{"id":"https://openalex.org/W2062583540","doi":"https://doi.org/10.1093/jnci/94.15.1126","title":"Colorectal Cancer Screening for Persons at Average Risk","display_name":"Colorectal Cancer Screening for Persons at Average Risk","publication_year":2002,"publication_date":"2002-08-07","ids":{"openalex":"https://openalex.org/W2062583540","doi":"https://doi.org/10.1093/jnci/94.15.1126","mag":"2062583540","pmid":"https://pubmed.ncbi.nlm.nih.gov/12165637"},"language":"en","primary_location":{"id":"doi:10.1093/jnci/94.15.1126","doi":"https://doi.org/10.1093/jnci/94.15.1126","is_oa":false,"landing_page_url":"https://doi.org/10.1093/jnci/94.15.1126","pdf_url":null,"source":{"id":"https://openalex.org/S98010888","display_name":"JNCI Journal of the National Cancer Institute","issn_l":"0027-8874","issn":["0027-8874","1460-2105"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"CancerSpectrum Knowledge Environment","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5104110059","display_name":"William Ferguson Anderson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"W. F. Anderson","raw_affiliation_strings":["Division of Cancer Prevention/Gastrointestinal and Other Cancer Research Group, National Cancer Institute, Bethesda, MD 20892-7117, USA. wanderso@mail.nih.gov","National Institutes of Health"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cancer Prevention/Gastrointestinal and Other Cancer Research Group, National Cancer Institute, Bethesda, MD 20892-7117, USA. wanderso@mail.nih.gov","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"raw_affiliation_string":"National Institutes of Health","institution_ids":["https://openalex.org/I1299303238"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5104110059"],"corresponding_institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884"],"apc_list":{"value":5436,"currency":"USD","value_usd":5436},"apc_paid":null,"fwci":2.8069,"has_fulltext":true,"cited_by_count":81,"citation_normalized_percentile":{"value":0.90239623,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"94","issue":"15","first_page":"1126","last_page":"1133"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10552","display_name":"Colorectal Cancer Screening and Detection","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10552","display_name":"Colorectal Cancer Screening and Detection","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10335","display_name":"Colorectal Cancer Surgical Treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11369","display_name":"Genetic factors in colorectal cancer","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/colorectal-cancer-screening","display_name":"colorectal cancer screening","score":0.9819999933242798},{"id":"https://openalex.org/keywords/average-risk-individuals","display_name":"average-risk population","score":0.6800000071525574},{"id":"https://openalex.org/keywords/colorectal-cancer","display_name":"colorectal cancer","score":0.8220000267028809},{"id":"https://openalex.org/keywords/adenoma-carcinoma-sequence","display_name":"adenoma-carcinoma sequence","score":0.8939999938011169},{"id":"https://openalex.org/keywords/colorectal-adenoma","display_name":"colorectal adenoma","score":0.7300000190734863},{"id":"https://openalex.org/keywords/colorectal-carcinogenesis","display_name":"colorectal carcinogenesis","score":0.8270000219345093},{"id":"https://openalex.org/keywords/screening-participation","display_name":"screening uptake","score":0.46799999475479126},{"id":"https://openalex.org/keywords/cancer-prevention","display_name":"cancer prevention","score":0.5509999990463257},{"id":"https://openalex.org/keywords/endoscopic-screening","display_name":"endoscopic screening","score":0.5320000052452087}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7477613091468811},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.6821545362472534},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5633542537689209},{"id":"https://openalex.org/C2780234812","wikidata":"https://www.wikidata.org/wiki/Q1787013","display_name":"Cancer prevention","level":3,"score":0.5368099212646484},{"id":"https://openalex.org/C61511704","wikidata":"https://www.wikidata.org/wiki/Q1671857","display_name":"Incidence (geometry)","level":2,"score":0.5081281661987305},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.43171849846839905},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4248022437095642},{"id":"https://openalex.org/C74909509","wikidata":"https://www.wikidata.org/wiki/Q10387","display_name":"Gerontology","level":1,"score":0.32018598914146423},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000236","descriptor_name":"Adenoma","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D000236","descriptor_name":"Adenoma","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D003113","descriptor_name":"Colonoscopy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D005243","descriptor_name":"Feces","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009780","descriptor_name":"Occult Blood","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012812","descriptor_name":"Sigmoidoscopy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D016032","descriptor_name":"Randomized Controlled Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1093/jnci/94.15.1126","doi":"https://doi.org/10.1093/jnci/94.15.1126","is_oa":false,"landing_page_url":"https://doi.org/10.1093/jnci/94.15.1126","pdf_url":null,"source":{"id":"https://openalex.org/S98010888","display_name":"JNCI Journal of the National Cancer Institute","issn_l":"0027-8874","issn":["0027-8874","1460-2105"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"CancerSpectrum Knowledge Environment","raw_type":"journal-article"},{"id":"pmid:12165637","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12165637","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the National Cancer Institute","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.622.7219","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.622.7219","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://jnci.oxfordjournals.org/content/94/15/1126.full.pdf","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":99,"referenced_works":["https://openalex.org/W86966061","https://openalex.org/W171690468","https://openalex.org/W270164465","https://openalex.org/W584338566","https://openalex.org/W1480542342","https://openalex.org/W1489044888","https://openalex.org/W1562197307","https://openalex.org/W1569091171","https://openalex.org/W1968605703","https://openalex.org/W1971225674","https://openalex.org/W1973043309","https://openalex.org/W1975280744","https://openalex.org/W1975890760","https://openalex.org/W1976975876","https://openalex.org/W1977602842","https://openalex.org/W1979895833","https://openalex.org/W1980590383","https://openalex.org/W1981412450","https://openalex.org/W1984884724","https://openalex.org/W1996143085","https://openalex.org/W1998485117","https://openalex.org/W2001258296","https://openalex.org/W2003915358","https://openalex.org/W2005688549","https://openalex.org/W2005756196","https://openalex.org/W2006628639","https://openalex.org/W2009164177","https://openalex.org/W2009460002","https://openalex.org/W2013763071","https://openalex.org/W2014320166","https://openalex.org/W2014495259","https://openalex.org/W2015213611","https://openalex.org/W2021362203","https://openalex.org/W2021608222","https://openalex.org/W2021661975","https://openalex.org/W2028697059","https://openalex.org/W2030362366","https://openalex.org/W2035833877","https://openalex.org/W2036322983","https://openalex.org/W2039167256","https://openalex.org/W2040262257","https://openalex.org/W2041791600","https://openalex.org/W2043314442","https://openalex.org/W2043539979","https://openalex.org/W2044573147","https://openalex.org/W2046686567","https://openalex.org/W2055461133","https://openalex.org/W2056459926","https://openalex.org/W2059972525","https://openalex.org/W2061596342","https://openalex.org/W2070368323","https://openalex.org/W2074814699","https://openalex.org/W2076083524","https://openalex.org/W2077348225","https://openalex.org/W2078992272","https://openalex.org/W2083285870","https://openalex.org/W2091723114","https://openalex.org/W2109608605","https://openalex.org/W2118835794","https://openalex.org/W2120507833","https://openalex.org/W2121142188","https://openalex.org/W2123244768","https://openalex.org/W2130113095","https://openalex.org/W2134997723","https://openalex.org/W2142217125","https://openalex.org/W2145602937","https://openalex.org/W2155039597","https://openalex.org/W2163722616","https://openalex.org/W2169210449","https://openalex.org/W2225468978","https://openalex.org/W2231156824","https://openalex.org/W2277113186","https://openalex.org/W2290412188","https://openalex.org/W2292518646","https://openalex.org/W2316842579","https://openalex.org/W2319652951","https://openalex.org/W2321845872","https://openalex.org/W2328408799","https://openalex.org/W2333024423","https://openalex.org/W2336715068","https://openalex.org/W2398014323","https://openalex.org/W2405417663","https://openalex.org/W2405461780","https://openalex.org/W2411722769","https://openalex.org/W2415909384","https://openalex.org/W2416895380","https://openalex.org/W2427496861","https://openalex.org/W2429549010","https://openalex.org/W2431637623","https://openalex.org/W2736923483","https://openalex.org/W2746339049","https://openalex.org/W3211652293","https://openalex.org/W4229937330","https://openalex.org/W4231105422","https://openalex.org/W4233487535","https://openalex.org/W4237886326","https://openalex.org/W4252742741","https://openalex.org/W4297625496","https://openalex.org/W6689416344"],"related_works":["https://openalex.org/W2189465385","https://openalex.org/W1575091980","https://openalex.org/W2810359132","https://openalex.org/W3147185032","https://openalex.org/W2766086175","https://openalex.org/W1557656082","https://openalex.org/W2082490954","https://openalex.org/W202076911","https://openalex.org/W1981245808","https://openalex.org/W2402302296"],"abstract_inverted_index":{"In":[0],"the":[1,8,14,60,76,86,120,143,152],"United":[2],"States,":[3],"colorectal":[4,148],"carcinoma":[5],"(CRC)":[6],"is":[7,34,103],"fourth":[9],"most":[10,16,48],"frequently":[11],"diagnosed":[12],"and":[13,25,38,124,140],"second":[15],"common":[17],"cause":[18],"of":[19,31,147,175,188],"cancer-specific":[20],"death":[21],"for":[22,47],"both":[23],"men":[24],"women":[26],"(1).":[27],"The":[28],"lifetime":[29],"risk":[30,62],"developing":[32],"CRC":[33,51,83,102,108,117,189],"approximately":[35,90],"6%":[36],"(2),":[37],"treatment":[39],"costs":[40],"nearly":[41],"$6":[42],"billion":[43],"annually":[44],"(3).":[45],"As":[46],"epithelial":[49],"cancers,":[50],"age-specific":[52],"incidence":[53],"increases":[54],"continuously":[55],"with":[56,59,160],"biologic":[57],"aging,":[58],"greatest":[61],"occurring":[63],"in":[64,85,155,170],"those":[65],"individuals":[66],"aged":[67,178],"80":[68],"years":[69,98,180],"or":[70,132,181],"older":[71,182],"(2)":[72],"(Fig.":[73],"1).":[74],"Of":[75],"more":[77],"than":[78],"148":[79],"000":[80],"estimated":[81],"new":[82],"cases":[84],"year":[87],"2002":[88],"(4),":[89],"40%":[91],"are":[92],"expected":[93],"to":[94,122],"die":[95],"within":[96],"5":[97],"(2).":[99],"Death":[100],"from":[101],"especially":[104],"unfortunate,":[105],"given":[106],"that":[107],"prevention":[109],"often":[110],"can":[111],"be":[112,158],"achieved":[113,159],"through":[114],"screening":[115,118,190],"(5).":[116],"affords":[119],"opportunity":[121],"identify":[123],"remove":[125],"precursor":[126],"lesions":[127],"(e.g.,":[128],"preinvasive":[129],"adenomatous":[130],"polyps":[131],"adenomas)":[133],"(6).":[134],"Indeed,":[135],"direct,":[136],"longitudinal":[137],"observation":[138],"of,":[139],"intervention":[141],"in,":[142],"long-term,":[144],"multi-step":[145],"process":[146],"carcinogenesis\u2014partially":[149],"represented":[150],"by":[151],"adenoma-to-carcinoma":[153],"sequence":[154],"Fig.":[156],"2(7,8)\u2014can":[157],"existing":[161],"endoscopic":[162],"technologies":[163],"(6,9,10).":[164],"Although":[165],"efficacy":[166],"has":[167],"been":[168],"demonstrated":[169],"this":[171],"regard,":[172],"only":[173],"44%":[174],"U.S.":[176],"adults":[177],"50":[179],"have":[183],"recently":[184],"had":[185],"any":[186],"type":[187],"(11).":[191]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":4},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
