{"id":"https://openalex.org/W2062691987","doi":"https://doi.org/10.1038/sj.bjc.6605510","title":"Choline and betaine intake and risk of breast cancer among post-menopausal women","display_name":"Choline and betaine intake and risk of breast cancer among post-menopausal women","publication_year":2010,"publication_date":"2010-01-05","ids":{"openalex":"https://openalex.org/W2062691987","doi":"https://doi.org/10.1038/sj.bjc.6605510","mag":"2062691987","pmid":"https://pubmed.ncbi.nlm.nih.gov/20051955","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2822944"},"language":"en","primary_location":{"id":"doi:10.1038/sj.bjc.6605510","doi":"https://doi.org/10.1038/sj.bjc.6605510","is_oa":true,"landing_page_url":"https://doi.org/10.1038/sj.bjc.6605510","pdf_url":"https://www.nature.com/articles/6605510.pdf","source":{"id":"https://openalex.org/S62966998","display_name":"British Journal of Cancer","issn_l":"0007-0920","issn":["0007-0920","1532-1827"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Cancer","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://www.nature.com/articles/6605510.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5074009555","display_name":"Eunyoung Cho","orcid":"https://orcid.org/0000-0001-6594-2582","observed_orcids":["https://orcid.org/0000-0001-6594-2582"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"E Cho","raw_affiliation_strings":["Channing Laboratory, Department of Medicine, Harvard Medical School and Brigham and Women's Hospital, Boston, MA 02115, USA. eunyoung.cho@channing.harvard.edu","Department of Medicine, Channing Laboratory, Harvard Medical School and Brigham and Women's Hospital, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Channing Laboratory, Department of Medicine, Harvard Medical School and Brigham and Women's Hospital, Boston, MA 02115, USA. eunyoung.cho@channing.harvard.edu","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]},{"raw_affiliation_string":"Department of Medicine, Channing Laboratory, Harvard Medical School and Brigham and Women's Hospital, Boston, MA, USA","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073159738","display_name":"Michelle D. Holmes","orcid":"https://orcid.org/0000-0002-8664-2172","observed_orcids":["https://orcid.org/0000-0002-8664-2172"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M D Holmes","raw_affiliation_strings":["Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA","Department of Medicine, Channing Laboratory, Harvard Medical School and Brigham and Women's Hospital, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Department of Medicine, Channing Laboratory, Harvard Medical School and Brigham and Women's Hospital, Boston, MA, USA","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008373933","display_name":"Susan E. Hankinson","orcid":"https://orcid.org/0000-0001-9155-3767","observed_orcids":["https://orcid.org/0000-0001-9155-3767"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S E Hankinson","raw_affiliation_strings":["Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA","Department of Medicine, Channing Laboratory, Harvard Medical School and Brigham and Women's Hospital, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Department of Medicine, Channing Laboratory, Harvard Medical School and Brigham and Women's Hospital, Boston, MA, USA","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5083991449","display_name":"Walter Churchill Willett","orcid":"https://orcid.org/0000-0003-1458-7597","observed_orcids":["https://orcid.org/0000-0003-1458-7597"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"W C Willett","raw_affiliation_strings":["Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA","Department of Medicine, Channing Laboratory, Harvard Medical School and Brigham and Women's Hospital, Boston, MA, USA","Department of Nutrition, Harvard School of Public Health, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Department of Medicine, Channing Laboratory, Harvard Medical School and Brigham and Women's Hospital, Boston, MA, USA","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]},{"raw_affiliation_string":"Department of Nutrition, Harvard School of Public Health, Boston, MA, USA","institution_ids":["https://openalex.org/I136199984"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5074009555"],"corresponding_institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"],"apc_list":{"value":5190,"currency":"USD","value_usd":5190},"apc_paid":{"value":5190,"currency":"USD","value_usd":5190},"fwci":4.7431,"has_fulltext":true,"cited_by_count":47,"citation_normalized_percentile":{"value":0.94456982,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"102","issue":"3","first_page":"489","last_page":"494"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10499","display_name":"Folate and B Vitamins Research","score":0.7851999998092651,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10499","display_name":"Folate and B Vitamins Research","score":0.7851999998092651,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10866","display_name":"Nutritional