{"id":"https://openalex.org/W2062637858","doi":"https://doi.org/10.1021/la703900k","title":"Characterization and Biological Evaluation of Paclitaxel-Loaded Poly( l -lactic acid) Microparticles Prepared by Supercritical CO2","display_name":"Characterization and Biological Evaluation of Paclitaxel-Loaded Poly( l -lactic acid) Microparticles Prepared by Supercritical CO2","publication_year":2008,"publication_date":"2008-06-12","ids":{"openalex":"https://openalex.org/W2062637858","doi":"https://doi.org/10.1021/la703900k","mag":"2062637858","pmid":"https://pubmed.ncbi.nlm.nih.gov/18547089"},"language":"en","primary_location":{"id":"doi:10.1021/la703900k","doi":"https://doi.org/10.1021/la703900k","is_oa":false,"landing_page_url":"https://doi.org/10.1021/la703900k","pdf_url":null,"source":{"id":"https://openalex.org/S75741262","display_name":"Langmuir","issn_l":"0743-7463","issn":["0743-7463","1520-5827"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Langmuir","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5030831103","display_name":"Yunqing Kang","orcid":"https://orcid.org/0000-0002-9721-1837","observed_orcids":["https://orcid.org/0000-0002-9721-1837"]},"institutions":[{"id":"https://openalex.org/I24185976","display_name":"Sichuan University","ror":"https://ror.org/011ashp19","country_code":"CN","type":"education","lineage":["https://openalex.org/I24185976"]},{"id":"https://openalex.org/I2800091995","display_name":"West China Medical Center of Sichuan University","ror":"https://ror.org/040nggs60","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I24185976","https://openalex.org/I2800091995"]},{"id":"https://openalex.org/I4210089228","display_name":"West China Second University Hospital of Sichuan University","ror":"https://ror.org/00726et14","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210089228"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yunqing Kang","raw_affiliation_strings":["College of Materials Science and Engineering, Sichuan University, Chengdu, Sichuan 610064, PR China, Institute of Biomedical Engineering, West China Center of Medical Sciences, Sichuan University,Chengdu, Sichuan 610041, PR China, and Department of Obstetrics and Gynecology, West China Second Hospital, Sichuan University, Chengdu, Sichuan 610041, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Materials Science and Engineering, Sichuan University, Chengdu, Sichuan 610064, PR China, Institute of Biomedical Engineering, West China Center of Medical Sciences, Sichuan University,Chengdu, Sichuan 610041, PR China, and Department of Obstetrics and Gynecology, West China Second Hospital, Sichuan University, Chengdu, Sichuan 610041, PR China","institution_ids":["https://openalex.org/I24185976","https://openalex.org/I2800091995","https://openalex.org/I4210089228"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100588958","display_name":"Jiang Wu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I24185976","display_name":"Sichuan University","ror":"https://ror.org/011ashp19","country_code":"CN","type":"education","lineage":["https://openalex.org/I24185976"]},{"id":"https://openalex.org/I2800091995","display_name":"West China Medical Center of Sichuan University","ror":"https://ror.org/040nggs60","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I24185976","https://openalex.org/I2800091995"]},{"id":"https://openalex.org/I4210089228","display_name":"West China Second University Hospital of Sichuan University","ror":"https://ror.org/00726et14","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210089228"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiang Wu","raw_affiliation_strings":["College of Materials Science and Engineering, Sichuan University, Chengdu, Sichuan 610064, PR China, Institute of Biomedical Engineering, West China Center of Medical Sciences, Sichuan University,Chengdu, Sichuan 610041, PR China, and Department of Obstetrics and Gynecology, West China Second Hospital, Sichuan University, Chengdu, Sichuan 610041, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Materials Science and Engineering, Sichuan University, Chengdu, Sichuan 610064, PR China, Institute of Biomedical Engineering, West China Center of Medical Sciences, Sichuan University,Chengdu, Sichuan 610041, PR China, and Department of Obstetrics and Gynecology, West China Second Hospital, Sichuan University, Chengdu, Sichuan 610041, PR China","institution_ids":["https://openalex.org/I24185976","https://openalex.org/I2800091995","https://openalex.org/I4210089228"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081107253","display_name":"Guangfu