{"id":"https://openalex.org/W20628536","doi":null,"title":"R\u00f4le de l'oxydation mitochondriale h\u00e9patique des acides gras dans la st\u00e9atose h\u00e9patique, l'insulinor\u00e9sistance et la lipotoxicit\u00e9","display_name":"R\u00f4le de l'oxydation mitochondriale h\u00e9patique des acides gras dans la st\u00e9atose h\u00e9patique, l'insulinor\u00e9sistance et la lipotoxicit\u00e9","publication_year":2012,"publication_date":"2012-01-01","ids":{"openalex":"https://openalex.org/W20628536","mag":"20628536"},"language":"fr","primary_location":{"id":"pmh:hdl:10068/886411","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10068/886411","pdf_url":null,"source":{"id":"https://openalex.org/S4377196900","display_name":"OpenGrey (Institut de l'Information Scientifique et Technique)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1295345811","host_organization_name":"Institut de l'Information Scientifique et Technique","host_organization_lineage":["https://openalex.org/I1295345811"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"U - Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5034539999","display_name":"J. Monsenego","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Julia Monsenego","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5034539999"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10351","display_name":"Liver Disease Diagnosis and Treatment","score":0.9775000214576721,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10351","display_name":"Liver Disease Diagnosis and Treatment","score":0.9775000214576721,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12964","display_name":"Diet, Metabolism, and Disease","score":0.003000000026077032,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11465","display_name":"Drug-Induced Hepatotoxicity and Protection","score":0.0017999999690800905,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hepatic-steatosis","display_name":"hepatic steatosis","score":0.8560000061988831},{"id":"https://openalex.org/keywords/insulin-resistance","display_name":"insulin resistance","score":0.9909999966621399},{"id":"https://openalex.org/keywords/lipotoxicity","display_name":"lipotoxicity","score":0.9879999756813049},{"id":"https://openalex.org/keywords/cpt1a","display_name":"CPT1A","score":0.9430000185966492},{"id":"https://openalex.org/keywords/obesity","display_name":"obesity","score":0.5950000286102295},{"id":"https://openalex.org/keywords/glucose-tolerance","display_name":"glucose tolerance","score":0.6119999885559082},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.7390000224113464},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.6779999732971191},{"id":"https://openalex.org/keywords/non-alcoholic-steatohepatitis","display_name":"nonalcoholic steatohepatitis","score":0.9319999814033508},{"id":"https://openalex.org/keywords/hepatic-lipid-metabolism","display_name":"hepatic lipid metabolism","score":0.7749999761581421},{"id":"https://openalex.org/keywords/ob-ob-mice","display_name":"ob/ob mice","score":0.9160000085830688}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6835892796516418},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.65311199426651},{"id":"https://openalex.org/C2778435403","wikidata":"https://www.wikidata.org/wiki/Q243309","display_name":"Carnitine","level":2,"score":0.4422876238822937},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.14600002765655518},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.09311637282371521}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:hdl:10068/886411","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10068/886411","pdf_url":null,"source":{"id":"https://openalex.org/S4377196900","display_name":"OpenGrey (Institut de l'Information Scientifique et Technique)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1295345811","host_organization_name":"Institut