{"id":"https://openalex.org/W2062779036","doi":"https://doi.org/10.1172/jci118644","title":"Expression of the immunoglobulin VH gene 51p1 is proportional to its germline gene copy number.","display_name":"Expression of the immunoglobulin VH gene 51p1 is proportional to its germline gene copy number.","publication_year":1996,"publication_date":"1996-05-01","ids":{"openalex":"https://openalex.org/W2062779036","doi":"https://doi.org/10.1172/jci118644","mag":"2062779036","pmid":"https://pubmed.ncbi.nlm.nih.gov/8621797","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/507282"},"language":"en","primary_location":{"id":"doi:10.1172/jci118644","doi":"https://doi.org/10.1172/jci118644","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci118644","pdf_url":"http://www.jci.org/articles/view/118644/files/pdf","source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://www.jci.org/articles/view/118644/files/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5040915422","display_name":"Eric H. Sasso","orcid":"https://orcid.org/0000-0001-6891-7980","observed_orcids":["https://orcid.org/0000-0001-6891-7980"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"E H Sasso","raw_affiliation_strings":["Division of Rheumatology, University of Washington, Seattle 98105, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Rheumatology, University of Washington, Seattle 98105, USA","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020723410","display_name":"Todd A. Johnson","orcid":"https://orcid.org/0000-0003-3377-6692","observed_orcids":["https://orcid.org/0000-0003-3377-6692"]},"institutions":[{"id":"https://openalex.org/I2802336062","display_name":"Harborview Medical Center","ror":"https://ror.org/059jq5127","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2801852214","https://openalex.org/I2802336062"]},{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"T Johnson","raw_affiliation_strings":["Department of Medicine, University of California at San Diego, La Jolla, California 92093-0663","Harborview Medical Cen - ter , Box 359785 , 325 Ninth Avenue , Seattle , WA 98104 "],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, University of California at San Diego, La Jolla, California 92093-0663","institution_ids":["https://openalex.org/I36258959"]},{"raw_affiliation_string":"Harborview Medical Cen - ter , Box 359785 , 325 Ninth Avenue , Seattle , WA 98104 ","institution_ids":["https://openalex.org/I2802336062"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5036828560","display_name":"Thomas J. Kipps","orcid":"https://orcid.org/0000-0002-0064-4549","observed_orcids":["https://orcid.org/0000-0002-0064-4549"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"T J Kipps","raw_affiliation_strings":["Department of Medicine, University of California at San Diego, La Jolla, California 92093-0663"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, University of California at San Diego, La Jolla, California 92093-0663","institution_ids":["https://openalex.org/I36258959"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5200,"currency":"USD","value_usd":5200},"apc_paid":null,"fwci":2.105,"has_fulltext":true,"cited_by_count":72,"citation_normalized_percentile":{"value":0.87532587,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"97","issue":"9","first_page":"2074","last_page":"2080"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.48899999260902405,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.48899999260902405,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11157","display_name":"Chronic Lymphocytic Leukemia Research","score":0.35350000858306885,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment","score":0.08250000327825546,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/immunoglobulin-heavy-chain-variable-region","display_name":"immunoglobulin heavy chain variable region","score":0.722000002861023},{"id":"https://openalex.org/keywords/gene-dosage","display_name":"gene dosage","score":0.8029999732971191},{"id":"https://openalex.org/keywords/chronic-lymphocytic-leukemia","display_name":"chronic lymphocytic leukemia","score":0.7960000038146973},{"id":"https://openalex.org/keywords/b-cell-ontogeny","display_name":"B cell ontogeny","score":0.8870000243186951},{"id":"https://openalex.org/keywords/tonsillar-b-cells","display_name":"tonsillar B cells","score":0.8149999976158142},{"id":"https://openalex.org/keywords/hypervariable-region","display_name":"hypervariable region","score":0.6230000257492065},{"id":"https://openalex.org/keywords/gene-duplication","display_name":"gene