Yin","orcid":"https://orcid.org/0000-0001-9750-443X","observed_orcids":["https://orcid.org/0000-0001-9750-443X"]},"institutions":[{"id":"https://openalex.org/I24185976","display_name":"Sichuan University","ror":"https://ror.org/011ashp19","country_code":"CN","type":"education","lineage":["https://openalex.org/I24185976"]},{"id":"https://openalex.org/I2800091995","display_name":"West China Medical Center of Sichuan University","ror":"https://ror.org/040nggs60","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I24185976","https://openalex.org/I2800091995"]},{"id":"https://openalex.org/I4210089228","display_name":"West China Second University Hospital of Sichuan University","ror":"https://ror.org/00726et14","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210089228"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Guangfu Yin","raw_affiliation_strings":["College of Materials Science and Engineering, Sichuan University, Chengdu, Sichuan 610064, PR China, Institute of Biomedical Engineering, West China Center of Medical Sciences, Sichuan University,Chengdu, Sichuan 610041, PR China, and Department of Obstetrics and Gynecology, West China Second Hospital, Sichuan University, Chengdu, Sichuan 610041, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Materials Science and Engineering, Sichuan University, Chengdu, Sichuan 610064, PR China, Institute of Biomedical Engineering, West China Center of Medical Sciences, Sichuan University,Chengdu, Sichuan 610041, PR China, and Department of Obstetrics and Gynecology, West China Second Hospital, Sichuan University, Chengdu, Sichuan 610041, PR China","institution_ids":["https://openalex.org/I24185976","https://openalex.org/I2800091995","https://openalex.org/I4210089228"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086930226","display_name":"Zhongbing Huang","orcid":"https://orcid.org/0000-0001-9210-1842","observed_orcids":["https://orcid.org/0000-0001-9210-1842"]},"institutions":[{"id":"https://openalex.org/I24185976","display_name":"Sichuan University","ror":"https://ror.org/011ashp19","country_code":"CN","type":"education","lineage":["https://openalex.org/I24185976"]},{"id":"https://openalex.org/I2800091995","display_name":"West China Medical Center of Sichuan University","ror":"https://ror.org/040nggs60","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I24185976","https://openalex.org/I2800091995"]},{"id":"https://openalex.org/I4210089228","display_name":"West China Second University Hospital of Sichuan University","ror":"https://ror.org/00726et14","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210089228"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhongbing Huang","raw_affiliation_strings":["College of Materials Science and Engineering, Sichuan University, Chengdu, Sichuan 610064, PR China, Institute of Biomedical Engineering, West China Center of Medical Sciences, Sichuan University,Chengdu, Sichuan 610041, PR China, and Department of Obstetrics and Gynecology, West China Second Hospital, Sichuan University, Chengdu, Sichuan 610041, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Materials Science and Engineering, Sichuan University, Chengdu, Sichuan 610064, PR China, Institute of Biomedical Engineering, West China Center of Medical Sciences, Sichuan University,Chengdu, Sichuan 610041, PR China, and Department of Obstetrics and Gynecology, West China Second Hospital, Sichuan University, Chengdu, Sichuan 610041, PR China","institution_ids":["https://openalex.org/I24185976","https://openalex.org/I2800091995","https://openalex.org/I4210089228"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031374620","display_name":"Xiaoming Liao","orcid":"https://orcid.org/0000-0003-0784-9018","observed_orcids":["https://orcid.org/0000-0003-0784-9018","https://orcid.org/0000-0002-3876-5151"]},"institutions":[{"id":"https://openalex.org/I24185976","display_name":"Sichuan University","ror":"https://ror.org/011ashp19","country_code":"CN","type":"education","lineage":["https://openalex.org/I24185976"]},{"id":"https://openalex.org/I2800091995","display_name":"West China Medical Center of Sichuan University","ror":"https://ror.org/040nggs60","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I24185976","https://openalex.org/I2800091995"]},{"id":"https://openalex.org/I4210089228","display_name":"West China Second University Hospital of Sichuan University","ror":"https://ror.org/00726et14","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210089228"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaoming Liao","raw_affiliation_strings":["College of Materials Science and Engineering, Sichuan