{"id":"https://openalex.org/W2062960163","doi":"https://doi.org/10.1159/000110008","title":"Sonodynamic Antitumor Effect of Protoporphyrin IX Disodium Salt on S180 Solid Tumor","display_name":"Sonodynamic Antitumor Effect of Protoporphyrin IX Disodium Salt on S180 Solid Tumor","publication_year":2007,"publication_date":"2007-01-01","ids":{"openalex":"https://openalex.org/W2062960163","doi":"https://doi.org/10.1159/000110008","mag":"2062960163","pmid":"https://pubmed.ncbi.nlm.nih.gov/17952003"},"language":"en","primary_location":{"id":"doi:10.1159/000110008","doi":"https://doi.org/10.1159/000110008","is_oa":false,"landing_page_url":"https://doi.org/10.1159/000110008","pdf_url":null,"source":{"id":"https://openalex.org/S92531173","display_name":"Chemotherapy","issn_l":"0009-3157","issn":["0009-3157","1421-9794"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","medline","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemotherapy","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101596176","display_name":"Quanhong Liu","orcid":"https://orcid.org/0000-0002-5912-4257","observed_orcids":["https://orcid.org/0000-0002-5912-4257"]},"institutions":[{"id":"https://openalex.org/I88830068","display_name":"Shaanxi Normal University","ror":"https://ror.org/0170z8493","country_code":"CN","type":"education","lineage":["https://openalex.org/I88830068"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Quanhong Liu","raw_affiliation_strings":["College of Life Science, Shaanxi Normal University, Xi'an, China. lshaof@snnu.edu.cn","College of Life Science, Shaanxi Normal University, Xi'an, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Life Science, Shaanxi Normal University, Xi'an, China. lshaof@snnu.edu.cn","institution_ids":["https://openalex.org/I88830068"]},{"raw_affiliation_string":"College of Life Science, Shaanxi Normal University, Xi'an, China","institution_ids":["https://openalex.org/I88830068"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113593143","display_name":"Xiaobing Wang","orcid":"https://orcid.org/0000-0002-7589-9618","observed_orcids":["https://orcid.org/0000-0002-7589-9618"]},"institutions":[{"id":"https://openalex.org/I88830068","display_name":"Shaanxi Normal University","ror":"https://ror.org/0170z8493","country_code":"CN","type":"education","lineage":["https://openalex.org/I88830068"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaobing Wang","raw_affiliation_strings":["College of Life Science, Shaanxi Normal University, Xi\u2019an, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Life Science, Shaanxi Normal University, Xi\u2019an, China","institution_ids":["https://openalex.org/I88830068"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038202726","display_name":"Pan Wang","orcid":"https://orcid.org/0000-0001-5868-8037","observed_orcids":["https://orcid.org/0000-0001-5868-8037"]},"institutions":[{"id":"https://openalex.org/I88830068","display_name":"Shaanxi Normal University","ror":"https://ror.org/0170z8493","country_code":"CN","type":"education","lineage":["https://openalex.org/I88830068"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Pan Wang","raw_affiliation_strings":["College of Life Science, Shaanxi Normal University, Xi\u2019an, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Life Science, Shaanxi Normal University, Xi\u2019an, China","institution_ids":["https://openalex.org/I88830068"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5103091015","display_name":"Li\u2010Na Xiao","orcid":"https://orcid.org/0000-0002-9629-9304","observed_orcids":["https://orcid.org/0000-0002-9629-9304"]},"institutions":[{"id":"https://openalex.org/I88830068","display_name":"Shaanxi Normal University","ror":"https://ror.org/0170z8493","country_code":"CN","type":"education","lineage":["https://openalex.org/I88830068"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lina Xiao","raw_affiliation_strings":["College of Life Science, Shaanxi Normal University, Xi\u2019an, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Life Science, Shaanxi Normal University, Xi\u2019an, China","institution_ids":["https://openalex.org/I88830068"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I88830068"],"apc_list":null,"apc_paid":null,"fwci":0.8099,"has_fulltext":false,"cited_by_count":28,"citation_normalized_percentile":{"value":0.71663758,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"53","issue":"6","first_page":"429","last_page":"436"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10957","display_name":"Photodynamic