{"id":"https://openalex.org/W2062408475","doi":"https://doi.org/10.1002/dvdy.21146","title":"Gene expression analysis of the hedgehog signaling cascade in the chick midbrain and spinal cord","display_name":"Gene expression analysis of the hedgehog signaling cascade in the chick midbrain and spinal cord","publication_year":2007,"publication_date":"2007-04-13","ids":{"openalex":"https://openalex.org/W2062408475","doi":"https://doi.org/10.1002/dvdy.21146","mag":"2062408475","pmid":"https://pubmed.ncbi.nlm.nih.gov/17436280"},"language":"en","primary_location":{"id":"doi:10.1002/dvdy.21146","doi":"https://doi.org/10.1002/dvdy.21146","is_oa":false,"landing_page_url":"https://doi.org/10.1002/dvdy.21146","pdf_url":null,"source":{"id":"https://openalex.org/S104993753","display_name":"Developmental Dynamics","issn_l":"1058-8388","issn":["1058-8388","1097-0177"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Developmental Dynamics","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5046971601","display_name":"Galina V. Aglyamova","orcid":"https://orcid.org/0000-0001-6105-6399","observed_orcids":["https://orcid.org/0000-0001-6105-6399"]},"institutions":[{"id":"https://openalex.org/I86519309","display_name":"The University of Texas at Austin","ror":"https://ror.org/00hj54h04","country_code":"US","type":"education","lineage":["https://openalex.org/I86519309"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Galina V. Aglyamova","raw_affiliation_strings":["Section of Neurobiology, University of Texas at Austin, Austin, Texas 78712, USA","Section of Neurobiology, University of Texas at Austin, Austin, Texas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section of Neurobiology, University of Texas at Austin, Austin, Texas 78712, USA","institution_ids":["https://openalex.org/I86519309"]},{"raw_affiliation_string":"Section of Neurobiology, University of Texas at Austin, Austin, Texas","institution_ids":["https://openalex.org/I86519309"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5023754362","display_name":"Seema Agarwala","orcid":"https://orcid.org/0000-0002-6495-2962","observed_orcids":["https://orcid.org/0000-0002-6495-2962"]},"institutions":[{"id":"https://openalex.org/I86519309","display_name":"The University of Texas at Austin","ror":"https://ror.org/00hj54h04","country_code":"US","type":"education","lineage":["https://openalex.org/I86519309"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Seema Agarwala","raw_affiliation_strings":["Institute for Cell and Molecular Biology, and Institute for Neuroscience, University of Texas at Austin, Austin, Texas","Section of Neurobiology, University of Texas at Austin, Austin, Texas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Cell and Molecular Biology, and Institute for Neuroscience, University of Texas at Austin, Austin, Texas","institution_ids":["https://openalex.org/I86519309"]},{"raw_affiliation_string":"Section of Neurobiology, University of Texas at Austin, Austin, Texas","institution_ids":["https://openalex.org/I86519309"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5023754362"],"corresponding_institution_ids":["https://openalex.org/I86519309"],"apc_list":{"value":4430,"currency":"USD","value_usd":4430},"apc_paid":null,"fwci":0.6551,"has_fulltext":false,"cited_by_count":22,"citation_normalized_percentile":{"value":0.63064329,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"236","issue":"5","first_page":"1363","last_page":"1373"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12009","display_name":"Hedgehog Signaling Pathway Studies","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12009","display_name":"Hedgehog Signaling Pathway Studies","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10929","display_name":"Wnt/\u03b2-catenin signaling in development and cancer","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sonic-hedgehog-signaling","display_name":"Sonic hedgehog signaling","score":0.8059999942779541},{"id":"https://openalex.org/keywords/spinal-cord","display_name":"spinal cord","score":0.9480000138282776},{"id":"https://openalex.org/keywords/ptch1","display_name":"PTCH1","score":0.5550000071525574},{"id":"https://openalex.org/keywords/ptch2","display_name":"PTCH2","score":1.0},{"id":"https://openalex.org/keywords/hhip","display_name":"HHIP","score":0.7379999756813049},{"id":"https://openalex.org/keywords/boc","display_name":"BOC","score":0.9380000233650208},{"id":"https://openalex.org/keywords/megalin","display_name":"megalin","score":0.9779999852180481},{"id":"https://openalex.org/keywords/smo","display_name":"SMO","score":0.7429999709129333},{"id":"https://openalex.org/keywords/suppressor-of-fused","display_name":"SUFU","score":0.9980000257492065},{"id":"https://openalex.org/keywords/ihh","display_name":"Ihh","score":0.6919999718666077},{"id":"https://openalex.org/keywords/midbrain-hindbrain-boundary","display_name":"midbrain-hindbrain