{"id":"https://openalex.org/W2062820102","doi":"https://doi.org/10.1039/b813398k","title":"Bioinorganic chemistry of copper and zinc ions coordinated to amyloid-\u03b2 peptide","display_name":"Bioinorganic chemistry of copper and zinc ions coordinated to amyloid-\u03b2 peptide","publication_year":2008,"publication_date":"2008-11-27","ids":{"openalex":"https://openalex.org/W2062820102","doi":"https://doi.org/10.1039/b813398k","mag":"2062820102","pmid":"https://pubmed.ncbi.nlm.nih.gov/19322475"},"language":"en","primary_location":{"id":"doi:10.1039/b813398k","doi":"https://doi.org/10.1039/b813398k","is_oa":false,"landing_page_url":"https://doi.org/10.1039/b813398k","pdf_url":null,"source":{"id":"https://openalex.org/S166159787","display_name":"Dalton Transactions","issn_l":"1477-9226","issn":["1477-9226","1477-9234"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320556","host_organization_name":"Royal Society of Chemistry","host_organization_lineage":["https://openalex.org/P4310320556"],"host_organization_lineage_names":["Royal Society of Chemistry"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Dalton Trans.","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5059223921","display_name":"Peter Faller","orcid":"https://orcid.org/0000-0001-8013-0806","observed_orcids":["https://orcid.org/0000-0001-8013-0806"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I134560555","display_name":"Universit\u00e9 Toulouse III - Paul Sabatier","ror":"https://ror.org/02v6kpv12","country_code":"FR","type":"education","lineage":["https://openalex.org/I134560555","https://openalex.org/I4405258862"]},{"id":"https://openalex.org/I4210119060","display_name":"Laboratoire de Chimie de Coordination","ror":"https://ror.org/01rtzw447","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I205747304","https://openalex.org/I4210119060","https://openalex.org/I4210128300","https://openalex.org/I4405258862"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Peter Faller","raw_affiliation_strings":["Laboratoire de Chimie de Coordination du CNRS and Universit\u00e9 Paul Sabatier, 205 Route de Narbonne, 31077, Toulouse Cedex, France. peter.faller@lcc-toulouse.fr","Laboratoire de Chimie de Coordination du CNRS and Universit\u00e9 Paul Sabatier, 205 Route de Narbonne,Toulouse Cedex,France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire de Chimie de Coordination du CNRS and Universit\u00e9 Paul Sabatier, 205 Route de Narbonne, 31077, Toulouse Cedex, France. peter.faller@lcc-toulouse.fr","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I134560555","https://openalex.org/I4210119060"]},{"raw_affiliation_string":"Laboratoire de Chimie de Coordination du CNRS and Universit\u00e9 Paul Sabatier, 205 Route de Narbonne,Toulouse Cedex,France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I134560555","https://openalex.org/I4210119060"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5080013997","display_name":"Christelle Hureau","orcid":"https://orcid.org/0000-0003-3339-0239","observed_orcids":["https://orcid.org/0000-0003-3339-0239"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I134560555","display_name":"Universit\u00e9 Toulouse III - Paul Sabatier","ror":"https://ror.org/02v6kpv12","country_code":"FR","type":"education","lineage":["https://openalex.org/I134560555","https://openalex.org/I4405258862"]},{"id":"https://openalex.org/I4210119060","display_name":"Laboratoire de Chimie de Coordination","ror":"https://ror.org/01rtzw447","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I205747304","https://openalex.org/I4210119060","https://openalex.org/I4210128300","https://openalex.org/I4405258862"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Christelle Hureau","raw_affiliation_strings":["Laboratoire de Chimie de Coordination du CNRS and Universit\u00e9 Paul Sabatier, 205 Route de Narbonne, Toulouse Cedex, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire de Chimie de Coordination du CNRS and Universit\u00e9 Paul Sabatier, 205 Route de Narbonne, Toulouse Cedex, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I134560555","https://openalex.org/I4210119060"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5059223921"],"corresponding_institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I134560555","https://openalex.org/I4210119060"],"apc_list":null,"apc_paid":null,"fwci":3.1012,"has_fulltext":false,"cited_by_count":542,"citation_normalized_percentile":{"value":0.93909192,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":null,"issue":"7","first_page":"1080","last_page":"1094"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10163","display_name":"Metal