{"id":"https://openalex.org/W2062432663","doi":"https://doi.org/10.1016/j.ijpharm.2009.12.056","title":"Novel multifunctional pharmaceutical excipients derived from microcrystalline cellulose\u2013starch microparticulate composites prepared by compatibilized reactive polymer blending","display_name":"Novel multifunctional pharmaceutical excipients derived from microcrystalline cellulose\u2013starch microparticulate composites prepared by compatibilized reactive polymer blending","publication_year":2010,"publication_date":"2010-01-08","ids":{"openalex":"https://openalex.org/W2062432663","doi":"https://doi.org/10.1016/j.ijpharm.2009.12.056","mag":"2062432663","pmid":"https://pubmed.ncbi.nlm.nih.gov/20060448"},"language":"en","primary_location":{"id":"doi:10.1016/j.ijpharm.2009.12.056","doi":"https://doi.org/10.1016/j.ijpharm.2009.12.056","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.ijpharm.2009.12.056","pdf_url":null,"source":{"id":"https://openalex.org/S131016564","display_name":"International Journal of Pharmaceutics","issn_l":"0378-5173","issn":["0378-5173","1873-3476"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Pharmaceutics","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112491710","display_name":"Philip F. Builders","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210104694","display_name":"National Institute for Pharmaceutical Research and Development","ror":"https://ror.org/01c7jsk34","country_code":"NG","type":"government","lineage":["https://openalex.org/I4210104694"]}],"countries":["NG"],"is_corresponding":true,"raw_author_name":"Philip F. Builders","raw_affiliation_strings":["Department of Pharmaceutical Technology and Raw Materials Development, National Institute for Pharmaceutical Research and Development, Abuja, Nigeria. philsonsky@yahoo.com","Department of Pharmaceutical Technology and Raw Materials Development, National Institute for Pharmaceutical Research and Development, Abuja, Nigeria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Technology and Raw Materials Development, National Institute for Pharmaceutical Research and Development, Abuja, Nigeria. philsonsky@yahoo.com","institution_ids":["https://openalex.org/I4210104694"]},{"raw_affiliation_string":"Department of Pharmaceutical Technology and Raw Materials Development, National Institute for Pharmaceutical Research and Development, Abuja, Nigeria","institution_ids":["https://openalex.org/I4210104694"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061607242","display_name":"Agbo M. Bonaventure","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210104694","display_name":"National Institute for Pharmaceutical Research and Development","ror":"https://ror.org/01c7jsk34","country_code":"NG","type":"government","lineage":["https://openalex.org/I4210104694"]}],"countries":["NG"],"is_corresponding":false,"raw_author_name":"Agbo M. Bonaventure","raw_affiliation_strings":["Department of Pharmaceutical Technology and Raw Materials Development, National Institute for Pharmaceutical Research and Development, Abuja, Nigeria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Technology and Raw Materials Development, National Institute for Pharmaceutical Research and Development, Abuja, Nigeria","institution_ids":["https://openalex.org/I4210104694"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112780013","display_name":"Tiwalade A. Adelakun","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210104694","display_name":"National Institute for Pharmaceutical Research and Development","ror":"https://ror.org/01c7jsk34","country_code":"NG","type":"government","lineage":["https://openalex.org/I4210104694"]}],"countries":["NG"],"is_corresponding":false,"raw_author_name":"Adelakun Tiwalade","raw_affiliation_strings":["Department of Medicinal Chemistry and Quality Control, National Institute for Pharmaceutical Research and Development, Abuja, Nigeria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicinal Chemistry and Quality Control, National Institute for Pharmaceutical Research and Development, Abuja, Nigeria","institution_ids":["https://openalex.org/I4210104694"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002015151","display_name":"Larry C. Okpako","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I139894009","display_name":"University of Bradford","ror":"https://ror.org/00vs8d940","country_code":"GB","type":"education","lineage":["https://openalex.org/I139894009"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Larry C. Okpako","raw_affiliation_strings":["School of Pharmacy, University of Bradford, Bradford, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Pharmacy, University of Bradford, Bradford, United Kingdom","institution_ids":["https://openalex.org/I139894009"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5029862208","display_name":"Anthony