{"id":"https://openalex.org/W2062387196","doi":"https://doi.org/10.1158/1538-7445.am2012-2678","title":"Abstract 2678: Traditional Chinese Medicine (TCM) in combination with S. typhimurium A1-R for cancer treatment","display_name":"Abstract 2678: Traditional Chinese Medicine (TCM) in combination with S. typhimurium A1-R for cancer treatment","publication_year":2012,"publication_date":"2012-04-01","ids":{"openalex":"https://openalex.org/W2062387196","doi":"https://doi.org/10.1158/1538-7445.am2012-2678","mag":"2062387196"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.am2012-2678","doi":"https://doi.org/10.1158/1538-7445.am2012-2678","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2012-2678","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100419770","display_name":"Yong Zhang","orcid":"https://orcid.org/0000-0002-1303-0458","observed_orcids":["https://orcid.org/0000-0002-1303-0458","https://orcid.org/0000-0002-9916-3832","https://orcid.org/0000-0001-6577-5235"]},"institutions":[{"id":"https://openalex.org/I4210121314","display_name":"AntiCancer (United States)","ror":"https://ror.org/02pp1v282","country_code":"US","type":"company","lineage":["https://openalex.org/I4210121314"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yong Zhang","raw_affiliation_strings":["1AntiCancer, Inc, San Diego, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1AntiCancer, Inc, San Diego, CA","institution_ids":["https://openalex.org/I4210121314"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100331321","display_name":"Nan Zhang","orcid":"https://orcid.org/0000-0003-0679-6188","observed_orcids":["https://orcid.org/0000-0003-0679-6188"]},"institutions":[{"id":"https://openalex.org/I4210121314","display_name":"AntiCancer (United States)","ror":"https://ror.org/02pp1v282","country_code":"US","type":"company","lineage":["https://openalex.org/I4210121314"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nan Zhang","raw_affiliation_strings":["1AntiCancer, Inc, San Diego, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1AntiCancer, Inc, San Diego, CA","institution_ids":["https://openalex.org/I4210121314"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041247351","display_name":"Shi-Bing Su","orcid":"https://orcid.org/0000-0002-1003-6424","observed_orcids":["https://orcid.org/0000-0002-1003-6424"]},"institutions":[{"id":"https://openalex.org/I4210098460","display_name":"Shanghai University of Traditional Chinese Medicine","ror":"https://ror.org/00z27jk27","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210098460"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shibing Su","raw_affiliation_strings":["2Shanghai University of Traditional Chinese Medicine, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Shanghai University of Traditional Chinese Medicine, Shanghai, China","institution_ids":["https://openalex.org/I4210098460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040819666","display_name":"Robert M. Hoffman","orcid":"https://orcid.org/0000-0002-0049-0041","observed_orcids":["https://orcid.org/0000-0002-0049-0041"]},"institutions":[{"id":"https://openalex.org/I4210121314","display_name":"AntiCancer (United States)","ror":"https://ror.org/02pp1v282","country_code":"US","type":"company","lineage":["https://openalex.org/I4210121314"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert M. Hoffman","raw_affiliation_strings":["1AntiCancer, Inc, San Diego, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1AntiCancer, Inc, San Diego, CA","institution_ids":["https://openalex.org/I4210121314"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5083743508","display_name":"Ming Dan Zhao","orcid":"https://orcid.org/0000-0002-1025-8895","observed_orcids":["https://orcid.org/0000-0002-1025-8895"]},"institutions":[{"id":"https://openalex.org/I4210121314","display_name":"AntiCancer (United States)","ror":"https://ror.org/02pp1v282","country_code":"US","type":"company","lineage":["https://openalex.org/I4210121314"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ming Zhao","raw_affiliation_strings":["1AntiCancer, Inc, San Diego, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1AntiCancer, Inc, San Diego, CA","institution_ids":["https://openalex.org/I4210121314"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"72","issue":"8_Supplement","first_page":"2678","last_page":"2678"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12996","display_name":"Bacterial Cancer Therapy","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12996","display_name":"Bacterial Cancer Therapy","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10782","display_name":"Nanoplatforms for cancer theranostics","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T13444","display_name":"Traditional Chinese Medicine Clinical Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/traditional-chinese-medicine","display_name":"traditional Chinese medicine","score":0.9330000281333923},{"id":"https://openalex.org/keywords/salmonella-typhimurium-a1-r","display_name":"Salmonella typhimurium A1-R","score":0.9950000047683716},{"id":"https://openalex.org/keywords/bacterial-cancer-therapy","display_name":"bacterial