complexes synthesis and properties","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10915","display_name":"Trace Elements in Health","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/amyloid-beta","display_name":"amyloid-beta","score":0.9309999942779541},{"id":"https://openalex.org/keywords/cu-ii-complexes","display_name":"copper(II) complexes","score":0.7850000262260437},{"id":"https://openalex.org/keywords/zinc-ii-complexes","display_name":"zinc(II) complexes","score":1.0},{"id":"https://openalex.org/keywords/metal-peptide-coordination","display_name":"metal-peptide coordination","score":0.8700000047683716},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.8730000257492065},{"id":"https://openalex.org/keywords/coordination-sphere","display_name":"coordination sphere","score":0.671999990940094},{"id":"https://openalex.org/keywords/dissociation-constant","display_name":"dissociation constant","score":0.7279999852180481},{"id":"https://openalex.org/keywords/binding-affinity","display_name":"binding affinity","score":0.6800000071525574},{"id":"https://openalex.org/keywords/square-planar-geometry","display_name":"square-planar coordination","score":0.6399999856948853},{"id":"https://openalex.org/keywords/histidine-ligands","display_name":"histidine ligands","score":0.8669999837875366},{"id":"https://openalex.org/keywords/structural-model","display_name":"structural model","score":0.44699999690055847}],"concepts":[{"id":"https://openalex.org/C167816639","wikidata":"https://www.wikidata.org/wiki/Q803925","display_name":"Bioinorganic chemistry","level":2,"score":0.9651349782943726},{"id":"https://openalex.org/C544778455","wikidata":"https://www.wikidata.org/wiki/Q753","display_name":"Copper","level":2,"score":0.6718794107437134},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6330476999282837},{"id":"https://openalex.org/C535196362","wikidata":"https://www.wikidata.org/wiki/Q758","display_name":"Zinc","level":2,"score":0.6099149584770203},{"id":"https://openalex.org/C2779281246","wikidata":"https://www.wikidata.org/wiki/Q172847","display_name":"Peptide","level":2,"score":0.562533974647522},{"id":"https://openalex.org/C145148216","wikidata":"https://www.wikidata.org/wiki/Q36496","display_name":"Ion","level":2,"score":0.48108503222465515},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.35136476159095764},{"id":"https://openalex.org/C179104552","wikidata":"https://www.wikidata.org/wiki/Q11165","display_name":"Inorganic chemistry","level":1,"score":0.3276979327201843},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.30610090494155884},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.20107319951057434},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.12956655025482178}],"mesh":[{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D003300","descriptor_name":"Copper","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003300","descriptor_name":"Copper","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010446","descriptor_name":"Peptide Fragments","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010446","descriptor_name":"Peptide Fragments","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D015032","descriptor_name":"Zinc","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015032","descriptor_name":"Zinc","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D015393","descriptor_name":"Chemistry, Bioinorganic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016229","descriptor_name":"Amyloid beta-Peptides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016229","descriptor_name":"Amyloid beta-Peptides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1039/b813398k","doi":"https://doi.org/10.1039/b813398k","is_oa":false,"landing_page_url":"https://doi.org/10.1039/b813398k","pdf_url":null,"source":{"id":"https://openalex.org/S166159787","display_name":"Dalton Transactions","issn_l":"1477-9226","issn":["1477-9226","1477-9234"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320556","host_organization_name":"Royal Society of Chemistry","host_organization_lineage":["https://openalex.org/P4310320556"],"host_organization_lineage_names":["Royal Society of Chemistry"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Dalton