{"id":"https://openalex.org/W2062887429","doi":"https://doi.org/10.3389/fnins.2015.00025","title":"Optical triggered seizures using a caged 4-Aminopyridine","display_name":"Optical triggered seizures using a caged 4-Aminopyridine","publication_year":2015,"publication_date":"2015-02-04","ids":{"openalex":"https://openalex.org/W2062887429","doi":"https://doi.org/10.3389/fnins.2015.00025","mag":"2062887429","pmid":"https://pubmed.ncbi.nlm.nih.gov/25698919","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4316705"},"language":"en","primary_location":{"id":"doi:10.3389/fnins.2015.00025","doi":"https://doi.org/10.3389/fnins.2015.00025","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fnins.2015.00025","pdf_url":"https://www.frontiersin.org/articles/10.3389/fnins.2015.00025/pdf","source":{"id":"https://openalex.org/S115201632","display_name":"Frontiers in Neuroscience","issn_l":"1662-453X","issn":["1662-453X","1662-4548"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Neuroscience","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/articles/10.3389/fnins.2015.00025/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5089091399","display_name":"Mingrui Zhao","orcid":"https://orcid.org/0009-0006-3882-8526","observed_orcids":["https://orcid.org/0009-0006-3882-8526"]},"institutions":[{"id":"https://openalex.org/I1340179700","display_name":"NewYork\u2013Presbyterian Hospital","ror":"https://ror.org/03gzbrs57","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1340179700"]},{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]},{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Mingrui Zhao","raw_affiliation_strings":["Department of Neurological Surgery, Brain and Mind Center, New York Presbyterian Hospital, Weill Medical College of Cornell University New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurological Surgery, Brain and Mind Center, New York Presbyterian Hospital, Weill Medical College of Cornell University New York, NY, USA","institution_ids":["https://openalex.org/I1340179700","https://openalex.org/I205783295","https://openalex.org/I4387153466"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063761595","display_name":"Laura M. McGarry","orcid":"https://orcid.org/0000-0001-6553-057X","observed_orcids":["https://orcid.org/0000-0001-6553-057X"]},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Laura M. McGarry","raw_affiliation_strings":["Department of Biological Sciences, Columbia University New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, Columbia University New York, NY, USA","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090263544","display_name":"Hongtao Ma","orcid":"https://orcid.org/0000-0002-1583-0483","observed_orcids":["https://orcid.org/0000-0002-1583-0483"]},"institutions":[{"id":"https://openalex.org/I1340179700","display_name":"NewYork\u2013Presbyterian Hospital","ror":"https://ror.org/03gzbrs57","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1340179700"]},{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]},{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hongtao Ma","raw_affiliation_strings":["Department of Neurological Surgery, Brain and Mind Center, New York Presbyterian Hospital, Weill Medical College of Cornell University New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurological Surgery, Brain and Mind Center, New York Presbyterian Hospital, Weill Medical College of Cornell University New York, NY, USA","institution_ids":["https://openalex.org/I1340179700","https://openalex.org/I205783295","https://openalex.org/I4387153466"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078818236","display_name":"Sam Harris","orcid":"https://orcid.org/0000-0001-6666-9485","observed_orcids":["https://orcid.org/0000-0001-6666-9485"]},"institutions":[{"id":"https://openalex.org/I1340179700","display_name":"NewYork\u2013Presbyterian Hospital","ror":"https://ror.org/03gzbrs57","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1340179700"]},{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]},{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]},{"id":"https://openalex.org/I91136226","display_name":"University of Sheffield","ror":"https://ror.org/05krs5044","country_code":"GB","type":"education","lineage":["https://openalex.org/I91136226"]}],"countries":["GB","US"],"is_corresponding":false,"raw_author_name":"Samuel Harris","raw_affiliation_strings":["Department of Neurological Surgery, Brain and Mind