duplication","score":0.765999972820282}],"concepts":[{"id":"https://openalex.org/C48010095","wikidata":"https://www.wikidata.org/wiki/Q79447","display_name":"Immunoglobulin D","level":4,"score":0.7408626079559326},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.7082380056381226},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6780484318733215},{"id":"https://openalex.org/C84597430","wikidata":"https://www.wikidata.org/wiki/Q106227","display_name":"Locus (genetics)","level":3,"score":0.6026351451873779},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5688846111297607},{"id":"https://openalex.org/C7602840","wikidata":"https://www.wikidata.org/wiki/Q746284","display_name":"Gene duplication","level":3,"score":0.5490413904190063},{"id":"https://openalex.org/C120821319","wikidata":"https://www.wikidata.org/wiki/Q1501491","display_name":"Copy-number variation","level":4,"score":0.5190834999084473},{"id":"https://openalex.org/C96007430","wikidata":"https://www.wikidata.org/wiki/Q3776943","display_name":"Immunoglobulin heavy chain","level":3,"score":0.5018181800842285},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.49895191192626953},{"id":"https://openalex.org/C2778453870","wikidata":"https://www.wikidata.org/wiki/Q188930","display_name":"B cell","level":3,"score":0.48536884784698486},{"id":"https://openalex.org/C2992511266","wikidata":"https://www.wikidata.org/wiki/Q1093098","display_name":"Gene rearrangement","level":3,"score":0.4825972318649292},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.420744389295578},{"id":"https://openalex.org/C109825262","wikidata":"https://www.wikidata.org/wiki/Q1139164","display_name":"Germline","level":3,"score":0.41004693508148193},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.10176140069961548}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001402","descriptor_name":"B-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D001402","descriptor_name":"B-Lymphocytes","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002452","descriptor_name":"Cell Count","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006239","descriptor_name":"Haplotypes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007135","descriptor_name":"Immunoglobulin Variable Region","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D007135","descriptor_name":"Immunoglobulin Variable Region","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014066","descriptor_name":"Palatine Tonsil","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D014066","descriptor_name":"Palatine Tonsil","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D014069","descriptor_name":"Tonsillitis","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D014069","descriptor_name":"Tonsillitis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D018628","descriptor_name":"Gene Dosage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1172/jci118644","doi":"https://doi.org/10.1172/jci118644","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci118644","pdf_url":"http://www.jci.org/articles/view/118644/files/pdf","source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:507282","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/507282","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Clin Invest","raw_type":"Text"},{"id":"pmid:8621797","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8621797","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of clinical investigation","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1172/jci118644","doi":"https://doi.org/10.1172/jci118644","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci118644","pdf_url":"http://www.jci.org/articles/view/118644/files/pdf","source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.8048999905586243,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G1253628694","display_name":null,"funder_award_id":"RR05432","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G1286174873","display_name":"Antibody V Gene Expression B Cell Lymphocytic Leukemia","funder_award_id":"R37CA049870","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G4469688223","display_name":null,"funder_award_id":"AR 40561","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"},{"id":"https://openalex.org/G516886806","display_name":null,"funder_award_id":"R37 CA49870-08","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G7897593758","display_name":"V GENE