{"id":"https://openalex.org/W2062810728","doi":"https://doi.org/10.1038/ki.1997.163","title":"Renal function in the elderly: Impact of hypertension and cardiac function","display_name":"Renal function in the elderly: Impact of hypertension and cardiac function","publication_year":1997,"publication_date":"1997-04-01","ids":{"openalex":"https://openalex.org/W2062810728","doi":"https://doi.org/10.1038/ki.1997.163","mag":"2062810728","pmid":"https://pubmed.ncbi.nlm.nih.gov/9083286"},"language":"en","primary_location":{"id":"doi:10.1038/ki.1997.163","doi":"https://doi.org/10.1038/ki.1997.163","is_oa":true,"landing_page_url":"https://doi.org/10.1038/ki.1997.163","pdf_url":null,"source":{"id":"https://openalex.org/S97303050","display_name":"Kidney International","issn_l":"0085-2538","issn":["0085-2538","1523-1755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Kidney International","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W2062810728"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://doi.org/10.1038/ki.1997.163","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5012419218","display_name":"Danilo Fliser","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Danilo Fliser","raw_affiliation_strings":["Department of Internal Medicine, Ruperto-Carola University, Heidelberg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Ruperto-Carola University, Heidelberg, Germany","institution_ids":["https://openalex.org/I223822909"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030909625","display_name":"Edward Franek","orcid":"https://orcid.org/0000-0002-5953-7908","observed_orcids":["https://orcid.org/0000-0002-5953-7908"]},"institutions":[{"id":"https://openalex.org/I114090438","display_name":"Goethe University Frankfurt","ror":"https://ror.org/04cvxnb49","country_code":"DE","type":"education","lineage":["https://openalex.org/I114090438"]},{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Edward Franek","raw_affiliation_strings":["Department of Pharmacology, J. W.-Goethe University, Frankfurt/Main, Germany","Division of Nephrology, Department of Internal Medicine, Ruperto-Carola University, Heidelberg"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, J. W.-Goethe University, Frankfurt/Main, Germany","institution_ids":["https://openalex.org/I114090438"]},{"raw_affiliation_string":"Division of Nephrology, Department of Internal Medicine, Ruperto-Carola University, Heidelberg","institution_ids":["https://openalex.org/I223822909"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010342821","display_name":"Markus Joest","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114090438","display_name":"Goethe University Frankfurt","ror":"https://ror.org/04cvxnb49","country_code":"DE","type":"education","lineage":["https://openalex.org/I114090438"]},{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Markus Joest","raw_affiliation_strings":["Department of Pharmacology, J. W.-Goethe University, Frankfurt/Main, Germany","Division of Nephrology, Department of Internal Medicine, Ruperto-Carola University, Heidelberg"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, J. W.-Goethe University, Frankfurt/Main, Germany","institution_ids":["https://openalex.org/I114090438"]},{"raw_affiliation_string":"Division of Nephrology, Department of Internal Medicine, Ruperto-Carola University, Heidelberg","institution_ids":["https://openalex.org/I223822909"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059205861","display_name":"Stefan Block","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114090438","display_name":"Goethe University Frankfurt","ror":"https://ror.org/04cvxnb49","country_code":"DE","type":"education","lineage":["https://openalex.org/I114090438"]},{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Stefan Block","raw_affiliation_strings":["Department of Pharmacology, J. W.-Goethe University, Frankfurt/Main, Germany","Division of Nephrology, Department of Internal Medicine, Ruperto-Carola University, Heidelberg"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, J. W.-Goethe University, Frankfurt/Main, Germany","institution_ids":["https://openalex.org/I114090438"]},{"raw_affiliation_string":"Division of Nephrology, Department of Internal Medicine, Ruperto-Carola University, Heidelberg","institution_ids":["https://openalex.org/I223822909"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110395215","display_name":"Ernst Mutschler","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114090438","display_name":"Goethe University Frankfurt","ror":"https://ror.org/04cvxnb49","country_code":"DE","type":"education","lineage":["https://openalex.org/I114090438"]},{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Ernst Mutschler","raw_affiliation_strings":["Department of Pharmacology, J. W.-Goethe University, Frankfurt/Main, Germany","Division of Nephrology, Department of Internal Medicine, Ruperto-Carola University, Heidelberg"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, J. W.