boundary","score":0.8939999938011169},{"id":"https://openalex.org/keywords/gene-expression-timing","display_name":"gene expression timing","score":0.48399999737739563}],"concepts":[{"id":"https://openalex.org/C552161191","wikidata":"https://www.wikidata.org/wiki/Q185080","display_name":"Midbrain","level":3,"score":0.9428660869598389},{"id":"https://openalex.org/C2776637008","wikidata":"https://www.wikidata.org/wiki/Q14860072","display_name":"Sonic hedgehog","level":3,"score":0.8643765449523926},{"id":"https://openalex.org/C2777075493","wikidata":"https://www.wikidata.org/wiki/Q1137072","display_name":"Hindbrain","level":3,"score":0.7769308686256409},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7605376243591309},{"id":"https://openalex.org/C2778539099","wikidata":"https://www.wikidata.org/wiki/Q6120","display_name":"Hedgehog","level":3,"score":0.7516086101531982},{"id":"https://openalex.org/C2779933373","wikidata":"https://www.wikidata.org/wiki/Q14886430","display_name":"GLI1","level":4,"score":0.7347586154937744},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.562430202960968},{"id":"https://openalex.org/C2776094402","wikidata":"https://www.wikidata.org/wiki/Q17927891","display_name":"FGF8","level":4,"score":0.5190287828445435},{"id":"https://openalex.org/C88498014","wikidata":"https://www.wikidata.org/wiki/Q14859918","display_name":"Hedgehog signaling pathway","level":3,"score":0.5127092599868774},{"id":"https://openalex.org/C2780775167","wikidata":"https://www.wikidata.org/wiki/Q9606","display_name":"Spinal cord","level":2,"score":0.4344385862350464},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.3670409321784973},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.3604738712310791},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.32012370228767395},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.2714638113975525},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.24911832809448242},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.19235184788703918},{"id":"https://openalex.org/C196843134","wikidata":"https://www.wikidata.org/wiki/Q33196","display_name":"Embryo","level":2,"score":0.0875958502292633},{"id":"https://openalex.org/C74373430","wikidata":"https://www.wikidata.org/wiki/Q24727126","display_name":"Fibroblast growth factor","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002352","descriptor_name":"Carrier Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002642","descriptor_name":"Chick Embryo","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003001","descriptor_name":"Cloning, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008636","descriptor_name":"Mesencephalon","qualifier_ui":"Q000196","qualifier_name":"embryology","is_major_topic":true},{"descriptor_ui":"D008636","descriptor_name":"Mesencephalon","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011956","descriptor_name":"Receptors, Cell Surface","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D013116","descriptor_name":"Spinal Cord","qualifier_ui":"Q000196","qualifier_name":"embryology","is_major_topic":true},{"descriptor_ui":"D013116","descriptor_name":"Spinal Cord","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017403","descriptor_name":"In Situ Hybridization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017931","descriptor_name":"DNA Primers","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018507","descriptor_name":"Gene Expression Regulation, Developmental","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053823","descriptor_name":"Hedgehog Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1002/dvdy.21146","doi":"https://doi.org/10.1002/dvdy.21146","is_oa":false,"landing_page_url":"https://doi.org/10.1002/dvdy.21146","pdf_url":null,"source":{"id":"https://openalex.org/S104993753","display_name":"Developmental Dynamics","issn_l":"1058-8388","issn":["1058-8388","1097-0177"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Developmental Dynamics","raw_type":"journal-article"},{"id":"pmid:17436280","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17436280","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Developmental dynamics : an official publication of the American Association of