University, Chengdu, Sichuan 610064, PR China, Institute of Biomedical Engineering, West China Center of Medical Sciences, Sichuan University,Chengdu, Sichuan 610041, PR China, and Department of Obstetrics and Gynecology, West China Second Hospital, Sichuan University, Chengdu, Sichuan 610041, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Materials Science and Engineering, Sichuan University, Chengdu, Sichuan 610064, PR China, Institute of Biomedical Engineering, West China Center of Medical Sciences, Sichuan University,Chengdu, Sichuan 610041, PR China, and Department of Obstetrics and Gynecology, West China Second Hospital, Sichuan University, Chengdu, Sichuan 610041, PR China","institution_ids":["https://openalex.org/I24185976","https://openalex.org/I2800091995","https://openalex.org/I4210089228"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101544225","display_name":"Yadong Yao","orcid":"https://orcid.org/0000-0002-2507-9267","observed_orcids":["https://orcid.org/0000-0002-2507-9267"]},"institutions":[{"id":"https://openalex.org/I24185976","display_name":"Sichuan University","ror":"https://ror.org/011ashp19","country_code":"CN","type":"education","lineage":["https://openalex.org/I24185976"]},{"id":"https://openalex.org/I2800091995","display_name":"West China Medical Center of Sichuan University","ror":"https://ror.org/040nggs60","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I24185976","https://openalex.org/I2800091995"]},{"id":"https://openalex.org/I4210089228","display_name":"West China Second University Hospital of Sichuan University","ror":"https://ror.org/00726et14","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210089228"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yadong Yao","raw_affiliation_strings":["College of Materials Science and Engineering, Sichuan University, Chengdu, Sichuan 610064, PR China, Institute of Biomedical Engineering, West China Center of Medical Sciences, Sichuan University,Chengdu, Sichuan 610041, PR China, and Department of Obstetrics and Gynecology, West China Second Hospital, Sichuan University, Chengdu, Sichuan 610041, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Materials Science and Engineering, Sichuan University, Chengdu, Sichuan 610064, PR China, Institute of Biomedical Engineering, West China Center of Medical Sciences, Sichuan University,Chengdu, Sichuan 610041, PR China, and Department of Obstetrics and Gynecology, West China Second Hospital, Sichuan University, Chengdu, Sichuan 610041, PR China","institution_ids":["https://openalex.org/I24185976","https://openalex.org/I2800091995","https://openalex.org/I4210089228"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Ping Ouyang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I24185976","display_name":"Sichuan University","ror":"https://ror.org/011ashp19","country_code":"CN","type":"education","lineage":["https://openalex.org/I24185976"]},{"id":"https://openalex.org/I2800091995","display_name":"West China Medical Center of Sichuan University","ror":"https://ror.org/040nggs60","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I24185976","https://openalex.org/I2800091995"]},{"id":"https://openalex.org/I4210089228","display_name":"West China Second University Hospital of Sichuan University","ror":"https://ror.org/00726et14","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210089228"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ping Ouyang","raw_affiliation_strings":["College of Materials Science and Engineering, Sichuan University, Chengdu, Sichuan 610064, PR China, Institute of Biomedical Engineering, West China Center of Medical Sciences, Sichuan University,Chengdu, Sichuan 610041, PR China, and Department of Obstetrics and Gynecology, West China Second Hospital, Sichuan University, Chengdu, Sichuan 610041, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Materials Science and Engineering, Sichuan University, Chengdu, Sichuan 610064, PR China, Institute of Biomedical Engineering, West China Center of Medical Sciences, Sichuan University,Chengdu, Sichuan 610041, PR China, and Department of Obstetrics and Gynecology, West China Second Hospital, Sichuan University, Chengdu, Sichuan 610041, PR China","institution_ids":["https://openalex.org/I24185976","https://openalex.org/I2800091995","https://openalex.org/I4210089228"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024324765","display_name":"Hongjing Wang","orcid":"https://orcid.org/0000-0003-0641-3909","observed_orcids":["https://orcid.org/0000-0003-0641-3909","https://orcid.org/0000-0003-3389-4031"]},"institutions":[{"id":"https://openalex.org/I24185976","display_name":"Sichuan