/C541997718","wikidata":"https://www.wikidata.org/wiki/Q188151","display_name":"Ischemia","level":2,"score":0.6107459664344788},{"id":"https://openalex.org/C2781161787","wikidata":"https://www.wikidata.org/wiki/Q48360","display_name":"Hippocampus","level":2,"score":0.5584902167320251},{"id":"https://openalex.org/C180526460","wikidata":"https://www.wikidata.org/wiki/Q356240","display_name":"Adenylate kinase","level":3,"score":0.47113555669784546},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4678400754928589},{"id":"https://openalex.org/C92020748","wikidata":"https://www.wikidata.org/wiki/Q420457","display_name":"Neurotrophin","level":3,"score":0.4568087160587311},{"id":"https://openalex.org/C2778677841","wikidata":"https://www.wikidata.org/wiki/Q422301","display_name":"Secretin","level":3,"score":0.45322972536087036},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.44759705662727356},{"id":"https://openalex.org/C160539049","wikidata":"https://www.wikidata.org/wiki/Q3064187","display_name":"Neurotrophic factors","level":3,"score":0.43601831793785095},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.42806529998779297},{"id":"https://openalex.org/C8330315","wikidata":"https://www.wikidata.org/wiki/Q414964","display_name":"Vasoactive intestinal peptide","level":4,"score":0.42147788405418396},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.40595367550849915},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.356722354888916},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.3320853114128113},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.32471367716789246},{"id":"https://openalex.org/C118303440","wikidata":"https://www.wikidata.org/wiki/Q419968","display_name":"Neuropeptide","level":3,"score":0.3220648169517517},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.254024863243103},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.08515310287475586},{"id":"https://openalex.org/C49039625","wikidata":"https://www.wikidata.org/wiki/Q84230","display_name":"Secretion","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001812","descriptor_name":"Blood-Brain Barrier","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002546","descriptor_name":"Ischemic Attack, Transient","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002546","descriptor_name":"Ischemic Attack, Transient","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D009479","descriptor_name":"Neuropeptides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009479","descriptor_name":"Neuropeptides","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D009479","descriptor_name":"Neuropeptides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D016923","descriptor_name":"Cell Death","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D018377","descriptor_name":"Neurotransmitter Agents","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051219","descriptor_name":"Pituitary Adenylate Cyclase-Activating Polypeptide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1111/j.1749-6632.1996.tb17489.x","doi":"https://doi.org/10.1111/j.1749-6632.1996.tb17489.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1749-6632.1996.tb17489.x","pdf_url":null,"source":{"id":"https://openalex.org/S8802318","display_name":"Annals of the New York Academy of Sciences","issn_l":"0077-8923","issn":["0077-8923","1749-6632"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of the New York Academy of Sciences","raw_type":"journal-article"},{"id":"pmid:8993409","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8993409","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of the New York Academy of Sciences","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":49,"referenced_works":["https://openalex.org/W1527707083","https://openalex.org/W1550381156","https://openalex.org/W1598800837","https://openalex.org/W1626208403","https://openalex.org/W1886831098","https://openalex.org/W1907196977","https://openalex.org/W1907212729","https://openalex.org/W1967610405","https://openalex.org/W1968309695","https://openalex.org/W1974760551","https://openalex.org/W1976490782","https://openalex.org/W1979409628","https://openalex.org/W1980251089","https://openalex.org/W1981423842","https://openalex.org/W1996836354","https://openalex.org/W1997975361","https://openalex.org/W1998411920","https://openalex.org/W1998929064","https://openalex.org/W2000998644","https://openalex.org/W2004469687","https://openalex.org/W2006642654","https://openalex.org/W2009658745","https://openalex.org/W2018177128","https://openalex.org/W2026545417","https://openalex.org/W2028049923","https://openalex.org/W2028563627","https://openalex.org/W2033650768","https://openalex.org/W2043900443","https://openalex.org/W2047523044","https://openalex.org/W2051905481","https://openalex.org/W2060060795","https://openalex.org/W2065509231","https://openalex.org/W2071317058","https://openalex.org/W2080937879","https://openalex.org/W2081874091","https://openalex.org/W2088739429","https://openalex.org/W2092078486","https://openalex.org/W2093538032","https://openalex.org/W2095381691","https://openalex.org/W2118785340","https://openalex.org/W2135456335","https://openalex.org/W2136632189","https://openalex.org/W2162986335","https://openalex.org/W2254240946","https://openalex.org/W2280348805","https://openalex.org/W2333968613","https://openalex.org/W2403816027","https://openalex.org/W2417935474","https://openalex.org/W6639586655"],"related_works":["https://openalex.org/W2089822614","https://openalex.org/W36065637","https://openalex.org/W2040585119","https://openalex.org/W1194913466","https://openalex.org/W3030862618","https://openalex.org/W2044033043","https://openalex.org/W2343013641","https://openalex.org/W2901895844","https://openalex.org/W3027814383","https://openalex.org/W2181679876"],"abstract_inverted_index":{"PACAP":[0,25,40,77,92,109,123],"is":[1,41],"a":[2,30,36,84],"member":[3],"of":[4,8,35,55,66,76,100,108],"the":[5,27,44,52,56,60,73,80,98,106,116],"secretin/glucagon/VIP":[6],"family":[7],"peptides":[9],"and":[10,13,131],"demonstrates":[11],"neurotrophic":[12],"neuroprotective":[14,85,126],"effects":[15],"at":[16],"very":[17],"low":[18,74],"concentrations.":[19],"We":[20,58,89,119],"have":[21],"previously":[22],"shown":[23],"that":[24,62,91,121],"crosses":[26],"BBB":[28,45],"to":[29,50,71,82],"modest":[31,64],"degree":[32],"by":[33],"way":[34],"saturable":[37],"transport":[38,67],"system.":[39],"transported":[42],"across":[43],"as":[46],"an":[47],"intact":[48],"peptide":[49],"enter":[51],"parenchymal":[53],"space":[54],"brain.":[57],"tested":[59],"possibility":[61],"this":[63],"rate":[65],"would":[68],"be":[69,125],"sufficient":[70],"produce":[72],"levels":[75],"needed":[78],"in":[79],"brain":[81],"exert":[83],"effect":[86],"against":[87],"ischemia.":[88],"found":[90],"given":[93],"intravenously":[94],"could":[95,124],"indeed":[96],"prevent":[97],"death":[99],"CA1":[101],"hippocampal":[102],"neurons,":[103],"even":[104],"if":[105],"administration":[107],"was":[110],"delayed":[111],"for":[112],"24":[113],"h":[114],"after":[115,127],"ischemic":[117],"event.":[118],"suggest":[120],"iv":[122],"stroke,":[128],"cardiac":[129],"arrest,":[130],"hypotensive":[132],"episodes.":[133]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}