Center, New York Presbyterian Hospital, Weill Medical College of Cornell University New York, NY, USA ; Department of Psychology, University of Sheffield Sheffield, UK","Department of Neurological Surgery, Brain and Mind Center, New York Presbyterian Hospital, Weill Medical College of Cornell University, New York, NY, USA","Department of Psychology, University of Sheffield, Sheffield, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurological Surgery, Brain and Mind Center, New York Presbyterian Hospital, Weill Medical College of Cornell University New York, NY, USA ; Department of Psychology, University of Sheffield Sheffield, UK","institution_ids":["https://openalex.org/I1340179700","https://openalex.org/I205783295","https://openalex.org/I4387153466","https://openalex.org/I91136226"]},{"raw_affiliation_string":"Department of Neurological Surgery, Brain and Mind Center, New York Presbyterian Hospital, Weill Medical College of Cornell University, New York, NY, USA","institution_ids":["https://openalex.org/I1340179700","https://openalex.org/I205783295","https://openalex.org/I4387153466"]},{"raw_affiliation_string":"Department of Psychology, University of Sheffield, Sheffield, UK","institution_ids":["https://openalex.org/I91136226"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013005945","display_name":"Jason Berwick","orcid":"https://orcid.org/0000-0003-4026-0088","observed_orcids":["https://orcid.org/0000-0003-4026-0088"]},"institutions":[{"id":"https://openalex.org/I91136226","display_name":"University of Sheffield","ror":"https://ror.org/05krs5044","country_code":"GB","type":"education","lineage":["https://openalex.org/I91136226"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Jason Berwick","raw_affiliation_strings":["Department of Psychology, University of Sheffield Sheffield, UK","Department of Psychology, University of Sheffield, Sheffield, UK#TAB#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychology, University of Sheffield Sheffield, UK","institution_ids":["https://openalex.org/I91136226"]},{"raw_affiliation_string":"Department of Psychology, University of Sheffield, Sheffield, UK#TAB#","institution_ids":["https://openalex.org/I91136226"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083888813","display_name":"Rafael Yuste","orcid":"https://orcid.org/0000-0003-4206-497X","observed_orcids":["https://orcid.org/0000-0003-4206-497X"]},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Rafael Yuste","raw_affiliation_strings":["Department of Biological Sciences, Columbia University New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, Columbia University New York, NY, USA","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5046589830","display_name":"Theodore H. Schwartz","orcid":"https://orcid.org/0000-0003-4464-7394","observed_orcids":["https://orcid.org/0000-0003-4464-7394"]},"institutions":[{"id":"https://openalex.org/I1340179700","display_name":"NewYork\u2013Presbyterian Hospital","ror":"https://ror.org/03gzbrs57","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1340179700"]},{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]},{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Theodore H. Schwartz","raw_affiliation_strings":["Department of Neurological Surgery, Brain and Mind Center, New York Presbyterian Hospital, Weill Medical College of Cornell University New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurological Surgery, Brain and Mind Center, New York Presbyterian Hospital, Weill Medical College of Cornell University New York, NY, USA","institution_ids":["https://openalex.org/I1340179700","https://openalex.org/I205783295","https://openalex.org/I4387153466"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5046589830","https://openalex.org/A5083888813","https://openalex.org/A5089091399"],"corresponding_institution_ids":["https://openalex.org/I1340179700","https://openalex.org/I205783295","https://openalex.org/I4387153466","https://openalex.org/I78577930"],"apc_list":{"value":3150,"currency":"CHF","value_usd":3801},"apc_paid":{"value":3150,"currency":"CHF","value_usd":3801},"fwci":1.3103,"has_fulltext":true,"cited_by_count":17,"citation_normalized_percentile":{"value":0.79438311,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"9","issue":null,"first_page":"25","last_page":"25"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10094","display_name":"Epilepsy research and treatment","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10094","display_name":"Epilepsy