University","ror":"https://ror.org/011ashp19","country_code":"CN","type":"education","lineage":["https://openalex.org/I24185976"]},{"id":"https://openalex.org/I2800091995","display_name":"West China Medical Center of Sichuan University","ror":"https://ror.org/040nggs60","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I24185976","https://openalex.org/I2800091995"]},{"id":"https://openalex.org/I4210089228","display_name":"West China Second University Hospital of Sichuan University","ror":"https://ror.org/00726et14","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210089228"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hongjing Wang","raw_affiliation_strings":["College of Materials Science and Engineering, Sichuan University, Chengdu, Sichuan 610064, PR China, Institute of Biomedical Engineering, West China Center of Medical Sciences, Sichuan University,Chengdu, Sichuan 610041, PR China, and Department of Obstetrics and Gynecology, West China Second Hospital, Sichuan University, Chengdu, Sichuan 610041, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Materials Science and Engineering, Sichuan University, Chengdu, Sichuan 610064, PR China, Institute of Biomedical Engineering, West China Center of Medical Sciences, Sichuan University,Chengdu, Sichuan 610041, PR China, and Department of Obstetrics and Gynecology, West China Second Hospital, Sichuan University, Chengdu, Sichuan 610041, PR China","institution_ids":["https://openalex.org/I24185976","https://openalex.org/I2800091995","https://openalex.org/I4210089228"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5070838435","display_name":"Qin Yang","orcid":"https://orcid.org/0000-0001-9370-8144","observed_orcids":["https://orcid.org/0000-0001-9370-8144"]},"institutions":[{"id":"https://openalex.org/I24185976","display_name":"Sichuan University","ror":"https://ror.org/011ashp19","country_code":"CN","type":"education","lineage":["https://openalex.org/I24185976"]},{"id":"https://openalex.org/I2800091995","display_name":"West China Medical Center of Sichuan University","ror":"https://ror.org/040nggs60","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I24185976","https://openalex.org/I2800091995"]},{"id":"https://openalex.org/I4210089228","display_name":"West China Second University Hospital of Sichuan University","ror":"https://ror.org/00726et14","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210089228"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qin Yang","raw_affiliation_strings":["College of Materials Science and Engineering, Sichuan University, Chengdu, Sichuan 610064, PR China, Institute of Biomedical Engineering, West China Center of Medical Sciences, Sichuan University,Chengdu, Sichuan 610041, PR China, and Department of Obstetrics and Gynecology, West China Second Hospital, Sichuan University, Chengdu, Sichuan 610041, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Materials Science and Engineering, Sichuan University, Chengdu, Sichuan 610064, PR China, Institute of Biomedical Engineering, West China Center of Medical Sciences, Sichuan University,Chengdu, Sichuan 610041, PR China, and Department of Obstetrics and Gynecology, West China Second Hospital, Sichuan University, Chengdu, Sichuan 610041, PR China","institution_ids":["https://openalex.org/I24185976","https://openalex.org/I2800091995","https://openalex.org/I4210089228"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5081107253"],"corresponding_institution_ids":["https://openalex.org/I24185976","https://openalex.org/I2800091995","https://openalex.org/I4210089228"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":1.2911,"has_fulltext":false,"cited_by_count":36,"citation_normalized_percentile":{"value":0.77374497,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"24","issue":"14","first_page":"7432","last_page":"7441"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.9218999743461609,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.9218999743461609,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.05389999970793724,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10256","display_name":"Drug Solubulity and Delivery Systems","score":0.004600000102072954,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/paclitaxel","display_name":"paclitaxel","score":1.0},{"id":"https://openalex.org/keywords/poly-l-lactic-acid","display_name":"poly(L-lactic acid)","score":0.9789999723434448},{"id":"https://openalex.org/keywords/microparticles","display_name":"microparticles","score":0.9480000138282776},{"id":"https://openalex.org/keywords/supercritical-carbon-dioxide","display_name":"supercritical