Amaechi Attama","orcid":"https://orcid.org/0000-0002-5751-2280","observed_orcids":["https://orcid.org/0000-0002-5751-2280","https://orcid.org/0000-0003-4418-1088"]},"institutions":[{"id":"https://openalex.org/I11892038","display_name":"University of Nigeria","ror":"https://ror.org/01sn1yx84","country_code":"NG","type":"education","lineage":["https://openalex.org/I11892038"]}],"countries":["NG"],"is_corresponding":false,"raw_author_name":"Anthony A. Attama","raw_affiliation_strings":["Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, University of Nigeria, Nsukka, Nigeria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, University of Nigeria, Nsukka, Nigeria","institution_ids":["https://openalex.org/I11892038"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5112491710"],"corresponding_institution_ids":["https://openalex.org/I4210104694"],"apc_list":{"value":4650,"currency":"USD","value_usd":4650},"apc_paid":null,"fwci":3.7576,"has_fulltext":false,"cited_by_count":49,"citation_normalized_percentile":{"value":0.9309475,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"388","issue":"1-2","first_page":"159","last_page":"167"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10256","display_name":"Drug Solubulity and Delivery Systems","score":0.8579000234603882,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10256","display_name":"Drug Solubulity and Delivery Systems","score":0.8579000234603882,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10615","display_name":"Granular flow and fluidized beds","score":0.05460000038146973,"subfield":{"id":"https://openalex.org/subfields/2206","display_name":"Computational Mechanics"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12192","display_name":"Polysaccharides Composition and Applications","score":0.025100000202655792,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/microcrystalline-cellulose","display_name":"microcrystalline cellulose","score":0.9359999895095825},{"id":"https://openalex.org/keywords/cornstarch","display_name":"corn starch","score":0.9919999837875366},{"id":"https://openalex.org/keywords/starch-based-composites","display_name":"starch composites","score":0.5630000233650208},{"id":"https://openalex.org/keywords/pharmaceutical-excipients","display_name":"pharmaceutical excipients","score":0.9300000071525574},{"id":"https://openalex.org/keywords/direct-compression","display_name":"direct compression","score":0.7990000247955322},{"id":"https://openalex.org/keywords/tablet-disintegration","display_name":"tablet disintegration","score":0.9419999718666077},{"id":"https://openalex.org/keywords/freeze-thaw-cycles","display_name":"freeze-thaw cycles","score":0.7979999780654907},{"id":"https://openalex.org/keywords/powder-flow-properties","display_name":"powder flow properties","score":0.8610000014305115},{"id":"https://openalex.org/keywords/moisture-sorption-isotherms","display_name":"moisture sorption isotherms","score":0.8399999737739563},{"id":"https://openalex.org/keywords/tablet-hardness","display_name":"tablet hardness","score":0.7269999980926514},{"id":"https://openalex.org/keywords/aspirin-tablets","display_name":"aspirin tablets","score":0.9039999842643738},{"id":"https://openalex.org/keywords/acetaminophen-tablets","display_name":"acetaminophen tablets","score":0.9710000157356262},{"id":"https://openalex.org/keywords/multifunctional-excipients","display_name":"multifunctional excipients","score":0.6539999842643738}],"concepts":[{"id":"https://openalex.org/C2779351475","wikidata":"https://www.wikidata.org/wiki/Q417374","display_name":"Microcrystalline cellulose","level":3,"score":0.9072056412696838},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.7447662353515625},{"id":"https://openalex.org/C2777239854","wikidata":"https://www.wikidata.org/wiki/Q902638","display_name":"Excipient","level":2,"score":0.6225473880767822},{"id":"https://openalex.org/C159985019","wikidata":"https://www.wikidata.org/wiki/Q181790","display_name":"Composite material","level":1,"score":0.5420530438423157},{"id":"https://openalex.org/C529335014","wikidata":"https://www.wikidata.org/wiki/Q41534","display_name":"Starch","level":2,"score":0.5180413722991943},{"id":"https://openalex.org/C26771246","wikidata":"https://www.wikidata.org/wiki/Q321095","display_name":"Scanning electron microscope","level":2,"score":0.49378690123558044},{"id":"https://openalex.org/C42360764","wikidata":"https://www.wikidata.org/wiki/Q83588","display_name":"Chemical engineering","level":1,"score":0.48394113779067993},{"id":"https://openalex.org/C187404810","wikidata":"https://www.wikidata.org/wiki/Q733193","display_name":"Polymer blend","level":4,"score":0.43398264050483704},{"id":"https://openalex.org/C104779481","wikidata":"https://www.wikidata.org/wiki/Q50707","display_name":"Composite