research and treatment","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11708","display_name":"Photochromic and Fluorescence Chemistry","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/photorelease","display_name":"photorelease","score":0.7099999785423279},{"id":"https://openalex.org/keywords/interictal-spikes","display_name":"interictal spikes","score":0.7409999966621399},{"id":"https://openalex.org/keywords/polyspikes","display_name":"polyspikes","score":0.8309999704360962},{"id":"https://openalex.org/keywords/ictal-discharges","display_name":"ictal discharges","score":0.9779999852180481},{"id":"https://openalex.org/keywords/seizure-propagation","display_name":"seizure propagation","score":0.7419999837875366},{"id":"https://openalex.org/keywords/blue-light-excitation","display_name":"blue excitation","score":0.5299999713897705}],"concepts":[{"id":"https://openalex.org/C17755696","wikidata":"https://www.wikidata.org/wiki/Q16564780","display_name":"Ictal","level":3,"score":0.9087820053100586},{"id":"https://openalex.org/C2778186239","wikidata":"https://www.wikidata.org/wiki/Q41571","display_name":"Epilepsy","level":2,"score":0.7148743867874146},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.6811994910240173},{"id":"https://openalex.org/C2780922449","wikidata":"https://www.wikidata.org/wiki/Q372539","display_name":"4-Aminopyridine","level":3,"score":0.5146018266677856},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.44471949338912964},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3304330110549927},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.2434338927268982},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.19091278314590454},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.11546367406845093},{"id":"https://openalex.org/C83743174","wikidata":"https://www.wikidata.org/wiki/Q423778","display_name":"Potassium channel","level":2,"score":0.0},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[],"locations_count":7,"locations":[{"id":"doi:10.3389/fnins.2015.00025","doi":"https://doi.org/10.3389/fnins.2015.00025","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fnins.2015.00025","pdf_url":"https://www.frontiersin.org/articles/10.3389/fnins.2015.00025/pdf","source":{"id":"https://openalex.org/S115201632","display_name":"Frontiers in Neuroscience","issn_l":"1662-453X","issn":["1662-453X","1662-4548"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Neuroscience","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:3298064","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4316705","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:4316705","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4316705","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Neurosci","raw_type":"Text"},{"id":"pmid:25698919","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25698919","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in neuroscience","raw_type":"Journal Article"},{"id":"pmh:oai:eprints.whiterose.ac.uk:84921","doi":null,"is_oa":false,"landing_page_url":"http://eprints.whiterose.ac.uk/84921/8/WRRO_84921.pdf","pdf_url":"http://eprints.whiterose.ac.uk/84921/8/WRRO_84921.pdf","source":{"id":"https://openalex.org/S4306400854","display_name":"White Rose Research Online (University of Leeds, The University of Sheffield, University of York)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2800616092","host_organization_name":"White Rose University Consortium","host_organization_lineage":["https://openalex.org/I2800616092"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.773.4671","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.773.4671","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/90/49/fnins-09-00025.PMC4316705.pdf","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:b2a775d4279c4c369f66bb5ab0e65c8a","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/b2a775d4279c4c369f66bb5ab0e65c8a","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Neuroscience, Vol 9 (2015)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fnins.2015.00025","doi":"https://doi.org/10.3389/fnins.2015.00025","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fnins.2015.00025","pdf_url":"https://www.frontiersin.org/articles/10.3389/fnins.2015.00025/pdf","source":{"id":"https://openalex.org/S115201632","display_name":"Frontiers in