Studies and Diet","score":0.18310000002384186,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12103","display_name":"Cancer Risks and Factors","score":0.020400000736117363,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/choline","display_name":"choline","score":0.9390000104904175},{"id":"https://openalex.org/keywords/betaine","display_name":"betaine","score":1.0},{"id":"https://openalex.org/keywords/breast-cancer-risk","display_name":"breast cancer risk","score":0.9629999995231628},{"id":"https://openalex.org/keywords/postmenopausal-women","display_name":"postmenopausal women","score":0.9409999847412109},{"id":"https://openalex.org/keywords/one-carbon-metabolism","display_name":"one-carbon metabolism","score":0.9319999814033508},{"id":"https://openalex.org/keywords/food-consumption","display_name":"dietary intake","score":0.8220000267028809},{"id":"https://openalex.org/keywords/nurses-health-study","display_name":"Nurses' Health Study","score":0.765999972820282},{"id":"https://openalex.org/keywords/alcohol-consumption","display_name":"alcohol consumption","score":0.765999972820282},{"id":"https://openalex.org/keywords/hormone-receptor-status","display_name":"hormone receptor status","score":0.8600000143051147},{"id":"https://openalex.org/keywords/folic-acid","display_name":"folic acid","score":0.6539999842643738}],"concepts":[{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.8410939574241638},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7362239956855774},{"id":"https://openalex.org/C2781123555","wikidata":"https://www.wikidata.org/wiki/Q193166","display_name":"Choline","level":2,"score":0.6668025851249695},{"id":"https://openalex.org/C2777248517","wikidata":"https://www.wikidata.org/wiki/Q72052841","display_name":"Betaine","level":2,"score":0.5463682413101196},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5299322009086609},{"id":"https://openalex.org/C29456083","wikidata":"https://www.wikidata.org/wiki/Q1221899","display_name":"Gynecology","level":1,"score":0.5003812313079834},{"id":"https://openalex.org/C2779880527","wikidata":"https://www.wikidata.org/wiki/Q4959796","display_name":"Breast disease","level":4,"score":0.47858238220214844},{"id":"https://openalex.org/C2780221984","wikidata":"https://www.wikidata.org/wiki/Q131191","display_name":"Body mass index","level":2,"score":0.4744613766670227},{"id":"https://openalex.org/C42407357","wikidata":"https://www.wikidata.org/wiki/Q521","display_name":"Physiology","level":1,"score":0.4741501212120056},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.47196802496910095},{"id":"https://openalex.org/C82789193","wikidata":"https://www.wikidata.org/wiki/Q2142611","display_name":"Relative risk","level":3,"score":0.43114161491394043},{"id":"https://openalex.org/C188816634","wikidata":"https://www.wikidata.org/wiki/Q2113324","display_name":"Prospective cohort study","level":2,"score":0.42736756801605225},{"id":"https://openalex.org/C2778562196","wikidata":"https://www.wikidata.org/wiki/Q177708","display_name":"Menopause","level":2,"score":0.41316357254981995},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4065464735031128},{"id":"https://openalex.org/C131872663","wikidata":"https://www.wikidata.org/wiki/Q5284418","display_name":"Obstetrics","level":1,"score":0.37622198462486267},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.3407747745513916},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.13586369156837463},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001622","descriptor_name":"Betaine","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D002794","descriptor_name":"Choline","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005492","descriptor_name":"Folic Acid","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011960","descriptor_name":"Receptors, Estrogen","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D011980","descriptor_name":"Receptors, Progesterone","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D012306","descriptor_name":"Risk","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017698","descriptor_name":"Postmenopause","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1038/sj.bjc.6605510","doi":"https://doi.org/10.1038/sj.bjc.6605510","is_oa":true,"landing_page_url":"https://doi.org/10.1038/sj.bjc.6605510","pdf_url":"https://www.nature.com/articles/6605510.pdf","source":{"id":"https://openalex.org/S62966998","display_name":"British Journal of Cancer","issn_l":"0007-0920","issn":["0007-0920","1532-1827"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Cancer","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2822944","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2822944","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Br J Cancer","raw_type":"Text"},{"id":"pmid:20051955","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20051955","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British journal of