{"id":"https://openalex.org/W2062331608","doi":"https://doi.org/10.1111/bjd.13482","title":"Phenotypic modulation of smooth muscle cells in lymphoedema","display_name":"Phenotypic modulation of smooth muscle cells in lymphoedema","publication_year":2014,"publication_date":"2014-10-15","ids":{"openalex":"https://openalex.org/W2062331608","doi":"https://doi.org/10.1111/bjd.13482","mag":"2062331608","pmid":"https://pubmed.ncbi.nlm.nih.gov/25319851"},"language":"en","primary_location":{"id":"doi:10.1111/bjd.13482","doi":"https://doi.org/10.1111/bjd.13482","is_oa":false,"landing_page_url":"https://doi.org/10.1111/bjd.13482","pdf_url":null,"source":{"id":"https://openalex.org/S45720283","display_name":"British Journal of Dermatology","issn_l":"0007-0963","issn":["0007-0963","1365-2133"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Dermatology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110535308","display_name":"Fusa Ogata","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"F. Ogata","raw_affiliation_strings":["Department of Cardiovascular Medicine, Graduate School of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo, Tokyo, 113-8655 Japan","Department of Plastic, Reconstructive and Aesthetic Surgery, Graduate School of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo, Tokyo, 113-8655 Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiovascular Medicine, Graduate School of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo, Tokyo, 113-8655 Japan","institution_ids":["https://openalex.org/I74801974"]},{"raw_affiliation_string":"Department of Plastic, Reconstructive and Aesthetic Surgery, Graduate School of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo, Tokyo, 113-8655 Japan","institution_ids":["https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003165755","display_name":"Katsuhito Fujiu","orcid":"https://orcid.org/0000-0002-1889-9291","observed_orcids":["https://orcid.org/0000-0002-1889-9291"]},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"K. Fujiu","raw_affiliation_strings":["Department of Cardiovascular Medicine, Graduate School of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo, Tokyo, 113-8655 Japan","Translational Systems Biology and Medicine Initiative, Graduate School of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo, Tokyo, 113-8655 Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiovascular Medicine, Graduate School of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo, Tokyo, 113-8655 Japan","institution_ids":["https://openalex.org/I74801974"]},{"raw_affiliation_string":"Translational Systems Biology and Medicine Initiative, Graduate School of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo, Tokyo, 113-8655 Japan","institution_ids":["https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087714404","display_name":"Isao Koshima","orcid":"https://orcid.org/0000-0003-2307-5905","observed_orcids":["https://orcid.org/0000-0003-2307-5905"]},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"I. Koshima","raw_affiliation_strings":["Department of Plastic, Reconstructive and Aesthetic Surgery, Graduate School of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo, Tokyo, 113-8655 Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Plastic, Reconstructive and Aesthetic Surgery, Graduate School of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo, Tokyo, 113-8655 Japan","institution_ids":["https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113726888","display_name":"R Nagai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I146500386","display_name":"Jichi Medical University","ror":"https://ror.org/010hz0g26","country_code":"JP","type":"education","lineage":["https://openalex.org/I146500386"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"R. Nagai","raw_affiliation_strings":["Jichi Medical University, 3311-1 Yakushiji, Shimotsuke-shi, Tochigi-ken, 329-0498 Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Jichi Medical University, 3311-1 Yakushiji, Shimotsuke-shi, Tochigi-ken, 329-0498 Japan","institution_ids":["https://openalex.org/I146500386"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5030554556","display_name":"Ichiro Manabe","orcid":"https://orcid.org/0000-0001-9481-6673","observed_orcids":["https://orcid.org/0000-0001-9481-6673"]},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"I. Manabe","raw_affiliation_strings":["Department of Cardiovascular Medicine, Graduate School of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo, Tokyo, 113-8655 Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiovascular Medicine, Graduate School of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo, Tokyo, 