Trans.","raw_type":"journal-article"},{"id":"pmid:19322475","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19322475","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Dalton transactions (Cambridge, England : 2003)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":133,"referenced_works":["https://openalex.org/W157666778","https://openalex.org/W1480108665","https://openalex.org/W1506028353","https://openalex.org/W1538720707","https://openalex.org/W1595368494","https://openalex.org/W1632936309","https://openalex.org/W1778245994","https://openalex.org/W1963712466","https://openalex.org/W1965488489","https://openalex.org/W1966618264","https://openalex.org/W1970159001","https://openalex.org/W1970452111","https://openalex.org/W1970503230","https://openalex.org/W1973737342","https://openalex.org/W1973897761","https://openalex.org/W1974643980","https://openalex.org/W1975098194","https://openalex.org/W1977687419","https://openalex.org/W1979543098","https://openalex.org/W1979987517","https://openalex.org/W1980350354","https://openalex.org/W1980825524","https://openalex.org/W1981471614","https://openalex.org/W1983735656","https://openalex.org/W1986091822","https://openalex.org/W1988690043","https://openalex.org/W1991039509","https://openalex.org/W1991647860","https://openalex.org/W1992240624","https://openalex.org/W1995999409","https://openalex.org/W1996579240","https://openalex.org/W1996735580","https://openalex.org/W1996837502","https://openalex.org/W2001591118","https://openalex.org/W2002416269","https://openalex.org/W2003470534","https://openalex.org/W2007003497","https://openalex.org/W2008966525","https://openalex.org/W2009833553","https://openalex.org/W2010149959","https://openalex.org/W2011810121","https://openalex.org/W2016292471","https://openalex.org/W2017550829","https://openalex.org/W2018333394","https://openalex.org/W2019511555","https://openalex.org/W2020397423","https://openalex.org/W2021989110","https://openalex.org/W2022830173","https://openalex.org/W2024443281","https://openalex.org/W2026536857","https://openalex.org/W2027123848","https://openalex.org/W2028969924","https://openalex.org/W2029205225","https://openalex.org/W2029667189","https://openalex.org/W2032881767","https://openalex.org/W2032920422","https://openalex.org/W2037387044","https://openalex.org/W2039161703","https://openalex.org/W2040506379","https://openalex.org/W2040650067","https://openalex.org/W2043104518","https://openalex.org/W2044755714","https://openalex.org/W2045261923","https://openalex.org/W2046423382","https://openalex.org/W2046847750","https://openalex.org/W2047687145","https://openalex.org/W2051516838","https://openalex.org/W2052120254","https://openalex.org/W2054072494","https://openalex.org/W2054393674","https://openalex.org/W2054978422","https://openalex.org/W2058170418","https://openalex.org/W2058548939","https://openalex.org/W2060409666","https://openalex.org/W2064867676","https://openalex.org/W2070090190","https://openalex.org/W2070377130","https://openalex.org/W2071658935","https://openalex.org/W2071713054","https://openalex.org/W2075420978","https://openalex.org/W2076189730","https://openalex.org/W2079264862","https://openalex.org/W2079323065","https://openalex.org/W2079663400","https://openalex.org/W2080274663","https://openalex.org/W2081099437","https://openalex.org/W2081881251","https://openalex.org/W2082995873","https://openalex.org/W2083500052","https://openalex.org/W2083652733","https://openalex.org/W2083715632","https://openalex.org/W2084174305","https://openalex.org/W2085110197","https://openalex.org/W2085271736","https://openalex.org/W2088743030","https://openalex.org/W2090718260","https://openalex.org/W2094808560","https://openalex.org/W2095674336","https://openalex.org/W2096297439","https://openalex.org/W2096410114","https://openalex.org/W2098079657","https://openalex.org/W2107225636","https://openalex.org/W2108188016","https://openalex.org/W2110101020","https://openalex.org/W2112587738","https://openalex.org/W2113472155","https://openalex.org/W2113950441","https://openalex.org/W2114078421","https://openalex.org/W2114518943","https://openalex.org/W2114648545","https://openalex.org/W2116876598","https://openalex.org/W2120937046","https://openalex.org/W2122083637","https://openalex.org/W2123321976","https://openalex.org/W2124866182","https://openalex.org/W2126476325","https://openalex.org/W2130137989","https://openalex.org/W2131020167","https://openalex.org/W2131633241","https://openalex.org/W2138417832","https://openalex.org/W2148080737","https://openalex.org/W2148468867","https://