cancer therapy","score":0.871999979019165},{"id":"https://openalex.org/keywords/combination-cancer-therapy","display_name":"combination cancer therapy","score":0.671999990940094},{"id":"https://openalex.org/keywords/metastatic-lung-cancer","display_name":"metastatic lung cancer","score":0.8399999737739563},{"id":"https://openalex.org/keywords/immunocompetent-mice","display_name":"immunocompetent mice","score":0.8009999990463257},{"id":"https://openalex.org/keywords/tumor-virulence","display_name":"tumor virulence","score":0.5090000033378601},{"id":"https://openalex.org/keywords/bleeding-prevention","display_name":"bleeding prevention","score":0.46399998664855957}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7489308714866638},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.7104262709617615},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.52447909116745},{"id":"https://openalex.org/C2781065037","wikidata":"https://www.wikidata.org/wiki/Q150839","display_name":"Salmonella","level":3,"score":0.4855908751487732},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4752768576145172},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.4738117754459381},{"id":"https://openalex.org/C2776999253","wikidata":"https://www.wikidata.org/wiki/Q1304270","display_name":"Combination therapy","level":2,"score":0.47019585967063904},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.41717061400413513},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.33787763118743896},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3189740777015686},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1418645977973938},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.10861733555793762},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.am2012-2678","doi":"https://doi.org/10.1158/1538-7445.am2012-2678","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2012-2678","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2329922796","https://openalex.org/W1483838708","https://openalex.org/W1969428252","https://openalex.org/W2118819732","https://openalex.org/W2024303992","https://openalex.org/W1974548520","https://openalex.org/W2949824679","https://openalex.org/W3135629475","https://openalex.org/W2411588284","https://openalex.org/W4320481505"],"abstract_inverted_index":{"Abstract":[0],"Traditional":[1],"Chinese":[2],"Medicine":[3],"(TCM)":[4],"has":[5,199],"long":[6],"shown":[7],"promise":[8],"for":[9,33,202,222],"the":[10,24,101,145,187,214,219],"treatment":[11,85,130,175],"of":[12,93,147,163,186,193,213,218],"cancer.":[13,95],"We":[14],"have":[15],"previously":[16],"developed":[17],"a":[18,136,161,167],"bacterial":[19,87,107,129],"cancer":[20,60,139,203],"therapy":[21,88],"strategy":[22],"using":[23],"genetically-engineered":[25],"strain,":[26],"Salmonella":[27],"typhimurium":[28,49,122,151,155,182,195],"A1-R,":[29],"which":[30,37],"is":[31,51],"auxotrophic":[32],"arg":[34],"and":[35,58,68,75,104,111,149,197],"leu,":[36],"attenuates":[38],"growth":[39],"in":[40,72,89,117,142,170],"normal":[41],"tissue":[42],"but":[43],"allows":[44],"high":[45],"tumor":[46],"virulence.":[47],"S.":[48,121,150,154,181,194],"A1-R":[50,152,196],"effective":[52],"against":[53],"metastatic":[54,90,140],"human":[55,94],"prostate,":[56],"breast,":[57],"pancreatic":[59],"cell":[61,70],"lines":[62,71],"as":[63,65,83],"well":[64],"osteosarcoma,":[66],"fibrosarcoma,":[67],"glioma":[69],"clinically-relevant":[73],"nude-mouse":[74],"syngeneic-mouse":[76],"models.":[77],"The":[78,184],"current":[79],"study":[80,189],"evaluated":[81],"TCM":[82,96,148,198],"combination":[84,146,192],"during":[86],"mouse":[91],"models":[92],"prevented":[97],"hemorrhagic":[98],"spots":[99],"on":[100],"skin,":[102],"liver,":[103],"spleen":[105],"after":[106],"infection.":[108],"Fur":[109],"discoloration":[110],"reduced":[112],"activity":[113],"was":[114,131],"also":[115],"observed":[116],"mice":[118,172],"treated":[119],"with":[120,133,173,180],"A1-R.":[123,183],"These":[124],"symptoms":[125],"were":[126],"ameliorated":[127],"when":[128],"combined":[132],"TCM.":[134],"In":[135],"syngeneic":[137],"lung":[138],"model":[141],"immunocompetent":[143],"mice,":[144],"enabled":[153],"to":[156,178],"be":[157],"safely":[158],"administered":[159],"at":[160],"dose":[162],"2\u00d7105":[164],"CFU":[165],"twice":[166],"week":[168],"i.v.":[169],"immunocompotent":[171],"increased":[174],"efficacy":[176],"compared":[177],"monotherapy":[179],"results":[185],"present":[188],"suggest":[190],"that":[191],"important":[200],"potential":[201],"therapy.":[204],"Citation":[205],"Format:":[206],"{Authors}.":[207],"{Abstract":[208],"title}":[209],"[abstract].":[210],"In:":[211],"Proceedings":[212],"103rd":[215],"Annual":[216],"Meeting":[217],"American":[220],"Association":[221],"Cancer":[223,234],"Research;":[224],"2012":[225],"Mar":[226],"31-Apr":[227],"4;":[228],"Chicago,":[229],"IL.":[230],"Philadelphia":[231],"(PA):":[232],"AACR;":[233],"Res":[235],"2012;72(8":[236],"Suppl):Abstract":[237],"nr":[238],"2678.":[239],"doi:1538-7445.AM2012-2678":[240]},"counts_by_year":[{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}