carbon dioxide","score":0.7799999713897705},{"id":"https://openalex.org/keywords/drug-encapsulation","display_name":"drug encapsulation","score":0.7360000014305115},{"id":"https://openalex.org/keywords/encapsulation-efficiency","display_name":"encapsulation efficiency","score":0.8379999995231628},{"id":"https://openalex.org/keywords/cytotoxicity","display_name":"cytotoxicity","score":0.8209999799728394},{"id":"https://openalex.org/keywords/a549-cells","display_name":"A549 cells","score":0.8510000109672546},{"id":"https://openalex.org/keywords/skov-3-cells","display_name":"SKOV3 cells","score":0.9990000128746033},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.6589999794960022},{"id":"https://openalex.org/keywords/sustained-release","display_name":"sustained drug release","score":0.8600000143051147},{"id":"https://openalex.org/keywords/anticancer-activity","display_name":"anticancer activity","score":0.75}],"concepts":[{"id":"https://openalex.org/C118419359","wikidata":"https://www.wikidata.org/wiki/Q682585","display_name":"Supercritical fluid","level":2,"score":0.607695460319519},{"id":"https://openalex.org/C2777521759","wikidata":"https://www.wikidata.org/wiki/Q61186","display_name":"Microparticle","level":2,"score":0.5416373014450073},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.4890335500240326},{"id":"https://openalex.org/C187530423","wikidata":"https://www.wikidata.org/wiki/Q7140503","display_name":"Particle size","level":2,"score":0.4810043275356293},{"id":"https://openalex.org/C26771246","wikidata":"https://www.wikidata.org/wiki/Q321095","display_name":"Scanning electron microscope","level":2,"score":0.47973886132240295},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.453251451253891},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.39031222462654114},{"id":"https://openalex.org/C13965031","wikidata":"https://www.wikidata.org/wiki/Q243545","display_name":"Nuclear chemistry","level":1,"score":0.37977883219718933},{"id":"https://openalex.org/C42360764","wikidata":"https://www.wikidata.org/wiki/Q83588","display_name":"Chemical engineering","level":1,"score":0.35771870613098145},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.20460191369056702},{"id":"https://openalex.org/C159985019","wikidata":"https://www.wikidata.org/wiki/Q181790","display_name":"Composite material","level":1,"score":0.07037237286567688},{"id":"https://openalex.org/C147789679","wikidata":"https://www.wikidata.org/wiki/Q11372","display_name":"Physical chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D002152","descriptor_name":"Calorimetry, Differential Scanning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002214","descriptor_name":"Capsules","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002245","descriptor_name":"Carbon Dioxide","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008855","descriptor_name":"Microscopy, Electron, Scanning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010316","descriptor_name":"Particle Size","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011091","descriptor_name":"Polyesters","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011108","descriptor_name":"Polymers","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D014961","descriptor_name":"X-Ray Diffraction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017239","descriptor_name":"Paclitaxel","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D017239","descriptor_name":"Paclitaxel","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D019344","descriptor_name":"Lactic Acid","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D046529","descriptor_name":"Microscopy, Electron, Transmission","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1021/la703900k","doi":"https://doi.org/10.1021/la703900k","is_oa":false,"landing_page_url":"https://doi.org/10.1021/la703900k","pdf_url":null,"source":{"id":"https://openalex.org/S75741262","display_name":"Langmuir","issn_l":"0743-7463","issn":["0743-7463","1520-5827"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Langmuir","raw_type":"journal-article"},{"id":"pmid:18547089","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18547089","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Langmuir : the ACS journal of surfaces and