{"id":"https://openalex.org/W2062963248","doi":"https://doi.org/10.1089/jop.2000.16.337","title":"Acetaminophen Produces Cataract in DBA2 Mice by Ah Receptor-Independent Induction of CYP1A2","display_name":"Acetaminophen Produces Cataract in DBA2 Mice by Ah Receptor-Independent Induction of CYP1A2","publication_year":2000,"publication_date":"2000-08-01","ids":{"openalex":"https://openalex.org/W2062963248","doi":"https://doi.org/10.1089/jop.2000.16.337","mag":"2062963248","pmid":"https://pubmed.ncbi.nlm.nih.gov/10977129"},"language":"en","primary_location":{"id":"doi:10.1089/jop.2000.16.337","doi":"https://doi.org/10.1089/jop.2000.16.337","is_oa":false,"landing_page_url":"https://doi.org/10.1089/jop.2000.16.337","pdf_url":null,"source":{"id":"https://openalex.org/S192126995","display_name":"Journal of Ocular Pharmacology and Therapeutics","issn_l":"1080-7683","issn":["1080-7683","1557-7732","8756-3320"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320443","host_organization_name":"Mary Ann Liebert, Inc.","host_organization_lineage":["https://openalex.org/P4310320443","https://openalex.org/P4310320017"],"host_organization_lineage_names":["Mary Ann Liebert, Inc.","SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Ocular Pharmacology and Therapeutics","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"WEI QIAN","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I185443292","display_name":"Wayne State University","ror":"https://ror.org/01070mq45","country_code":"US","type":"education","lineage":["https://openalex.org/I185443292"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"WEI QIAN","raw_affiliation_strings":["Department of Ophthalmology, Wayne State University, School of Medicine, Detroit, Michigan 48201, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, Wayne State University, School of Medicine, Detroit, Michigan 48201, USA","institution_ids":["https://openalex.org/I185443292"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5002507714","display_name":"Hitoshi Shichi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"HITOSHI SHICHI","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.5438,"has_fulltext":false,"cited_by_count":7,"citation_normalized_percentile":{"value":0.68196498,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"16","issue":"4","first_page":"337","last_page":"344"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.9214000105857849,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.9214000105857849,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11465","display_name":"Drug-Induced Hepatotoxicity and Protection","score":0.03200000151991844,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10122","display_name":"Toxic Organic Pollutants Impact","score":0.014999999664723873,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/paracetamol","display_name":"paracetamol","score":0.9470000267028809},{"id":"https://openalex.org/keywords/cataract","display_name":"cataract","score":0.9359999895095825},{"id":"https://openalex.org/keywords/cyp1a2","display_name":"CYP1A2","score":0.9769999980926514},{"id":"https://openalex.org/keywords/acenaphthylene","display_name":"acenaphthylene","score":0.9240000247955322},{"id":"https://openalex.org/keywords/n-acetyl-p-benzoquinone-imine","display_name":"N-acetyl-p-benzoquinone imine","score":0.9300000071525574},{"id":"https://openalex.org/keywords/aromatic-hydrocarbon-receptor","display_name":"aromatic hydrocarbon receptor","score":0.7400000095367432},{"id":"https://openalex.org/keywords/cytochrome-p450-induction","display_name":"cytochrome P450 induction","score":0.8149999976158142},{"id":"https://openalex.org/keywords/liver","display_name":"liver","score":0.4269999861717224},{"id":"https://openalex.org/keywords/crystalline-lens","display_name":"crystalline lens","score":0.36899998784065247},{"id":"https://openalex.org/keywords/drug-induced-cataract","display_name":"drug-induced cataract","score":0.6579999923706055}],"concepts":[{"id":"https://openalex.org/C86745063","wikidata":"https://www.wikidata.org/wiki/Q3737406","display_name":"CYP1A2","level":4,"score":0.8762390613555908},{"id":"https://openalex.org/C526171541","wikidata":"https://www.wikidata.org/wiki/Q407693","display_name":"Cytochrome P450","level":3,"score":0.778505802154541},{"id":"https://openalex.org/C2778722691","wikidata":"https://www.wikidata.org/wiki/Q57055","display_name":"Acetaminophen","level":2,"score":0.6498839855194092},{"id":"https://openalex.org/C155701950","wikidata":"https://www.wikidata.org/wiki/Q14905165","display_name":"CYP1B1","level":4,"score":0.5761889219284058},{"id":"https://openalex.org/C2780768313","wikidata":"https://www.wikidata.org/wiki/Q408068","display_name":"Cytochrome","level":3,"score":0.5643742084503174},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5170120000839233},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.47296661138534546},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3509666919708252},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.34725862741470337},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.24952617287635803},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.24922308325767517},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.2363845407962799}],"mesh":[{"descriptor_ui":"D000073","descriptor_name":"Acenaphthenes","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D000082","descriptor_name":"Acetaminophen","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002386","descriptor_name":"Cataract","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true},{"descriptor_ui":"D002386","descriptor_name":"Cataract","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D002386","descriptor_name":"Cataract","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D003577","descriptor_name":"Cytochrome