{"id":"https://openalex.org/W2062913405","doi":"https://doi.org/10.1002/sim.2394","title":"Modelling intervention effects after cancer relapses","display_name":"Modelling intervention effects after cancer relapses","publication_year":2005,"publication_date":"2005-11-30","ids":{"openalex":"https://openalex.org/W2062913405","doi":"https://doi.org/10.1002/sim.2394","mag":"2062913405","pmid":"https://pubmed.ncbi.nlm.nih.gov/16320269","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4066387"},"language":"en","primary_location":{"id":"doi:10.1002/sim.2394","doi":"https://doi.org/10.1002/sim.2394","is_oa":false,"landing_page_url":"https://doi.org/10.1002/sim.2394","pdf_url":null,"source":{"id":"https://openalex.org/S55189604","display_name":"Statistics in Medicine","issn_l":"0277-6715","issn":["0277-6715","1097-0258"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["abdc-a","anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Statistics in Medicine","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4066387","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100690068","display_name":"Juan R. Gonz\u00e1lez","orcid":"https://orcid.org/0000-0003-3267-2146","observed_orcids":["https://orcid.org/0000-0003-3267-2146","https://orcid.org/0000-0003-0284-5114"]},"institutions":[{"id":"https://openalex.org/I4210107147","display_name":"Institut Catal\u00e0 d'Oncologia","ror":"https://ror.org/01j1eb875","country_code":"ES","type":"government","lineage":["https://openalex.org/I4210107147"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"Juan R. Gonz\u00e1lez","raw_affiliation_strings":["Cancer Prevention and Control Unit, Catalan Institute of Oncology, Avda. Gran via s/n, km. 2.7, Hospitalet de Llobregat 08907, Spain. juanramon.gonzalez@crg.es","Cancer Prevention and Control Unit, Catalan Institute of Oncology, Avda. Gran via s/n, km. 2.7, Hospitalet de Llobregat 08907, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Prevention and Control Unit, Catalan Institute of Oncology, Avda. Gran via s/n, km. 2.7, Hospitalet de Llobregat 08907, Spain. juanramon.gonzalez@crg.es","institution_ids":["https://openalex.org/I4210107147"]},{"raw_affiliation_string":"Cancer Prevention and Control Unit, Catalan Institute of Oncology, Avda. Gran via s/n, km. 2.7, Hospitalet de Llobregat 08907, Spain","institution_ids":["https://openalex.org/I4210107147"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042128231","display_name":"Edsel A. Pe\u00f1a","orcid":"https://orcid.org/0000-0002-7106-2415","observed_orcids":["https://orcid.org/0000-0002-7106-2415"]},"institutions":[{"id":"https://openalex.org/I155781252","display_name":"University of South Carolina","ror":"https://ror.org/02b6qw903","country_code":"US","type":"education","lineage":["https://openalex.org/I155781252"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Edsel A. Pe\u00f1a","raw_affiliation_strings":["Department of Statistics, University of South Carolina, Columbia, SC 29208, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Statistics, University of South Carolina, Columbia, SC 29208, U.S.A","institution_ids":["https://openalex.org/I155781252"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113934076","display_name":"Elizabeth H. Slate","orcid":"https://orcid.org/0000-0001-6372-5277","observed_orcids":["https://orcid.org/0000-0001-6372-5277"]},"institutions":[{"id":"https://openalex.org/I153297377","display_name":"Medical University of South Carolina","ror":"https://ror.org/012jban78","country_code":"US","type":"education","lineage":["https://openalex.org/I153297377"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elizabeth H. Slate","raw_affiliation_strings":["Department of Biostatistics, Bioinformatics, and Epidemiology, Medical University of South Carolina, Charleston, SC 29425, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biostatistics, Bioinformatics, and Epidemiology, Medical University of South Carolina, Charleston, SC 29425, U.S.A","institution_ids":["https://openalex.org/I153297377"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5100690068"],"corresponding_institution_ids":["https://openalex.org/I4210107147"],"apc_list":{"value":5450,"currency":"USD","value_usd":5450},"apc_paid":null,"fwci":1.0343,"has_fulltext":false,"cited_by_count":13,"citation_normalized_percentile":{"value":0.791334,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"24","issue":"24","first_page":"3959","last_page":"3975"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10968","display_name":"Statistical Distribution Estimation and Applications","score":0.33959999680519104,"subfield":{"id":"https://openalex.org/subfields/2613","display_name":"Statistics and Probability"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10968","display_name":"Statistical Distribution Estimation and Applications","score":0.33959999680519104,"subfield":{"id":"https://openalex.org/subfields/2613","display_name":"Statistics