Neuroscience","issn_l":"1662-453X","issn":["1662-453X","1662-4548"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Neuroscience","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.4043000042438507,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1242600127","display_name":null,"funder_award_id":"W911NF1210594","funder_id":"https://openalex.org/F4320333591","funder_display_name":"Multidisciplinary University Research Initiative"},{"id":"https://openalex.org/G2723399458","display_name":null,"funder_award_id":"W911NF-12-1-0594","funder_id":"https://openalex.org/F4320338295","funder_display_name":"Army Research Laboratory"},{"id":"https://openalex.org/G3205720133","display_name":null,"funder_award_id":"RO1 NS49482","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G3425319098","display_name":"Understanding epilepsy in the active brain.","funder_award_id":"093069","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"},{"id":"https://openalex.org/G4012432327","display_name":null,"funder_award_id":"W911NF-12-1-0594","funder_id":"https://openalex.org/F4320338281","funder_display_name":"Army Research Office"},{"id":"https://openalex.org/G4360599310","display_name":"Optical imaging of epilepsy in rat and human neocortex","funder_award_id":"R01NS049482","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G5259331294","display_name":null,"funder_award_id":"W911NF","funder_id":"https://openalex.org/F4320338295","funder_display_name":"Army Research Laboratory"},{"id":"https://openalex.org/G6434418741","display_name":"Imaging Functional Connectivity in Visual Cortex","funder_award_id":"R01EY011787","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"},{"id":"https://openalex.org/G6790147850","display_name":"Functional connectomics of the neocortical microcircuit","funder_award_id":"DP1EY024503","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"},{"id":"https://openalex.org/G7452299184","display_name":null,"funder_award_id":"W911NF","funder_id":"https://openalex.org/F4320338281","funder_display_name":"Army Research Office"},{"id":"https://openalex.org/G7825952460","display_name":"Astrocytic regulation of neuronal synchronization","funder_award_id":"R21DA034195","funder_id":"https://openalex.org/F4320337347","funder_display_name":"National Institute on Drug Abuse"},{"id":"https://openalex.org/G8340509167","display_name":null,"funder_award_id":"W91NF-14-1-0269","funder_id":"https://openalex.org/F4320332180","funder_display_name":"Defense Advanced Research Projects Agency"},{"id":"https://openalex.org/G8656440009","display_name":"Two-photon optical control of astrocytic function","funder_award_id":"R01MH101218","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"},{"id":"https://openalex.org/G8739086985","display_name":"Novel caged Dopamine compounds","funder_award_id":"R21MH100646","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"},{"id":"https://openalex.org/G8975517730","display_name":"Clinical and Translational Science Center (UL1)","funder_award_id":"UL1RR024996","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"}],"funders":[{"id":"https://openalex.org/F4320306159","display_name":"W. M. Keck Foundation","ror":"https://ror.org/000dswa46"},{"id":"https://openalex.org/F4320311904","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08"},{"id":"https://openalex.org/F4320323257","display_name":"Universidad de Buenos Aires","ror":"https://ror.org/0081fs513"},{"id":"https://openalex.org/F4320332180","display_name":"Defense Advanced Research Projects Agency","ror":"https://ror.org/02caytj08"},{"id":"https://openalex.org/F4320333591","display_name":"Multidisciplinary University Research Initiative","ror":null},{"id":"https://openalex.org/F4320337346","display_name":"National Institute of Mental Health","ror":"https://ror.org/04xeg9z08"},{"id":"https://openalex.org/F4320337347","display_name":"National Institute on Drug Abuse","ror":"https://ror.org/00fq5cm18"},{"id":"https://openalex.org/F4320337350","display_name":"National Eye Institute","ror":"https://ror.org/03wkg3b53"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"},{"id":"https://openalex.org/F4320338281","display_name":"Army Research Office","ror":"https://ror.org/05epdh915"},{"id":"https://openalex.org/F4320338295","display_name":"Army Research