{"id":"https://openalex.org/W2062394418","doi":"https://doi.org/10.1111/j.1365-2567.2006.02376.x","title":"E prostanoid 2 (EP2)/EP4\u2010mediated suppression of antigen\u2010specific human T\u2010cell responses by prostaglandin E2","display_name":"E prostanoid 2 (EP2)/EP4\u2010mediated suppression of antigen\u2010specific human T\u2010cell responses by prostaglandin E2","publication_year":2006,"publication_date":"2006-05-19","ids":{"openalex":"https://openalex.org/W2062394418","doi":"https://doi.org/10.1111/j.1365-2567.2006.02376.x","mag":"2062394418","pmid":"https://pubmed.ncbi.nlm.nih.gov/16827895","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1782299"},"language":"en","primary_location":{"id":"doi:10.1111/j.1365-2567.2006.02376.x","doi":"https://doi.org/10.1111/j.1365-2567.2006.02376.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1365-2567.2006.02376.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1365-2567.2006.02376.x","source":{"id":"https://openalex.org/S89865888","display_name":"Immunology","issn_l":"0019-2805","issn":["0019-2805","1365-2567"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1365-2567.2006.02376.x","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5015425721","display_name":"Mitsuhiro Okano","orcid":"https://orcid.org/0000-0002-4275-5781","observed_orcids":["https://orcid.org/0000-0002-4275-5781"]},"institutions":[{"id":"https://openalex.org/I163770644","display_name":"Okayama University","ror":"https://ror.org/02pc6pc55","country_code":"JP","type":"education","lineage":["https://openalex.org/I163770644"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Mitsuhiro Okano","raw_affiliation_strings":["Department of Otolaryngology-Head & Neck Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan. mokano@cc.okayama-u.ac.jp","Departments of Otolaryngology-Head & Neck Surgery"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Otolaryngology-Head & Neck Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan. mokano@cc.okayama-u.ac.jp","institution_ids":["https://openalex.org/I163770644"]},{"raw_affiliation_string":"Departments of Otolaryngology-Head & Neck Surgery","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014317642","display_name":"Yuji Sugata","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yuji Sugata","raw_affiliation_strings":["Departments of Otolaryngology-Head & Neck Surgery"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Otolaryngology-Head & Neck Surgery","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110356207","display_name":"Tazuko Fujiwara","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tazuko Fujiwara","raw_affiliation_strings":["Departments of Otolaryngology-Head & Neck Surgery"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Otolaryngology-Head & Neck Surgery","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Rie Matsumoto","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rie Matsumoto","raw_affiliation_strings":["Departments of Otolaryngology-Head & Neck Surgery"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Otolaryngology-Head & Neck Surgery","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052658056","display_name":"Masahiro Nishibori","orcid":"https://orcid.org/0000-0002-5565-6360","observed_orcids":["https://orcid.org/0000-0002-5565-6360"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Masahiro Nishibori","raw_affiliation_strings":["Pharmacology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharmacology","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029666084","display_name":"Kenji Shimizu","orcid":"https://orcid.org/0000-0003-4204-555X","observed_orcids":["https://orcid.org/0000-0003-4204-555X"]},"institutions":[{"id":"https://openalex.org/I163770644","display_name":"Okayama University","ror":"https://ror.org/02pc6pc55","country_code":"JP","type":"education","lineage":["https://openalex.org/I163770644"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kenji Shimizu","raw_affiliation_strings":["Molecular Genetics, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Genetics, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan","institution_ids":["https://openalex.org/I163770644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102898370","display_name":"Megumi Maeda","orcid":"https://orcid.org/0000-0001-5704-4694","observed_orcids":["https://orcid.org/0000-0001-5704-4694"]},"institutions":[{"id":"https://openalex.org/I163770644","display_name":"Okayama University","ror":"https://ror.org/02pc6pc55","country_code":"JP","type":"education","lineage":["https://openalex.org/I163770644"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Megumi Maeda","raw_affiliation_strings":["Division of Biomolecular Science, The Graduate School of Natural Science and Technology, Okayama University, Okayama, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Biomolecular Science, The Graduate School of Natural Science and Technology, Okayama University, Okayama, Japan","institution_ids":["https://openalex.org/I163770644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101759114","display_name":"Yoshinobu Kimura","orcid":"https://orcid.org/0000-0003-0329-1168","observed_orcids":["https://orcid.org/0000-0003-0329-1168"]},"institutions":[{"id":"https://openalex.org/I163770644","display_name":"Okayama