Therapy Research Studies","score":0.9404000043869019,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10957","display_name":"Photodynamic Therapy Research Studies","score":0.9404000043869019,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10958","display_name":"Ultrasound and Hyperthermia Applications","score":0.03590000048279762,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10782","display_name":"Nanoplatforms for cancer theranostics","score":0.021900000050663948,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/protoporphyrin-ix","display_name":"protoporphyrin IX","score":0.8389999866485596},{"id":"https://openalex.org/keywords/sonodynamic-therapy","display_name":"sonodynamic therapy","score":0.9819999933242798},{"id":"https://openalex.org/keywords/sarcoma-180","display_name":"sarcoma 180","score":0.921999990940094},{"id":"https://openalex.org/keywords/anticancer-activity","display_name":"anticancer activity","score":0.8119999766349792},{"id":"https://openalex.org/keywords/tumor-ultrastructure","display_name":"tumor ultrastructure","score":0.7950000166893005},{"id":"https://openalex.org/keywords/cell-death","display_name":"cell death","score":0.6620000004768372},{"id":"https://openalex.org/keywords/survival-time","display_name":"survival time","score":0.5329999923706055}],"concepts":[{"id":"https://openalex.org/C2779671804","wikidata":"https://www.wikidata.org/wiki/Q619815","display_name":"Protoporphyrin IX","level":3,"score":0.8356142044067383},{"id":"https://openalex.org/C2778448707","wikidata":"https://www.wikidata.org/wiki/Q7562147","display_name":"Sonodynamic therapy","level":3,"score":0.8086889982223511},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6707123517990112},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.5466901659965515},{"id":"https://openalex.org/C2778417259","wikidata":"https://www.wikidata.org/wiki/Q619815","display_name":"Protoporphyrin","level":3,"score":0.504423975944519},{"id":"https://openalex.org/C2781469039","wikidata":"https://www.wikidata.org/wiki/Q18388377","display_name":"Photosensitizer","level":2,"score":0.43148547410964966},{"id":"https://openalex.org/C143753070","wikidata":"https://www.wikidata.org/wiki/Q162564","display_name":"Ultrasound","level":2,"score":0.42649585008621216},{"id":"https://openalex.org/C2781323092","wikidata":"https://www.wikidata.org/wiki/Q1428072","display_name":"Photodynamic therapy","level":2,"score":0.41903120279312134},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.3912898600101471},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.34678149223327637},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2034347951412201},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1530381739139557},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.12642544507980347},{"id":"https://openalex.org/C2779480358","wikidata":"https://www.wikidata.org/wiki/Q422926","display_name":"Porphyrin","level":2,"score":0.07289916276931763},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008813","descriptor_name":"Mice, Inbred ICR","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011524","descriptor_name":"Protoporphyrins","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D011524","descriptor_name":"Protoporphyrins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D012510","descriptor_name":"Sarcoma 180","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012510","descriptor_name":"Sarcoma 180","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014018","descriptor_name":"Tissue Distribution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014464","descriptor_name":"Ultrasonic Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017319","descriptor_name":"Photosensitizing