and Probability"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T13500","display_name":"Probability and Statistical Research","score":0.24330000579357147,"subfield":{"id":"https://openalex.org/subfields/2613","display_name":"Statistics and Probability"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11235","display_name":"Statistical Methods in Clinical Trials","score":0.09059999883174896,"subfield":{"id":"https://openalex.org/subfields/2613","display_name":"Statistics and Probability"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tumor-recurrence","display_name":"tumor recurrence","score":0.9279999732971191},{"id":"https://openalex.org/keywords/recurrent-event-models","display_name":"recurrent event models","score":0.7310000061988831},{"id":"https://openalex.org/keywords/treatment-effects","display_name":"treatment effects","score":0.5450000166893005},{"id":"https://openalex.org/keywords/treatment-response","display_name":"treatment response","score":0.7139999866485596},{"id":"https://openalex.org/keywords/remission","display_name":"remission","score":0.6539999842643738},{"id":"https://openalex.org/keywords/indolent-lymphoma","display_name":"indolent lymphoma","score":0.9010000228881836},{"id":"https://openalex.org/keywords/heterogeneity","display_name":"heterogeneity","score":0.5199999809265137},{"id":"https://openalex.org/keywords/covariate-effects","display_name":"covariate effects","score":0.7319999933242798}],"concepts":[{"id":"https://openalex.org/C119043178","wikidata":"https://www.wikidata.org/wiki/Q320723","display_name":"Covariate","level":2,"score":0.7785016298294067},{"id":"https://openalex.org/C27415008","wikidata":"https://www.wikidata.org/wiki/Q7256382","display_name":"Psychological intervention","level":2,"score":0.5859038233757019},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.544488251209259},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5310139060020447},{"id":"https://openalex.org/C2780665704","wikidata":"https://www.wikidata.org/wiki/Q959298","display_name":"Intervention (counseling)","level":2,"score":0.45002585649490356},{"id":"https://openalex.org/C50382708","wikidata":"https://www.wikidata.org/wiki/Q223218","display_name":"Proportional hazards model","level":2,"score":0.44919514656066895},{"id":"https://openalex.org/C207103383","wikidata":"https://www.wikidata.org/wiki/Q3930246","display_name":"Hazard ratio","level":3,"score":0.4245627522468567},{"id":"https://openalex.org/C148220186","wikidata":"https://www.wikidata.org/wiki/Q7111912","display_name":"Outcome (game theory)","level":2,"score":0.4192524552345276},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3836771547794342},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2884690761566162},{"id":"https://openalex.org/C149782125","wikidata":"https://www.wikidata.org/wiki/Q160039","display_name":"Econometrics","level":1,"score":0.2508649528026581},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.23987898230552673},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.144959956407547},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.07640668749809265},{"id":"https://openalex.org/C144237770","wikidata":"https://www.wikidata.org/wiki/Q747534","display_name":"Mathematical economics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008228","descriptor_name":"Lymphoma, Non-Hodgkin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012008","descriptor_name":"Recurrence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1002/sim.2394","doi":"https://doi.org/10.1002/sim.2394","is_oa":false,"landing_page_url":"https://doi.org/10.1002/sim.2394","pdf_url":null,"source":{"id":"https://openalex.org/S55189604","display_name":"Statistics in Medicine","issn_l":"0277-6715","issn":["0277-6715","1097-0258"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["abdc-a","anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Statistics in Medicine","raw_type":"journal-article"},{"id":"pmid:16320269","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16320269","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Statistics in medicine","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4066387","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4066387","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Stat Med","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:4066387","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4066387","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Stat Med","raw_type":"Text"},"sustainable_development_goals":[{"score":0.9476000070571899,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"score":0.7400000095367432,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1086750761","display_name":null,"funder_award_id":"RR7698","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G1090864618","display_name":null,"funder_award_id":"17-02-1-0138","funder_id":"https://openalex.org/F4320332505","funder_display_name":"U.S. Public