de l'Information Scientifique et Technique","host_organization_lineage":["https://openalex.org/I1295345811"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"U - Thesis"},{"id":"mag:20628536","doi":null,"is_oa":false,"landing_page_url":"http://www.theses.fr/2012PA066255","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8560000061988831}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7043225353","https://openalex.org/W2077578087","https://openalex.org/W161102395","https://openalex.org/W7042941550","https://openalex.org/W2167995450","https://openalex.org/W2064666623","https://openalex.org/W2335490175","https://openalex.org/W1983167131","https://openalex.org/W2230147219","https://openalex.org/W3004643789"],"abstract_inverted_index":{"Une":[0],"diminution":[1,158],"de":[2,26,43,48,53,58,85,147,150,159,166,175,188,208,220,240],"la":[3,76,86,104,109,133,148,160,170,221,241],"\u00df-oxydation":[4],"mitochondriale":[5],"des":[6,142,229,243],"acides":[7,230],"gras":[8,231],"(OAG)":[9],"dans":[10,88,205],"le":[11,37,140,202,206],"foie":[12,141,207],"peut":[13],"entra\u00eener":[14],"l":[15,24,27,44,59,62,80,121,137,145,151,167,184,226,238,250],"apparition":[16],"d":[17,64,92,156],"une":[18,56,65,71,130,157,173],"st\u00e9atose":[19,77,105,134],"h\u00e9patique":[20,34,42,78,84,106,135],"et":[21,79,98,117,119,136,165],"contribuer":[22],"\u00e0":[23,183,195,199],"instauration":[25],"insulinor\u00e9sistance":[28],"(IR).":[29],"La":[30],"carnitine":[31],"palmitoyltransf\u00e9rase":[32],"1":[33],"(CPT1A)":[35],"est":[36,172,233],"site":[38],"majeur":[39],"du":[40,162,218,246,267],"contr\u00f4le":[41],"OAG.":[45],"L":[46,82],"objectif":[47],"ma":[49,189],"th\u00e8se":[50],"a":[51],"\u00e9t\u00e9":[52],"d\u00e9terminer":[54],"si":[55],"augmentation":[57],"OAG,":[60],"via":[61],"expression":[63,83,239],"CPT1":[66],"constitutivement":[67],"active":[68],"(CPT1mt),":[69],"repr\u00e9sente":[70],"cible":[72,174],"potentielle":[73],"pour":[74,177],"corriger":[75],"IR.":[81,138],"CPT1mt":[87],"deux":[89],"mod\u00e8les":[90],"animaux":[91],"ob\u00e9sit\u00e9":[93],"(souris":[94],"ob/ob,":[95],"r\u00e9gime":[96],"hyperlipidique":[97],"hyperglucidique":[99],"(HF/HS))":[100],"ne":[101],"modifie":[102],"pas":[103,234],"mais":[107],"am\u00e9liore":[108],"tol\u00e9rance":[110],"au":[111,216,265],"glucose":[112],"chez":[113,123,255],"les":[114,124,179,256],"souris":[115,125,143],"HF/HS":[116],"ob/ob":[118],"diminue":[120],"IR":[122],"ob/ob.":[126],"Ces":[127],"r\u00e9sultats":[128,212],"sugg\u00e8rent":[129],"dissociation":[131],"entre":[132],"Dans":[139],"HF/HS,":[144],"am\u00e9lioration":[146],"signalisation":[149],"insuline":[152],"r\u00e9sulte":[153],"en":[154],"partie":[155],"lipotoxicit\u00e9,":[161],"stress":[163,268],"oxydant":[164,269],"inflammation.":[168],"Ainsi,":[169],"CPT1A":[171],"choix":[176],"diminuer":[178],"d\u00e9sordres":[180],"m\u00e9taboliques":[181],"associ\u00e9s":[182],"ob\u00e9sit\u00e9.":[185],"Au":[186],"cours":[187,217],"th\u00e8se,":[190],"j":[191],"ai":[192],"aussi":[193],"particip\u00e9":[194],"un":[196],"projet":[197],"visant":[198],"mieux":[200],"comprendre":[201],"m\u00e9tabolisme":[203,247],"lipidique":[204],"patients":[209,257],"ob\u00e8ses.":[210],"Nos":[211],"pr\u00e9liminaires":[213],"montrent":[214],"qu":[215],"d\u00e9veloppement":[219,266],"st\u00e9atoh\u00e9patite":[222],"non":[223],"alcoolique":[224],"(NASH)":[225],"orientation":[227],"m\u00e9tabolique":[228],"n":[232],"modifi\u00e9e":[235],"ainsi":[236],"que":[237],"plupart":[242],"g\u00e8nes":[244],"cl\u00e9s":[245],"glucido-lipidique.":[248],"Cependant,":[249],"OAG":[251],"semble":[252],"\u00eatre":[253],"incompl\u00e8te":[254],"ob\u00e8ses":[258],"avec":[259],"NASH,":[260],"ce":[261],"qui":[262],"pourrait":[263],"participer":[264]},"counts_by_year":[],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2016-06-24T00:00:00"}