number","level":2,"score":0.42429319024086},{"id":"https://openalex.org/C521977710","wikidata":"https://www.wikidata.org/wiki/Q81163","display_name":"Polymer","level":2,"score":0.4191407859325409},{"id":"https://openalex.org/C2779251873","wikidata":"https://www.wikidata.org/wiki/Q80294","display_name":"Cellulose","level":2,"score":0.29242146015167236},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.23028084635734558},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.20999956130981445},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.1432514488697052},{"id":"https://openalex.org/C15920480","wikidata":"https://www.wikidata.org/wiki/Q421281","display_name":"Copolymer","level":3,"score":0.09666189551353455},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000082","descriptor_name":"Acetaminophen","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000082","descriptor_name":"Acetaminophen","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D001241","descriptor_name":"Aspirin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D001241","descriptor_name":"Aspirin","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D002152","descriptor_name":"Calorimetry, Differential Scanning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002482","descriptor_name":"Cellulose","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D002626","descriptor_name":"Chemistry, Pharmaceutical","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D003313","descriptor_name":"Zea mays","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D005079","descriptor_name":"Excipients","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D005615","descriptor_name":"Freezing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006244","descriptor_name":"Hardness","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008855","descriptor_name":"Microscopy, Electron, Scanning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013213","descriptor_name":"Starch","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D013607","descriptor_name":"Tablets","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013696","descriptor_name":"Temperature","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.ijpharm.2009.12.056","doi":"https://doi.org/10.1016/j.ijpharm.2009.12.056","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.ijpharm.2009.12.056","pdf_url":null,"source":{"id":"https://openalex.org/S131016564","display_name":"International Journal of Pharmaceutics","issn_l":"0378-5173","issn":["0378-5173","1873-3476"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Pharmaceutics","raw_type":"journal-article"},{"id":"pmid:20060448","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20060448","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of pharmaceutics","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.5683000087738037}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":40,"referenced_works":["https://openalex.org/W578549168","https://openalex.org/W658417414","https://openalex.org/W1566408227","https://openalex.org/W1641358704","https://openalex.org/W1822956910","https://openalex.org/W1967983079","https://openalex.org/W1974191979","https://openalex.org/W1975051423","https://openalex.org/W1977712203","https://openalex.org/W1980213567","https://openalex.org/W1980704616","https://openalex.org/W1989480064","https://openalex.org/W1994598866","https://openalex.org/W2011141984","https://openalex.org/W2015926566","https://openalex.org/W2020260586","https://openalex.org/W2037533163","https://openalex.org/W2044628190","https://openalex.org/W2048298448","https://openalex.org/W2059573879","https://openalex.org/W2075179133","https://openalex.org/W2082231024","https://openalex.org/W2084687638","https://openalex.org/W2085962137","https://openalex.org/W2088445383","https://openalex.org/W2098988099","https://openalex.org/W2114057030","https://openalex.org/W2132190003","https://openalex.org/W2135155684","https://openalex.org/W2152276250","https://openalex.org/W2159269801","https://openalex.org/W2160458846","https://openalex.org/W2321951569","https://openalex.org/W2337922562","https://openalex.org/W2417581664","https://openalex.org/W2485941347","https://openalex.org/W2492909077","https://openalex.org/W3005605915","https://openalex.org/W3141673278","https://openalex.org/W4235533903"],"related_works":["https://openalex.org/W2057942445","https://openalex.org/W3118063961","https://openalex.org/W3127382954","https://openalex.org/W7218295453","https://openalex.org/W2903419655","https://openalex.org/W6949148057","https://openalex.org/W7098862758","https://openalex.org/W2902519594","https://openalex.org/W2092119127","https://openalex.org/W2184605046"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":8},{"year":2012,"cited_by_count":6}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}