POLYMORPHISM","funder_award_id":"R29AR040561","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337362","display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","ror":"https://ror.org/006zn3t30"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2062779036.pdf","grobid_xml":"https://content.openalex.org/works/W2062779036.grobid-xml"},"referenced_works_count":36,"referenced_works":["https://openalex.org/W89133373","https://openalex.org/W285804845","https://openalex.org/W292110951","https://openalex.org/W1484092314","https://openalex.org/W1509307817","https://openalex.org/W1524023204","https://openalex.org/W1573788703","https://openalex.org/W1573830653","https://openalex.org/W1910043022","https://openalex.org/W1976411430","https://openalex.org/W1978828565","https://openalex.org/W1994590517","https://openalex.org/W2001101301","https://openalex.org/W2008713578","https://openalex.org/W2011632789","https://openalex.org/W2016057691","https://openalex.org/W2016697979","https://openalex.org/W2020430156","https://openalex.org/W2029003135","https://openalex.org/W2030459950","https://openalex.org/W2031824271","https://openalex.org/W2036050361","https://openalex.org/W2039151199","https://openalex.org/W2043100810","https://openalex.org/W2047490934","https://openalex.org/W2048872477","https://openalex.org/W2054040503","https://openalex.org/W2064302901","https://openalex.org/W2114461520","https://openalex.org/W2134721677","https://openalex.org/W2146328913","https://openalex.org/W2149538750","https://openalex.org/W2161243339","https://openalex.org/W2164503950","https://openalex.org/W2615924216","https://openalex.org/W6640271206"],"related_works":["https://openalex.org/W1978828565","https://openalex.org/W1930648416","https://openalex.org/W2164503950","https://openalex.org/W1780399938","https://openalex.org/W2150013151","https://openalex.org/W2068868786","https://openalex.org/W2553591819","https://openalex.org/W2106168587","https://openalex.org/W1979576043","https://openalex.org/W2025101897"],"abstract_inverted_index":{"51p1":[0,23],"is":[1,7,26,256],"an":[2],"immunoglobulin":[3],"VH":[4],"gene":[5,24,71,136,187,216],"that":[6,33,146,207,238],"frequently":[8],"expressed":[9,242],"in":[10,18,48,92],"B":[11,19,144,162,179,194,205,234,251],"cell":[12,20],"chronic":[13],"lymphocytic":[14],"leukemia":[15],"and":[16,138,253],"early":[17],"ontogeny.":[21],"The":[22],"locus":[25],"highly":[27],"polymorphic,":[28],"consisting":[29],"of":[30,55,80,85,133,141,156,169,176,192,203,231,248,263],"13":[31],"alleles":[32],"can":[34,76,108],"be":[35,109],"classified":[36],"as":[37,61],"being":[38],"either":[39],"51p1-related":[40,57,86,106,134,157,170,215,239,264],"or":[41],"hy1263-related,":[42],"based":[43],"on":[44,65],"distinctive":[45],"sequence":[46],"motifs":[47],"the":[49,56,66,128,131,139,173,197,201,214,232,259],"second":[50],"complementarity":[51],"determining":[52],"region.":[53],"Two":[54],"genes":[58,89,107,158,171,240],"usually":[59],"occur":[60],"a":[62,74,78,113,244],"linked":[63],"pair":[64],"same":[67],"haopltype,":[68],"resulting":[69],"from":[70,122],"duplication.":[72],"Consequently,":[73],"person":[75],"have":[77,118],"total":[79],"zero":[81,154],"to":[82,126,182,213,258],"four":[83,167],"copies":[84,137,155,168],"genes.":[87,265],"These":[88],"are":[90,241],"detectable":[91],"genomic":[93],"DNA":[94],"by":[95,104,111,243],"sequence-specific":[96],"RFLP":[97],"analysis":[98],"using":[99],"oligonucleotide":[100],"probes.":[101],"Ig":[102],"encoded":[103],"nonmutated":[105],"detected":[110],"G6,":[112],"murine":[114],"antiidiotypic":[115],"mAb.":[116],"We":[117,236],"now":[119],"studied":[120],"lymphocytes":[121],"35":[123],"human":[124],"tonsils":[125],"examine":[127],"relation":[129],"between":[130],"number":[132,218,262],"germlime":[135],"proportion":[140],"IgD-bearing":[142,204,233],"tonsillar":[143,250],"cells":[145,206,252],"react":[147],"with":[148,166,185,209,225],"G6.":[149],"All":[150],"subjects":[151],"who":[152],"had":[153,172,189],"lacked":[159],"any":[160],"G6-reactive":[161,193],"cells,":[163,180],"whereas":[164],"those":[165],"highest":[174],"proportions":[175,191],"G6-positive":[177],"IgD":[178],"up":[181],"11.4%.":[183],"Subjects":[184],"intermediate":[186,190],"doses":[188],"cells.":[195,235],"Over":[196],"entire":[198],"data":[199],"set,":[200],"percentage":[202,247,255],"reacted":[208],"G6":[210],"was":[211],"proportional":[212,257],"copy":[217,227,261],"(r":[219],"=":[220],"0.92,":[221],"p":[222],"<":[223],"0.001),":[224],"each":[226],"accounting":[228],"for":[229],"2.4-4.0%":[230],"conclude":[237],"relatively":[245],"large":[246],"IgD+":[249],"this":[254],"germline":[260]},"counts_by_year":[{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2016-06-24T00:00:00"}