Laboratory","ror":"https://ror.org/011hc8f90"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2062887429.pdf","grobid_xml":"https://content.openalex.org/works/W2062887429.grobid-xml"},"referenced_works_count":67,"referenced_works":["https://openalex.org/W34943291","https://openalex.org/W59410255","https://openalex.org/W131216487","https://openalex.org/W1501385736","https://openalex.org/W1529844353","https://openalex.org/W1542020233","https://openalex.org/W1578187492","https://openalex.org/W1604539019","https://openalex.org/W1604724533","https://openalex.org/W1839453224","https://openalex.org/W1901440685","https://openalex.org/W1963937305","https://openalex.org/W1972679916","https://openalex.org/W1974347565","https://openalex.org/W1974583466","https://openalex.org/W1979635428","https://openalex.org/W1980040815","https://openalex.org/W1981508990","https://openalex.org/W1991233288","https://openalex.org/W1991558584","https://openalex.org/W1999872834","https://openalex.org/W2007494471","https://openalex.org/W2009578021","https://openalex.org/W2010866903","https://openalex.org/W2011267914","https://openalex.org/W2017398416","https://openalex.org/W2020994070","https://openalex.org/W2025395772","https://openalex.org/W2025603247","https://openalex.org/W2026514807","https://openalex.org/W2026920679","https://openalex.org/W2029144110","https://openalex.org/W2041922827","https://openalex.org/W2049069182","https://openalex.org/W2050932531","https://openalex.org/W2055249567","https://openalex.org/W2062842385","https://openalex.org/W2063210874","https://openalex.org/W2063542323","https://openalex.org/W2063997280","https://openalex.org/W2064139020","https://openalex.org/W2068794313","https://openalex.org/W2077109766","https://openalex.org/W2081112104","https://openalex.org/W2082255268","https://openalex.org/W2086132039","https://openalex.org/W2086653658","https://openalex.org/W2088909472","https://openalex.org/W2091362894","https://openalex.org/W2109930285","https://openalex.org/W2117586085","https://openalex.org/W2118395088","https://openalex.org/W2125390340","https://openalex.org/W2127954854","https://openalex.org/W2129410798","https://openalex.org/W2147376890","https://openalex.org/W2151718948","https://openalex.org/W2154888527","https://openalex.org/W2158256695","https://openalex.org/W2160961804","https://openalex.org/W2162691865","https://openalex.org/W2163438163","https://openalex.org/W2171509705","https://openalex.org/W2338928633","https://openalex.org/W2410169014","https://openalex.org/W2414865052","https://openalex.org/W4239908405"],"related_works":["https://openalex.org/W7096099902","https://openalex.org/W1991558584","https://openalex.org/W2615180884","https://openalex.org/W2917725521","https://openalex.org/W2032805218","https://openalex.org/W1963960938","https://openalex.org/W7056275990","https://openalex.org/W1553561298","https://openalex.org/W2091537946","https://openalex.org/W2124703305"],"abstract_inverted_index":{"Animal":[0],"models":[1],"of":[2,13,21,30,56,98,129],"epilepsy":[3,14],"are":[4],"critical":[5],"not":[6],"only":[7],"for":[8,17,51],"understanding":[9],"the":[10,19,96,127],"fundamental":[11],"mechanism":[12],"but":[15],"also":[16],"testing":[18],"efficacy":[20],"new":[22],"antiepileptic":[23],"drugs":[24],"and":[25,83,89,106,133],"novel":[26,61,113,136],"therapeutic":[27,138],"interventions.":[28,139],"Photorelease":[29],"caged":[31,62],"molecules":[32],"is":[33],"widely":[34],"used":[35,93],"in":[36,52,71,79,126],"biological":[37],"research":[38],"to":[39,94,134],"control":[40],"pharmacologic":[41],"events":[42,70],"with":[43,76,117],"high":[44,118],"spatio-temporal":[45,119],"resolution.":[46],"We":[47],"developed":[48],"a":[49,60,112],"technique":[50],"vivo":[53],"optical":[54,90],"triggering":[55],"neocortical":[57],"seizures":[58],"using":[59],"compound":[63],"based":[64],"on":[65],"ruthenium":[66],"photochemistry":[67],"(RuBi-4AP).":[68],"Epileptiform":[69],"mouse":[72],"cortex":[73],"were":[74,92],"induced":[75],"blue":[77],"light":[78],"both":[80],"whole":[81],"brain":[82],"focal":[84],"illumination.":[85],"Multi-electrode":[86],"array":[87],"recording":[88],"techniques":[91],"characterize":[95],"propagation":[97,132],"these":[99],"epileptic":[100],"events,":[101],"including":[102],"interictal":[103],"spikes,":[104],"polyspikes,":[105],"ictal":[107,130],"discharges.":[108],"These":[109],"results":[110],"demonstrate":[111],"optically-triggered":[114],"seizure":[115],"model,":[116],"control,":[120],"that":[121],"could":[122],"have":[123],"widespread":[124],"application":[125],"investigation":[128],"onset,":[131],"develop":[135],"light-based":[137]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}