University","ror":"https://ror.org/02pc6pc55","country_code":"JP","type":"education","lineage":["https://openalex.org/I163770644"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yoshinobu Kimura","raw_affiliation_strings":["Division of Biomolecular Science, The Graduate School of Natural Science and Technology, Okayama University, Okayama, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Biomolecular Science, The Graduate School of Natural Science and Technology, Okayama University, Okayama, Japan","institution_ids":["https://openalex.org/I163770644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056877091","display_name":"Shin Kariya","orcid":"https://orcid.org/0000-0002-7810-5844","observed_orcids":["https://orcid.org/0000-0002-7810-5844"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shin Kariya","raw_affiliation_strings":["Departments of Otolaryngology-Head & Neck Surgery"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Otolaryngology-Head & Neck Surgery","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102002367","display_name":"Hisashi Hattori","orcid":"https://orcid.org/0000-0001-9181-8948","observed_orcids":["https://orcid.org/0000-0001-9181-8948"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hisashi Hattori","raw_affiliation_strings":["Departments of Otolaryngology-Head & Neck Surgery"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Otolaryngology-Head & Neck Surgery","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067686739","display_name":"Minehiko Yokoyama","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405273579","display_name":"Meiji Co., Ltd. (Japan)","ror":"https://ror.org/002q6h737","country_code":"JP","type":"company","lineage":["https://openalex.org/I4405273579"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Minehiko Yokoyama","raw_affiliation_strings":["Meiji Co., Odawara, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Meiji Co., Odawara, Japan","institution_ids":["https://openalex.org/I4405273579"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108361677","display_name":"Kosuke Kino","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405273579","display_name":"Meiji Co., Ltd. (Japan)","ror":"https://ror.org/002q6h737","country_code":"JP","type":"company","lineage":["https://openalex.org/I4405273579"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kosuke Kino","raw_affiliation_strings":["Meiji Co., Odawara, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Meiji Co., Odawara, Japan","institution_ids":["https://openalex.org/I4405273579"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5057646685","display_name":"Kazunori Nishizaki","orcid":"https://orcid.org/0000-0002-3895-7858","observed_orcids":["https://orcid.org/0000-0002-3895-7858"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kazunori Nishizaki","raw_affiliation_strings":["Departments of Otolaryngology-Head & Neck Surgery"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Otolaryngology-Head & Neck Surgery","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5015425721"],"corresponding_institution_ids":["https://openalex.org/I163770644"],"apc_list":{"value":5330,"currency":"USD","value_usd":5330},"apc_paid":null,"fwci":3.4248,"has_fulltext":true,"cited_by_count":97,"citation_normalized_percentile":{"value":0.92352492,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"118","issue":"3","first_page":"343","last_page":"352"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10678","display_name":"Inflammatory mediators and NSAID effects","score":0.9843999743461609,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10678","display_name":"Inflammatory mediators and NSAID effects","score":0.9843999743461609,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.004999999888241291,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12910","display_name":"Eicosanoids and Hypertension Pharmacology","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/prostaglandin-e2","display_name":"prostaglandin E2","score":1.0},{"id":"https://openalex.org/keywords/ep2-receptor","display_name":"EP2 receptor","score":0.875},{"id":"https://openalex.org/keywords/ep4-receptor","display_name":"EP4 receptor","score":1.0},{"id":"https://openalex.org/keywords/e-prostanoid-receptors","display_name":"E-prostanoid receptors","score":0.8029999732971191},{"id":"https://openalex.org/keywords/antigen-specific-t-cell-responses","display_name":"antigen-specific T cell responses","score":0.8379999995231628},{"id":"https://openalex.org/keywords/cd4-t-cells","display_name":"CD4+ T cells","score":0.9549999833106995},{"id":"https://openalex.org/keywords/th1-th2-polarization","display_name":"Th1/Th2 polarization","score":0.8759999871253967},{"id":"https://openalex.org/keywords/il-4","display_name":"IL-4","score":0.9139999747276306},{"id":"https://openalex.org/keywords/interferon-gamma","display_name":"interferon-gamma","score":0.9980000257492065},{"id":"https://openalex.org/keywords/il-5","display_name":"IL-5","score":0.9900000095367432},{"id":"https://openalex.org/keywords/camp-signaling","display_name":"cAMP