cancer","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1038/sj.bjc.6605510","doi":"https://doi.org/10.1038/sj.bjc.6605510","is_oa":true,"landing_page_url":"https://doi.org/10.1038/sj.bjc.6605510","pdf_url":"https://www.nature.com/articles/6605510.pdf","source":{"id":"https://openalex.org/S62966998","display_name":"British Journal of Cancer","issn_l":"0007-0920","issn":["0007-0920","1532-1827"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Cancer","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G756856000","display_name":"Risk Factors for Breast Cancer in Younger Nurses","funder_award_id":"R01CA050385","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000907652","display_name":"Boston Area Nutrition Obesity Research Center (NORC)","funder_award_id":"P30DK040561","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2062691987.pdf","grobid_xml":"https://content.openalex.org/works/W2062691987.grobid-xml"},"referenced_works_count":33,"referenced_works":["https://openalex.org/W14698502","https://openalex.org/W1919771522","https://openalex.org/W1965315129","https://openalex.org/W1978014946","https://openalex.org/W1978469471","https://openalex.org/W2007701284","https://openalex.org/W2027523943","https://openalex.org/W2040648203","https://openalex.org/W2045328233","https://openalex.org/W2048403396","https://openalex.org/W2100946491","https://openalex.org/W2103277487","https://openalex.org/W2108210899","https://openalex.org/W2117312367","https://openalex.org/W2124040125","https://openalex.org/W2134445915","https://openalex.org/W2142257966","https://openalex.org/W2153224633","https://openalex.org/W2153272851","https://openalex.org/W2153309340","https://openalex.org/W2154888525","https://openalex.org/W2155614484","https://openalex.org/W2158322656","https://openalex.org/W2162527914","https://openalex.org/W2163079946","https://openalex.org/W2171753645","https://openalex.org/W2188742919","https://openalex.org/W2330233053","https://openalex.org/W2468052951","https://openalex.org/W2616217216","https://openalex.org/W3202451213","https://openalex.org/W4285719527","https://openalex.org/W4292996332"],"related_works":["https://openalex.org/W1968955250","https://openalex.org/W2283443781","https://openalex.org/W2475449085","https://openalex.org/W2045328233","https://openalex.org/W7095699999","https://openalex.org/W4318263515","https://openalex.org/W2160957891","https://openalex.org/W2153309340","https://openalex.org/W1994340899","https://openalex.org/W2537368962"],"abstract_inverted_index":{"BACKGROUND:":[0],"Choline":[1],"and":[2,13,29,45,47,100,143,183,225,238],"betaine,":[3,153],"similar":[4,166],"to":[5,15,34],"folate,":[6],"are":[7],"nutrients":[8],"involved":[9],"in":[10,32,56,119,157,167],"one-carbon":[11],"metabolism":[12],"hypothesised":[14],"reduce":[16,240],"breast":[17,35,48,90,116,168,184,204,212,217,243],"cancer":[18,36,49,169,185,205,244],"risk.":[19,37],"No":[20],"prospective":[21],"study":[22],"among":[23,51,245],"post-menopausal":[24,54,115,222,246],"women":[25,55],"has":[26],"examined":[27,40],"choline":[28,44,94,142,181,237],"betaine":[30,46,101,239],"intakes":[31,124,235],"relation":[33],"METHODS:":[38],"We":[39,229],"the":[41,57,120,158],"intake":[42,62,106,182,193],"of":[43,77,88,114,123,129,161,211,215,236,242],"risk":[50,113,186,206,241],"74":[52],"584":[53],"Nurses'":[58],"Health":[59],"Study.":[60],"Nutrient":[61],"was":[63,107],"assessed":[64],"using":[65],"a":[66,111],"validated":[67],"food-frequency":[68],"questionnaire":[69],"six":[70],"times":[71],"since":[72],"1984.":[73],"During":[74],"20":[75],"years":[76],"follow-up":[78],"from":[79],"1984":[80],"until":[81],"2004,":[82],"we":[83],"documented":[84],"3990":[85],"incident":[86],"cases":[87],"invasive":[89],"cancer.":[91,117],"RESULTS:":[92],"Overall,":[93],"(mean+/-s.d.;":[95],"326+/-61":[96],"mg":[97,103],"per":[98,104,199],"day)":[99,105,200],"(104+/-33":[102],"not":[108,188],"associated":[109],"with":[110,155],"reduced":[112],"Participants":[118],"highest":[121],"quintile":[122],"had":[125],"multivariate":[126],"relative":[127],"risks":[128],"1.10":[130],"(95%":[131,134,145],"confidence":[132],"interval":[133],"CI):":[135],"0.99-1.22;":[136],"P-value,":[137,148],"test":[138,149],"for":[139,141,150,152],"trend=0.14)":[140],"0.98":[144],"CI:":[146],"0.89-1.09;":[147],"trend=0.96)":[151],"compared":[154],"those":[156],"lowest":[159],"quintiles":[160],"intakes.":[162],"The":[163,178],"results":[164],"were":[165],"stratified":[170],"by":[171,191],"hormone":[172,223],"receptor":[173],"(oestrogen":[174],"receptor/progesterone":[175],"receptor)":[176],"status.":[177],"association":[179],"between":[180],"did":[187],"differ":[189],"appreciably":[190],"alcohol":[192],"(non-drinker,":[194],"<15":[195],"or":[196,201],"15+":[197],"g":[198],"several":[202],"other":[203],"factors,":[207],"including":[208],"family":[209],"history":[210,214],"cancer,":[213],"benign":[216],"disease,":[218],"body":[219],"mass":[220],"index,":[221],"use,":[224],"folate":[226],"intake.":[227],"CONCLUSION:":[228],"found":[230],"no":[231],"evidence":[232],"that":[233],"higher":[234],"women.":[247]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":7},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}