-Goethe University, Frankfurt/Main, Germany","institution_ids":["https://openalex.org/I114090438"]},{"raw_affiliation_string":"Division of Nephrology, Department of Internal Medicine, Ruperto-Carola University, Heidelberg","institution_ids":["https://openalex.org/I223822909"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111646516","display_name":"Eberhard Ritz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114090438","display_name":"Goethe University Frankfurt","ror":"https://ror.org/04cvxnb49","country_code":"DE","type":"education","lineage":["https://openalex.org/I114090438"]},{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Eberhard Ritz","raw_affiliation_strings":["Department of Pharmacology, J. W.-Goethe University, Frankfurt/Main, Germany","Division of Nephrology, Department of Internal Medicine, Ruperto-Carola University, Heidelberg"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, J. W.-Goethe University, Frankfurt/Main, Germany","institution_ids":["https://openalex.org/I114090438"]},{"raw_affiliation_string":"Division of Nephrology, Department of Internal Medicine, Ruperto-Carola University, Heidelberg","institution_ids":["https://openalex.org/I223822909"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3500,"currency":"USD","value_usd":3500},"apc_paid":null,"fwci":8.2643,"has_fulltext":false,"cited_by_count":271,"citation_normalized_percentile":{"value":0.97956577,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":100},"biblio":{"volume":"51","issue":"4","first_page":"1196","last_page":"1204"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10408","display_name":"Chronic Kidney Disease and Diabetes","score":0.9384999871253967,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10408","display_name":"Chronic Kidney Disease and Diabetes","score":0.9384999871253967,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10144","display_name":"Blood Pressure and Hypertension Studies","score":0.02669999934732914,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12067","display_name":"Renal and Vascular Pathologies","score":0.007300000172108412,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/renal-function","display_name":"renal function","score":0.5410000085830688},{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.9760000109672546},{"id":"https://openalex.org/keywords/older-adults","display_name":"older adults","score":0.7149999737739563},{"id":"https://openalex.org/keywords/hypertension","display_name":"hypertension","score":0.9620000123977661},{"id":"https://openalex.org/keywords/heart-failure","display_name":"heart failure","score":0.9789999723434448},{"id":"https://openalex.org/keywords/glomerular-filtration-rate","display_name":"glomerular filtration rate","score":0.9819999933242798},{"id":"https://openalex.org/keywords/effective-renal-plasma-flow","display_name":"effective renal plasma flow","score":0.984000027179718},{"id":"https://openalex.org/keywords/renal-hemodynamics","display_name":"renal hemodynamics","score":0.875},{"id":"https://openalex.org/keywords/renovascular-resistance","display_name":"renovascular resistance","score":0.7509999871253967},{"id":"https://openalex.org/keywords/filtration-fraction","display_name":"filtration fraction","score":0.9549999833106995},{"id":"https://openalex.org/keywords/fractional-excretion-of-sodium","display_name":"fractional excretion of sodium","score":0.8500000238418579},{"id":"https://openalex.org/keywords/lithium-clearance","display_name":"lithium clearance","score":0.9900000095367432},{"id":"https://openalex.org/keywords/parathyroid-hormone","display_name":"parathyroid hormone","score":0.8389999866485596},{"id":"https://openalex.org/keywords/vitamin-d","display_name":"vitamin D","score":0.5989999771118164},{"id":"https://openalex.org/keywords/phosphate","display_name":"phosphate","score":0.3869999945163727},{"id":"https://openalex.org/keywords/atherosclerosis","display_name":"atherosclerosis","score":0.6140000224113464},{"id":"https://openalex.org/keywords/renal-senescence","display_name":"renal senescence","score":0.6869999766349792},{"id":"https://openalex.org/keywords/cardiac-function","display_name":"cardiac function","score":0.4180000126361847},{"id":"https://openalex.org/keywords/creatinine-clearance","display_name":"creatinine clearance","score":0.42800000309944153}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.813236653804779},{"id":"https://openalex.org/C159641895","wikidata":"https://www.wikidata.org/wiki/Q108377937","display_name":"Renal function","level":2,"score":0.7772665023803711},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6582289338111877},{"id":"https://openalex.org/C21652263","wikidata":"https://www.wikidata.org/wiki/Q5347278","display_name":"Effective renal plasma flow","level":4,"score":0.5491646528244019},{"id":"https://openalex.org/C2780306776","wikidata":"https://www.wikidata.org/wiki/Q426660","display_name":"Creatinine","level":2,"score":0.5169665217399597},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.43731796741485596},{"id":"https://openalex.org/C77350462","wikidata":"https://www.wikidata.org/wiki/Q1125472","display_name":"Confounding","level":2,"score":0.4300461411476135},{"id":"https://openalex.org/C3018697994","wikidata":"https://www.wikidata.org/wiki/Q191089","display_name":"Elderly