{"id":"https://openalex.org/W2062597065","doi":"https://doi.org/10.1016/j.jss.2007.12.089","title":"78. NOD2 Activation Leads to an Inhibition of TLR4-Mediated Signaling in Enterocytes: A Role for Receptor Cross-Talk in the Pathogenesis of Intestinal Inflammation","display_name":"78. NOD2 Activation Leads to an Inhibition of TLR4-Mediated Signaling in Enterocytes: A Role for Receptor Cross-Talk in the Pathogenesis of Intestinal Inflammation","publication_year":2008,"publication_date":"2008-02-01","ids":{"openalex":"https://openalex.org/W2062597065","doi":"https://doi.org/10.1016/j.jss.2007.12.089","mag":"2062597065"},"language":"en","primary_location":{"id":"doi:10.1016/j.jss.2007.12.089","doi":"https://doi.org/10.1016/j.jss.2007.12.089","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.jss.2007.12.089","pdf_url":null,"source":{"id":"https://openalex.org/S45161156","display_name":"Journal of Surgical Research","issn_l":"0022-4804","issn":["0022-4804","1095-8673"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Surgical Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109075013","display_name":"Ward M. Richardson","orcid":"https://orcid.org/0009-0006-2408-7974","observed_orcids":["https://orcid.org/0009-0006-2408-7974"]},"institutions":[{"id":"https://openalex.org/I4210130600","display_name":"Children's Hospital of Pittsburgh","ror":"https://ror.org/03763ep67","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210098814","https://openalex.org/I4210130600","https://openalex.org/I4210134769"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ward M. Richardson","raw_affiliation_strings":["Children\u2019s Hospital of Pittsburgh, Pittsburgh, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Children\u2019s Hospital of Pittsburgh, Pittsburgh, PA","institution_ids":["https://openalex.org/I4210130600"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040484573","display_name":"Komli-Kofi Atsina","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210130600","display_name":"Children's Hospital of Pittsburgh","ror":"https://ror.org/03763ep67","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210098814","https://openalex.org/I4210130600","https://openalex.org/I4210134769"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Komli-Kofi Atsina","raw_affiliation_strings":["Children\u2019s Hospital of Pittsburgh, Pittsburgh, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Children\u2019s Hospital of Pittsburgh, Pittsburgh, PA","institution_ids":["https://openalex.org/I4210130600"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083663740","display_name":"Steven C. Gribar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210130600","display_name":"Children's Hospital of Pittsburgh","ror":"https://ror.org/03763ep67","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210098814","https://openalex.org/I4210130600","https://openalex.org/I4210134769"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Steven C. Gribar","raw_affiliation_strings":["Children\u2019s Hospital of Pittsburgh, Pittsburgh, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Children\u2019s Hospital of Pittsburgh, Pittsburgh, PA","institution_ids":["https://openalex.org/I4210130600"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102971782","display_name":"Chhinder P. Sodhi","orcid":"https://orcid.org/0000-0002-6284-3535","observed_orcids":["https://orcid.org/0000-0002-6284-3535"]},"institutions":[{"id":"https://openalex.org/I4210130600","display_name":"Children's Hospital of Pittsburgh","ror":"https://ror.org/03763ep67","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210098814","https://openalex.org/I4210130600","https://openalex.org/I4210134769"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C.P. Sodhi","raw_affiliation_strings":["Children\u2019s Hospital of Pittsburgh, Pittsburgh, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Children\u2019s Hospital of Pittsburgh, Pittsburgh, PA","institution_ids":["https://openalex.org/I4210130600"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100362092","display_name":"Jun Li","orcid":"https://orcid.org/0000-0003-3519-8638","observed_orcids":["https://orcid.org/0000-0003-3519-8638"]},"institutions":[{"id":"https://openalex.org/I4210130600","display_name":"Children's Hospital of Pittsburgh","ror":"https://ror.org/03763ep67","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210098814","https://openalex.org/I4210130600","https://openalex.org/I4210134769"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jun Li","raw_affiliation_strings":["Children\u2019s Hospital of Pittsburgh, Pittsburgh, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Children\u2019s Hospital of Pittsburgh, Pittsburgh, PA","institution_ids":["https://openalex.org/I4210130600"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111704621","display_name":"Maria F. Branca","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210130600","display_name":"Children's Hospital of Pittsburgh","ror":"https://ror.org/03763ep67","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210098814","https://openalex.org/I4210130600","https://openalex.org/I4210134769"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Maria F. Branca","raw_affiliation_strings":["Children\u2019s Hospital of Pittsburgh, Pittsburgh, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Children\u2019s Hospital of Pittsburgh, Pittsburgh, PA","institution_ids":["https://openalex.org/I4210130600"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070525145","display_name":"Theresa D. Dubowski","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210130600","display_name":"Children's Hospital of Pittsburgh","ror":"https://ror.org/03763ep67","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210098814","https://openalex.org/I4210130600","https://openalex.org/I4210134769"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Theresa D. Dubowski","raw_affiliation_strings":["Children\u2019s Hospital of Pittsburgh, Pittsburgh, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Children\u2019s Hospital of