Health Service"},{"id":"https://openalex.org/G2863166251","display_name":"Phase III Trial of Selenium for Prostate Cancer Prevention","funder_award_id":"R01CA077789","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G337271924","display_name":"Center for Colon Cancer Research","funder_award_id":"P20RR017698","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G3547591815","display_name":null,"funder_award_id":"RR17696","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G3884088967","display_name":null,"funder_award_id":"CA077789","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G6388392870","display_name":"New Statistical Models for Recurrent Event Data","funder_award_id":"R01GM056182","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G7562630315","display_name":"Oral Health Research Infrastructure Development at MUSC","funder_award_id":"U24DE016508","funder_id":"https://openalex.org/F4320337365","funder_display_name":"National Institute of Dental and Craniofacial Research"},{"id":"https://openalex.org/G807869115","display_name":"South Carolina COBRE for Oral Health Research","funder_award_id":"P20RR017696","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G8882287565","display_name":null,"funder_award_id":"GM056192","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320332505","display_name":"U.S. Public Health Service","ror":"https://ror.org/05xf94514"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337365","display_name":"National Institute of Dental and Craniofacial Research","ror":"https://ror.org/004a2wv92"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":34,"referenced_works":["https://openalex.org/W177109653","https://openalex.org/W1570622790","https://openalex.org/W1602480414","https://openalex.org/W1912693401","https://openalex.org/W1924771936","https://openalex.org/W1931321618","https://openalex.org/W1966947316","https://openalex.org/W1985881056","https://openalex.org/W1986705681","https://openalex.org/W2005790857","https://openalex.org/W2012199194","https://openalex.org/W2013689038","https://openalex.org/W2022993864","https://openalex.org/W2039595969","https://openalex.org/W2048525832","https://openalex.org/W2071120240","https://openalex.org/W2077428858","https://openalex.org/W2080660645","https://openalex.org/W2080683176","https://openalex.org/W2092648747","https://openalex.org/W2097411619","https://openalex.org/W2106896447","https://openalex.org/W2107305576","https://openalex.org/W2128112098","https://openalex.org/W2138511041","https://openalex.org/W2145159920","https://openalex.org/W2148012189","https://openalex.org/W2148296009","https://openalex.org/W2195672696","https://openalex.org/W2522144760","https://openalex.org/W2588779176","https://openalex.org/W4230978190","https://openalex.org/W4238889147","https://openalex.org/W4252168887"],"related_works":["https://openalex.org/W2144063788","https://openalex.org/W2026731674","https://openalex.org/W2965824466","https://openalex.org/W2085857101","https://openalex.org/W7011725375","https://openalex.org/W4200105978","https://openalex.org/W3128090568","https://openalex.org/W4252732947","https://openalex.org/W2094373438","https://openalex.org/W2099364220"],"abstract_inverted_index":{"This":[0],"article":[1],"addresses":[2],"the":[3,9,30,41,54,67,74,103,107,122,138],"problem":[4],"of":[5,11,32,56,76,105,109,133],"incorporating":[6],"information":[7],"regarding":[8],"effects":[10],"treatments":[12],"or":[13],"interventions":[14,33,57],"into":[15],"models":[16],"for":[17,44,126],"repeated":[18],"cancer":[19,77],"relapses.":[20],"In":[21],"contrast":[22],"to":[23,34,120,124,140],"many":[24],"existing":[25,144],"models,":[26],"our":[27,118],"approach":[28],"permits":[29],"impact":[31,108],"differ":[35],"after":[36],"each":[37],"relapse.":[38],"We":[39,116],"adopt":[40],"general":[42],"model":[43,100,119],"recurrent":[45],"events":[46],"proposed":[47,99],"by":[48,60],"Pe\u00f1a":[49],"and":[50,95,112,136],"Hollander,":[51],"in":[52],"which":[53],"effect":[55,104],"is":[58],"represented":[59],"an":[61,81],"effective":[62,82],"age":[63,83],"process":[64],"acting":[65],"on":[66],"baseline":[68],"hazard":[69],"rate":[70],"function.":[71],"To":[72],"accommodate":[73],"situation":[75],"relapse,":[78],"we":[79],"propose":[80],"function":[84],"that":[85],"encodes":[86],"three":[87],"possible":[88],"therapeutic":[89],"responses:":[90],"complete":[91],"remission,":[92,94],"partial":[93],"null":[96],"response.":[97],"The":[98],"also":[101],"incorporates":[102],"covariates,":[106],"previous":[110],"relapses,":[111],"heterogeneity":[113],"among":[114],"individuals.":[115],"use":[117],"analyse":[121],"times":[123],"relapse":[125],"63":[127],"patients":[128],"with":[129],"a":[130],"particular":[131],"subtype":[132],"indolent":[134],"lymphoma":[135],"compare":[137],"results":[139],"those":[141],"obtained":[142],"using":[143],"methods.":[145]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