113-8655 Japan","institution_ids":["https://openalex.org/I74801974"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5030554556"],"corresponding_institution_ids":["https://openalex.org/I74801974"],"apc_list":{"value":3731,"currency":"GBP","value_usd":4920},"apc_paid":null,"fwci":1.4743,"has_fulltext":false,"cited_by_count":38,"citation_normalized_percentile":{"value":0.82311078,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"172","issue":"5","first_page":"1286","last_page":"1293"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11469","display_name":"Lymphatic System and Diseases","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11469","display_name":"Lymphatic System and Diseases","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12426","display_name":"Lymphatic Disorders and Treatments","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11702","display_name":"Parasitic Diseases Research and Treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lymphedema","display_name":"lymphedema","score":0.9929999709129333},{"id":"https://openalex.org/keywords/smooth-muscle-cells","display_name":"smooth muscle cells","score":0.8849999904632568},{"id":"https://openalex.org/keywords/lymphatic-vessels","display_name":"lymphatic vessels","score":0.9779999852180481},{"id":"https://openalex.org/keywords/smooth-muscle-alpha-actin","display_name":"smooth muscle actin","score":0.9319999814033508},{"id":"https://openalex.org/keywords/smooth-muscle-myosin-heavy-chain","display_name":"smooth muscle myosin heavy chain","score":0.8960000276565552},{"id":"https://openalex.org/keywords/tunica-media","display_name":"tunica media","score":0.8190000057220459},{"id":"https://openalex.org/keywords/tunica-intima","display_name":"tunica intima","score":0.953000009059906},{"id":"https://openalex.org/keywords/lymphatic-dysfunction","display_name":"lymphatic dysfunction","score":0.7300000190734863}],"concepts":[{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.749325156211853},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4419679343700409},{"id":"https://openalex.org/C123079801","wikidata":"https://www.wikidata.org/wiki/Q750240","display_name":"Modulation (music)","level":2,"score":0.4382272958755493},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.361929714679718},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.36149725317955017},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1822650134563446},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.10450828075408936},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0846434235572815},{"id":"https://openalex.org/C24890656","wikidata":"https://www.wikidata.org/wiki/Q82811","display_name":"Acoustics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000199","descriptor_name":"Actins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002908","descriptor_name":"Chronic Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005355","descriptor_name":"Fibrosis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008209","descriptor_name":"Lymphedema","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008209","descriptor_name":"Lymphedema","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018995","descriptor_name":"Myosin Heavy Chains","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D024745","descriptor_name":"Smooth Muscle Myosins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D032389","descriptor_name":"Myocytes, Smooth Muscle","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D032389","descriptor_name":"Myocytes, Smooth Muscle","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D042601","descriptor_name":"Lymphatic Vessels","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D042601","descriptor_name":"Lymphatic Vessels","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D046529","descriptor_name":"Microscopy, Electron, Transmission","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1111/bjd.13482","doi":"https://doi.org/10.1111/bjd.13482","is_oa":false,"landing_page_url":"https://doi.org/10.1111/bjd.13482","pdf_url":null,"source":{"id":"https://openalex.org/S45720283","display_name":"British Journal of Dermatology","issn_l":"0007-0963","issn":["0007-0963","1365-2133"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Dermatology","raw_type":"journal-article"},{"id":"pmid:25319851","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25319851","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The British journal of dermatology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G8373970100","display_name":"Impacts of Dysfunction in Cardiac Macrophages