signaling","score":0.8259999752044678},{"id":"https://openalex.org/keywords/adenylate-cyclase","display_name":"adenylate cyclase","score":0.9150000214576721},{"id":"https://openalex.org/keywords/cry-j-1","display_name":"Cry j 1","score":0.7289999723434448},{"id":"https://openalex.org/keywords/purified-protein-derivative","display_name":"purified protein derivative","score":0.9829999804496765},{"id":"https://openalex.org/keywords/immunomodulation","display_name":"immunomodulation","score":0.7630000114440918},{"id":"https://openalex.org/keywords/receptor-agonists","display_name":"receptor agonists","score":0.5080000162124634}],"concepts":[{"id":"https://openalex.org/C178592051","wikidata":"https://www.wikidata.org/wiki/Q28208812","display_name":"Prostaglandin E2 receptor","level":4,"score":0.7526377439498901},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.6126666069030762},{"id":"https://openalex.org/C2778938600","wikidata":"https://www.wikidata.org/wiki/Q389934","display_name":"Agonist","level":3,"score":0.5642508864402771},{"id":"https://openalex.org/C19317047","wikidata":"https://www.wikidata.org/wiki/Q412037","display_name":"T-cell receptor","level":4,"score":0.5047174692153931},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.47211015224456787},{"id":"https://openalex.org/C2780664492","wikidata":"https://www.wikidata.org/wiki/Q209717","display_name":"Prostaglandin","level":2,"score":0.4491984248161316},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.437640905380249},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.4358013868331909},{"id":"https://openalex.org/C2777956040","wikidata":"https://www.wikidata.org/wiki/Q416554","display_name":"Prostaglandin E2","level":2,"score":0.4116588830947876},{"id":"https://openalex.org/C2778266237","wikidata":"https://www.wikidata.org/wiki/Q962217","display_name":"Prostanoid","level":3,"score":0.4111475944519043},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4110848009586334},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3510954976081848},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.34744584560394287},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.33984923362731934},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3019880950450897},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.2144206166267395},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.14621111750602722},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.13583019375801086}],"mesh":[{"descriptor_ui":"D000067956","descriptor_name":"Adenylyl Cyclase Inhibitors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000485","descriptor_name":"Allergens","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007108","descriptor_name":"Immune Tolerance","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D007111","descriptor_name":"Immunity, Cellular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010940","descriptor_name":"Plant Proteins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D014373","descriptor_name":"Tuberculin","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015232","descriptor_name":"Dinoprostone","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D016176","descriptor_name":"T-Lymphocyte Subsets","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D018078","descriptor_name":"Receptors, Prostaglandin E","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D018078","descriptor_name":"Receptors, Prostaglandin E","qualifier_ui":"Q000819","qualifier_name":"agonists","is_major_topic":false},{"descriptor_ui":"D018984","descriptor_name":"Epitopes, T-Lymphocyte","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D020133","descriptor_name":"Reverse Transcriptase Polymerase Chain Reaction","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D052179","descriptor_name":"Antigens, Plant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058307","descriptor_name":"Receptors, Prostaglandin E, EP2 Subtype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058309","descriptor_name":"Receptors, Prostaglandin E, EP4 Subtype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1111/j.1365-2567.2006.02376.x","doi":"https://doi.org/10.1111/j.1365-2567.2006.02376.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1365-2567.2006.02376.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1365-2567.2006.02376.x","source":{"id":"https://openalex.org/S89865888","display_name":"Immunology","issn_l":"0019-2805","issn":["0019-2805","1365-2567"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunology","raw_type":"journal-article"},{"id":"pmid:16827895","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16827895","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:1782299","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC1782299/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunology","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1111/j.1365-2567.2006.02376.x","doi":"https://doi.org/10.1111/j.1365-2567.2006.02376.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1365-2567.2006.02376.