Pittsburgh, Pittsburgh, PA","institution_ids":["https://openalex.org/I4210130600"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5083298871","display_name":"David Joel Hackam","orcid":"https://orcid.org/0000-0001-5195-8807","observed_orcids":["https://orcid.org/0000-0001-5195-8807"]},"institutions":[{"id":"https://openalex.org/I4210130600","display_name":"Children's Hospital of Pittsburgh","ror":"https://ror.org/03763ep67","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210098814","https://openalex.org/I4210130600","https://openalex.org/I4210134769"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David J. Hackam","raw_affiliation_strings":["Children\u2019s Hospital of Pittsburgh, Pittsburgh, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Children\u2019s Hospital of Pittsburgh, Pittsburgh, PA","institution_ids":["https://openalex.org/I4210130600"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210130600"],"apc_list":{"value":3590,"currency":"USD","value_usd":3590},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.16541938,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"144","issue":"2","first_page":"210","last_page":"211"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11078","display_name":"Inflammasome and immune disorders","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11591","display_name":"NF-\u03baB Signaling Pathways","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nod2","display_name":"NOD2","score":0.9950000047683716},{"id":"https://openalex.org/keywords/tlr4","display_name":"TLR4","score":0.953000009059906},{"id":"https://openalex.org/keywords/receptor-crosstalk","display_name":"receptor cross-talk","score":0.921999990940094},{"id":"https://openalex.org/keywords/enterocytes","display_name":"enterocytes","score":0.9269999861717224},{"id":"https://openalex.org/keywords/intestinal-inflammation","display_name":"intestinal inflammation","score":0.7039999961853027},{"id":"https://openalex.org/keywords/necrotizing-enterocolitis","display_name":"necrotizing enterocolitis","score":0.996999979019165},{"id":"https://openalex.org/keywords/nf-kappab-nuclear-translocation","display_name":"NF-\u03baB nuclear translocation","score":0.7710000276565552},{"id":"https://openalex.org/keywords/erk1-2-phosphorylation","display_name":"ERK1/2 phosphorylation","score":0.9319999814033508},{"id":"https://openalex.org/keywords/lipopolysaccharide","display_name":"lipopolysaccharide","score":0.8960000276565552},{"id":"https://openalex.org/keywords/muramyl-dipeptide","display_name":"muramyl dipeptide","score":0.9369999766349792},{"id":"https://openalex.org/keywords/innate-immunity","display_name":"innate immunity","score":0.796999990940094},{"id":"https://openalex.org/keywords/iec-6-cells","display_name":"IEC-6 cells","score":0.7379999756813049},{"id":"https://openalex.org/keywords/neonatal-mice","display_name":"neonatal mice","score":0.41600000858306885},{"id":"https://openalex.org/keywords/hypoxia","display_name":"hypoxia","score":0.5230000019073486},{"id":"https://openalex.org/keywords/bottle-feeding","display_name":"bottle feeding","score":0.6150000095367432},{"id":"https://openalex.org/keywords/ileum","display_name":"ileum","score":0.5640000104904175},{"id":"https://openalex.org/keywords/stoma-closure","display_name":"stoma closure","score":0.5899999737739563},{"id":"https://openalex.org/keywords/crohn-s-disease","display_name":"Crohn's disease","score":0.49300000071525574}],"concepts":[{"id":"https://openalex.org/C7573103","wikidata":"https://www.wikidata.org/wiki/Q416481","display_name":"NOD2","level":4,"score":0.8579853177070618},{"id":"https://openalex.org/C2779604457","wikidata":"https://www.wikidata.org/wiki/Q1340349","display_name":"Enterocyte","level":3,"score":0.8270723819732666},{"id":"https://openalex.org/C2776070231","wikidata":"https://www.wikidata.org/wiki/Q14914098","display_name":"TLR4","level":3,"score":0.8019932508468628},{"id":"https://openalex.org/C136449434","wikidata":"https://www.wikidata.org/wiki/Q428253","display_name":"Innate immune system","level":3,"score":0.6233912110328674},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.5776712894439697},{"id":"https://openalex.org/C2776709828","wikidata":"https://www.wikidata.org/wiki/Q408004","display_name":"Toll-like receptor","level":4,"score":0.5118536353111267},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5031608939170837},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.5008358955383301},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.49385911226272583},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4388478994369507},{"id":"https://openalex.org/C111289621","wikidata":"https://www.wikidata.org/wiki/Q418772","display_name":"Pattern recognition receptor","level":4,"score":0.43738508224487305},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.41772305965423584},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.15460747480392456},{"id":"https://openalex.org/C2777882243","wikidata":"https://www.wikidata.org/wiki/Q11090","display_name":"Small intestine","level":2,"score":0.13040542602539062},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.08845165371894836}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/j.jss.2007.12.089","doi":"https://doi.org/10.1016/j.jss.2007.12.089","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.jss.2007.12.089","pdf_url":null,"source":{"id":"https://openalex.org/S45161156","display_name":"Journal of Surgical Research","issn_l":"0022-4804","issn":["0022-4804","1095-8673"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Surgical Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8560000061988831,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2133462434","https://openalex.org/W318889839","https://openalex.org/W2411654190","https://openalex.org/W2006917381","https://openalex.org/W2057189445","https://openalex.org/W2109601788","https://openalex.org/W1030569489","https://openalex.org/W2056826548","https://openalex.org/W2077142034","https://openalex.org/W2002777031"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2016-06-24T00:00:00"}