Anatomists","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":66,"referenced_works":["https://openalex.org/W189211614","https://openalex.org/W1511606211","https://openalex.org/W1543890504","https://openalex.org/W1550985854","https://openalex.org/W1585922331","https://openalex.org/W1659071674","https://openalex.org/W1698663755","https://openalex.org/W1730711798","https://openalex.org/W1950508909","https://openalex.org/W1964929288","https://openalex.org/W1972091253","https://openalex.org/W1973017648","https://openalex.org/W1978833015","https://openalex.org/W1979414180","https://openalex.org/W1982087641","https://openalex.org/W1983341583","https://openalex.org/W1985109716","https://openalex.org/W1987228418","https://openalex.org/W1987785417","https://openalex.org/W1993902328","https://openalex.org/W1994620081","https://openalex.org/W1995172129","https://openalex.org/W1997862931","https://openalex.org/W1998880332","https://openalex.org/W2000258781","https://openalex.org/W2007909080","https://openalex.org/W2018456985","https://openalex.org/W2019150363","https://openalex.org/W2022148395","https://openalex.org/W2040538482","https://openalex.org/W2043289157","https://openalex.org/W2043384567","https://openalex.org/W2046825232","https://openalex.org/W2049484225","https://openalex.org/W2056994384","https://openalex.org/W2059614045","https://openalex.org/W2061623544","https://openalex.org/W2062277719","https://openalex.org/W2062928655","https://openalex.org/W2063266633","https://openalex.org/W2064604181","https://openalex.org/W2067263369","https://openalex.org/W2069226457","https://openalex.org/W2070350523","https://openalex.org/W2070723386","https://openalex.org/W2079120411","https://openalex.org/W2081235375","https://openalex.org/W2088598451","https://openalex.org/W2090204462","https://openalex.org/W2091810098","https://openalex.org/W2092423326","https://openalex.org/W2096108228","https://openalex.org/W2102345821","https://openalex.org/W2104033956","https://openalex.org/W2107658317","https://openalex.org/W2108707301","https://openalex.org/W2130631370","https://openalex.org/W2139168265","https://openalex.org/W2140034535","https://openalex.org/W2143140700","https://openalex.org/W2164274213","https://openalex.org/W2165048394","https://openalex.org/W2172253586","https://openalex.org/W2186043758","https://openalex.org/W2342738149","https://openalex.org/W7073899588"],"related_works":["https://openalex.org/W2107658317","https://openalex.org/W1964620825","https://openalex.org/W2040538482","https://openalex.org/W2338212236","https://openalex.org/W2745272902","https://openalex.org/W2027177102","https://openalex.org/W1793342589","https://openalex.org/W1990251289","https://openalex.org/W1963757127","https://openalex.org/W2086606983"],"abstract_inverted_index":{"The":[0],"signaling":[1,28,87],"molecule":[2],"Sonic":[3],"Hedgehog":[4,26],"(SHH)":[5],"plays":[6],"a":[7,39],"critical":[8],"role":[9],"in":[10,29,38,60,84,89,101,145,168,187],"patterning":[11],"the":[12,23,30,43,47,57,61,76,85,90,102,107,121,135,146,150,169,173,180,191],"ventral":[13,136],"midbrain":[14,32,44,62,91,147,171],"of":[15,49,51,79,109,190,202],"vertebrates.":[16],"Our":[17,95],"recent":[18],"studies":[19],"have":[20,72],"established":[21],"that":[22,54,82,98,183,201],"requirement":[24],"for":[25,179],"(HH)":[27],"chick":[31],"is":[33,185],"modulated":[34],"spatially":[35],"and":[36,92,124,129,142,159,172],"temporally":[37],"complex":[40],"manner":[41],"across":[42,74],"anlage.":[45],"Unfortunately,":[46],"patterns":[48],"expression":[50,77,100,108,144,196],"downstream":[52],"regulators":[53],"might":[55],"modulate":[56],"HH":[58,86,111,160],"signal":[59],"are":[63,127,166],"not":[64,198],"currently":[65],"known.":[66],"To":[67],"fill":[68],"this":[69],"gap,":[70],"we":[71,177],"examined":[73],"time,":[75],"pattern":[78],"14":[80],"genes":[81,126],"function":[83],"cascade":[88],"spinal":[93,192],"cord.":[94],"results":[96],"suggest":[97],"SHH":[99,151],"axial":[103],"mesendoderm":[104],"begins":[105],"before":[106],"known":[110],"receptors/HH-binding":[112],"proteins":[113,156],"(e.g.,":[114],"PTC1,":[115],"PTC2,":[116],"HHIP,":[117],"BOC,":[118],"MEGALIN).":[119],"In":[120],"midbrain,":[122],"PTC":[123],"GLI":[125],"expressed":[128,167,186],"then":[130],"eliminated":[131],"very":[132],"early":[133],"from":[134],"midline.":[137],"However,":[138],"they":[139],"exhibit":[140],"high":[141],"persistent":[143],"region":[148],"circumscribing":[149],"source.":[152],"Intriguingly,":[153],"multiple":[154],"HH-binding":[155],"(BOC,":[157],"MEGALIN)":[158],"effectors":[161],"(GLI1-3,":[162],"SMO,":[163],"SUFU,":[164],"DZIP)":[165],"dorsal":[170],"midbrain-hindbrain":[174],"boundary.":[175],"Finally,":[176],"report":[178],"first":[181],"time":[182],"IHH":[184],"intermediate":[188],"regions":[189],"cord,":[193],"where":[194],"its":[195],"does":[197],"overlap":[199],"with":[200],"SHH.":[203]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}