{"id":"https://openalex.org/W2062405903","doi":"https://doi.org/10.1073/pnas.84.19.6720","title":"The heavy chain of Acanthamoeba myosin IB is a fusion of myosin-like and non-myosin-like sequences.","display_name":"The heavy chain of Acanthamoeba myosin IB is a fusion of myosin-like and non-myosin-like sequences.","publication_year":1987,"publication_date":"1987-10-01","ids":{"openalex":"https://openalex.org/W2062405903","doi":"https://doi.org/10.1073/pnas.84.19.6720","mag":"2062405903","pmid":"https://pubmed.ncbi.nlm.nih.gov/3477803","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/299155"},"language":"en","primary_location":{"id":"doi:10.1073/pnas.84.19.6720","doi":"https://doi.org/10.1073/pnas.84.19.6720","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.84.19.6720","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://europepmc.org/pmc/articles/PMC299155","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5010530886","display_name":"Goeh Jung","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210106489","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210106489"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"G Jung","raw_affiliation_strings":["Laboratory of Cell Biology, National Heart, Lung, and Blood Institute, Bethesda, MD 20892"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Cell Biology, National Heart, Lung, and Blood Institute, Bethesda, MD 20892","institution_ids":["https://openalex.org/I4210106489"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056320284","display_name":"Edward D. Korn","orcid":"https://orcid.org/0000-0003-3867-6295","observed_orcids":["https://orcid.org/0000-0003-3867-6295"]},"institutions":[{"id":"https://openalex.org/I4210106489","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210106489"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"E D Korn","raw_affiliation_strings":["Laboratory of Cell Biology, National Heart, Lung, and Blood Institute, Bethesda, MD 20892"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Cell Biology, National Heart, Lung, and Blood Institute, Bethesda, MD 20892","institution_ids":["https://openalex.org/I4210106489"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5077641368","display_name":"John A. Hammer","orcid":"https://orcid.org/0000-0002-2496-5179","observed_orcids":["https://orcid.org/0000-0002-2496-5179"]},"institutions":[{"id":"https://openalex.org/I4210106489","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210106489"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J A Hammer","raw_affiliation_strings":["Laboratory of Cell Biology, National Heart, Lung, and Blood Institute, Bethesda, MD 20892"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Cell Biology, National Heart, Lung, and Blood Institute, Bethesda, MD 20892","institution_ids":["https://openalex.org/I4210106489"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210106489"],"apc_list":null,"apc_paid":null,"fwci":13.5692,"has_fulltext":false,"cited_by_count":123,"citation_normalized_percentile":{"value":0.99246922,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"84","issue":"19","first_page":"6720","last_page":"6724"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10882","display_name":"Cardiomyopathy and Myosin Studies","score":0.4839000105857849,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10882","display_name":"Cardiomyopathy and Myosin Studies","score":0.4839000105857849,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.13439999520778656,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.11240000277757645,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/myosin-heavy-chain","display_name":"myosin heavy chain","score":0.9649999737739563},{"id":"https://openalex.org/keywords/acanthamoeba-castellanii","display_name":"Acanthamoeba castellanii","score":0.8679999709129333},{"id":"https://openalex.org/keywords/myosin-tail","display_name":"myosin tail","score":0.5770000219345093},{"id":"https://openalex.org/keywords/coiled-coil-structure","display_name":"coiled-coil structure","score":0.6470000147819519},{"id":"https://openalex.org/keywords/exon-intron-structure","display_name":"exon-intron structure","score":0.671999990940094},{"id":"https://openalex.org/keywords/amino-acid-sequence","display_name":"amino acid sequence","score":0.6620000004768372},{"id":"https://openalex.org/keywords/glycine-rich-domain","display_name":"glycine-rich domain","score":0.5519999861717224},{"id":"https://openalex.org/keywords/gene-structure-conservation","display_name":"gene structure conservation","score":0.382999986410141}],"concepts":[{"id":"https://openalex.org/C6997183","wikidata":"https://www.wikidata.org/wiki/Q271727","display_name":"Myosin","level":2,"score":0.9175777435302734},{"id":"https://openalex.org/C15954220","wikidata":"https://www.wikidata.org/wiki/Q24780076","display_name":"Myosin head","level":4,"score":0.7302122712135315},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6484224200248718},{"id":"https://openalex.org/C8035138","wikidata":"https://www.wikidata.org/wiki/Q6017854","display_name":"Myosin light-chain kinase","level":3,"score":0.6105861067771912},{"id":"https://openalex.org/C167625842","wikidata":"https://www.wikidata.org/wiki/Q899763","display_name":"Peptide