colloids","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9476000070571899,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":46,"referenced_works":["https://openalex.org/W37295386","https://openalex.org/W1264540065","https://openalex.org/W1538072395","https://openalex.org/W1919221066","https://openalex.org/W1965780857","https://openalex.org/W1968900010","https://openalex.org/W1982285805","https://openalex.org/W1985627405","https://openalex.org/W1990366278","https://openalex.org/W1991916654","https://openalex.org/W1994228898","https://openalex.org/W1999478978","https://openalex.org/W2004217006","https://openalex.org/W2009974403","https://openalex.org/W2017031412","https://openalex.org/W2017865089","https://openalex.org/W2018100288","https://openalex.org/W2018482496","https://openalex.org/W2019886977","https://openalex.org/W2022139654","https://openalex.org/W2026637037","https://openalex.org/W2030212578","https://openalex.org/W2031104374","https://openalex.org/W2033357380","https://openalex.org/W2037951704","https://openalex.org/W2039444865","https://openalex.org/W2043015048","https://openalex.org/W2044647958","https://openalex.org/W2046080776","https://openalex.org/W2051285428","https://openalex.org/W2053026268","https://openalex.org/W2057460376","https://openalex.org/W2060378387","https://openalex.org/W2066354221","https://openalex.org/W2074133350","https://openalex.org/W2078816106","https://openalex.org/W2079301432","https://openalex.org/W2080022611","https://openalex.org/W2080879368","https://openalex.org/W2089682625","https://openalex.org/W2125552807","https://openalex.org/W2159319297","https://openalex.org/W2162250373","https://openalex.org/W2162901606","https://openalex.org/W4255762755","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W2461969034","https://openalex.org/W2044398726","https://openalex.org/W2341434307","https://openalex.org/W2035599707","https://openalex.org/W1601652642","https://openalex.org/W2218558150","https://openalex.org/W2025278631","https://openalex.org/W4403049397","https://openalex.org/W2077079096","https://openalex.org/W4396623044"],"abstract_inverted_index":{"In":[0,89],"this":[1],"study,":[2],"paclitaxel":[3],"loaded":[4,35],"poly(":[5],"L-lactic":[6],"acid)":[7],"(PTX-PLLA)":[8],"microparticles":[9,43,83,95,131],"were":[10,84],"prepared":[11],"using":[12],"solution":[13],"enhanced":[14],"dispersion":[15],"by":[16,134,140,194],"supercritical":[17,21],"CO2(SEDS)":[18],"technique.":[19],"This":[20,145],"antisolvent":[22],"technique":[23],"offers":[24],"the":[25,33,72,115,149,225,230],"advantage":[26],"of":[27,81,93,129,153,161,169,182,214,218,233],"negligible":[28],"organic":[29],"solvent":[30],"residua":[31],"in":[32,71,187,199,203,224],"drug":[34,76],"microparticles.":[36],"Scanning":[37],"electron":[38,142],"microscopy":[39,143],"(SEM)":[40],"showed":[41],"that":[42,66,108],"exhibited":[44],"rather":[45],"spherical":[46],"shape":[47],"and":[48,60,78,86,101,117,137,158,184,216],"small":[49],"particle":[50,54],"size":[51,55],"with":[52,122,173],"narrow":[53],"distribution.":[56],"X-ray":[57],"diffraction":[58],"(XRD)":[59],"differential":[61],"scanning":[62],"calorimeter":[63],"(DSC)":[64],"indicated":[65,107],"PTX":[67,124,154,162,215,220],"was":[68,132,146,171,197,210],"amorphously":[69],"dispersed":[70],"PLLA":[73,164,222],"matrix.":[74,165],"The":[75,126,166,189,206],"loading":[77],"encapsulation":[79,217],"efficiency":[80],"PTX-PLLA":[82,94,109,170,200,207],"14.33%":[85],"62.68%,":[87],"respectively.":[88],"vitro":[90],"cytotoxicity":[91],"evaluation":[92],"against":[96,114],"nonsmall-cell":[97],"lung":[98],"cancer":[99,103],"A549":[100,116],"ovarian":[102],"SKOV3":[104,118],"cell":[105,119,156,175,190],"lines":[106],"had":[110],"superior":[111],"antiproliferation":[112],"activity":[113,168,232],"lines,":[120],"compared":[121],"free":[123,204],"formulations.":[125],"cellular":[127],"internalization":[128],"fluorescent":[130],"evidenced":[133],"fluorescence":[135],"microscope":[136],"further":[138],"confirmed":[139],"transmission":[141],"(TEM).":[144],"attributed":[147],"to":[148],"efficient":[150],"intracellular":[151],"accumulation":[152],"via":[155],"phagocytosis":[157],"sustained":[159],"release":[160],"from":[163],"anticancer":[167,231],"associated":[172],"PTX-induced":[174],"apoptosis":[176,191],"such":[177],"as":[178],"nuclear":[179],"aberrations,":[180],"condensation":[181],"chromatin":[183],"swelling":[185],"damage":[186],"mitochondria.":[188],"index":[192],"detected":[193],"flow":[195],"cytometry":[196],"higher":[198],"group":[201],"than":[202],"PTX.":[205,234],"formulation,":[208],"which":[209],"obtained":[211],"through":[212],"micronization":[213],"micronized":[219],"into":[221],"simultaneously":[223],"SEDS":[226],"process,":[227],"significantly":[228],"potentiated":[229]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":8}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}