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1365-2567.2006.02376.x","source":{"id":"https://openalex.org/S89865888","display_name":"Immunology","issn_l":"0019-2805","issn":["0019-2805","1365-2567"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5082532191","display_name":null,"funder_award_id":"ONO-AE1-259-01","funder_id":"https://openalex.org/F4320327845","funder_display_name":"Ono Pharmaceutical"}],"funders":[{"id":"https://openalex.org/F4320321945","display_name":"Ministry of Health, Labour and Welfare","ror":"https://ror.org/03mwa7s65"},{"id":"https://openalex.org/F4320327845","display_name":"Ono Pharmaceutical","ror":"https://ror.org/022jefx64"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2062394418.pdf","grobid_xml":"https://content.openalex.org/works/W2062394418.grobid-xml"},"referenced_works_count":35,"referenced_works":["https://openalex.org/W1497022815","https://openalex.org/W1517765711","https://openalex.org/W1523969239","https://openalex.org/W1533914840","https://openalex.org/W1546944401","https://openalex.org/W1554649625","https://openalex.org/W1582061415","https://openalex.org/W1647832452","https://openalex.org/W1754684850","https://openalex.org/W1971686414","https://openalex.org/W1978143394","https://openalex.org/W1984414393","https://openalex.org/W2001038394","https://openalex.org/W2005745675","https://openalex.org/W2024934230","https://openalex.org/W2027259693","https://openalex.org/W2041647537","https://openalex.org/W2047174129","https://openalex.org/W2051947192","https://openalex.org/W2065564934","https://openalex.org/W2068403491","https://openalex.org/W2071780527","https://openalex.org/W2072696221","https://openalex.org/W2073827168","https://openalex.org/W2082729009","https://openalex.org/W2102221721","https://openalex.org/W2102287305","https://openalex.org/W2117036311","https://openalex.org/W2118025940","https://openalex.org/W2126043069","https://openalex.org/W2147211613","https://openalex.org/W2150546396","https://openalex.org/W2160572043","https://openalex.org/W2315018741","https://openalex.org/W4248634331"],"related_works":["https://openalex.org/W2091582203","https://openalex.org/W4253087849","https://openalex.org/W2017396583","https://openalex.org/W2044675695","https://openalex.org/W2033083608","https://openalex.org/W2120580301","https://openalex.org/W2757102604","https://openalex.org/W2077087977","https://openalex.org/W2073827168","https://openalex.org/W2147211613"],"abstract_inverted_index":{"Prostaglandin":[0],"E2":[1],"(PGE2)":[2],"is":[3,33,41],"a":[4,46,253],"lipid":[5],"mediator":[6],"that":[7,25,241],"displays":[8],"important":[9],"immunomodulatory":[10],"properties,":[11],"such":[12],"as":[13,107],"polarization":[14],"of":[15,28,60,63,82,94,139,147,156],"cytokine":[16,31],"production":[17,32,138,222],"by":[18,36,141,149,223],"T":[19,108],"cells.":[20],"Recent":[21],"investigations":[22],"have":[23],"revealed":[24],"the":[26,73,80,134],"effect":[27,81],"PGE2":[29,44,83,129,212,242],"on":[30,84],"greatly":[34],"influenced":[35],"external":[37],"stimuli;":[38],"however,":[39],"it":[40],"unclear":[42],"whether":[43],"plays":[45],"significant":[47],"role":[48],"in":[49,70,89,92,167,193,203,228],"major":[50],"histocompatibility":[51],"complex-mediated":[52],"antigen-specific":[53,85,248],"T-cell":[54,87,126,250],"responses":[55,88,166,251],"via":[56,252],"binding":[57],"to":[58,78,230],"one":[59],"four":[61],"subtypes":[62],"E":[64],"prostanoid":[65],"(EP)":[66],"receptor":[67,95,158,162,176,205,215],"alone":[68],"or":[69],"combination.":[71],"In":[72],"present":[74],"study,":[75],"we":[76],"sought":[77],"determine":[79],"CD4+":[86],"humans,":[90],"especially":[91],"terms":[93],"specificity.":[96],"We":[97,117],"used":[98],"purified":[99],"protein":[100],"derivative":[101],"(PPD)":[102],"and":[103,113,124,131,136,146,160,174,185,197,200,213,220,234,246],"Cry":[104,121,142,194,231],"j":[105,122,143,195,232],"1":[106,111,233],"helper":[109],"type":[110],"(Th1)":[112],"Th2-inducing":[114],"antigens,":[115],"respectively.":[116,237],"generated":[118],"several":[119],"different":[120],"1-":[123,196],"PPD-specific":[125,150,198],"lines":[127],"(TCLs).":[128],"significantly":[130,217],"dose-dependently":[132],"inhibited":[133,218],"proliferation":[135],"subsequent":[137],"interleukin-4":[140],"1-specific":[144],"TCLs":[145,151],"interferon-gamma":[148,221],"upon":[152],"antigen":[153],"stimulation.":[154],"Administration":[155],"EP2":[157,214],"agonist":[159,163,216],"EP4":[161],"suppressed":[164],"these":[165],"an":[168],"adenylate":[169],"cyclase-dependent":[170],"manner,":[171],"while":[172],"EP1":[173],"EP3":[175,184],"agonists":[177],"did":[178],"not.":[179],"Messenger":[180],"RNA":[181],"for":[182],"EP2,":[183],"EP4,":[186],"but":[187],"not":[188],"EP1,":[189],"receptors":[190],"were":[191,207],"detected":[192],"TCLs,":[199],"no":[201],"differences":[202],"EP":[204],"expression":[206],"observed":[208],"between":[209],"them.":[210],"Furthermore,":[211],"interleukin-5":[219],"peripheral":[224],"blood":[225],"mononuclear":[226],"cells":[227],"response":[229],"PPD":[235],"stimulation,":[236],"These":[238],"results":[239],"suggest":[240],"suppresses":[243],"both":[244],"Th1-":[245],"Th2-polarized":[247],"human":[249],"cAMP-dependent":[254],"EP2/EP4-mediated":[255],"pathway.":[256]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":8},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":8}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}