{"id":"https://openalex.org/W2062328082","doi":"https://doi.org/10.1097/00002480-200001000-00025","title":"Evaluation of Biodegradable, Three-Dimensional Matrices for Tissue Engineering of Heart Valves","display_name":"Evaluation of Biodegradable, Three-Dimensional Matrices for Tissue Engineering of Heart Valves","publication_year":2000,"publication_date":"2000-01-01","ids":{"openalex":"https://openalex.org/W2062328082","doi":"https://doi.org/10.1097/00002480-200001000-00025","mag":"2062328082","pmid":"https://pubmed.ncbi.nlm.nih.gov/10667727"},"language":"en","primary_location":{"id":"doi:10.1097/00002480-200001000-00025","doi":"https://doi.org/10.1097/00002480-200001000-00025","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00002480-200001000-00025","pdf_url":null,"source":{"id":"https://openalex.org/S8999885","display_name":"ASAIO Journal","issn_l":"1058-2916","issn":["1058-2916","1538-943X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ASAIO Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5051214840","display_name":"Ralf Sodian","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Ralf Sodian","raw_affiliation_strings":["Department of Cardiac Research, Children's Hospital Boston, Harvard Medical School, Massachusetts, USA","Department of Cardiac Research, Children's Hospital Boston, Harvard Medical School, Boston, Massachusetts, \u2020Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, and \u2021Metabolix, Inc., Cambridge, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiac Research, Children's Hospital Boston, Harvard Medical School, Massachusetts, USA","institution_ids":["https://openalex.org/I1288882113","https://openalex.org/I136199984"]},{"raw_affiliation_string":"Department of Cardiac Research, Children's Hospital Boston, Harvard Medical School, Boston, Massachusetts, \u2020Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, and \u2021Metabolix, Inc., Cambridge, Massachusetts","institution_ids":["https://openalex.org/I1288882113","https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037978981","display_name":"Simon Philipp Hoerstrup","orcid":"https://orcid.org/0000-0003-4755-8776","observed_orcids":["https://orcid.org/0000-0003-4755-8776","https://orcid.org/0000-0002-3879-2504"]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Simon P. Hoerstrup","raw_affiliation_strings":["Department of Cardiac Research, Children\u2019s Hospital Boston, Harvard Medical School, Boston, Massachusetts, \u2020Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, and \u2021Metabolix, Inc., Cambridge, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiac Research, Children\u2019s Hospital Boston, Harvard Medical School, Boston, Massachusetts, \u2020Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, and \u2021Metabolix, Inc., Cambridge, Massachusetts","institution_ids":["https://openalex.org/I1288882113","https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058652517","display_name":"Jason S. Sperling","orcid":"https://orcid.org/0009-0006-2184-7720","observed_orcids":["https://orcid.org/0009-0006-2184-7720"]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jason S. Sperling","raw_affiliation_strings":["Department of Cardiac Research, Children\u2019s Hospital Boston, Harvard Medical School, Boston, Massachusetts, \u2020Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, and \u2021Metabolix, Inc., Cambridge, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiac Research, Children\u2019s Hospital Boston, Harvard Medical School, Boston, Massachusetts, \u2020Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, and \u2021Metabolix, Inc., Cambridge, Massachusetts","institution_ids":["https://openalex.org/I1288882113","https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029546738","display_name":"David P. Martin","orcid":"https://orcid.org/0000-0002-3132-9576","observed_orcids":["https://orcid.org/0000-0002-3132-9576"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"David P. Martin","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021232552","display_name":"Sabine H Daebritz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Sabine Daebritz","raw_affiliation_strings":["Department of Cardiac Research, Children\u2019s Hospital Boston, Harvard Medical School, Boston, Massachusetts, \u2020Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, and \u2021Metabolix, Inc., Cambridge, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiac Research, Children\u2019s Hospital Boston, Harvard Medical School, Boston, Massachusetts, \u2020Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, and \u2021Metabolix, Inc., Cambridge, Massachusetts","institution_ids":["https://openalex.org/I1288882113","https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023064529","display_name":"John Eleanor Mayer","orcid":"https://orcid.org/0000-0002-5849-2971","observed_orcids":["https://orcid.org/0000-0002-5849-2971"]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"John E. Mayer","raw_affiliation_strings":["Department of Cardiac Research, Children\u2019s Hospital Boston, Harvard Medical School, Boston, Massachusetts, \u2020Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, and \u2021Metabolix, Inc., Cambridge, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiac Research, Children\u2019s Hospital Boston, Harvard Medical School, Boston, Massachusetts, \u2020Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, and \u2021Metabolix, Inc., Cambridge, Massachusetts","institution_ids":["https://openalex.org/I1288882113","https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109572012","display_name":"Joseph Phillip Vacanti","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Joseph P. Vacanti","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5021232552","https://openalex.org/A5023064529","https://openalex.org/A5037978981","https://openalex.org/A5051214840","https://openalex.org/A5058652517"],"corresponding_institution_ids":["https://openalex.org/I1288882113","https://openalex.org/I136199984","https://openalex.org/I4210087915"],"apc_list":null,"apc_paid":null,"fwci":8.6982,"has_fulltext":false,"cited_by_count":180,"citation_normalized_percentile":{"value":0.98055289,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"46","issue":"1","first_page":"107","last_page":"110"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12264","display_name":"Tissue Engineering and Regenerative Medicine","score":0.9330999851226807,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12264","display_name":"Tissue Engineering and Regenerative Medicine","score":0.9330999851226807,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10661","display_name":"biodegradable polymer synthesis and properties","score":0.051899999380111694,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10059","display_name":"Bone Tissue Engineering Materials","score":0.007000000216066837,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/heart-valve-tissue-engineering","display_name":"heart valve tissue engineering","score":0.9210000038146973},{"id":"https://openalex.org/keywords/biodegradable-scaffolds","display_name":"biodegradable scaffolds","score":0.8849999904632568},{"id":"https://openalex.org/keywords/polyglycolic-acid","display_name":"polyglycolic acid","score":0.9409999847412109},{"id":"https://openalex.org/keywords/polyhydroxyalkanoates","display_name":"polyhydroxyalkanoates","score":0.9860000014305115},{"id":"https://openalex.org/keywords/poly-4-hydroxybutyrate","display_name":"poly-4-hydroxybutyrate","score":0.9980000257492065},{"id":"https://openalex.org/keywords/salt-leaching","display_name":"salt leaching","score":0.8980000019073486},{"id":"https://openalex.org/keywords/cell-attachment","display_name":"cell attachment","score":0.6629999876022339},{"id":"https://openalex.org/keywords/collagen-content","display_name":"collagen content","score":0.6809999942779541},{"id":"https://openalex.org/keywords/thermoplastics","display_name":"thermoplastics","score":0.7789999842643738}],"concepts":[{"id":"https://openalex.org/C49892992","wikidata":"https://www.wikidata.org/wiki/Q1540285","display_name":"Tissue engineering","level":2,"score":0.7591958045959473},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.7105572819709778},{"id":"https://openalex.org/C2776229121","wikidata":"https://www.wikidata.org/wiki/Q215620","display_name":"Heart valve","level":2,"score":0.5961964726448059},{"id":"https://openalex.org/C79191276","wikidata":"https://www.wikidata.org/wiki/Q7259620","display_name":"Pulsatile flow","level":2,"score":0.5916858911514282},{"id":"https://openalex.org/C89429830","wikidata":"https://www.wikidata.org/wiki/Q735710","display_name":"Scaffold","level":2,"score":0.5704975128173828},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.5564268827438354},{"id":"https://openalex.org/C168170006","wikidata":"https://www.wikidata.org/wiki/Q864699","display_name":"Bioreactor","level":2,"score":0.5466310977935791},{"id":"https://openalex.org/C6648577","wikidata":"https://www.wikidata.org/wiki/Q622669","display_name":"Porosity","level":2,"score":0.4588615894317627},{"id":"https://openalex.org/C521977710","wikidata":"https://www.wikidata.org/wiki/Q81163","display_name":"Polymer","level":2,"score":0.4134077727794647},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.35397499799728394},{"id":"https://openalex.org/C159985019","wikidata":"https://www.wikidata.org/wiki/Q181790","display_name":"Composite material","level":1,"score":0.25122499465942383},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.1774851381778717},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.09879651665687561},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.08432433009147644},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001696","descriptor_name":"Biomechanical Phenomena","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001705","descriptor_name":"Bioprosthesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003094","descriptor_name":"Collagen","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D006350","descriptor_name":"Heart Valve Prosthesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008855","descriptor_name":"Microscopy, Electron, Scanning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011100","descriptor_name":"Polyglycolic Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012756","descriptor_name":"Sheep","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1097/00002480-200001000-00025","doi":"https://doi.org/10.1097/00002480-200001000-00025","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00002480-200001000-00025","pdf_url":null,"source":{"id":"https://openalex.org/S8999885","display_name":"ASAIO Journal","issn_l":"1058-2916","issn":["1058-2916","1538-943X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ASAIO Journal","raw_type":"journal-article"},{"id":"pmid:10667727","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10667727","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ASAIO journal (American Society for Artificial Internal Organs : 1992)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.5683000087738037,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":17,"referenced_works":["https://openalex.org/W66848992","https://openalex.org/W158909985","https://openalex.org/W1973296676","https://openalex.org/W1997667641","https://openalex.org/W2004181539","https://openalex.org/W2052932770","https://openalex.org/W2063140651","https://openalex.org/W2066419026","https://openalex.org/W2068518690","https://openalex.org/W2125565090","https://openalex.org/W2141043799","https://openalex.org/W2315476483","https://openalex.org/W2328536190","https://openalex.org/W2460816575","https://openalex.org/W2982920185","https://openalex.org/W4211147424","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W2106408936","https://openalex.org/W1996635343","https://openalex.org/W2351391337","https://openalex.org/W6967364522","https://openalex.org/W1931684896","https://openalex.org/W2389503522","https://openalex.org/W2176107140","https://openalex.org/W2366984745","https://openalex.org/W2070204604","https://openalex.org/W2952890697"],"abstract_inverted_index":{"A":[0],"crucial":[1],"factor":[2],"in":[3,69,169],"tissue":[4,37,297],"engineering":[5,38,298],"of":[6,12,39,88,134,267,292,299],"heart":[7,40,60,155,182,300],"valves":[8],"is":[9],"the":[10,16,78,109,191,217,234,275,290],"type":[11],"scaffold":[13,24,184,295],"material.":[14],"In":[15,74],"following":[17],"study,":[18],"we":[19,76],"tested":[20,67],"three":[21],"different":[22],"biodegradable":[23],"materials,":[25],"polyglycolic":[26],"acid":[27],"(PGA),":[28],"polyhydroxyalkanoate":[29],"(PHA),":[30],"and":[31,45,66,107,118,140,146,161,166,189,194,209,240,244,256,260,270,273],"poly-4-hydroxybutyrate":[32],"(P4HB),":[33],"as":[34],"scaffolds":[35,62,157],"for":[36,112,130,296],"valves.":[41,301],"We":[42,57,152],"modified":[43],"PHA":[44,160,208,255,259],"P4HB":[46,239,261],"by":[47,84],"a":[48,54,70,170,179,225,264,293],"salt":[49],"leaching":[50],"technique":[51],"to":[52,81,127,177,286],"create":[53,178],"porous":[55,159,162],"matrix.":[56],"constructed":[58],"trileaflet":[59,154,181],"valve":[61,156,183],"from":[63,158,185],"each":[64,89,100],"polymer":[65],"them":[68,288],"pulsatile":[71,171],"flow":[72,129,142,220],"bioreactor.":[73,172],"addition,":[75],"evaluated":[77],"cell":[79,268],"attachment":[80,243,269],"our":[82],"polymers":[83],"creating":[85],"four":[86],"tubes":[87],"material":[90],"(length":[91],"equals":[92],"4":[93],"cm;":[94],"inner":[95],"diameter,":[96],"0.5":[97],"cm),":[98],"seeding":[99,188],"sample":[101],"with":[102,207,238,254],"8,000,000":[103],"ovine":[104],"vascular":[105,123],"cells,":[106],"incubating":[108,190],"cell-polymer":[110],"construct":[111],"8":[113],"days":[114],"(37":[115],"degrees":[116],"C":[117],"5%":[119],"CO2).":[120],"The":[121],"seeded":[122],"constructs":[124],"were":[125,197,212],"exposed":[126],"continuous":[128],"1":[131],"hour.":[132],"Analysis":[133],"samples":[135,236,252],"included":[136],"DNA":[137],"assay":[138],"before":[139],"after":[141,219],"exposure,":[143,221],"4-hydroxyproline":[144],"assay,":[145],"environmental":[147],"scanning":[148],"electron":[149],"microscopy":[150],"(ESEM).":[151],"fabricated":[153],"P4HB,":[163],"which":[164],"opened":[165],"closed":[167],"synchronously":[168],"It":[173],"was":[174,224,247],"not":[175],"possible":[176,285],"functional":[180,294],"PGA.":[186],"After":[187],"PGA-,":[192],"PHA-,":[193],"P4HB-tubes,":[195],"there":[196,223],"significantly":[198,226,248],"(p":[199,230],"<":[200,231],"0.001)":[201],"more":[202],"cells":[203],"on":[204,233,250],"PGA":[205,235,251],"compared":[206,237,253],"P4HB.":[210,257],"There":[211],"no":[213],"significant":[214],"differences":[215],"among":[216],"materials":[218,280],"but":[222],"higher":[227,249],"collagen":[228,245,271],"content":[229,246],"0.017)":[232],"PHA.":[241],"Cell":[242],"However,":[258],"also":[262],"demonstrate":[263],"considerable":[265],"amount":[266],"development":[272],"share":[274],"major":[276],"advantage":[277],"that":[278],"both":[279],"are":[281],"thermoplastic,":[282],"making":[283],"it":[284],"mold":[287],"into":[289],"shape":[291]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":8},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":9},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":9},{"year":2012,"cited_by_count":7}],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2016-06-24T00:00:00"}