people","level":2,"score":0.42329925298690796},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.34842169284820557},{"id":"https://openalex.org/C142225936","wikidata":"https://www.wikidata.org/wiki/Q1129139","display_name":"Renal blood flow","level":3,"score":0.1935516595840454},{"id":"https://openalex.org/C74909509","wikidata":"https://www.wikidata.org/wiki/Q10387","display_name":"Gerontology","level":1,"score":0.14033806324005127}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005919","descriptor_name":"Glomerular Filtration Rate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006321","descriptor_name":"Heart","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D006333","descriptor_name":"Heart Failure","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006973","descriptor_name":"Hypertension","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009318","descriptor_name":"Natriuresis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012079","descriptor_name":"Renal Circulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017596","descriptor_name":"Renal Plasma Flow, Effective","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1038/ki.1997.163","doi":"https://doi.org/10.1038/ki.1997.163","is_oa":true,"landing_page_url":"https://doi.org/10.1038/ki.1997.163","pdf_url":null,"source":{"id":"https://openalex.org/S97303050","display_name":"Kidney International","issn_l":"0085-2538","issn":["0085-2538","1523-1755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Kidney International","raw_type":"journal-article"},{"id":"pmid:9083286","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9083286","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Kidney international","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1038/ki.1997.163","doi":"https://doi.org/10.1038/ki.1997.163","is_oa":true,"landing_page_url":"https://doi.org/10.1038/ki.1997.163","pdf_url":null,"source":{"id":"https://openalex.org/S97303050","display_name":"Kidney International","issn_l":"0085-2538","issn":["0085-2538","1523-1755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Kidney International","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":62,"referenced_works":["https://openalex.org/W923153342","https://openalex.org/W1485373511","https://openalex.org/W1537077061","https://openalex.org/W1550111394","https://openalex.org/W1970373800","https://openalex.org/W1972116384","https://openalex.org/W1974148619","https://openalex.org/W1975198613","https://openalex.org/W1977804080","https://openalex.org/W1983213514","https://openalex.org/W1992818686","https://openalex.org/W1992982390","https://openalex.org/W1993544958","https://openalex.org/W1994059773","https://openalex.org/W1995893393","https://openalex.org/W1996966072","https://openalex.org/W2002958863","https://openalex.org/W2007789292","https://openalex.org/W2008734668","https://openalex.org/W2016845511","https://openalex.org/W2022003821","https://openalex.org/W2024290518","https://openalex.org/W2032289480","https://openalex.org/W2033835060","https://openalex.org/W2036433572","https://openalex.org/W2037746903","https://openalex.org/W2042029418","https://openalex.org/W2051386984","https://openalex.org/W2052626743","https://openalex.org/W2054167696","https://openalex.org/W2067419903","https://openalex.org/W2070777185","https://openalex.org/W2078496536","https://openalex.org/W2090080506","https://openalex.org/W2092639422","https://openalex.org/W2096874990","https://openalex.org/W2096981403","https://openalex.org/W2109825936","https://openalex.org/W2116491415","https://openalex.org/W2123980341","https://openalex.org/W2133720010","https://openalex.org/W2140578325","https://openalex.org/W2147628130","https://openalex.org/W2148217123","https://openalex.org/W2202136774","https://openalex.org/W2208773892","https://openalex.org/W2233600339","https://openalex.org/W2256261541","https://openalex.org/W2330158494","https://openalex.org/W2336000481","https://openalex.org/W2398991453","https://openalex.org/W2399038450","https://openalex.org/W2401471834","https://openalex.org/W2405350620","https://openalex.org/W2409144219","https://openalex.org/W2409145924","https://openalex.org/W2409248425","https://openalex.org/W2410082815","https://openalex.org/W2415169289","https://openalex.org/W2432688848","https://openalex.org/W2472529935","https://openalex.org/W6720703187"],"related_works":["https://openalex.org/W1601705678","https://openalex.org/W7111777323","https://openalex.org/W22907178","https://openalex.org/W2516354435","https://openalex.org/W3025292126","https://openalex.org/W2160538102","https://openalex.org/W2023626089","https://openalex.org/W1993544958","https://openalex.org/W2423686447","https://openalex.org/W2148431769"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":13},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":8},{"year":2018,"cited_by_count":8},{"year":2017,"cited_by_count":7},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":11},{"year":2014,"cited_by_count":10},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":15}],"updated_date":"2026-11-14T11:04:58.165337","created_date":"2016-06-24T00:00:00"}