Agents","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D017319","descriptor_name":"Photosensitizing Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1159/000110008","doi":"https://doi.org/10.1159/000110008","is_oa":false,"landing_page_url":"https://doi.org/10.1159/000110008","pdf_url":null,"source":{"id":"https://openalex.org/S92531173","display_name":"Chemotherapy","issn_l":"0009-3157","issn":["0009-3157","1421-9794"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","medline","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemotherapy","raw_type":"journal-article"},{"id":"pmid:17952003","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17952003","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemotherapy","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":31,"referenced_works":["https://openalex.org/W135879197","https://openalex.org/W615401202","https://openalex.org/W1966935668","https://openalex.org/W1972025205","https://openalex.org/W1975125018","https://openalex.org/W1977241859","https://openalex.org/W1980977896","https://openalex.org/W1983311027","https://openalex.org/W1988363709","https://openalex.org/W1996833785","https://openalex.org/W2005089058","https://openalex.org/W2013298300","https://openalex.org/W2017446515","https://openalex.org/W2018843756","https://openalex.org/W2019520069","https://openalex.org/W2040709214","https://openalex.org/W2046287008","https://openalex.org/W2074696103","https://openalex.org/W2084190226","https://openalex.org/W2084621472","https://openalex.org/W2085925510","https://openalex.org/W2088044717","https://openalex.org/W2094352006","https://openalex.org/W2100044517","https://openalex.org/W2145779239","https://openalex.org/W2160813470","https://openalex.org/W2162576457","https://openalex.org/W2241368847","https://openalex.org/W2472153984","https://openalex.org/W3133924569","https://openalex.org/W4244008746"],"related_works":["https://openalex.org/W2038832028","https://openalex.org/W1999205130","https://openalex.org/W2019429201","https://openalex.org/W2084621472","https://openalex.org/W1994967058","https://openalex.org/W2426451500","https://openalex.org/W2169280580","https://openalex.org/W2104446423","https://openalex.org/W2040709214","https://openalex.org/W2056550724"],"abstract_inverted_index":{"BACKGROUND:":[0],"The":[1,203],"sonodynamically":[2],"induced":[3,199],"antitumor":[4,208],"effect":[5,136,155,209],"of":[6,29,34,52,78,88,107,113,137,210,218],"protoporphyrin":[7],"IX":[8],"(PPIX)":[9],"disodium":[10],"salt":[11],"was":[12,142,156],"studied":[13],"in":[14,39,99,177,215,224],"mice":[15,80],"bearing":[16],"sarcoma":[17,89],"180":[18,90],"solid":[19],"tumors.":[20],"METHODS:":[21],"In":[22],"order":[23],"to":[24,115],"determine":[25],"the":[26,36,49,61,74,85,111,207,216],"optimum":[27],"timing":[28],"ultrasound":[30,119,123,138,160,211],"exposure":[31],"after":[32,81,110],"administration":[33,112],"PPIX,":[35],"PPIX":[37,114,129,141,164,219],"concentrations":[38],"plasma,":[40],"skin,":[41],"muscle":[42],"and":[43,72,127,147,187,197],"tumor":[44,70,145,195],"were":[45,66,92,190],"estimated":[46,67],"by":[47,68,94],"measuring":[48,69],"fluorescence":[50,57],"intensity":[51,124],"tissue":[53],"extractions":[54],"with":[55,140],"a":[56,105,128,133,225],"photometer":[58],"based":[59],"on":[60],"standard":[62],"curve.":[63],"Antitumor":[64],"effects":[65],"size":[71],"calculating":[73],"average":[75,149],"survival":[76,151],"time":[77,106],"tumor-bearing":[79],"sonodynamic":[82],"therapy;":[83],"additionally,":[84],"morphological":[86],"changes":[87,176],"cells":[91],"evaluated":[93],"transmission":[95],"electron":[96,171],"microscope":[97,172],"observation":[98,173],"vivo.":[100],"RESULTS:":[101],"Our":[102],"experiments":[103],"suggested":[104],"24":[108],"h":[109],"be":[116,213,222],"best":[117],"for":[118],"exposure.":[120],"At":[121],"an":[122],">or=5":[125,131],"W/cm(2)":[126],"dose":[130],"mg/kg,":[132],"significant":[134,168],"synergistic":[135,154],"combined":[139],"observed,":[143],"reducing":[144],"volume":[146],"increasing":[148],"animal":[150],"time;":[152],"this":[153],"obviously":[157],"stronger":[158],"than":[159],"treatment":[161],"alone,":[162],"while":[163],"alone":[165],"showed":[166],"no":[167],"effect.":[169],"Transmission":[170],"indicated":[174],"that":[175,193,206],"cell":[178,182,200],"ultrastructure,":[179],"such":[180],"as":[181],"membrane":[183],"destruction,":[184],"mitochondria":[185],"swelling":[186],"chromatin":[188],"condensation,":[189],"important":[191],"factors":[192],"inhibited":[194],"growth":[196],"even":[198],"death.":[201],"CONCLUSION:":[202],"results":[204],"implied":[205],"could":[212],"enhanced":[214],"presence":[217],"which":[220],"might":[221],"involved":[223],"sonochemical":[226],"mechanism.":[227]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}