sequence","level":3,"score":0.5434998273849487},{"id":"https://openalex.org/C36823959","wikidata":"https://www.wikidata.org/wiki/Q373027","display_name":"Exon","level":3,"score":0.5109883546829224},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4526878595352173},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.44837579131126404},{"id":"https://openalex.org/C94671646","wikidata":"https://www.wikidata.org/wiki/Q207551","display_name":"Intron","level":3,"score":0.4318930506706238},{"id":"https://openalex.org/C55988834","wikidata":"https://www.wikidata.org/wiki/Q903650","display_name":"Coiled coil","level":2,"score":0.41322463750839233},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3908892571926117}],"mesh":[{"descriptor_ui":"D000048","descriptor_name":"Acanthamoeba","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005091","descriptor_name":"Exons","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005796","descriptor_name":"Genes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007438","descriptor_name":"Introns","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009218","descriptor_name":"Myosins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D046911","descriptor_name":"Macromolecular Substances","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1073/pnas.84.19.6720","doi":"https://doi.org/10.1073/pnas.84.19.6720","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.84.19.6720","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:55482","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC299155","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:299155","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/299155","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"},{"id":"pmid:3477803","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3477803","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences of the United States of America","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:55482","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC299155","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":17,"referenced_works":["https://openalex.org/W1540784621","https://openalex.org/W1553432184","https://openalex.org/W1558285759","https://openalex.org/W1558516755","https://openalex.org/W1578752164","https://openalex.org/W1579490087","https://openalex.org/W1965051773","https://openalex.org/W1983288469","https://openalex.org/W1988310026","https://openalex.org/W1991487165","https://openalex.org/W1995945233","https://openalex.org/W2006424626","https://openalex.org/W2062738309","https://openalex.org/W2127963615","https://openalex.org/W2138270253","https://openalex.org/W2172335639","https://openalex.org/W4300325666"],"related_works":["https://openalex.org/W2006424626","https://openalex.org/W2041084404","https://openalex.org/W2097014018","https://openalex.org/W1604615261","https://openalex.org/W1482201556","https://openalex.org/W2083243989","https://openalex.org/W1512970527","https://openalex.org/W2054175799","https://openalex.org/W2115423638","https://openalex.org/W1490562986"],"abstract_inverted_index":{"Acanthamoeba":[0],"castellanii":[1],"myosins":[2],"IA":[3],"and":[4,13,19,35,71,82,133,136,191,215,236],"IB":[5,58,234],"demonstrate":[6],"the":[7,49,55,65,69,75,86,99,108,138,151,163,180,197,228,232,237],"catalytic":[8],"properties":[9],"of":[10,17,54,68,80,91,103,113,121,142,155,209,231,239],"a":[11,78,156,193,206,216],"myosin":[12,57,123,157,167,184,201,219,233,240],"can":[14],"support":[15,179],"analogues":[16],"contractile":[18],"motile":[20],"activity":[21],"in":[22,130,225],"vitro,":[23],"but":[24,170],"their":[25],"single,":[26],"low":[27],"molecular":[28],"weight":[29],"heavy":[30,59],"chains,":[31],"roughly":[32],"globular":[33,100,158],"shapes,":[34],"inabilities":[36],"to":[37,98,118,162,172,227],"self-assemble":[38],"into":[39],"filaments":[40],"make":[41],"them":[42],"structurally":[43],"atypical":[44],"myosins.":[45,105],"We":[46,147,221],"now":[47],"present":[48],"complete":[50],"amino":[51,92],"acid":[52,93],"sequence":[53,67,94,114,140],"128-kDa":[56],"chain,":[60],"which":[61,72],"we":[62,204],"deduced":[63],"from":[64],"nucleotide":[66],"gene":[70,214,235,241],"reveals":[73],"that":[74,127,150,182],"polypeptide":[76],"is":[77,95,153,185],"fusion":[79],"myosin-like":[81],"non-myosin-like":[83],"sequences.":[84],"Specifically,":[85],"amino-terminal":[87],"approximately":[88,110],"76":[89],"kDa":[90,112],"highly":[96],"similar":[97],"head":[101,159],"sequences":[102],"conventional":[104,122],"By":[106],"contrast,":[107],"remaining":[109],"51":[111],"shows":[115],"no":[116],"similarity":[117],"any":[119],"portion":[120],"sequences,":[124],"contains":[125],"regions":[126],"are":[128],"rich":[129],"glycine,":[131],"proline,":[132],"alanine":[134],"residues,":[135],"lacks":[137],"distinctive":[139],"characteristics":[141],"an":[143,173],"alpha-helical,":[144],"coiled-coil":[145,165],"structure.":[146,243],"conclude,":[148],"therefore,":[149],"protein":[152],"composed":[154],"fused":[160],"not":[161,186],"typical":[164],"rod-like":[166],"tail":[168],"structure":[169,211],"rather":[171],"unusual":[174],"carboxyl-terminal":[175],"domain.":[176],"These":[177],"results":[178],"conclusion":[181],"filamentous":[183],"required":[187],"for":[188,200],"force":[189],"generation":[190],"provide":[192],"further":[194],"perspective":[195],"on":[196],"structural":[198],"requirements":[199],"function.":[202],"Finally,":[203],"find":[205],"striking":[207],"conservation":[208],"intron/exon":[210,242],"between":[212],"this":[213,223],"vertebrate":[217],"muscle":[218],"gene.":[220],"discuss":[222],"observation":[224],"relation":[226],"evolutionary":[229],"origin":[230],"antiquity":[238]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}