P-450 Enzyme System","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004790","descriptor_name":"Enzyme Induction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007274","descriptor_name":"Injections, Intraperitoneal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007908","descriptor_name":"Lens, Crystalline","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D007908","descriptor_name":"Lens, Crystalline","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D007908","descriptor_name":"Lens, Crystalline","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008811","descriptor_name":"Mice, Inbred DBA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008862","descriptor_name":"Microsomes, Liver","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D010088","descriptor_name":"Oxidoreductases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018336","descriptor_name":"Receptors, Aryl Hydrocarbon","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D019388","descriptor_name":"Cytochrome P-450 CYP1A2","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1089/jop.2000.16.337","doi":"https://doi.org/10.1089/jop.2000.16.337","is_oa":false,"landing_page_url":"https://doi.org/10.1089/jop.2000.16.337","pdf_url":null,"source":{"id":"https://openalex.org/S192126995","display_name":"Journal of Ocular Pharmacology and Therapeutics","issn_l":"1080-7683","issn":["1080-7683","1557-7732","8756-3320"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320443","host_organization_name":"Mary Ann Liebert, Inc.","host_organization_lineage":["https://openalex.org/P4310320443","https://openalex.org/P4310320017"],"host_organization_lineage_names":["Mary Ann Liebert, Inc.","SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Ocular Pharmacology and Therapeutics","raw_type":"journal-article"},{"id":"pmid:10977129","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10977129","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8999999761581421,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3838664701","display_name":"DRUG METABOLISM IN THE EYE","funder_award_id":"5r01ey004694-20","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G5465999589","display_name":null,"funder_award_id":"EY04694","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"}],"funders":[{"id":"https://openalex.org/F4320306811","display_name":"Research to Prevent Blindness","ror":"https://ror.org/04drjs621"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337350","display_name":"National Eye Institute","ror":"https://ror.org/03wkg3b53"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":12,"referenced_works":["https://openalex.org/W1967684747","https://openalex.org/W1970852556","https://openalex.org/W1974074767","https://openalex.org/W1974450454","https://openalex.org/W1988466250","https://openalex.org/W1990874048","https://openalex.org/W1996641704","https://openalex.org/W2038657917","https://openalex.org/W2059485107","https://openalex.org/W2077394267","https://openalex.org/W2145337751","https://openalex.org/W2154266443"],"related_works":["https://openalex.org/W1995873252","https://openalex.org/W2027003667","https://openalex.org/W2034466782","https://openalex.org/W2045861104","https://openalex.org/W4235650914","https://openalex.org/W2018635608","https://openalex.org/W2085605364","https://openalex.org/W1974074767","https://openalex.org/W2404536063","https://openalex.org/W2089110523"],"abstract_inverted_index":{"The":[0],"metabolic":[1],"transformation":[2],"of":[3,40,105,132,141,155,185,193],"acetaminophen":[4,54,106],"to":[5,50,65,81,107,191],"N-acetyl-p-benzoquinone":[6,108,195],"imine":[7],"by":[8,53,70,92,109,114],"cytochrome":[9,13,31,66,83,110,165,186],"P450":[10,14,32,67,84,111,166,187],"enzymes":[11],"(e.g.,":[12],"1A2)":[15],"is":[16],"a":[17,161],"prerequisite":[18],"for":[19],"acetaminophen-induced":[20],"cataract":[21,51,118,146,200],"formation":[22,52],"in":[23,34,58,88,119,160,164,171,196,202],"mice.":[24,122],"Aromatic":[25],"hydrocarbons,":[26,74],"such":[27,75],"as":[28,76],"beta-naphthoflavone,":[29],"induce":[30,82],"1A2":[33,68,85,112,188],"C57BL6":[35],"mice":[36,60,91,125,158],"via":[37],"the":[38,41,47,172,177,180,197,203],"mediation":[39],"aromatic":[42,93,181],"hydrocarbon":[43,94,182],"receptor":[44],"and":[45,199],"render":[46],"animals":[48],"susceptible":[49],"administration":[55],"but":[56],"not":[57,63],"DBA2":[59,90,121,124,157],"which":[61],"do":[62],"respond":[64],"induction":[69,113,184],"these":[71],"compounds.":[72],"Polycyclic":[73],"acenaphthylene,":[77],"were":[78,126],"recently":[79],"found":[80],"gene":[86],"expression":[87],"young":[89,120,156],"receptor-independent":[95,183],"pathways.":[96],"In":[97,143],"this":[98],"work,":[99],"we":[100],"investigated":[101],"whether":[102],"enhanced":[103],"metabolism":[104],"acenaphthylene":[115,133,151],"could":[116],"produce":[117],"Fifteen-day-old":[123],"pretreated":[127],"with":[128,138],"two":[129],"intraperitoneal":[130],"injections":[131],"and,":[134],"24":[135],"hr":[136,149],"later,":[137],"one":[139],"injection":[140],"acetaminophen.":[142],"most":[144],"mice,":[145],"developed":[147],"18-24":[148],"after":[150],"injection.":[152],"Acenaphthylene":[153],"treatment":[154],"resulted":[159],"2-fold":[162],"increase":[163],"1A2-dependent":[167],"methoxyresorufin":[168],"O-demethylase":[169],"activity":[170],"liver.":[173],"These":[174],"results":[175],"support":[176],"hypothesis":[178],"that":[179],"enzyme":[189],"leads":[190],"accumulation":[192],"sufficient":[194],"liver":[198],"development":[201],"eye.":[204]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