on Arrhythmia","funder_award_id":"26461125","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"}],"funders":[{"id":"https://openalex.org/F4320320912","display_name":"Ministry of Education, Culture, Sports, Science and Technology","ror":"https://ror.org/048rj2z13"},{"id":"https://openalex.org/F4320322832","display_name":"University of Tokyo","ror":"https://ror.org/057zh3y96"},{"id":"https://openalex.org/F4320325855","display_name":"Council for Science and Technology Policy","ror":null},{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":33,"referenced_works":["https://openalex.org/W103599387","https://openalex.org/W260637170","https://openalex.org/W1599392598","https://openalex.org/W1982183902","https://openalex.org/W1982481909","https://openalex.org/W1992101966","https://openalex.org/W1994499415","https://openalex.org/W1997447547","https://openalex.org/W2015089110","https://openalex.org/W2021795001","https://openalex.org/W2022814792","https://openalex.org/W2025608933","https://openalex.org/W2044743132","https://openalex.org/W2048606411","https://openalex.org/W2054596710","https://openalex.org/W2062545425","https://openalex.org/W2071447017","https://openalex.org/W2072804874","https://openalex.org/W2083533265","https://openalex.org/W2084598094","https://openalex.org/W2087336192","https://openalex.org/W2087909966","https://openalex.org/W2104166641","https://openalex.org/W2117676716","https://openalex.org/W2124634637","https://openalex.org/W2130232389","https://openalex.org/W2134960604","https://openalex.org/W2136324267","https://openalex.org/W2206051487","https://openalex.org/W2324841714","https://openalex.org/W2417495206","https://openalex.org/W2917346947","https://openalex.org/W4243748055"],"related_works":["https://openalex.org/W2131424443","https://openalex.org/W2321444652","https://openalex.org/W3045493001","https://openalex.org/W2758277271","https://openalex.org/W1976149350","https://openalex.org/W4402928152","https://openalex.org/W2039904257","https://openalex.org/W2071436097","https://openalex.org/W2613043854","https://openalex.org/W2489688912"],"abstract_inverted_index":{"BACKGROUND:":[0],"Lymphoedema":[1],"is":[2,8,22,34],"a":[3,151,207],"debilitating":[4],"progressive":[5],"condition":[6],"that":[7,24,189,204],"frequently":[9],"observed":[10,126],"following":[11],"cancer":[12],"surgery":[13],"and":[14,27,74,83,136,143,148,169,180,194,203],"severely":[15],"restricts":[16],"quality":[17],"of":[18,47,64,69,113,115,153,182,199,213],"life.":[19],"Although":[20],"it":[21],"known":[23],"lymphatic":[25,58,93,97,159,183,191],"dysfunction":[26],"obstruction":[28],"underlie":[29],"lymphoedema,":[30],"the":[31,45,61,111,120,128,167,177,190,211],"pathogenic":[32],"mechanism":[33],"poorly":[35],"understood.":[36],"Smooth":[37],"muscle":[38,71,76],"cells":[39,138],"(SMCs)":[40],"play":[41,206],"pivotal":[42],"roles":[43],"in":[44,57,99,110,119,127,158,161,176,210],"pathogenesis":[46],"various":[48],"vascular":[49],"diseases,":[50],"including":[51],"atherosclerosis.":[52],"OBJECTIVES:":[53],"We":[54],"analysed":[55],"SMCs":[56,118,123,205],"vessels":[59,98,160],"from":[60],"lymphoedematous":[62],"legs":[63],"29":[65],"patients.":[66],"METHODS:":[67],"Expression":[68],"smooth":[70,75],"\u03b1-actin":[72],"(SM\u03b1A)":[73],"myosin":[77],"heavy":[78],"chain":[79],"(SM-MHC)":[80],"isoforms":[81],"SM1":[82,147],"SM2":[84],"was":[85],"investigated":[86],"using":[87],"immunohistochemistry.":[88],"RESULTS:":[89],"Compared":[90],"with":[91],"normal":[92],"vessels,":[94],"all":[95],"affected":[96],"chronic":[100],"lymphoedema":[101,164],"showed":[102],"marked":[103],"wall":[104],"thickening.":[105],"In":[106],"addition":[107],"to":[108],"increases":[109],"numbers":[112],"rows":[114],"SM\u03b1A(+)":[116],"SM1(+)":[117,168],"tunica":[121,178,192,195],"media,":[122],"were":[124,139,173],"also":[125],"subendothelial":[129],"region":[130],"(tunica":[131],"intima).":[132],"While":[133],"most":[134],"intimal":[135],"medial":[137],"positive":[140],"for":[141,146],"SM\u03b1A":[142],"SM1,":[144],"staining":[145],"particularly":[149],"SM2,":[150],"marker":[152],"mature":[154],"SMCs,":[155,202],"progressively":[156],"declined":[157],"increasingly":[162],"severe":[163],"lesions.":[165],"Consequently,":[166],"SM2(+)":[170],"cell":[171],"fractions":[172],"significantly":[174],"reduced":[175],"media":[179,193],"intima":[181,196],"vessels.":[184],"CONCLUSIONS:":[185],"These":[186],"observations":[187],"indicate":[188],"consist":[197],"mainly":[198],"phenotypically":[200],"modulated":[201],"key":[208],"role":[209],"development":[212],"lymphoedema.":[214]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}