openalex.org/W2152058429","https://openalex.org/W2157935345","https://openalex.org/W2163552626","https://openalex.org/W2164371651","https://openalex.org/W2165186407","https://openalex.org/W2168334242","https://openalex.org/W2169152986","https://openalex.org/W2171092661","https://openalex.org/W2416463139","https://openalex.org/W4245768405","https://openalex.org/W4294550630"],"related_works":["https://openalex.org/W2164371651","https://openalex.org/W2952680323","https://openalex.org/W2002084883","https://openalex.org/W95915979","https://openalex.org/W2321225818","https://openalex.org/W2157903175","https://openalex.org/W2148080737","https://openalex.org/W2021989110","https://openalex.org/W1965556101","https://openalex.org/W4388268766"],"abstract_inverted_index":{"In":[0,167,191],"the":[1,10,14,21,39,42,46,52,59,62,82,87,93,97,100,104,111,116,121,133,148,152,168,171,177,181,186,189,192,196,199,208,232,239,242,266,285,288,291,295,306,309],"present":[2],"perspective,":[3],"we":[4,79],"give":[5],"a":[6,130,227],"critical":[7],"review":[8,81],"on":[9,35],"coordination":[11,43,145],"chemistry":[12],"of":[13,41,45,54,99,115,123,151,180,188,202,210,213,231,238,259,268,290],"metal":[15,56],"ions":[16,50,57],"copper":[17],"and":[18,48,51,75,89,96,185,198,212,226,252,294],"zinc":[19],"to":[20,30,64,126,138,270],"amyloid-beta":[22],"(Abeta)":[23],"peptide;":[24],"such":[25,316],"complexes":[26,118,154],"have":[27],"been":[28],"linked":[29],"Alzheimer's":[31],"disease.":[32],"We":[33,107],"focus":[34],"two":[36,221],"main":[37],"issues:":[38],"identification":[40],"sphere":[44],"Cu(ii)":[47,172],"Zn(ii)":[49,286],"affinity":[53,77],"these":[55,220],"towards":[58],"peptide.":[60],"With":[61],"aim":[63],"come":[65],"up":[66],"with":[67,129,207],"as":[68,70,317],"few":[69],"possible":[71],"valuable":[72],"structural":[73],"models":[74],"binding":[76],"values,":[78],"critically":[80],"divergent":[83],"propositions":[84],"reported":[85],"in":[86,103,120,241,261,265],"literature":[88],"take":[90],"into":[91],"account":[92],"experimental":[94],"differences":[95],"limits":[98],"methods":[101],"used":[102],"published":[105,243],"studies.":[106],"propose":[108],"that:":[109],"(i)":[110],"conditional":[112,277],"dissociation":[113,257,278],"constant":[114,279],"Cu(Abeta)":[117,153],"lies":[119],"range":[122,267],"10":[124,274],"pM":[125,137],"100":[127,136],"nM,":[128],"preference":[131],"for":[132,147],"region":[134],"between":[135,219,247],"1":[139,269],"nM.":[140],"(ii)":[141],"Two":[142],"most":[143,237],"likely":[144],"modes":[146],"predominant":[149],"form":[150],"at":[155,223],"physiological":[156],"pH":[157],"can":[158,280,302],"be":[159,281,303],"retained,":[160],"both":[161,195],"being":[162],"3N1O":[163],"distorted":[164],"square":[165],"planar.":[166],"first":[169],"model,":[170,194],"ion":[173],"is":[174,298],"coordinated":[175,304],"by":[176,250,305],"Ntau":[178,209],"atoms":[179],"three":[182,292],"His":[183,293],"residues":[184,297],"carboxylate":[187,200,307],"Asp1.":[190],"second":[193,233],"N-terminus":[197,310],"functions":[201],"Asp1":[203,296,301],"are":[204,264,314],"ligated":[205],"together":[206],"His6":[211],"His13":[214],"(or":[215],"His14).":[216],"An":[217],"equilibrium":[218],"forms":[222],"room":[224],"temperature,":[225],"preferentially":[228],"freezing":[229],"out":[230],"one":[234],"would":[235],"explain":[236],"divergences":[240],"results":[244],"(in":[245],"particular,":[246],"those":[248],"obtained":[249],"EPR":[251],"NMR).":[253],"(iii)":[254],"The":[255,300],"apparent":[256],"constants":[258],"Zn(Abeta)":[260],"various":[262],"buffers":[263],"20":[271],"muM":[272],"(a":[273],"times":[275],"lower":[276],"estimated.":[282],"(iv)":[283],"For":[284],"coordination,":[287],"implication":[289],"consensual.":[299],"and/or":[308],"functions.":[311],"Additional":[312],"ligands":[313],"possible,":[315],"Glu11":[318],"or":[319],"H(2)O.":[320]},"counts_by_year":[{"year":2026,"cited_by_count":16},{"year":2025,"cited_by_count":20},{"year":2024,"cited_by_count":18},{"year":2023,"cited_by_count":20},{"year":2022,"cited_by_count":15},{"year":2021,"cited_by_count":25},{"year":2020,"cited_by_count":24},{"year":2019,"cited_by_count":29},{"year":2018,"cited_by_count":34},{"year":2017,"cited_by_count":37},{"year":2016,"cited_by_count":26},{"year":2015,"cited_by_count":28},{"year":2014,"cited_by_count":36},{"year":2013,"cited_by_count":42},{"year":2012,"cited_by_count":58}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}